SK284858B6 - Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe - Google Patents

Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe Download PDF

Info

Publication number
SK284858B6
SK284858B6 SK269-2001A SK2692001A SK284858B6 SK 284858 B6 SK284858 B6 SK 284858B6 SK 2692001 A SK2692001 A SK 2692001A SK 284858 B6 SK284858 B6 SK 284858B6
Authority
SK
Slovakia
Prior art keywords
ethyl
fluorophenyl
acid
sleep
dimethoxyphenyl
Prior art date
Application number
SK269-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK2692001A3 (en
Inventor
Cesare Mondadori
Stephen M. Sorensen
Janice M. Hitchcock
Original Assignee
Aventis Pharmaceuticals Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharmaceuticals Inc. filed Critical Aventis Pharmaceuticals Inc.
Publication of SK2692001A3 publication Critical patent/SK2692001A3/sk
Publication of SK284858B6 publication Critical patent/SK284858B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK269-2001A 1998-08-28 1999-07-29 Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe SK284858B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14313598A 1998-08-28 1998-08-28
PCT/US1999/017331 WO2000012090A1 (en) 1998-08-28 1999-07-29 THE USE OF R(+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL FOR THE TREATMENT OF SLEEP DISORDERS

Publications (2)

Publication Number Publication Date
SK2692001A3 SK2692001A3 (en) 2001-07-10
SK284858B6 true SK284858B6 (sk) 2006-01-05

Family

ID=22502745

Family Applications (1)

Application Number Title Priority Date Filing Date
SK269-2001A SK284858B6 (sk) 1998-08-28 1999-07-29 Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe

Country Status (32)

Country Link
EP (2) EP1105132B1 (ko)
JP (1) JP2002523460A (ko)
KR (3) KR100764532B1 (ko)
CN (1) CN1127954C (ko)
AT (1) ATE249830T1 (ko)
AU (1) AU764604B2 (ko)
BG (2) BG109953A (ko)
BR (1) BR9913242A (ko)
CA (2) CA2629396A1 (ko)
CZ (1) CZ300781B6 (ko)
DE (2) DE69911436T2 (ko)
DK (1) DK1105132T3 (ko)
EA (1) EA003791B1 (ko)
EE (1) EE04951B1 (ko)
ES (1) ES2204146T3 (ko)
HK (1) HK1040907B (ko)
HR (2) HRP20010140A2 (ko)
HU (1) HUP0202145A3 (ko)
ID (1) ID29601A (ko)
IL (2) IL141603A0 (ko)
ME (1) MEP20308A (ko)
MX (1) MXPA01002026A (ko)
NO (2) NO20010984L (ko)
NZ (1) NZ510083A (ko)
PL (1) PL195022B1 (ko)
PT (1) PT1105132E (ko)
SK (1) SK284858B6 (ko)
TR (1) TR200100670T2 (ko)
TW (1) TWI233802B (ko)
UA (1) UA74773C2 (ko)
WO (1) WO2000012090A1 (ko)
ZA (1) ZA200101466B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099076A1 (en) * 2000-05-25 2002-07-25 Richard Scheyer D. Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
KR20050025628A (ko) 2002-07-19 2005-03-14 바이오비트럼 에이비 5-ｈｔ2ａ 수용체 관련 장애의 치료를 위한 신규피페라지닐-피라지논 유도체

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169096A (en) 1985-07-02 1992-12-08 Merrell Dow Pharmaceuticals Inc. N-aralkyl-piperidine-methanol derivatives
US4877798A (en) * 1987-11-23 1989-10-31 Merrell Dow Pharmaceuticals Inc. Treatment of fibromyalgia
ATE102482T1 (de) * 1988-01-21 1994-03-15 Merrell Dow Pharma Verwendung von 1,4-disubstituierten-piperidinyl- verbindungen zur herstellung eines arzneimittels zur behandlung von schlaflosigkeit.
JP2869512B2 (ja) 1990-06-01 1999-03-10 メレルダウファーマスーティカルズ インコーポレイテッド （＋）―α―（２，３―ジメトキシフェニル）―１―［２―（４―フルオロフェニル）エチル］―４―ピペリジンメタノール
JPH05134149A (ja) * 1991-11-08 1993-05-28 Nippondenso Co Ltd 光半導体モジユール
US5618824A (en) * 1994-03-09 1997-04-08 Merrell Pharmaceuticals Inc. Treatment of obsessive-compulsive disorders with 5-HT2 antagonists
EP0796619A1 (en) * 1996-03-21 1997-09-24 Merrell Pharmaceuticals Inc. Use of (+)-alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US9702597B1 (en) 2016-02-18 2017-07-11 King Fahd University Of Petroleum And Minerals System and method for preventing absorbent crystallization in a continuously operating solar-powered absorption cooling system with hybrid storage

