SI9210252A - Inhaler - Google Patents
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- SI9210252A SI9210252A SI9210252A SI9210252A SI9210252A SI 9210252 A SI9210252 A SI 9210252A SI 9210252 A SI9210252 A SI 9210252A SI 9210252 A SI9210252 A SI 9210252A SI 9210252 A SI9210252 A SI 9210252A
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Abstract
Inhalator za vnašanje dozirane količine trdnih teles, npr. farmacevtsko užinkovitih praškov, v zračni tok, vsesan od uporabnika, obsega zalogovno komoro (4), v katero štrli dozirni zatič (5). Dozirni zatič (5) je opremljen z dozirno zarezo (50), katera določa količino trdnih teles, ki se jih primeša zračnemu toku. Zaiogovna komora (4) in dozirni zatič (5) sta relativno drug proti drugemu tako gibljiva, da se v prvem relativnem položaju dozirnega zatiča (5) in zalogovne komore (4) dozirna zareza (50) dozirnega zatiča (5) nahaja v zalogovni komori (4), kjer se napolni s trdnimi telesi, v drugem relativnem položaju pa se nahaja v zračnem kanalu, kjer se trdna telesa primeša zračnemu toku. Osno relativno gibanje se pri tem doseže z zavrtitvijo dveh ohišnih delov (101, 102) preko nagnjenih ploskev (103).Inhaler for injecting solid dosage bodies, e.g. pharmaceutically effective powders, in air the flow drawn in by the user comprises a storage chamber (4) into which the dosing pin (5) protrudes. The metering pin (5) is fitted with a metering notch (50) to determine the amount of solids mixed with the air stream. The nozzle chamber (4) and the metering pin (5) are relative so flexible with each other that in the first the relative position of the metering pin (5) and the stock chambers (4) metering notch (50) metering pin (5) located in the storage chamber (4) where it is filled with solids bodies, and in another relative position is located in air duct where solids are mixed with air flow. Axial relative motion is thus achieved by rotating two housing parts (101, 102) via inclined surfaces (103).
Description
CIBA-GEIGYAGCIBA-GEIGYAG
InhalatorInhaler
Izum se nanaša na inhalator za vnašanje dozirane količine trdnih teles v zračni tok, vsesan od uporabnika, po uvodnem delu 1. patentnega zahtevka.The invention relates to an inhaler for introducing a metered amount of solids into a user-aspirated air stream according to the introductory part of claim 1.
Trdnotelesni inhalatorji so dandanes dosegljivi v velikem številu in veliko izvedbenih primerih. S temi inhalatorji inhalira uporabnik predvsem farmacevstsko učinkovite snovi ali zmesi snovi, zlasti prašnatih snovi ali zmesi snovi. Takšen inhalator je znan npr. iz CH-A-666,823. Tam opisani inhalator obsega zalogovno komoro za trna telesa kot tudi zračni kanal, ki povezuje vstopno, zračno odprtino za vsesani zrak z izstopom za zmes trdna telesa-zrak, nastalo v inhalatorju. Za določitev količine trdnih teles in za vnos te določene količine trdnih teles v zračni tok je predviden z dozirno zarezo opremljen dozirni zatič, ki je zasnovan vrtljivo okoli svoje vzdolžne osi. Dozirna zareza dozirnega zatiča sprejme v prvem položaju z volumnom dozirne zareze določeno količino trdnih teles. Zatem se dozirni zatič zavrti za 180° okoli svoje osi v drugi položaj, v katerem lahko trdna telesa padejo iz dozirne zareze in tako dospejo v zračni kanal, kjer se primešajo zračnemu toku.Solid-state inhalers are now available in a large number and many embodiments. With these inhalers, the user is primarily inhaled by a pharmaceutically effective substance or mixture of substances, in particular powders or mixtures of substances. Such an inhaler is known e.g. from CH-A-666,823. The inhaler described therein comprises a storage chamber for the thorn bodies as well as an air duct connecting the inlet air intake port with the outlet for the solid-air mixture formed in the inhaler. To determine the amount of solids and to enter that specified amount of solids into the air stream, a metering pin is provided with a metering notch designed to rotate about its longitudinal axis. The metering notch of the metering pin adopts a certain amount of solids in the first position with the volume of the metering notch. The dosing pin is then rotated 180 ° about its axis to another position in which the solid bodies can fall out of the metering notch and thus reach the air duct where they are mixed with the air stream.
Opisani inhalator ima različne pomanjkljivosti. Tako je potrebno, da so trdna telesa sposobna dobrega tečenja, s čimer je zagotovljeno, da se dozirno zarezo stalno hitro, zanesljivo in popolnoma napolni. Ker granulati in siceršnja večja trdna telesa niso primerna za inhaliranje, so farmacevtsko učinkovite snovi ali zmesi snovi, npr. antiastmatično učinkovite snovi ali zmesi snovi, pogosto na razpolago kot zelo drobnozrnati praški. Ti drobnozrnati praški pa imajo večidel zelo pomanjkljivo lastnost, da niso oz. so sposobni zelo slabega tečenja. To pa ima lahko ponovno zaThe inhaler described has various drawbacks. It is thus necessary for the solid bodies to be able to flow well, ensuring that the dosing notch is constantly fast, reliable and fully filled. Because granules and other large solids are not suitable for inhalation, pharmaceutically effective substances or mixtures of substances, e.g. anti-asthmatically active substances or mixtures of substances, often available as very fine-grained powders. These fine-grained powders, however, have the very disadvantage that they are not or are not. are capable of very poor flow. This, however, may again be for
22000PP0.1V posledico, da se dozirno zarezo nepopolno napolni, s čimer pa se spreminja tudi dozirana količina trdnih teles. Ravno pri težavnem dihanju (npr. pogojenem z astmatičnim napadom), na katerega naleti uporabnik, mora le-la za hitro olajšanje hitro in zanesljivo inhalirati določeno količino praška.22000PP0.1On consequence, the dosage notch is incompletely filled, thereby changing the dosage amount of solids. It is precisely in the case of difficulty breathing (eg conditioned by asthmatic attack) that the user encounters that he or she must inhale a certain amount of powder quickly and reliably for quick relief.
