SMT201400013B - Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici - Google Patents

Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici

Info

Publication number
SMT201400013B
SMT201400013B SM201400013T SM201400013T SMT201400013B SM T201400013 B SMT201400013 B SM T201400013B SM 201400013 T SM201400013 T SM 201400013T SM 201400013 T SM201400013 T SM 201400013T SM T201400013 B SMT201400013 B SM T201400013B
Authority
SM
San Marino
Prior art keywords
tieno
ampk
activators
therapeutic uses
dione
Prior art date
Application number
SM201400013T
Other languages
English (en)
Italian (it)
Inventor
Daniel Cravo
Sophie Hallakou-Bozec
Sebastien Bolze
Franck Lepifre
Laurent Faveriel
Jean-Denis Durand
Christine Charon
Original Assignee
Poxel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poxel filed Critical Poxel
Publication of SMT201400013B publication Critical patent/SMT201400013B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM201400013T 2009-12-29 2014-01-29 Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici SMT201400013B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09306344 2009-12-29
PCT/EP2010/070811 WO2011080277A1 (en) 2009-12-29 2010-12-28 Thieno [2,3-b] pyridinedione activators of ampk and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
SMT201400013B true SMT201400013B (it) 2014-05-07

Family

ID=41691577

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201400013T SMT201400013B (it) 2009-12-29 2014-01-29 Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici

Country Status (24)

Country Link
US (1) US9365584B2 (me)
EP (1) EP2519527B1 (me)
JP (1) JP5559894B2 (me)
KR (1) KR101469002B1 (me)
CN (1) CN102803269B (me)
AU (1) AU2010338280B2 (me)
BR (1) BR112012016330B8 (me)
CA (1) CA2784553C (me)
CY (1) CY1114952T1 (me)
DK (1) DK2519527T3 (me)
EA (1) EA020588B1 (me)
ES (1) ES2445537T3 (me)
HR (1) HRP20140035T1 (me)
IL (1) IL220432A (me)
ME (1) ME01558B (me)
MX (1) MX2012007548A (me)
PL (1) PL2519527T3 (me)
PT (1) PT2519527E (me)
RS (1) RS53282B (me)
SI (1) SI2519527T1 (me)
SM (1) SMT201400013B (me)
TW (1) TWI574968B (me)
WO (1) WO2011080277A1 (me)
ZA (1) ZA201205604B (me)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855372C (en) * 2011-11-11 2022-03-22 Nimbus Apollo, Inc. 2,4-dioxo-thieno[2,3-d]pyrimidinyl derivatives and pharmaceutical compositions thereof used as acc inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk
US10143703B2 (en) 2014-01-02 2018-12-04 Massachusetts Eye And Ear Infirmary Treating ocular neovascularization
WO2017011917A1 (en) * 2015-07-23 2017-01-26 Thrasos Therapeutics Inc. Methods for treating and preventing polycystic kidney diseases (pkd) using amp-activated protein kinase (ampk) modulators and activators
AR106472A1 (es) 2015-10-26 2018-01-17 Gilead Apollo Llc Inhibidores de acc y usos de los mismos
CN108349995B (zh) 2015-11-25 2021-08-03 吉利德阿波罗公司 吡唑acc抑制剂及其用途
PL3380479T3 (pl) 2015-11-25 2023-05-08 Gilead Apollo, Llc Triazolowe inhibitory acc i ich zastosowania
WO2017091602A1 (en) 2015-11-25 2017-06-01 Gilead Apollo, Llc Ester acc inhibitors and uses thereof
EA201890910A1 (ru) 2015-11-25 2018-11-30 Джилид Аполло, Ллс ФУНГИЦИДНЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ПРОИЗВОДНЫЕ 2,4-ДИОКСО-1,4-ДИГИДРОТИЕНО[2,3-d]ПИРИМИДИНА
TWI818828B (zh) 2016-03-02 2023-10-11 美商基利阿波羅有限責任公司 噻吩并嘧啶二酮ａｃｃ抑制劑之固體型式及其製造方法
TWI680122B (zh) * 2016-09-07 2019-12-21 國立陽明大學 活化腺苷單磷酸活化蛋白激酶之化合物
EP4122464B1 (en) 2017-03-28 2024-05-15 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases
WO2019185413A1 (en) 2018-03-27 2019-10-03 Basf Se Pesticidal substituted cyclopropyl derivatives
UY39222A (es) 2020-05-19 2021-11-30 Kallyope Inc Activadores de la ampk
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators
CN116322663A (zh) 2020-09-30 2023-06-23 比奥维拉迪维治疗股份有限公司 Ampk激活剂及其使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7119205B2 (en) 2003-05-16 2006-10-10 Abbott Laboratories Thienopyridones as AMPK activators for the treatment of diabetes and obesity
DK2262500T3 (en) * 2008-04-11 2016-08-15 Merck Patent Gmbh THIENOPYRIDON DERIVATIVES AS AMP-ACTIVATED PROTEINKINASE (AMPK) ACTIVATORS

