SK283637B6 - Substituované chinoxalín-2,3-diónové deriváty, farmaceutický prípravok obsahujúci tieto deriváty, ich medicínske použitie a medziprodukt na ich výrobu - Google Patents
Substituované chinoxalín-2,3-diónové deriváty, farmaceutický prípravok obsahujúci tieto deriváty, ich medicínske použitie a medziprodukt na ich výrobu Download PDFInfo
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- SK283637B6 SK283637B6 SK1589-97A SK158997A SK283637B6 SK 283637 B6 SK283637 B6 SK 283637B6 SK 158997 A SK158997 A SK 158997A SK 283637 B6 SK283637 B6 SK 283637B6
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- alkyl
- carbon atoms
- aralkyl
- hydroxy
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- SEPKUNXLGWMPHL-UHFFFAOYSA-N quinoxaline-2,3-dione Chemical class C1=CC=CC2=NC(=O)C(=O)N=C21 SEPKUNXLGWMPHL-UHFFFAOYSA-N 0.000 title claims abstract description 30
- 239000000825 pharmaceutical preparation Chemical class 0.000 title 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 11
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
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- 125000000217 alkyl group Chemical group 0.000 claims description 55
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 33
- 125000004432 carbon atom Chemical group C* 0.000 claims description 30
- 229910052739 hydrogen Inorganic materials 0.000 claims description 30
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 30
- 239000001257 hydrogen Substances 0.000 claims description 27
- -1 1,3-benzodioxol-5-yl group Chemical group 0.000 claims description 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 239000002253 acid Substances 0.000 claims description 17
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- 150000003839 salts Chemical class 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 13
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 10
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 239000011593 sulfur Chemical group 0.000 claims description 8
- 229910052717 sulfur Chemical group 0.000 claims description 8
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 125000004181 carboxyalkyl group Chemical group 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 7
- 239000001301 oxygen Chemical group 0.000 claims description 7
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 7
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- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
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- BNRHOJBZJFRBFW-UHFFFAOYSA-N 2-[(7-bromo-6-ethyl-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl-methylamino]acetic acid Chemical compound N1C(=O)C(=O)NC2=C(CN(C)CC(O)=O)C(CC)=C(Br)C=C21 BNRHOJBZJFRBFW-UHFFFAOYSA-N 0.000 claims description 3
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- DVKDTKVRVXOOED-UHFFFAOYSA-N ethyl 2-[(6-ethyl-7-nitro-2,3-dioxo-1,4-dihydroquinoxalin-5-yl)methyl-methylamino]acetate Chemical compound N1C(=O)C(=O)NC2=C1C=C([N+]([O-])=O)C(CC)=C2CN(C)CC(=O)OCC DVKDTKVRVXOOED-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
- C07F9/650994—Six-membered rings having the nitrogen atoms in the positions 1 and 4 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
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- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/474,878 US5614508A (en) | 1995-06-07 | 1995-06-07 | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