Nadaljnja pomanjkljivost opisanega inhalatorja je, da vnos trdnih teles v zračni kanal sledi s pomočjo vrtljivega dozirnega zatiča. Tako se lahko zgodi, da trdna telesa lahko vdrejo v votline (uležiščenje) okoli vrtljivega dozirnega zatiča in povzročijo, da je dozirni zatič bodisi le zelo težko vrtljiv ali pa se celo popolnoma zadre1, kar ima lahko zlasti za uporabnike, nagnjene k astmi, pomembne posledice, kajti potemtakem v primeru potrebe naprava ni zmožna delovanja.A further disadvantage of the inhaler described is that solids are introduced into the air duct by means of a rotary dosing pin. It may happen that solid bodies can penetrate the cavities (bearings) around the rotating dosing pin and cause the dosing pin to be either very difficult to rotate or even completely clogged 1 , which may be particularly so for users prone to asthma, important consequences, because the device is therefore incapable of operating when needed.
Nadalje je pri opisanem inhalatorju pomanjkljivo tudi dejstvo, da se drobnozrnat prašek v zalogovni komori ne da vskladiščiti v posebnem zalogovniku, npr. kapsuli. To je zlasti pomanjkljivo za tiste praške, katerih farmacevtski učinek pade zaradi shranjevanja v trajnem stiku z zrakom. Razen tega se lahko pri zgoraj opisanem inhalatorju zgodi, da z vlago, ki vdre v inhalator in njegovo zalogovno komoro (npr. z nenamernim kašljanjem uporabnika v inhalator), in ki tako ali tako večidel dodatno vpliva na slabo sposobnost tečenja praška oz. lahko pride do grudičenja.Furthermore, the inhaler described is also disadvantaged by the fact that the fine-grained powder cannot be stored in a special container, e.g. capsules. This is particularly disadvantageous for those powders whose pharmaceutical effect is compromised by storage in permanent contact with air. In addition, in the inhaler described above, moisture entering the inhaler and its storage chamber (eg by accidentally coughing the user into the inhaler) and which in any case may additionally affect the poor flowability of the powder or the inhaler. clumping may occur.
Zato je naloga izuma razviti inhalator za trdna telesa, ki se izogne zgoraj omenjenim pomanjkljivostim, ki omogoča hitro, enostavno in zanesljivo doziranje trdnih teles, ki omogoča skladiščenje trdnih teles v posebnem zalogovniku, npr. kapsuli, in ki je enostaven za uporabo. Razen tega naj bo inhalator zasnovan za veliko število inhalacij, torej ne kot t.i. inhalator za enkratno uporabo.Therefore, it is an object of the invention to develop a solids inhaler which avoids the aforementioned drawbacks, which enables the rapid, easy and reliable dosing of solids, which enables the storage of solids in a special container, e.g. capsules, and which is easy to use. In addition, the inhaler should be designed for a large number of inhalations, ie not as so. disposable inhaler.
To nalogo se reši z izumom, kot je definirano v značilnostnem delu 1. patentnega zahtevka. Dozirni zatič štrli skozi odprtino zalogovne komore vanjo. Zalogovna komora in dozirni zatič sta drug proti drugemu relativno tako premakljiva, da se v dozirnem zatiču puščena zareza v prvem relativnem položaju nahaja v zalogovni komori, v drugem relativnem položaju pa v zračnem kanalu. S tem se doseže, da je dozirni zatič v prvem relativnem položaju potopljen v zalogo trdnih teles. Kot trdnaThis task is solved by the invention as defined in the characteristic part of claim 1. The metering pin protrudes through the opening of the storage chamber into it. The storage chamber and the metering pin are relatively movable relative to each other such that, in the metering pin, the notch in the first relative position is in the storage chamber and in the second relative position in the air duct. This achieves that the metering pin is immersed in the first solid position in the solid body. As solid
1. zariba (op. prev.)1. Zariba
22000PP0.IV telesa se ima pri tem v sledečem primeru prašek brez ali le s slabo sposobnostjo tečenja, ki se ga pri polnjenju dozirne zareze v prvem relativnem položaju potisne v to zarezo. Razen tega se da prašek uskladiščiti tudi v posebnem zalogovniku v zalogovni komori, npr. v kapsuli. To je lahko, kot že pojasnjeno, pomembno za takšne praške, katerih farmacevtski učinek pade zaradi skladiščenja v stalnem stiku z zrakom. Razen tega nudi skladiščenje praška v kapsuli tudi zaščito proti morebitni vdirajoči vlagi, tako da se da izogniti grudičenju in s tem nadaljnjemu vplivanju na sposobnost tečenja kot tudi vplivanju na farmacevtski učinek s stikom praška z vlago.22000PP0.IV In this case, in the following case, the powder has either no or only poor flowability, which is pushed into this notch when filling the dosing slit in the first relative position. In addition, the powder can also be stored in a special container in the storage chamber, e.g. in the capsule. This may, as explained above, be relevant for such powders whose pharmaceutical effect is impaired by storage in constant contact with air. In addition, the storage of the powder in the capsule also provides protection against possible moisture ingress, so as to avoid clumping and thereby further affect the flowability as well as affect the pharmaceutical effect by contacting the powder with moisture.
V izvedbenem primeru inhalatorja po izumu je dozirni zatič glede na ohišje naprave inhalatorja trdno razporejen, zalogovna komora pa je proti dozirnemu zatiču gibljivo razporejena. Ta izvedbeni primer se odlikuje z enostavno konstrukcijo in enostavnim rokovanjem, kar bo na osnovi detajlnega opisa še natančneje pojasnjeno.In the embodiment of the inhaler according to the invention, the metering pin is firmly disposed relative to the housing of the inhaler device, and the storage chamber is movably arranged against the metering pin. This embodiment is characterized by its simple construction and easy handling, which will be explained in greater detail on the basis of a detailed description.