Also Published As

Publication number Publication date
CY1114952T1 (el) 2016-12-14
BR112012016330B8 (pt) 2021-05-25
SI2519527T1 (sl) 2014-06-30
WO2011080277A1 (en) 2011-07-07
JP5559894B2 (ja) 2014-07-23
BR112012016330A2 (pt) 2018-04-03
RS53282B (en) 2014-08-29
ZA201205604B (en) 2013-05-29
ME01558B (me) 2014-04-20
AU2010338280A1 (en) 2012-07-26
EP2519527A1 (en) 2012-11-07
HRP20140035T1 (hr) 2014-02-14
BR112012016330B1 (pt) 2021-03-23
KR20120120232A (ko) 2012-11-01
US9365584B2 (en) 2016-06-14
CA2784553C (en) 2014-08-19
IL220432A (en) 2015-02-26
EA201200975A1 (ru) 2012-12-28
TWI574968B (zh) 2017-03-21
PT2519527E (pt) 2014-02-17
ES2445537T3 (es) 2014-03-03
EP2519527B1 (en) 2013-12-18
EA020588B1 (ru) 2014-12-30
AU2010338280B2 (en) 2013-08-22
KR101469002B1 (ko) 2014-12-04
DK2519527T3 (da) 2014-01-27
US20130053401A1 (en) 2013-02-28
JP2013515758A (ja) 2013-05-09
TW201144318A (en) 2011-12-16
CN102803269A (zh) 2012-11-28
PL2519527T3 (pl) 2014-06-30
CA2784553A1 (en) 2011-07-07
CN102803269B (zh) 2016-01-13
MX2012007548A (es) 2012-07-23

Similar Documents

Publication Publication Date Title
SMT201400013B (it) Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici
HK1253364A1 (zh) 1h-吡唑並[3，4-b]吡啶及其治療應用
HK1222520A1 (zh) 發刷及其使用方法與製造方法
BRPI0919292A2 (pt) 3h-imidazo[4,5-b] piridina-6-carboxamidas como agentes anti-inflamatórios
IL216609A0 (en) Preparation and uses of 1,2,4-triazolo [1,5a] pyridine derivatives
BRPI1009118A2 (pt) 3h-imidazo[4,5-c] piridina-6-carboxamidas como agentes anti-inflamatórios
HK1187606A1 (zh) 取代的 -稠合含氮雜環化合物及其用途
BR112013015959A2 (pt) Derivados de 2-arilimidazo [1,2-b] piridazina, 2- fenilimidazo [1,2-a] piridina, e 2-fenilimidazo [1,2-a] pirazina.
DK2229391T3 (da) Pyrido[2,3-B]pyrazin-8-substituerede forbindelser og deres anvendelse
DK2172240T3 (da) Kraftmålende kateter med forbundet midterstiver
HK1148686A1 (en) Vitamin e derivatives and their uses
IL211892A0 (en) Pyrazolo pyridine derivatives, compositions comprising the same and uses thereof
BR112013012965A2 (pt) derivados de imidazo (1,2-b] piridazina e imidazo [4, 5 -b] piridina como inibidores de jak
IL211890A0 (en) Pyrazolo pyridine derivatives, compositions comprising the same and uses thereof
IL211889A0 (en) Pyrazolo pyridine derivatives, compositions comprising the same and uses thereof
BRPI1014459A2 (pt) derivados de 3-(1,2,3-triazol-4-il)pirrolo[2,3-b]-piridina"
BRPI0818658A2 (pt) Derivados de piridina úteis como ativadores de glicoquinase
NO20081642L (no) Kraftverk, fremgangsmåte for kraftproduksjon, samt anvendelse av kraftverket.
IT1393337B1 (it) Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
IL211891A0 (en) Pyrazolo pyridine derivatives, compositions comprising the same and uses thereof
IL201264A0 (en) Neuraminic acid derivatives and methods of manufacturing the same
SMT201500273B (it) Diidroetorfine e loro preparazione
BRPI0818121A2 (pt) diespiro 1,2,4-trioxolano e seus métodos de fabricação e utilização
PL2603217T3 (pl) Nowe pochodne 6,7-dipodstawionej izochinoliny i ich zastosowanie
IL246841A0 (en) Bicyclic derivatives [2,2,2] and methods of use