SK285076B6 - Chinolinylpiperidin-4-ylidénmetylbenzamidové deriváty, ich použitie a farmaceutické kompozície s ich obsahom - Google Patents
Chinolinylpiperidin-4-ylidénmetylbenzamidové deriváty, ich použitie a farmaceutické kompozície s ich obsahom Download PDFInfo
- Publication number
- SK285076B6 SK285076B6 SK1424-2002A SK14242002A SK285076B6 SK 285076 B6 SK285076 B6 SK 285076B6 SK 14242002 A SK14242002 A SK 14242002A SK 285076 B6 SK285076 B6 SK 285076B6
- Authority
- SK
- Slovakia
- Prior art keywords
- compound
- methyl
- quinolinyl
- benzamide
- diethyl
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- YUPPDBUZMGCMLI-UHFFFAOYSA-N 2-methyl-n-piperidin-4-ylidene-3-quinolin-2-ylbenzamide Chemical class C1=CC=C(C=2N=C3C=CC=CC3=CC=2)C(C)=C1C(=O)N=C1CCNCC1 YUPPDBUZMGCMLI-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 64
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 12
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 208000002193 Pain Diseases 0.000 claims abstract description 9
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 8
- 230000036407 pain Effects 0.000 claims abstract description 7
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229910052794 bromium Inorganic materials 0.000 claims abstract description 5
- 125000002541 furyl group Chemical group 0.000 claims abstract description 5
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 5
- 125000001424 substituent group Chemical group 0.000 claims abstract description 5
- 125000001544 thienyl group Chemical group 0.000 claims abstract description 5
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 3
- 239000011630 iodine Substances 0.000 claims abstract description 3
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 3
- 125000001425 triazolyl group Chemical group 0.000 claims abstract description 3
- -1 CF 3 Chemical group 0.000 claims description 24
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 16
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000018522 Gastrointestinal disease Diseases 0.000 claims description 3
- XZKPIIQIENCHBC-UHFFFAOYSA-N N1=C(C=CC2=CC=CC=C12)C=1C(=C(C(=O)N)C=CC1)C=C1CCNCC1 Chemical class N1=C(C=CC2=CC=CC=C12)C=1C(=C(C(=O)N)C=CC1)C=C1CCNCC1 XZKPIIQIENCHBC-UHFFFAOYSA-N 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
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- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- OMRRUNXAWXNVFW-UHFFFAOYSA-N fluoridochlorine Chemical compound ClF OMRRUNXAWXNVFW-UHFFFAOYSA-N 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 239000000460 chlorine Substances 0.000 abstract description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract description 3
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- 229910052801 chlorine Inorganic materials 0.000 abstract description 3
- 239000011737 fluorine Substances 0.000 abstract description 3
- 229910052731 fluorine Inorganic materials 0.000 abstract description 3
- 125000004122 cyclic group Chemical group 0.000 abstract description 2
- 238000006467 substitution reaction Methods 0.000 abstract description 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 7
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- YAJMDTQJMYBPOP-UHFFFAOYSA-N n,n-diethyl-4-[piperidin-4-ylidene(quinolin-8-yl)methyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C2=NC=CC=C2C=CC=1)=C1CCNCC1 YAJMDTQJMYBPOP-UHFFFAOYSA-N 0.000 description 6
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- BRAQYUZYDPJYAJ-UHFFFAOYSA-N tert-butyl 4-[bromo-[4-(diethylcarbamoyl)phenyl]methylidene]piperidine-1-carboxylate Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(Br)=C1CCN(C(=O)OC(C)(C)C)CC1 BRAQYUZYDPJYAJ-UHFFFAOYSA-N 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
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- ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0001208A SE0001208D0 (sv) | 2000-04-04 | 2000-04-04 | Novel compounds |
| PCT/SE2001/000708 WO2001074806A1 (en) | 2000-04-04 | 2001-03-30 | Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK14242002A3 SK14242002A3 (sk) | 2003-06-03 |
| SK285076B6 true SK285076B6 (sk) | 2006-05-04 |
Family
ID=20279147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1424-2002A SK285076B6 (sk) | 2000-04-04 | 2001-03-30 | Chinolinylpiperidin-4-ylidénmetylbenzamidové deriváty, ich použitie a farmaceutické kompozície s ich obsahom |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6753335B2 (enExample) |
| EP (1) | EP1286986B1 (enExample) |
| JP (1) | JP2003529598A (enExample) |
| KR (1) | KR100755153B1 (enExample) |
| CN (1) | CN1182134C (enExample) |
| AR (1) | AR029823A1 (enExample) |
| AT (1) | ATE289603T1 (enExample) |