Nadaljnja zasnova inhalatorja po izumu obsega ločen prožilni organ za gibanje zalogovne komore. Ob proženju giblje ta prožilni organ zalogovno komoro nasproti sili povratne vzmeti v prvi relativni položaj k dozirnemu zatiču. Stena zalogovne komore je opremljena s stenskim podaljškom, ki v tem prvem relativnem položaju zapre zračni kanal. V tem stenskem podaljšku je predvidena odprtina, ki po povratku zalogovne komore v drugi relativni položaj ponovno sprosti zračni kanal. S to zasnovo inhalatorja se doseže, da se pri polnjenju dozirne zareze ne da inhalirati in tudi ne pihati (npr. kašljati) v zračni kanal, s čimer se v tem relativnem položaju dozirnega zatiča in zalogovne komore prepreči vdiranje vlage v zračni kanal. Po temu sledečem odvzemu količine praška iz zalogovne komore oz. iz v njej uležiščenega zalogovnika, se zalogovno komoro postavi nazaj v drugi relativni položaj, s čimer dospe napolnjena dozirna zareza dozirnega zatiča v zračni kanal. Odprtina v stenskem podaljšku zalogovne komore sprosti zračni kanal in inhalacijo se lahko opravi.A further design of the inhaler according to the invention comprises a separate actuator for moving the storage chamber. When actuated, this actuator moves the storage chamber opposite to the force of the return spring in the first relative position to the metering pin. The storage chamber wall is provided with a wall extension that closes the air duct in this first relative position. This wall extension provides an opening which, upon returning the stock chamber to another relative position, releases the air duct again. This design of the inhaler achieves that when filling the metering notch, it cannot be inhaled nor blow (eg coughing) into the air duct, thus preventing moisture from entering the air duct in this relative position of the metering pin and the storage chamber. After that, the next quantity of powder is taken from the storage chamber. from the storage tank therein, the storage chamber is placed back to the second relative position, thereby reaching the filled dosing notch of the metering pin into the air duct. An opening in the wall extension of the storage chamber releases the air duct and inhalation can be done.
Pri nadaljnji izvedbi inhalatorja po izumu je prožilni organ opremljen še s stresalnim elementom, ki je lahko izveden npr. kot udarna vzmet. Ta stresalni element povzroči, da se pri dosegu prvega relativnega položaju dozirnega zatiča in zalogovne komore, torej pri polnjenju dozirne zareze, zalogovno komoro strese, s čimer se tudi v primeru praška z zlasti slabo sposobnostjo tečenja dozirno zarezo popolnoma, varno in hitro napolni.In a further embodiment of the inhaler according to the invention, the actuating body is further provided with a shaking element which can be performed e.g. like a shock spring. This shaking element causes the storage chamber to shake when it reaches the first relative position of the metering pin and the storage chamber, thus filling the metering notch, thus filling the metering notch completely, safely and quickly in the case of a powder with particularly poor flowability.
22000PPO.IV22000PPO.IV
Da bi uporabniku postalo očitno, da je ravnokar vzel dozo in tudi da bi pri prašku s slabo sposobnostjo tečenja omogočili stresanje zalogovne komore, medtem ko dozirni zatič z dozirno zarezo štrli v prašek, je .predvidena nadaljnja zasnova inhalatorja po izumu z aretirno napravo. Ta aretirna naprava trdno drži zalogovno komoro oz. dozirni zatič drugega proti drugemu v prvem relativnem položaju. Po zaključku doziranja se da aretiranje s proženjem odpahnilnega elementa ponovno sprostiti. Na ta način se da razen tega izogniti nenamernemu večkratnemu doziranju.In order to make it obvious to the user that he has just taken the dose and also to allow the storage chamber to shake in a powder with poor flowability, while the dosing pin with the dosage notch protrudes into the powder, a further design of the inhaler according to the invention with the arresting device is provided. This arresting device firmly holds the storage chamber. the dosing pin of each other in the first relative position. Once the dosing is complete, the arrest by releasing the release element can be released again. In this way, inadvertent multiple dosing can also be avoided.
Pri prednostni izvedbi izuma obsega inhalator poseben sesalni nastavek, v katerem se prečni presek zračnega kanala povečuje v smeri k izstopu. Tovrsten sesalni nastavek deluje obratno kot šoba in povzroči popolno deaglomeracijo praška, tako da ta v zračnem toku lahko dospe do pljuč uporabnika. Na ta sesalni nastavek je namestljiva zapiralna kapa, v kateri je predvideno sušilno sredstvo, da izloči morebitno vlago, ki bi vdrla.In a preferred embodiment of the invention, the inhaler comprises a special suction nozzle in which the cross section of the air duct is increased in the direction of outlet. Such a suction nozzle acts inversely as a nozzle and causes complete deagglomeration of the powder so that it can reach the user's lungs in the air stream. This suction nozzle is fitted with a closure cap, which provides a desiccant to remove any moisture that may intrude.
Da bi se preprečilo, da uporabnik po nastali določitvi količine praška in po vnosu praška v zračni kanal s pihanjem (npr. s kašljanjem) v inhalator izpihne prašek skozi vstop zraka, je pri nadalnji izvedbi izuma na vstopu zraka predviden protipovratni ventil.In order to prevent the user from blowing the powder through the air inlet after the determination of the amount of powder and after introducing the powder into the air duct by blowing (eg coughing), a non-return valve is provided in the further embodiment of the invention.
Nadaljnja izvedba inhalatorja po izumu je opremljena s števcem2, ki se ga da vrniti v začetni položaj, in ki pri dosegu prvega relativnega položaja zalogovne komore in dozirnega zatiča poraste. Uporabnik lahko tako razpozna, koliko doziranj je že vzel oz. koliko doziranj mu je še ostalo in lahko v danem primeru ponovno napolni zalogovno komoro.A further embodiment of the inhaler according to the invention is provided with a counter 2 , which can be reset to its initial position and which, upon reaching the first relative position of the storage chamber and the metering pin, increases. The user can thus recognize how many dosages he or she has already taken. how much dosage he has left and can refill the storage chamber if necessary.
Inhalator je zlasti primeren za inhalacijo astmatsko učinkovitih snovi ali zmesi snovi, npr. za zmes formoterola in laktoze, kar je spodaj šepobliže pojasnjeno.The inhaler is particularly suitable for the inhalation of asthmatically effective substances or mixtures of substances, e.g. for a mixture of formoterol and lactose, which is explained below in the whispers below.
