SK111294A3 - Amine oxidic disinfectants containig isopropyl alcohol - Google Patents

Abstract

Disclosed are disinfectants based on long-chain linear or branched alkyldimethylamineoxides with the content of isopropyl alcohol which serves the function of an excipient exhibiting antimicrobial activity. Organic ammonium salt, chlorhexidine and glycerol are further components. Amine oxide, organic ammonium salt and chlorhexidine provide a wide spectrum and stability of antimicrobial activity together with detergent and penetration activity; and glycerol prevents the skin from dehydrating. Isopropyl alcohol gives potential and widens the antimicrobial activity of basic components. This composition can be used for instant disinfecting of hands, skin and other surfaces in the health service, communal hygiene, food-processing industry and agriculture, etc..

Description

Technical field

The invention relates to disinfectants comprising an amine oxide and other active ingredients soluble in an aqueous solution of isopropyl alcohol. Isopropanol potency and extended antimicrobial surface-účinnok alkyldimetylammínoxidu a straight or branched having carbon chain of C to C _{1Q g.} These disinfectants are intended for use in the rapid disinfection of hands, skin and other surfaces in healthcare, municipal hygiene, food and agriculture.

The state of the art

Disinfectants containing surfactant amine oxides are known, but the onset of action is slow and the spectrum of microorganisms to which they act is relatively narrow. However, their advantages are their low acute toxicity, low side effects, compatibility with a wide range of compounds used in this field, relatively low skin and eye irritation, surface activity synergistically enhancing the effect of other disinfectants. Therefore, it is advantageous to use them together with more vigorous and more drastic substances, while in the resulting combinations the advantages of the individual components can be exploited while at the same time reducing their drawbacks.

Aliphatic alcohols are known as disinfectants with relatively low antimicrobial activity and are often used as solvents for others e.g. cosmetic, pharmaceutical products. However, several of these alcohols are unsuitable for wider use e.g. for high toxicity to humans.

Isopropyl alcohol is the most preferred of the water-miscible alcohols because it is the most antimicrobial of them. Isopropyl alcohol disinfectants are considered the best practice in hand disinfection. However, isopropyl alcohol also has a number of disadvantages. After its evaporation, which is relatively rapid, the antimicrobial effect rapidly subsides and the treated surfaces are easily recontaminated. Its spectrum of action is also not satisfactory. When applied to the skin, it degreases and dehydrates. These drawbacks can be overcome by suitable combination of this alcohol with other antimicrobial compounds and optionally other ingredients.

SUMMARY OF THE INVENTION

SUMMARY OF THE INVENTION The present invention is based on the fact that the solution eliminates the above mentioned disadvantages of amine oxides and isopropyl alcohol as a disinfectant, according to which with a suitable combination of amine oxide, isopropyl alcohol, organic ammonium salt and chlorhexidine. which is ultimately higher than the effect of separate individual components. The presence of surface-active disinfectants provides not only an antimicrobial effect, but also a cleaning effect and a residual very strong antimicrobial effect remains even after the isopropyl alcohol has been evaporated. Due to the presence of isopropyl alcohol, the preparation has a very rapid onset of action (according to microbiological classifications, the onset of action is almost immediate). The preparation also acts on those microorganisms to which the aqueous solutions of the individual components are not effective.

DETAILED DESCRIPTION OF THE INVENTION

An aqueous solution of an alkyldimethylamine oxide surfactant e.g. (1-methyldodecyl) dimethylamino oxide (10%), alkyltrimethylammonium bromide e.g. Carbetopendecin bromide (10%), chlorhexidine digluconate (20%) are mixed in the necessary volume with pure isopropyl alcohol. The concentration of the resulting solution was adjusted to a final 70% with distilled water. Glycerol whose final concentration in the solution does not exceed 1% by volume is added.

The antimicrobial activity of the individual components and the resulting product was tested on microorganisms from Cs. the State Collection of Type Cultures in Prague, as well as on microorganisms isolated from health facilities. Standard methods used for testing disinfectants were used, from microorganisms to Gram-positive and Gram-negative bacteria and microscopic fungi. These microorganisms are effective even in high dilutions within 1 minute. Protein presence does not significantly affect efficacy, as fluctuations in temperature of 10 ° C over room temperature do not affect the antimicrobial activity of the preparation.

To illustrate the efficacy, the results of the laboratory tests are shown in the tables

Tab. 1 Minimum inhibitory concentrations (MIC) of the preparation in gg.crn ' ³ .

Staphylococcus aureus of Bacillus subtilis

Escherichia coli

195.3

195.3

781.2

Salmonel la typhimurium (Pseudomonas aeruginosa) Proteus vulgaris Candida albicans

1562.5

3125

6250

97.6

Tab. 2 Antimicrobial activity in suspension test - maximum dilution killing microorganisms per minute in%

Staphylococcus aureus 0.2 Bacillus subtilis 0.3 Escherichia coli 0.2 Salmonella typhimurium 0.2 Pseudomonas aeruginosa 0.3 Proteus vulgaris 0.3 Candida albicans 0.2

* In the presence of 20% protein, the efficacy of S. aureus is not altered in this test, the maximum effective dilution is increased to 0.3% on E. coli

Tab. 3 Concentration of preparation required to kill microorganisms dried on carriers in%

time [min] 1 3 5 Staphylococcus aureus 00:06 O.OS 00:05 Escherichia coli 1.0 1.0 0.3 Candida albicans 1.0 0.5 0.3

f u n v - p

Claims (1)

PATENT CLAIMS Amine oxide disinfectants containing isopropyl alcohol, characterized in that the disinfectant is composed of the antimicrobial active components of the alkyldimethylamine oxide of the general formula R (CH ₃ ) ₂ N ⁺ - O "and the structure ch ₃ IR - N ⁺ - 0 I CH ₃ wherein R is a straight or branched alkyl chain having a carbon number from 10 to 18 preferably 14 in a concentration of 0.1 to 1%, preferably 0.3%, dialkyldimethylammonium salts of the formula R ₁ R ₂ (CH _{3) 2} N ⁺ X "and the structure ch ₃ IR _T - N ⁺ - R ₂ I CH ₃ wherein a linear or branched substituted or unsubstituted alkyl chain with carbon number 12 to 16 and R ₂ is either a methyl or a benzyl radical, and X "is a halide, preferably bromide, in a concentration 0.5 to 1.5%, preferably 0.7%, and chlorhexidine in the form of digluconate at a concentration of 0.1 to 1%, preferably 0.4%, dissolved in an aqueous solution of isopropyl alcohol at a concentration of 30 to 95%, preferably 70%.