PL2603217T3 - Nowe pochodne 6,7-dipodstawionej izochinoliny i ich zastosowanie - Google Patents

Nowe pochodne 6,7-dipodstawionej izochinoliny i ich zastosowanie

Info

Publication number
PL2603217T3
PL2603217T3 PL11770473T PL11770473T PL2603217T3 PL 2603217 T3 PL2603217 T3 PL 2603217T3 PL 11770473 T PL11770473 T PL 11770473T PL 11770473 T PL11770473 T PL 11770473T PL 2603217 T3 PL2603217 T3 PL 2603217T3
Authority
PL
Poland
Prior art keywords
disubstituted
novel
isoquinoline derivatives
isoquinoline
derivatives
Prior art date
Application number
PL11770473T
Other languages
English (en)
Inventor
Ville Takio
Matti Ekholm
Original Assignee
Montisera Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Montisera Ltd filed Critical Montisera Ltd
Publication of PL2603217T3 publication Critical patent/PL2603217T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL11770473T 2010-08-11 2011-08-10 Nowe pochodne 6,7-dipodstawionej izochinoliny i ich zastosowanie PL2603217T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10397511A EP2420237A1 (en) 2010-08-11 2010-08-11 Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways
EP11770473.4A EP2603217B1 (en) 2010-08-11 2011-08-10 Novel 6,7-disubstituted-isoquinoline derivatives and their use
PCT/FI2011/050707 WO2012020170A1 (en) 2010-08-11 2011-08-10 Novel 6,7-disubstituted-isoquinoline derivatives and their use

Publications (1)

Publication Number Publication Date
PL2603217T3 true PL2603217T3 (pl) 2015-09-30

Family

ID=43827823

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11770473T PL2603217T3 (pl) 2010-08-11 2011-08-10 Nowe pochodne 6,7-dipodstawionej izochinoliny i ich zastosowanie

Country Status (16)

Country Link
US (1) US8815898B2 (pl)
EP (2) EP2420237A1 (pl)
CN (1) CN103179971A (pl)
CA (1) CA2808016C (pl)
CY (1) CY1116588T1 (pl)
DK (1) DK2603217T3 (pl)
ES (1) ES2541401T3 (pl)
HR (1) HRP20150668T1 (pl)
HU (1) HUE026482T2 (pl)
PL (1) PL2603217T3 (pl)
PT (1) PT2603217E (pl)
RS (1) RS54081B1 (pl)
RU (1) RU2636938C2 (pl)
SI (1) SI2603217T1 (pl)
SM (1) SMT201500160B (pl)
WO (1) WO2012020170A1 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105585527B (zh) * 2015-12-17 2018-06-26 浙江工业大学 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用
CN105461626B (zh) * 2015-12-17 2018-05-08 浙江工业大学 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用
FI130627B (en) 2021-03-31 2023-12-18 Equinorm Ltd Novel heterocyclic compounds and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2716548B2 (ja) * 1989-11-01 1998-02-18 雅昭 廣部 パーキンソニズム予防・治療剤
DE9017900U1 (de) 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 55218 Ingelheim 3,4-Dihydro-1-benzyl-6,7-dimethoxy-α- [di-2-(2,3,4-trimethoxyphenyl)ethyl] aminocarbonyl-isochinolin
US5491148A (en) 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
EP0929527B1 (en) 1996-09-27 2004-10-27 Aventis Pharmaceuticals Inc. Pictet-spengler reaction for the synthesis of tetrahydroisoquinolines and related heterocyclic compounds
KR20080065707A (ko) * 1999-11-03 2008-07-14 에이엠알 테크놀로지, 인크. 4-페닐-치환 테트라히드로이소퀴놀린, 및 노르에피네프린과도파민과 세로토닌의 재흡수를 차단하기 위한 이의 용도
WO2006035280A1 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited 3,4-dihydroisoquinoline compounds as muscrinic receptor antagonists for the treatment of respiratory, urinary and gastrointestinal diseases
US20060111393A1 (en) * 2004-11-22 2006-05-25 Molino Bruce F 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
EP2090576A1 (en) * 2008-02-01 2009-08-19 Merz Pharma GmbH & Co.KGaA 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators

Also Published As

Publication number Publication date
DK2603217T3 (en) 2015-07-13
CA2808016A1 (en) 2012-02-16
SMT201500160B (it) 2015-09-07
ES2541401T3 (es) 2015-07-20
CN103179971A (zh) 2013-06-26
WO2012020170A1 (en) 2012-02-16
EP2603217B1 (en) 2015-04-08
RS54081B1 (sr) 2015-10-30
US8815898B2 (en) 2014-08-26
PT2603217E (pt) 2015-08-26
EP2603217A1 (en) 2013-06-19
SI2603217T1 (sl) 2015-08-31
HUE026482T2 (en) 2016-06-28
CA2808016C (en) 2018-10-30
RU2013110377A (ru) 2014-09-20
CY1116588T1 (el) 2017-03-15
EP2420237A1 (en) 2012-02-22
RU2636938C2 (ru) 2017-11-29
US20130137719A1 (en) 2013-05-30
HRP20150668T1 (hr) 2015-09-11

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