Zasnova po izumu znatnega pomena predvideva osno prestavljanje dozirnega zatiča z relativno zavrtitvijo med ohišnim telesom, ki nosi zatič, po eni strani in ohišnim delom, ki vsebuje zalogovno komoro, po drugi strani, pri čemer se to vrtilno gibanjeThe design according to the invention substantially provides for axial movement of the metering pin with relative rotation between the housing body carrying the pin, on the one hand, and the housing part containing the storage chamber, on the other, whereby this rotational motion
2. rucksetzbar2. rucksetzbar
220O0PP0.IV preko nagnjenih ploskev prisilno pretvori v osno gibanje. Inhalator po izumu je k temu značilen po tem, da sta zalogovno komoro obsegajoč ohišni del in telo naprave, ki nosi dozirni zatič, iz prvega skupaj potisnjenega položaja drug k drugemu premakljiva v drug, drug iz drugega izvlečen položaj s tem, da sta zavrtljiva relativno drug k drugemu, vsaj ena nagnjena ploskev na telesu naprave in/ali ohišnem delu ter na njej voden protikos pa pretvori vrtilno gibanje v osno gibanje. To vodi k bistveno udobnejšem dozirnem gibanju, ker je vrtilno gibanje varneje izvedljivo kot sorazmerno kratko osno gibanje, pri katerem se mora dva dela izvleči drugega iz drugega.220O0PP0.IV Forcibly transforms inclined surfaces into axial motion. The inhaler according to the invention is characterized in that the storage chamber comprising the housing part and the body of the device carrying the metering pin are movable from each other to the other, pushed apart from each other by being rotatable relative to each other. to one another, and at least one inclined surface on the body of the device and / or housing, and the guided counter thereon, converts rotational motion into axial motion. This leads to significantly more comfortable dosing movement because rotary motion is safer to do than a relatively short axial motion in which two parts must be pulled out of the other.
Ohišni del ali telo naprave lahko obsegata več na svojem obodu porazdeljeno razporejenih nagnjenih ploskev enake strmine in dolžine, relativno k temu pa vrtljiva telesa ali deli ustrezno število z njimi sodelujočih štrlin ali protikosov. S tem se vrtilno gibanje na več mestih istočasno pretvori v osno gibanje, tako da med vrtenjem nastopi simetričen prijem sile in natančna osna prestavitev.The housing part or body of the device may comprise more of the inclined surfaces distributed along its periphery of the same slope and length, relative to which the rotating bodies or share an appropriate number of projecting projections or proticos. In this way, the rotational motion in several places is simultaneously converted into axial motion, so that during the rotation a symmetrical grip of force and precise axial gearing occurs.
Kot ugodno se je pokazalo, kadar so predvidene vsakokrat štiri, preko približno 90° raztezajoče se, na isti višini ležeče in v isto smer dvigajoče se nagnjene ploskve, ki sodelujejo s kot štrline zasnovanimi protielementi, in kadar so na koncu nagnjenih ploskev predvideni v navpični smeri orientirani prehodi, utori ali podobno za štrline, tako da sta ohišni del z zalogovno komoro in protikos po zavrtitvi in vzdolžnem zdrsu štrlin na nagnjenih ploskvah z iz tega rezultirajočo osno prestavitvijo dozirnega zatiča skupaj prestavljiva v osni smeri in premakljiva nazaj v izhodiščni položaj. Kot vodila služeče nagnjene ploskve potekajo torej na delu vijačnice, končujejo pa se na osnem prehodu, tako da pri zavrtitvi sledi najprej želeni osni premik s transportom doziranega materiala iz zalogovne komore v zračno pot, medtem ko za povraten premik dozirnega zatiča v zalogovno komoro zadostuje enostaven osni skupni premik telesa naprave in ohišnega dela, ker na koncu vrtilnega gibanja ni več na razpolago nikakršnih več takšen premik ovirajočih nagnjenih ploskev.It proved to be advantageous when four inclined, over 90 ° extending, inclining and inclining planes cooperating with projection-like projections were projected each time, and when they were envisaged at the end of inclined planes direction-oriented transitions, grooves or the like for projections, such that the housing part with the stock chamber and the counter-rotation after the rotation and longitudinal slip of the projections on inclined surfaces, thereby resulting in axially adjusting the metering pin, are movable in the axial direction and move back to the starting position. The inclined surfaces serve as guides on the part of the helix and end at the axial passage, so that when rotating, the desired axial movement is followed by transporting the metered material from the storage chamber into the air path, while a simple movement of the metering pin into the storage chamber is sufficient. the axial joint displacement of the body of the device and the housing, since no such displacement of the obstructed inclined surfaces is available at the end of the rotational motion.
S tem, da je po eni strani mogoč poprej omenjen osni povratni premik, po drugi strani pa se že pri začetku vrtilnega gibanja štrlina, npr. palec, prisilno vodi preko nagnjene ploskve, je lahko v poteku osnih povratnih vodilnih utorov razporejena vsaj ena, kot žagin zob zasnovana štrlina (zob), katere strmo padajoča stran je razporejena sovpadajoče z delujočo nagnjeno ploskvijo za palec, palec pa je lahko preko dvigajoče se nagnjene strani tega zoba prestavljiv v osni smeri in v začetnem položajuBy the fact that, on the one hand, the aforementioned axial reverse movement is possible, and on the other hand, at the beginning of the rotational movement a projection, e.g. the thumb, forcibly leading over an inclined surface, may have at least one projection in the course of the axial return guide grooves, a saw-tooth projection (tooth), the steeply descending side of which is arranged coincident with the operatively inclined surface by the thumb, and the thumb may be over the rising one. inclined sides of this tooth adjustable in the axial direction and in the starting position
22000PP0.IV naslednjega dozirnega gibanja razporejen za strmo padajočo stranjo. Pri osni prestavitvi v izhodiščni položaj se da torej vsakokratno štrlino (palec) znotraj osnega povratnega vodilnega utora zdrsniti proč preko, kot žagin zob zasnovane štrline (zoba), se pa zatem z druge strani ovira ustrezno nasprotno gibanje, tako da tudi ta kot žagin zob zasnovana štrlina že pripada vodilni ali nagnjeni ploskvi, ki pripomore k temu, da se vrtilno gibanje obeh ohišnih delov relativno drug proti drugemu pretvori v osno gibanje.22000PP0.IV of the next dosing movement arranged for a steeply descending side. When axially moved to the starting position, the projection (thumb) within the axial return guide groove can then slide away over the saw-shaped tooth (tooth), but then, on the other hand, the corresponding opposite movement is impeded, so that the saw tooth as well. the projected projection already belongs to a leading or inclined plane, which helps to rotate the movement of the two housing parts relative to each other in an axial motion.
Nagnjene ploskve ustrezajo na smotrn način delu navojnega koraka in so razporejene zlasti na notranji strani stenskega kosa ohišnega dela. V tem primeru ima potem telo naprave z nagnjenimi ploskvami sodelujoče štrline. Te nagnjene ploskve so seveda lahko prav tako predvidene na stenskem kosu telesa ohišja, ohišni del pa obsega z nagnjenimi ploskvami sodelujoče štrline.The sloping surfaces correspond in a sensible manner to the work of the threaded step and are arranged especially on the inside of the wall piece of the housing part. In this case, then, the body of the device with inclined surfaces has a projecting projection. These inclined surfaces may, of course, also be provided on the wall part of the body of the housing, and the housing portion comprises inclined surfaces of the cooperating projection.