PCT/US1996/006816 WO1996040649A1 (en) | 1995-06-07 | 1996-05-13 | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
Publications (2)
Publication Number | Publication Date |
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SK158997A3 SK158997A3 (en) | 1998-05-06 |
SK283637B6 true SK283637B6 (sk) | 2003-11-04 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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SK1589-97A SK283637B6 (sk) | 1995-06-07 | 1996-05-13 | Substituované chinoxalín-2,3-diónové deriváty, farmaceutický prípravok obsahujúci tieto deriváty, ich medicínske použitie a medziprodukt na ich výrobu |
Country Status (25)
Country | Link |
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US (1) | US5614508A (da) |
EP (1) | EP0832074B1 (da) |
JP (1) | JPH11509176A (da) |
KR (1) | KR19990022483A (da) |
CN (1) | CN1125818C (da) |
AT (1) | ATE223388T1 (da) |
AU (1) | AU714332B2 (da) |
BG (1) | BG63306B1 (da) |
CA (1) | CA2219417A1 (da) |
CZ (1) | CZ290418B6 (da) |
DE (1) | DE69623471T2 (da) |
DK (1) | DK0832074T3 (da) |
EA (1) | EA000605B1 (da) |
EE (1) | EE03352B1 (da) |
ES (1) | ES2180771T3 (da) |
GE (1) | GEP19991869B (da) |
MX (1) | MX9708432A (da) |
NO (1) | NO309473B1 (da) |
NZ (1) | NZ308316A (da) |
PL (1) | PL323738A1 (da) |
PT (1) | PT832074E (da) |
SK (1) | SK283637B6 (da) |
UA (1) | UA54396C2 (da) |
WO (1) | WO1996040649A1 (da) |
ZA (1) | ZA964787B (da) |
Families Citing this family (11)
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GB9419318D0 (en) * | 1994-09-24 | 1994-11-09 | Pfizer Ltd | Therapeutic agents |
WO1997046539A1 (en) * | 1996-06-05 | 1997-12-11 | Warner-Lambert Company | Amide derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
AU3571997A (en) * | 1996-08-01 | 1998-02-25 | Warner-Lambert Company | Novel glutamate receptor antagonists: fused cycloalkyl quinoxalinediones |
US6015800A (en) * | 1997-09-03 | 2000-01-18 | Warner-Lambert Company | Substituted quinoxaline-2-ones as glutamate receptor antagonists |
IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
US6391922B1 (en) | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
US20040152694A1 (en) * | 2003-02-04 | 2004-08-05 | Istvan Kurucz | Methods and compositions for treating inflammatory disorders of the airways |
EP2338492A1 (en) | 2009-12-24 | 2011-06-29 | Universidad del Pais Vasco | Methods and compositions for the treatment of alzheimer |
CN103435561B (zh) * | 2013-08-19 | 2016-08-10 | 上海交通大学 | 一种新型d-氨基酸氧化酶抑制剂及其制备和应用 |
CN103664806B (zh) * | 2013-12-16 | 2016-06-29 | 山东汇海医药化工有限公司 | 一种n-乙酰乙酰基-6-甲氧基-7-氨基喹喔啉-2,3-二酮的制备方法 |
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US2271187A (en) * | 1939-09-12 | 1942-01-27 | Aluminum Co Of America | Sheet handling apparatus |
US4156734A (en) * | 1976-02-13 | 1979-05-29 | Merck & Co., Inc. | Antihypertensive compositions containing an aryl-substituted alanine azo and an arylhydrazino-propionic acid |
US4206216A (en) * | 1976-02-13 | 1980-06-03 | Merck & Co., Inc. | Antihypertensive N-heterocyclicalanines |
EP0484437A4 (en) * | 1989-07-27 | 1994-06-01 | Searle & Co | Renal-selective prodrugs for the treatment of hypertension |
EP0488959A3 (en) * | 1990-11-28 | 1992-08-05 | Sandoz Ltd. | New uses of competitive nmda receptor antagonists |
JPH05117276A (ja) * | 1991-10-23 | 1993-05-14 | Sumitomo Pharmaceut Co Ltd | 新規な3環性キノキサリンジオン誘導体 |
