SI9400290B - Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku - Google Patents

Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku Download PDF

Info

Publication number
SI9400290B
SI9400290B SI9400290A SI9400290A SI9400290B SI 9400290 B SI9400290 B SI 9400290B SI 9400290 A SI9400290 A SI 9400290A SI 9400290 A SI9400290 A SI 9400290A SI 9400290 B SI9400290 B SI 9400290B
Authority
SI
Slovenia
Prior art keywords
formula
preparation
ace
compounds
compound
Prior art date
Application number
SI9400290A
Other languages
English (en)
Other versions
SI9400290A (sl
Inventor
Serra Sonia Mortes
Palomo Alberto Coll
Rok Zupet
Original Assignee
Lek,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek, filed Critical Lek,
Priority to SI9400290A priority Critical patent/SI9400290B/sl
Priority to US08/596,214 priority patent/US5789597A/en
Priority to AU29424/95A priority patent/AU2942495A/en
Priority to PCT/SI1995/000017 priority patent/WO1996002564A1/en
Priority to EP95925228A priority patent/EP0719280B1/en
Priority to CA002170872A priority patent/CA2170872C/en
Publication of SI9400290A publication Critical patent/SI9400290A/sl
Publication of SI9400290B publication Critical patent/SI9400290B/sl

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Description

(54) POSTOPEK ZA PRIPRAVO SPOJIN Z ACE INHIBITORNIM DELOVANJEM TER NOVE SPOJINE, UPORABNE KOT IZHODNE SNOVI ALI INTERMEDIATI V TEM POSTOPKU
Sl 9400290 B

Claims (2)

1. Postopek za pripravo spojin z ACE inhibitornim delovanjem s formulo in njihovih farmacevtsko sprejemljivih soli, kjer ima R naslednje pomene i
^/Nyy\CWH
-N ch2-cooh i
•N\ λλοοοη s
označen s tem, da karboksilno skupino stereospecifičner amino kisline N-[1-(S) etoksikarbonil-3-fenilpropil]-L-alanina s formulo
OOOEt CHj
CH2
CH, '-ir
I
H
ΟΟΟΗ aktiviramo s klortionilimidazolom s formulo (I) (I) oz. s tionildiimidazolom s formulo (II) (II) v prisotnosti neprotičnega organskega topila ob odstranitvi oborjenega imidazol hidroklorida v vmesno novo spojino A oz. v vmesno novo spojino B
OCH,
COOEt CH,
H........O (B) dobljeno vmesno spojino (Α,Β) Pa presnovimo z amino kislino, prednostno v mononosililirani obliki, najbolj prednostno v disililirani obliki, izbrano iz skupine, v kateri so
H
.....COOH
H
H
H
I .N, .uVCOOH
H i
pri čemer mora biti reakcijski medij v vseh stopnjah brezvoden, nato pa dobljene spojine na običajen način prevedemo v njihove farmacevtsko sprejemljive soli.
2. Spojina s formulo A =N
SI9400290A 1994-07-13 1994-07-13 Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku SI9400290B (sl)

Priority Applications (6)

Application Number Priority Date Filing Date Title
SI9400290A SI9400290B (sl) 1994-07-13 1994-07-13 Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku
US08/596,214 US5789597A (en) 1994-07-13 1995-07-13 Process for the preparation of compounds having ACE inhibitory action and intermediates in said process
AU29424/95A AU2942495A (en) 1994-07-13 1995-07-13 Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
PCT/SI1995/000017 WO1996002564A1 (en) 1994-07-13 1995-07-13 Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
EP95925228A EP0719280B1 (en) 1994-07-13 1995-07-13 Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process
CA002170872A CA2170872C (en) 1994-07-13 1995-07-13 Process for the preparation of compounds having ace inhibitory action as well as novel compounds useful as starting materials or intermediates in said process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9400290A SI9400290B (sl) 1994-07-13 1994-07-13 Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku

Publications (2)

Publication Number Publication Date
SI9400290A SI9400290A (sl) 1996-02-29
SI9400290B true SI9400290B (sl) 2002-02-28

Family

ID=20431424

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9400290A SI9400290B (sl) 1994-07-13 1994-07-13 Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku

Country Status (1)

Country Link
SI (1) SI9400290B (sl)

Also Published As

Publication number Publication date
SI9400290A (sl) 1996-02-29

Similar Documents

Publication Publication Date Title
EP0457163B1 (de) Verwendung von Oxalyl-Aminosäurederivaten als Arzneimittel zur Inhibierung der Prolyl-Hydroxylase
KR950013849B1 (ko) 프롤리날 유도체 이의 제조방법 및 이를 포함하는 약제학적 조성물
US4977180A (en) Novel prolinal derivatives
UY25843A1 (es) Compuestos orgánicos inhibidores de peptidasa de dipeptidilo-iv
PL143010B1 (en) Process for preparing novel derivatives of 1,2,3,5-tetrahydroimidazo/2,1-b/quinazoline
DE19542189A1 (de) Cyclische N-substituierte alpha-Iminohydroxamsäuren
US3852338A (en) N-substituted phenylalanine derivatives
US5254550A (en) Prolinal derivatives and pharmaceutical compositions thereof
RU2212405C2 (ru) Замещенные 6- и 7-аминотетрагидроизохинолин-карбоновые кислоты
EP1124797B1 (de) N-arylsulfonyl-aminosäure-omega-amide
HU192868B (en) Process for producing particularly antiasthmatic medicine preparations
US3534100A (en) 2-methylhydrazine-methyl benzenes
SI9400290B (sl) Postopek za pripravo spojin z ACE inhibitornim delovanjem ter nove spojine, uporabne kot izhodne snovi ali intermediati v tem postopku
JP3196106B2 (ja) ロイコトリエンａ４ヒドロラーゼ阻害剤
US3846476A (en) N-benzyloxycarbonyl-dopa derivatives
FR2641534A1 (fr) Nouveaux derives de glycine utiles comme medicaments antagonistes du thromboxane a2 et procede pour leur preparation
US4235918A (en) Benzenesulfonamide derivatives and processes for their manufacture
DE4041780A1 (de) Neue amine, verfahren zu ihrer herstellung, sowie diese verbindungen enthaltende arzneimittel
US3824288A (en) Substituted hydrazine derivatives and process for the manufacture thereof
CA1193606A (en) Substituted phenylpyrazole derivatives, process for their preparation, medicaments based therein, and their use
US3830840A (en) 1-methyl-2-(lower sulfonylaminobenzyl)-hydrazines
MXPA98003750A (en) Acids 6- and 7-amino-tetrahidroisoquinolina-carboxilicos sustitui
EP0008657B1 (en) Alpha-vinyl-alpha-aminoacids and their esters and pharmaceutical compositions containing them
US3621061A (en) New formamidine derivatives and process for the preparation thereof
SI9400450A1 (sl) Postopek za pripravo spojin z ace inhibitornim delovanjem

Legal Events

Date Code Title Description
IF Valid on the prs date