Izvedbena oblika inhalatorja, pri kateri se vnos trdnih teles povzroči s prestavitvijo vrtilnega v osno prestavno gibanje, dovoli izvedbo znatnega pomena, pri kateri se po eni strani zavre vrtenje ohišnega dela proti dozirnemu gibanju, in pri tem to vrtilno gibanje k temu istočasno lahko izkoristi zato, da se inhalator tako pretrese, da lahko praškasta trdna telesa dobro stečejo v dozirno zarezo. Tovrstna smotrna nadaljnja izvedba lahko sestoji v tem, daje na dotikalnih mestih med relativno drug k drugemu zavrtljivih ohišnih delov razporejena zapora, raglja ali podobno, ki blokira protismiselno vrtenje ohišnih delov nasproti dozirnemu gibanju. Po eni strani se s tem izključi napačno povezavo, ker je vrtenje za uporabnika mogoče le v eni smeri, po drugi strani pa se z ragljo naprava med vrtenjem zadosti pretrese, da se omogoči dobro tečenje praška v dozirno zarezo.The embodiment of the inhaler, in which the introduction of solids is caused by the rotation of the rotary in axial gear movement, permits the implementation of a significant value, in which, on the one hand, the rotation of the housing part is prevented against the metering movement, and at the same time it can be used for this rotational motion to shake the inhaler so that the powder solids can flow well into the dosage notch. Such a reasonable further embodiment may consist in the fact that, at touching points, relative to each other of the rotatable housing parts, there is a lock, a ratchet or the like, which blocks the antisense rotation of the housing parts opposite to the metering movement. On the one hand, this eliminates the wrong connection, since the rotation is only possible for the user in one direction, and on the other, the machine shakes sufficiently during rotation to allow the powder to flow properly into the dosing slit.
Pri tem lahko zapora obsega zaporno kolo z žagastimi zobmi na prvem ohišnem delu in z vsakokrat v obodni smeri drug'proti drugemu zamaknjenimi protizobmi ali skupinami protizob na drugem ohišnem delu ali telesu naprave, pri čemer je zamik vsakokratnih predvidenih protizob v obodni smeri drug proti drugemu tako izbran, da je rageljni korak zapore manjši od delitve zob. Pri takšni zapori zadostuje, kadar je vsakokrat en zob zapornega kolesa v prijemu s protizobom. Ker je na inhalatoiju predvidenih več v obodni smeri drug proti drugemu zamaknjenih protizob, katerih zamik odstopa od delitve zob, se dobi ustrezno majhen korak v vrtilni smeri, kateremu vsakokrat ponovno sledi blokiranje. Ustrezno mnogo pretresanj nastopiIn this case, the closure may comprise a locking wheel with saw teeth on the first housing part and with each other in circumferential direction mutually displaced counter-teeth or groups of counter-teeth on the second housing part or body of the device, the offset of each intended counter-teeth in circumferential direction with respect to each other so selected that the ratchet step of the closure is smaller than the tooth splitting. In such a closure, it is sufficient when one tooth of the locking wheel is in the grip with the tooth. As more in the circumferential direction of the displaced counter-teeth, whose displacement deviates from the tooth division, is provided in the inhalatoi, a correspondingly small step in the rotational direction is obtained, which is again followed by blocking. Adequate number of searches occur
22000PPO.IV tudi med celotnim vrtilnim gibanjem.22000PPO.IV also during the entire rotational motion.
Pri tem je prednostno, da se zobje, zobne vrzeli iri protizobje raztezajo premočrtno v osni smeri. S tem ne ovirajo na koncu dozirnega gibanja izvajajoče povratne prestavitve.In this case, it is preferable that the teeth, tooth gaps, and teeth are extended in a straight line in the axial direction. This does not interfere with performing reverse gears at the end of the dosing movement.
Da bi se lahko na ozkem prostoru namestilo po eni strani vodilne ali nagnjene ploskve, po drugi strani pa ragljo ali zaporo, ima lahko dozirno iglo obsegajoče telo naprave ali ohišni del deloma dvojno ostenje, katerega notranje ostenje nosi z nagnjenimi ploskvami na drugem ohišnem delu sodelujoče štrline, ki štrlijo od tega notranjega ostenja radialno navzven, zunanje ostenje pa lahko zunaj objema nagnjene ploskve obsegajoč stenski del drugega ohišnega dela in obsega protizobe za tiste protizobe, ki obremenjujejo na zunanji strani ohišnega dela, vsebujočega zalogovno komoro, razporejeno zaporno kolo. Telo naprave ima torej praktično dve ostenji, v katerih vmesni prostor lahko prijemlje ustrezno ostenje ohišnega dela, ki nato na prvi strani lahko nosi nagnjene ploskve, na drugi, zunajležeči strani pa del zapore. Tovrstna, s prostorom zelo varčna razporeditev različnih sodelujočih komponent celotnega sistema je mogoča zlasti s tem, da so deli zaradi svoje relativne zavrtljivosti drugega proti drugemu krožni, torej dovoljujejo koncentrično razporeditev različnih ostenij.In order to accommodate a guide or inclined surface on one side of the leading or inclined surface and a ratchet or lock on the other, the dosing needle may comprise a body of the device or a housing part partially double-sided, the inner wall of which is supported by inclined surfaces on the other housing part. projections projecting radially outward from this inner wall, and the outer wall may extend beyond the circumference of the inclined surface, comprising the wall portion of the second housing portion and comprising counter-teeth for those bearings which exert a locking wheel on the outside of the housing portion containing the storage chamber. The body of the device thus has practically two slots, in which the intermediate space can accommodate a suitable sling of the housing part, which can then carry inclined surfaces on the first side, and a part of the barrier on the other, non-bearing side. Such a space-saving arrangement of the various cooperating components of the whole system is possible in particular by the fact that the parts, due to their relative rotation to each other, are circular, thus permitting the concentric arrangement of the different walls.