Also Published As

Publication number Publication date
CZ300781B6 (cs) 2009-08-12
KR100682799B1 (ko) 2007-02-15
TR200100670T2 (tr) 2001-06-21
SK2692001A3 (en) 2001-07-10
NO20010984L (no) 2001-04-25
DE69911436T2 (de) 2004-07-01
HK1040907A1 (en) 2002-06-28
DK1105132T3 (da) 2003-11-24
EE200100122A (et) 2002-06-17
EA200100201A1 (ru) 2001-08-27
JP2002523460A (ja) 2002-07-30
IL141603A (en) 2006-08-20
PT1105132E (pt) 2004-02-27
EP1105132B1 (en) 2003-09-17
BG65416B1 (bg) 2008-07-31
HRP20010140A2 (en) 2002-02-28
KR100764532B1 (ko) 2007-10-09
WO2000012090A1 (en) 2000-03-09
BG109953A (en) 2007-12-28
CZ2001726A3 (en) 2001-06-13
MXPA01002026A (es) 2003-03-27
EA003791B1 (ru) 2003-10-30
EP1105132A1 (en) 2001-06-13
AU764604B2 (en) 2003-08-21
EP1362589B1 (en) 2009-07-15
CA2629396A1 (en) 2000-03-09
BG105289A (en) 2001-11-30
CN1315861A (zh) 2001-10-03
DE69911436D1 (de) 2003-10-23
ATE249830T1 (de) 2003-10-15
EP1362589A1 (en) 2003-11-19
EE04951B1 (et) 2008-02-15
HRP20080389A2 (en) 2008-11-30
HK1040907B (zh) 2004-04-02
HUP0202145A2 (hu) 2003-01-28
ID29601A (id) 2001-09-06
NO20091111L (no) 2001-04-25
NZ510083A (en) 2003-08-29
IL141603A0 (en) 2002-03-10
HUP0202145A3 (en) 2003-02-28
MEP20308A (en) 2010-06-10
ZA200101466B (en) 2002-05-21
KR20060023197A (ko) 2006-03-13
KR20060057029A (ko) 2006-05-25
ES2204146T3 (es) 2004-04-16
TWI233802B (en) 2005-06-11
AU5135999A (en) 2000-03-21
KR20010073026A (ko) 2001-07-31
KR100735513B1 (ko) 2007-07-06
PL195022B1 (pl) 2007-08-31
CA2341891C (en) 2009-05-12
PL346342A1 (en) 2002-02-11
CA2341891A1 (en) 2000-03-09
DE69941134D1 (de) 2009-08-27
UA74773C2 (en) 2006-02-15
CN1127954C (zh) 2003-11-19
NO20010984D0 (no) 2001-02-27
BR9913242A (pt) 2001-05-15

Similar Documents

Publication Publication Date Title
EP1003373B1 (en) Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
JP3861250B2 (ja) ５−ｈｔ２拮抗剤による強迫性障害処置剤
US6277864B1 (en) Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
EP0888114B1 (en) Use of (+)-alpha-(2,3-dimethoxyphenyl)-1- 2-(4-fluorophenyl)ethyl]-4-piperidinemethanol in treating depressive disorders and bipolar disorders
US20050272773A1 (en) Use of R (+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-flurophenyl)-ethyl]-4- piperidinemethanol for the treatment of sleep disorders and process for making pharmaceutical composition
JP2011506353A (ja) セロトニントランスポーター、セロトニン受容体およびノルアドレナリントランスポーターに親和性を有する化合物の治療的使用
SK284858B6 (sk) Použitie R-(+)-alfa-(2,3-dimetoxyfenyl)-1-[2-(4-fluórfenyl)etyl]- 4-piperidínmetanolu na prípravu liečiva na liečenie obštrukčného spánkového apnoe
JP2009504760A (ja) 催眠剤及びＲ（＋）−α−（２，３−ジメトキシ−フェニル）−１−［２−（４−フルオロフェニル）エチル］−４−ピペリジンメタノールの組み合わせ物並びに治療でのその使用
WO2002016347A1 (en) Active metabolite of gepirone
JPH056526B2 (ko)

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100729