JPH06228112A (ja) * | 1993-02-05 | 1994-08-16 | Yamanouchi Pharmaceut Co Ltd | (1h,4h)キノキサリン誘導体 |
TW260660B (da) * | 1993-04-22 | 1995-10-21 | Sumitomo Pharma | |
WO1994026747A1 (en) * | 1993-05-13 | 1994-11-24 | Neurosearch A/S | Ampa antagonists and a method of treatment therewith |
US5631373A (en) * | 1993-11-05 | 1997-05-20 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones |
-
1995
- 1995-06-07 US US08/474,878 patent/US5614508A/en not_active Expired - Fee Related
-
1996
- 1996-05-13 SK SK1589-97A patent/SK283637B6/sk unknown
- 1996-05-13 CA CA002219417A patent/CA2219417A1/en not_active Abandoned
- 1996-05-13 AU AU57918/96A patent/AU714332B2/en not_active Ceased
- 1996-05-13 EE EE9700337A patent/EE03352B1/xx not_active IP Right Cessation
- 1996-05-13 DE DE69623471T patent/DE69623471T2/de not_active Expired - Fee Related
- 1996-05-13 JP JP9500556A patent/JPH11509176A/ja active Pending
- 1996-05-13 PL PL96323738A patent/PL323738A1/xx unknown
- 1996-05-13 ES ES96914615T patent/ES2180771T3/es not_active Expired - Lifetime
- 1996-05-13 AT AT96914615T patent/ATE223388T1/de not_active IP Right Cessation
- 1996-05-13 EP EP96914615A patent/EP0832074B1/en not_active Expired - Lifetime
- 1996-05-13 CN CN96194485A patent/CN1125818C/zh not_active Expired - Fee Related
- 1996-05-13 WO PCT/US1996/006816 patent/WO1996040649A1/en not_active Application Discontinuation
- 1996-05-13 MX MX9708432A patent/MX9708432A/es not_active IP Right Cessation
- 1996-05-13 PT PT96914615T patent/PT832074E/pt unknown
- 1996-05-13 EA EA199800006A patent/EA000605B1/ru not_active IP Right Cessation
- 1996-05-13 KR KR1019970708964A patent/KR19990022483A/ko not_active Application Discontinuation
- 1996-05-13 GE GEAP19964089A patent/GEP19991869B/en unknown
- 1996-05-13 CZ CZ19973710A patent/CZ290418B6/cs not_active IP Right Cessation
- 1996-05-13 UA UA98010045A patent/UA54396C2/uk unknown
- 1996-05-13 NZ NZ308316A patent/NZ308316A/en unknown
- 1996-05-13 DK DK96914615T patent/DK0832074T3/da active
- 1996-06-06 ZA ZA964787A patent/ZA964787B/xx unknown
-
1997
- 1997-11-27 BG BG102080A patent/BG63306B1/bg unknown
- 1997-12-05 NO NO975701A patent/NO309473B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
EE03352B1 (et) | 2001-02-15 |
NO309473B1 (no) | 2001-02-05 |
DE69623471T2 (de) | 2003-08-07 |
NO975701L (no) | 1998-01-30 |
PT832074E (pt) | 2003-01-31 |
EP0832074A1 (en) | 1998-04-01 |
AU714332B2 (en) | 1999-12-23 |
CN1125818C (zh) | 2003-10-29 |
NZ308316A (en) | 2001-04-27 |
UA54396C2 (uk) | 2003-03-17 |
ES2180771T3 (es) | 2003-02-16 |
CZ290418B6 (cs) | 2002-07-17 |
SK158997A3 (en) | 1998-05-06 |
WO1996040649A1 (en) | 1996-12-19 |
MX9708432A (es) | 1998-02-28 |
ATE223388T1 (de) | 2002-09-15 |
CA2219417A1 (en) | 1996-12-19 |
PL323738A1 (en) | 1998-04-14 |
GEP19991869B (en) | 1999-12-06 |
KR19990022483A (ko) | 1999-03-25 |
JPH11509176A (ja) | 1999-08-17 |
AU5791896A (en) | 1996-12-30 |
BG102080A (en) | 1998-11-30 |
CN1187190A (zh) | 1998-07-08 |
EA000605B1 (ru) | 1999-12-29 |
NO975701D0 (no) | 1997-12-05 |
DK0832074T3 (da) | 2002-12-16 |
CZ371097A3 (cs) | 1998-05-13 |
EA199800006A1 (ru) | 1998-08-27 |
DE69623471D1 (de) | 2002-10-10 |
EP0832074B1 (en) | 2002-09-04 |
US5614508A (en) | 1997-03-25 |
ZA964787B (en) | 1997-01-08 |
BG63306B1 (bg) | 2001-09-28 |
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