Medtem ko sta notranje ostenje dozirno iglo obsegajočega ohišnega dela in vodilne ploskve obsegajoča stena zalogovno komoro obsegajočega ohišnega dela - vsaj v območju njunega sodelovanja - krožna, ima lahko zunanje ostenje prvega ohišnega dela od te krožne oblike odstopajoč prečni presek, tako da se med ostenji tvorijo vogalna območja, zlasti pri zavrtenih in/ali osno drug iz drugega izvlečenih ohišnih delih pa se da zrak vsesati preko teh, tedaj odprtih vogalnih območij, s predori na notranjih stenskih delih kot tudi z vsaj eno protipovratno kapo pa voditi k dozirnim kanalom in dozirni igli. Ta, od krožne oblike odstopajoča oblika prečnega preseka zunanjega ostenja dovoljuje tudi, da se na njegovi notranji strani vsakokrat predvidi vpadne protizobe, ki so v obodni smeri tako zamaknjeni drug proti drugemu, da zaporno kolo že po manj kot eni zobni delitvi najde oporo na protizobu.While the inner wall of the dosing needle of the enclosing housing part and the guide surface of the enclosing wall of the storage chamber of the enclosing housing part is circular - at least in the area of their cooperation - the outer wall of the first housing part may have a cross-section deviating from this circular shape so that the walls form corner areas, especially in case of rotated and / or axially extracted housing parts, air can be drawn in through these then open corner areas, with tunnels on the inner wall parts as well as with at least one non-return cap leading to the metering channels and the metering needle . This circular shape, which deviates from the cross-section of the outer wall, also allows the inside of each side to be provided with striking countersinks, which are displaced in a circumferential direction so that, after less than one tooth division, the locking wheel finds support in the counter tooth .
Nadalje pridejo ta vogalna območja pri zavrtitvi izven celotnega obrisa, tako da je zraku olajšan dostop.Further, these corner areas come out of rotation beyond the entire contour, giving the air easier access.
22000PP0.IV22000PP0.IV
Čelna stran zunanjega ostenja dozirno iglo obsegajočega ohišnega dela lahko v skupaj potisnjenem položaju s skladno krožečo konturo nalegajo proti prislonski ploskvi drugega ohišnega dela in v tem položaju se lahko pot zraka preseka ter notranjost inhalatorja zrakotesno zapre. To ima prednost, da vlaga ne more vstopiti tako dolgo, dokler je naprava neuporabljena, tako da se izognemu temu, da bi se prašek, ki naj bi se ga doziralo, pri naslednji uporabi zapekel zaradi vlage.The metering needle of the enclosing housing part can be pushed against the front surface of the second housing part in a jointly pushed position with the front side of the outer housing and in this position the air path can be crossed and the inhaler can be closed airtightly. This has the advantage that moisture cannot enter as long as the appliance is unused, so that the powder to be dosed is not clogged with moisture the next time it is used.
Vrtljivost po izumu obeh ohišnih delov relativno drugega proti drugemu za izvedbo osne prestavitve dozirnega zatiča dovoljuje nadaljnjo prednostno in smotrno zasnovo tako, da lahko prvi od ohišnih delov vsebuje relativno k prikazovalnemu oknu vrtljiv prikazovalni obroč, ki je z relativno zavrtitvijo obeh ohišnih delov drugega proti drugemu pri doziranju vsakokrat premakljiv naprej za majhno vrednost kota enake velikosti in iste smeri. S tem lahko uporabnik neposredno preko tega prikazovalnega obroča določi napredovanje praznjenja, torej pravočasno vzame v uporabo nov inhalator ali razpoložljivi inhalator - v kolikor je mogoče - ponovno napolni.The rotation according to the invention of the two housing parts relative to each other for axially adjusting the metering pin permits a further advantageous and efficient design such that the first of the housing parts may include a rotating display ring relative to the display window, which is relative to the other housing parts relative to each other in the case of dosing, always move forward by a small value of an angle of the same size and direction. In this way, the user can directly determine the discharge progression directly through this display ring, in a timely manner using a new inhaler or refilling the available inhaler as soon as possible.
Prikazovalni obroč je lahko zasnovan kot zobnik, ki je izsredno glede na votli zobnik ali notranje ozobljenje uležajeno v dozirno iglo obsegajočem ohišnem delu, in se s svojim zunanjim ozobljenjem prilega v notranje ozobljenje tega votlega kolesa, pri čemer število zob tega notranjega zobnika tako malo odstopa od števila zob votlega kolesa, da je notranji zobnik proti votlemu zobniku zavrtljiv za okoli en sam vrtljaj ali njegov del, kadar je izvedeno preddoločeno število npr. 200 doziranj. Številčna delna-vrtilna gibanja pri vsakokratnem doziranju vodijo torej k zelo počasnem zložnem vrtenju prikazovalnega obroča, ki z določenimi barvnimi dodatki ali podobnim lahko signalizira uporabniku na prikazovalnem oknu porabo trdnega telesa, ki se naj ga inhalira. Pri tem je ponovno prednostno, da se vrtilna gibanja na napravi vedno izvaja le v eni smeri, vrtenje nazaj pa je blokirano.The display ring may be designed as a sprocket, which is mounted relative to the hollow sprocket or inner gearing in a dosing needle comprising the housing part, and with its outer gearing fits into the inner gearing of this hollow wheel, leaving so little teeth of this inner gearing. from the number of teeth of the hollow wheel, that the inner gear against the hollow gear is rotatable by about a single revolution or part thereof, when a predetermined number e.g. 200 dosages. Numerous partial-rotational movements at each dosage therefore lead to a very slow folding rotation of the display ring, which, with certain color additives or the like, can signal to the user on the display window the consumption of the solid to be inhaled. Again, it is preferred that the rotational motion of the device is always performed in one direction only, and that the reverse rotation is blocked.
Da bi se doseglo, da uporabnik ne poizkuša inhalirati še naprej, kadar je bila dosežena predvidena največja količina posamičnega doziranja, se da kot prikazovalni obroč Služeče zobato kolo in s tem dozirno gibanje po dosegu predvidenega števila doziranj blokirati. To se da doseči na različne načine.In order to ensure that the user does not attempt to continue inhaling when the intended maximum amount of individual dosage has been reached, the gear wheel may be used as a display ring and thus the dosing movement is blocked after reaching the intended number of dosages. This can be achieved in various ways.