| AU (2) | AU2001244982B2 (enExample) |
| BR (1) | BR0109817A (enExample) |
| CA (1) | CA2403600A1 (enExample) |
| CZ (1) | CZ20023288A3 (enExample) |
| DE (1) | DE60109032T2 (enExample) |
| EE (1) | EE200200577A (enExample) |
| ES (1) | ES2236203T3 (enExample) |
| HU (1) | HUP0300402A3 (enExample) |
| IL (1) | IL151891A0 (enExample) |
| IS (1) | IS6574A (enExample) |
| MX (1) | MXPA02009759A (enExample) |
| NO (1) | NO323466B1 (enExample) |
| NZ (1) | NZ522143A (enExample) |
| PL (1) | PL357770A1 (enExample) |
| PT (1) | PT1286986E (enExample) |
| RU (1) | RU2002125506A (enExample) |
| SE (1) | SE0001208D0 (enExample) |
| SK (1) | SK285076B6 (enExample) |
| WO (1) | WO2001074806A1 (enExample) |
| ZA (1) | ZA200207973B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| SE0101765D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101766D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0101768D0 (sv) | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| SE0103313D0 (sv) | 2001-10-03 | 2001-10-03 | Astrazeneca Ab | Novel compounds |
| PL372096A1 (en) | 2002-01-02 | 2005-07-11 | Ardent Pharmaceuticals, Inc. | Method of treating sexual dysfunctions with delta opioid receptor agonist compounds |
| SE0301441D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| RU2005136524A (ru) * | 2003-05-16 | 2006-06-27 | Астразенека Аб (Se) | Производные диарилметилиденпиперидина, способы их получения и их применение |
| SE0301442D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| CN1890208A (zh) * | 2003-12-12 | 2007-01-03 | 伊莱利利公司 | 类鸦片受体拮抗剂 |
| SE0400026D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0402485D0 (sv) | 2004-10-13 | 2004-10-13 | Astrazeneca Ab | Polymorph of N,N-Diethyl-4-(3-Fluorophenyl-Piperidin-4-Ylidene-Methyl)-Benzamide Hydrochloride salt |
| MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5140029A (en) | 1989-01-09 | 1992-08-18 | Janssen Pharmaceutica N.V. | 2-aminopyrimidinone derivatives |
| US4939137A (en) | 1989-06-28 | 1990-07-03 | Ortho Pharmaceutical Corporation | Ring-fused thienopyrimidinedione derivatives |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5574159A (en) | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| SE9504661D0 (sv) | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| TW548271B (en) * | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| CA2316341A1 (en) | 1997-12-24 | 1999-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor |
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2000
- 2000-04-04 SE SE0001208A patent/SE0001208D0/xx unknown
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2001
- 2001-03-28 AR ARP010101478A patent/AR029823A1/es not_active Application Discontinuation
- 2001-03-30 CZ CZ20023288A patent/CZ20023288A3/cs unknown
- 2001-03-30 NZ NZ522143A patent/NZ522143A/en unknown
- 2001-03-30 DE DE60109032T patent/DE60109032T2/de not_active Expired - Fee Related
- 2001-03-30 IL IL15189101A patent/IL151891A0/xx unknown
- 2001-03-30 CA CA002403600A patent/CA2403600A1/en not_active Abandoned
- 2001-03-30 PL PL01357770A patent/PL357770A1/xx not_active Application Discontinuation
- 2001-03-30 EE EEP200200577A patent/EE200200577A/xx unknown
- 2001-03-30 SK SK1424-2002A patent/SK285076B6/sk unknown
- 2001-03-30 US US10/240,114 patent/US6753335B2/en not_active Expired - Fee Related
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- 2001-03-30 WO PCT/SE2001/000708 patent/WO2001074806A1/en not_active Ceased
- 2001-03-30 RU RU2002125506/04A patent/RU2002125506A/ru not_active Application Discontinuation
- 2001-03-30 EP EP01918114A patent/EP1286986B1/en not_active Expired - Lifetime
- 2001-03-30 ES ES01918114T patent/ES2236203T3/es not_active Expired - Lifetime
- 2001-03-30 KR KR1020027013208A patent/KR100755153B1/ko not_active Expired - Fee Related
- 2001-03-30 AT AT01918114T patent/ATE289603T1/de not_active IP Right Cessation
- 2001-03-30 CN CNB018104231A patent/CN1182134C/zh not_active Expired - Fee Related
- 2001-03-30 JP JP2001572496A patent/JP2003529598A/ja not_active Abandoned
- 2001-03-30 HU HU0300402A patent/HUP0300402A3/hu unknown
- 2001-03-30 MX MXPA02009759A patent/MXPA02009759A/es active IP Right Grant
- 2001-03-30 PT PT01918114T patent/PT1286986E/pt unknown
- 2001-03-30 BR BR0109817-9A patent/BR0109817A/pt not_active IP Right Cessation
- 2001-03-30 AU AU4498201A patent/AU4498201A/xx active Pending
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2002
- 2002-09-30 IS IS6574A patent/IS6574A/is unknown
- 2002-10-03 NO NO20024777A patent/NO323466B1/no unknown
- 2002-10-03 ZA ZA200207973A patent/ZA200207973B/en unknown
Also Published As
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