SK282457B6 - [1,2,4]Triazolo[4,3-a]chinoxalinónové zlúčeniny, farmaceutický prostriedok, spôsob prípravy [1,2,4]triazolo[4,3-a]chinoxalinónových zlúčenín a ich použitie - Google Patents
[1,2,4]Triazolo[4,3-a]chinoxalinónové zlúčeniny, farmaceutický prostriedok, spôsob prípravy [1,2,4]triazolo[4,3-a]chinoxalinónových zlúčenín a ich použitie Download PDFInfo
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- SK282457B6 SK282457B6 SK334-97A SK33497A SK282457B6 SK 282457 B6 SK282457 B6 SK 282457B6 SK 33497 A SK33497 A SK 33497A SK 282457 B6 SK282457 B6 SK 282457B6
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- triazolo
- defined above
- alkoxy
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- NBXOKUUXBOFVIJ-UHFFFAOYSA-N 2h-[1,2,4]triazolo[4,3-a]quinoxalin-1-one Chemical class C1=CC=C2N3C(=O)NN=C3C=NC2=C1 NBXOKUUXBOFVIJ-UHFFFAOYSA-N 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 title description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 24
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 22
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 21
- 239000001257 hydrogen Substances 0.000 claims abstract description 21
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 14
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 10
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- 229910052736 halogen Inorganic materials 0.000 claims abstract description 5
- 150000002367 halogens Chemical class 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
- 125000001425 triazolyl group Chemical group 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims description 116
- -1 [1,2,4] Triazolo [4,3-a] quinoxalinone compound Chemical class 0.000 claims description 34
- 150000003839 salts Chemical class 0.000 claims description 17
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- 238000000034 method Methods 0.000 claims description 7
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- RVFUUIZPAHUNPZ-UHFFFAOYSA-N [4-oxo-8-(2-propan-2-ylimidazol-1-yl)-7-(trifluoromethyl)-5h-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl]methylphosphonic acid Chemical compound CC(C)C1=NC=CN1C1=CC(N2C(CP(O)(O)=O)=NN=C2C(=O)N2)=C2C=C1C(F)(F)F RVFUUIZPAHUNPZ-UHFFFAOYSA-N 0.000 claims description 3
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- GUGQQGROXHPINL-UHFFFAOYSA-N 2-oxobutanoyl chloride Chemical compound CCC(=O)C(Cl)=O GUGQQGROXHPINL-UHFFFAOYSA-N 0.000 claims description 2
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- 230000009291 secondary effect Effects 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 208000020431 spinal cord injury Diseases 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000009782 synaptic response Effects 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK106694 | 1994-09-16 | ||
| PCT/DK1995/000365 WO1996008493A1 (fr) | 1994-09-16 | 1995-09-12 | Derives de la [1,2,4]triazolo[4,3-a]quinoxalinone, leur preparation et utilisation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK33497A3 SK33497A3 (en) | 1998-02-04 |
| SK282457B6 true SK282457B6 (sk) | 2002-02-05 |
Family
ID=8100607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK334-97A SK282457B6 (sk) | 1994-09-16 | 1995-09-12 | [1,2,4]Triazolo[4,3-a]chinoxalinónové zlúčeniny, farmaceutický prostriedok, spôsob prípravy [1,2,4]triazolo[4,3-a]chinoxalinónových zlúčenín a ich použitie |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0781282B1 (fr) |
| JP (1) | JPH10506620A (fr) |
| KR (1) | KR970706285A (fr) |
| CN (1) | CN1193973A (fr) |
| AT (1) | ATE183186T1 (fr) |
| AU (1) | AU694554B2 (fr) |
| CA (1) | CA2200056A1 (fr) |
| CZ (1) | CZ284930B6 (fr) |
| DE (1) | DE69511420T2 (fr) |
| DK (1) | DK0781282T3 (fr) |
| ES (1) | ES2138233T3 (fr) |
| FI (1) | FI971076A (fr) |
| GR (1) | GR3031788T3 (fr) |
| HU (1) | HUT76802A (fr) |
| IL (1) | IL115299A0 (fr) |
| NO (1) | NO308797B1 (fr) |
| NZ (1) | NZ292108A (fr) |