Smotrna možnost, ki istočasno izkorišča tudi z vrtenjem povzročeno osno gibanje, lahko sestoji v tem, da kot prikazovalni obroč služeče zobato kolo obsega prislon, kiA reasonable option, which also takes advantage of the rotational axial motion at the same time, may be that the gear wheel serves as a display ring, which includes a stop which
22O00PP0.IV smiselno sodeluje s protiprislonom relativno k njemu zavrtljivega ohišnega dela, da sta prislona v izhodišni legi blizu drug drugemu ali se dotikata in se z dozirnim gibanjem polagoma gibljeta narazen v obodni smeri, pri čemer prideta z istočasno osno prestavitvijo tadva prislona vsakokrat v druga proti drugi po višini zamaknjeni ravnini, s povratnim gibanjem pa ponovno dospeta v sovpadajočo ravnino, in da smotrno kot štrlini zasnovana - prislona po približno enem vrtljaju prikazovalnega obroča in zadnjem dozirnem koraku v obeh ravninah tako nalegata drug na drugega, da je osna povratna prestavitev v izhodiščno lego in s tem ponovni dozirni korak blokiran.22O00PP0.IV mutatis mutandis cooperates with the counter-relative to the rotatable housing part thereof, so that the stops in the initial position are close to each other or touch and move slowly apart in the circumferential direction by the metering movement, whereby the two axles are moved axially at the same time. towards the second plane, which is displaced in height, and again, in a reciprocal motion, they again reach the coincident plane, and that they are designed as projections - the stops, after about one rotation of the display ring and the last dosing step in both planes, so that each other is axially reversed. starting position and thereby blocking the dosing step again.
Nadaljnja izvedba izuma z znatno prednostjo lahko sestoji v tem, da je v zalogovni komori na strani, nasprotni dozirnemu zatiču, razporejen s šibko vzmetjo obremenjen, pojemanju vsebine komore sledeč bat ali podobno, pri čemer je vzmetna sila tako majhna, da je preprečeno stiskanje trdnih teles, pri čemer pa je vzmetna sila vseeno tako velika, da potisne bat tudi proti sili težnosti trdnih teles in njegovi lastni teži, ki sledi pojemanju volumna komore. S to razporeditvijo je mogoče inhalator uporabiti v praktično poljubni legi in še pri vsakem dozirnem gibanju zagotoviti tudi polnjenje dozirne zareze. Zaradi tega se s temi ukrepi in stalnim lahkim potiskanjem praškastega trdnega telesa prepreči zapečenje le-tega ali tvorba kanala na mestu, na katerem dozirni zatič vstopa ali izstopa. Ker vzmet, ki obremenjuje sledilni bat, povzroča s tem, da pri vsakem dozirnem gibanju, najbolje po predhodnem stresanju inhalatorja, resnično sledi tudi popolno doziranje.A further advantageous embodiment of the invention may consist in the fact that in the storage chamber on the side opposite to the metering pin, disposed with a weak spring, the following is plunged into the chamber, or the like, the spring force being so small as to prevent solid compression However, the spring force is still so large that it also pushes the piston against the gravity of the solids and its own weight following the decay of the volume of the chamber. With this arrangement, the inhaler can be used in virtually any position and even at each dosing movement the filling of the metering notch can be ensured. As a result, these measures and the constant light pushing of the powder solid prevents it from sealing it or forming a channel at the point where the metering pin enters or exits. Because the spring that loads the tracer piston causes the complete dosing to follow in every dosing motion, preferably after shaking the inhaler first.
Zalogovna komora je lahko znotraj ohišnega dela razporejena sprostljivo in zamenljivo in/ali ima sprostljiv pokrov. S tem se da po izpraznitvi zalogovne komore bodisi to zalogovno komoro samo zamenjati ali ponovno napolniti, namesto da se mora uporabiti popolnoma nov inhalator, izpraznjenega pa vreči proč.The storage chamber may be arranged freely and interchangeably within the housing portion and / or may have a release lid. In this way, after emptying the storage chamber, either this storage chamber can only be replaced or refilled, instead of using a brand new inhaler and throwing the emptied away.
V ohišnem delu zamenljivo razporejena zalogovna komora lahko v izhodiščni legi pred montažo obsega predirno in/ali preko vnaprej določenih lomnih točk tesno pritrjeno zaporo prehodnega kanala za dozirni zatič, katera je z vstavitvijo zalogovne komore v njen ohišni del samodejno odpirljiva z dozirnim zatičem. Če se torej izpraznjeno zalogovno komoro nadomesti s takšno novo zalogovno komoro, povzroči vsatvitev v ohišni del istočasno tudi vnos dozirnega zatiča v to zalogovno komoro, ne da bi ta morala biti poprej že odprta.In the housing part, the interchangeably arranged storage chamber may, in its initial position, comprise a piercing and / or through pre-defined breaking points, a tightly secured passageway passage for the metering pin, which is automatically opened with a metering pin by inserting the stock chamber into its housing part. Therefore, if the emptied storage chamber is replaced by such a new storage chamber, the insertion into the housing portion will at the same time cause the dosing pin to be introduced into that storage chamber without it having to be opened beforehand.
22000PPO.IV22000PPO.IV
Da bi z dozirnim zatičem odpirljiva zapora pri kasnejši uporabi ne dospela v dozirno zarezo in motila dozirna gibanja, je smotrno, če je s to montažo odpirljiva zapora zalogovne komore izvihtljiva v notranjost zalogovne komore, njen premer pa je večji kakor osni razpon dozirne zareze. Pri tem so vsekakor mogoče tudi drugačne tehnične izvedbe tega principa.In order to prevent the opening bar from being used later in the dosage notch and disrupting the metering movements with a metering pin, it is advisable to use this mounting to open the locking chamber of the storage chamber inside the storage chamber with a diameter greater than the axial range of the metering slot. However, different technical implementations of this principle are certainly possible.
V nadaljevanju so izvedbeni primeri pobliže pojasnjeni s pomočjo risb. V deloma shematski predstavitvi kaže sl. 1 inhalator po izumu v izhodiščnem položaju (drugi relativni položaj) in v vzdolžnem prerezu, sl. 2 inhalator s sl. Iv prvem relativnem položaju in v vzdložnem prerezu, sl. 3 zgornji del inhalatorja v pogledu od spredaj (v ravnini risbe s sl.The following examples are explained in greater detail by means of drawings. In a partly schematic representation, FIG. 1 shows an inhaler according to the invention in a starting position (second relative position) and in longitudinal section; 2 shows the inhaler of FIG. Iv in the first relative position and in the longitudinal section, FIG. 3 is a top view of the inhaler from the front (in the plane of the drawing in FIG.