| PL (1) | PL319175A1 (fr) |
| SK (1) | SK282457B6 (fr) |
| TW (1) | TW397835B (fr) |
| WO (1) | WO1996008493A1 (fr) |
| ZA (1) | ZA957794B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL125950A0 (en) * | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
| CN1285834A (zh) | 1997-11-11 | 2001-02-28 | 小野药品工业株式会社 | 稠合吡嗪化合物 |
| BRPI1009287A2 (pt) | 2009-03-05 | 2019-09-24 | Astellas Pharma Inc | composto de quinoxalina |
| CN103097393B (zh) | 2010-09-07 | 2015-09-16 | 安斯泰来制药株式会社 | 喹喔啉化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4354027A (en) * | 1980-05-19 | 1982-10-12 | Usv Pharmaceutical Corporation | Triazoloquinoxalin-4-ones |
| US5153196A (en) * | 1991-06-05 | 1992-10-06 | Eli Lilly And Company | Excitatory amino acid receptor antagonists and methods for the use thereof |
| DK162491D0 (da) * | 1991-09-20 | 1991-09-20 | Novo Nordisk As | Heterocycliske forbindelser, deres fremstilling og farmaceutiske praeparater indeholdende forbindelserne |
| WO1993020077A1 (fr) * | 1992-04-03 | 1993-10-14 | Yamanouchi Pharmaceutical Co., Ltd. | Derive de quinoxalinone fondue et composition pharmaceutique le contenant |
| DK31093D0 (fr) * | 1993-03-19 | 1993-03-19 | Novo Nordisk As | |
| CN1041931C (zh) * | 1993-05-06 | 1999-02-03 | 诺沃-诺迪斯克有限公司 | [1,2,4]三唑并[4,3－a]喹喔啉化合物,它们的制备及其应用 |
-
1995
- 1995-09-12 KR KR1019970701669A patent/KR970706285A/ko not_active Application Discontinuation
- 1995-09-12 DE DE69511420T patent/DE69511420T2/de not_active Expired - Fee Related
- 1995-09-12 CZ CZ97753A patent/CZ284930B6/cs not_active IP Right Cessation
- 1995-09-12 CA CA002200056A patent/CA2200056A1/fr not_active Abandoned
- 1995-09-12 JP JP8509828A patent/JPH10506620A/ja active Pending
- 1995-09-12 DK DK95930410T patent/DK0781282T3/da active
- 1995-09-12 TW TW084109492A patent/TW397835B/zh not_active IP Right Cessation
- 1995-09-12 WO PCT/DK1995/000365 patent/WO1996008493A1/fr not_active Application Discontinuation
- 1995-09-12 HU HU9701241A patent/HUT76802A/hu unknown
- 1995-09-12 SK SK334-97A patent/SK282457B6/sk unknown
- 1995-09-12 AU AU33808/95A patent/AU694554B2/en not_active Ceased
- 1995-09-12 ES ES95930410T patent/ES2138233T3/es not_active Expired - Lifetime
- 1995-09-12 AT AT95930410T patent/ATE183186T1/de not_active IP Right Cessation
- 1995-09-12 PL PL95319175A patent/PL319175A1/xx unknown
- 1995-09-12 CN CN95195697A patent/CN1193973A/zh active Pending
- 1995-09-12 EP EP95930410A patent/EP0781282B1/fr not_active Expired - Lifetime
- 1995-09-12 NZ NZ292108A patent/NZ292108A/xx unknown
- 1995-09-14 IL IL11529995A patent/IL115299A0/xx unknown
- 1995-09-15 ZA ZA957794A patent/ZA957794B/xx unknown
-
1997
- 1997-03-14 FI FI971076A patent/FI971076A/fi unknown
- 1997-03-14 NO NO971187A patent/NO308797B1/no not_active IP Right Cessation
-
1999
- 1999-11-09 GR GR990402881T patent/GR3031788T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69511420T2 (de) | 2000-03-30 |
| WO1996008493A1 (fr) | 1996-03-21 |
| DE69511420D1 (de) | 1999-09-16 |
| CZ284930B6 (cs) | 1999-04-14 |
| GR3031788T3 (en) | 2000-02-29 |
| ZA957794B (en) | 1996-05-14 |
| AU3380895A (en) | 1996-03-29 |
| TW397835B (en) | 2000-07-11 |
| NO971187L (no) | 1997-05-15 |
| JPH10506620A (ja) | 1998-06-30 |
| EP0781282A1 (fr) | 1997-07-02 |
| ATE183186T1 (de) | 1999-08-15 |
| PL319175A1 (en) | 1997-08-04 |
| CN1193973A (zh) | 1998-09-23 |
| DK0781282T3 (da) | 2000-02-28 |
| NO971187D0 (no) | 1997-03-14 |
| SK33497A3 (en) | 1998-02-04 |
| NZ292108A (en) | 1999-02-25 |
| HUT76802A (en) | 1997-11-28 |
| FI971076A0 (fi) | 1997-03-14 |
| CZ75397A3 (en) | 1997-08-13 |
| ES2138233T3 (es) | 2000-01-01 |
| KR970706285A (ko) | 1997-11-03 |
| FI971076A (fi) | 1997-05-13 |
| NO308797B1 (no) | 2000-10-30 |
| IL115299A0 (en) | 1995-12-31 |
| AU694554B2 (en) | 1998-07-23 |
| CA2200056A1 (fr) | 1996-03-21 |
| EP0781282B1 (fr) | 1999-08-11 |
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