2), sl. 4 zgornji del s sl. 3 v pogledu s strani v smeri puščice IV, sl. 5 spodnji del inhalatorja v tlorisnem pogledu v smeri puščice V s sl.2), FIG. 4 is a top view of FIG. 3 is a side view in the direction of arrow IV, FIG. 5 is a plan view of the bottom of the inhaler in the direction of arrow V in FIG.
2, sl. 6 vzdolžni prerez skozi zalogovno komoro inhalatorja (prerezna ravnina je identična s prerezno ravnino na sl. 1 in 2), sl. 7 zalogovno komoro v prerezu vzdolž črte VTI-VII s sl. 6, sl. 8 zalogovno komoro v nadaljnjem prerezu vzdolž črte VIII-VIII s sl. 6, sl. 9 zunanji izgled inhalatorja, sl. 10 prerez vzdolž črte Χ-Χ s sl. 11 skozi aretirno napravo v izhodiščnem položaju (drugi relativni položaj), sl. 11 aretirno napravo v tlorisnem pogledu v smeri puščice XI s sl. 10, sl. 12 aretirno napravo v prvem relativnem položaju in v prerezu vzdolž črte ΧΙΙ-ΧΙΙ s sl. 13, sl. 13 aretirno napravo v tlorisnem pogledu v smeri puščice ΧΙΠ s sl.2, FIG. 6 is a longitudinal section through the inhalation chamber of the inhaler (the cross-sectional plane is identical to the cross-sectional plane of FIGS. 1 and 2); FIG. 7 is a cross-sectional view of the storage chamber along the line VTI-VII of FIG. 6, FIG. 8 is a further cross-sectional view of the storage chamber along line VIII-VIII of FIG. 6, FIG. 9 is an external view of the inhaler, FIG. 10 is a section along the line vzd-Χ of FIG. 11 through the arresting device in the starting position (second relative position), FIG. 11 is a plan view of the arresting device in the direction of arrow XI of FIG. 10, FIG. 12 shows the arresting device in the first relative position and in cross-section along the line ΧΙΙ-ΧΙΙ of FIG. 13, fig. 13 is a plan view of the arresting device in the direction of the arrow ΧΙΠ; FIG.
12, sl. 14 vzdolžni prerez modificiranega inhalatorja po izumu v prvem relativnem položaju, v katerem je dozirna zareza pozicionirana v zalogovni komori, pri čemer je osna prestavitev izvedljiva z zavrtitvijo telesa naprave, ki nosi dozirni zatič, nasproti ohišnemu12, FIG. 14 is a longitudinal cross section of a modified inhaler according to the invention in a first relative position in which the metering notch is positioned in the storage chamber, wherein the axial shift is feasible by rotating the body of the device carrying the metering pin opposite the housing
22000PPO.IV delu, ki vsebuje zalogovno komoro, sl. 15 deloma shematski prečni prerez inhalatorja po črti D-D s sl. 14, sl. 16 pogled na razvito, preko npr. približno četrtino obsega segajočo, nagnjeno ploskev ohišnega dela, preko katere se s pomočjo štrline na telesu naprave vrtilno gibanje pretvori v zahtevano osno prestavitev dozirnega zatiča iz njegove, na sl. 14 predstavljene, izhodiščne lege v položaj, prikazan na sl. 19, sl. 17 prerez po črti C-C s sl. 15 skozi protipovratno loputo, ležečo znotraj zračne poti, sl. 18 delni prerez po črti B-B s sl. 15 skozi k dozirnemu zatiču speljan kanal s pogledom na vstopa v naslednja kanala, sl. 19 inhalator v vzdolžnem prerezu po sl. 14 po izvršitvi vrtilnega gibanja, pretvorjenega v osno prestavitev, sl. 20 prečni prerez po črti E-E s sl. 19 skozi zaporo, predvideno med relativno drug proti drugemu zavrtljivima ohišnima deloma, sl. 21 inhalator v vzdolžnem prerezu, ustrezajočem tistemu s sl. 19, pri čemer je desni del nasproti razporeditvi s sl. 14 do 19 prikazan zavrteno, tako da prerez poteka tam skozi protipovratno loputo in zračne kanale, sl. 22 inhalator v prvem relativnem položaju v prerezu, ki je glede na sl. 14 zavrten za 90°, sl. 23 prečni prerez po črti F-F s sl. 22 skozi prikazovalno pripravo, sl. 24 do sl. 28 prikazovalno pripravo po sl. 23 v različnih položajih vsakokrat po naraščajočem številu doziranj, pri čemer je na sl. 28 predstavljeno blokiranje po predvidenem največjem številu doziranj, sl. 29 vzdolžni prerez modificiranega inhalatoija v drugem relativnem položaju, pri čemer je v zalogovni komori predviden vzmetno obremenjen sledilni bat za trdna telesa, nahajajoča se v zalogovni komori, sl. 30 vzdolžni prerez skozi zamenljivo zalogovno komoro z zaporo, zaprto z vnaprej določenimi lomnimi točkami ali podobnim, ki je z vstavitvijo v inhalator z dozirnim za tičem samodejno odpirljiva, pri čemer je v tem izvedbenem primeru prav tako predviden22000PPO.IV of the part containing the storage chamber, FIG. 15 is a schematic cross-sectional view of the inhaler along line D-D of FIG. 14, FIG. 16 view of developed, e.g. about a quarter comprises a projecting, inclined surface of the housing portion, through which the rotational movement is converted by the projection on the body of the device into the required axial movement of the metering pin from its, in FIG. 14 shows the starting positions in the position shown in FIG. 19, FIG. 17 is a cross-sectional view taken along line C-C of FIG. 15 through a non-return flap lying within the airway, FIG. 18 is a partial cross-section along line B-B of FIG. 15 shows a channel through the dosing pin with a view of the entrances to the following channels; FIG. 19 is a longitudinal section inhaler of FIG. 14 after executing the rotational movement converted to axial gearing, FIG. 20 is a cross-section along line E-E of FIG. 19 through the barrier provided between the relatively rotatable housing parts relative to each other, FIG. 21 is a longitudinal section inhaler corresponding to that of FIG. 19, the right side opposite to the arrangement of FIG. 14 to 19 are shown rotated such that the cross-section passes there through the non-return flap and the air ducts, FIG. 22 is a cross-sectional view of the inhaler in the first relative position according to FIG. 14 is rotated 90 °, FIG. 23 is a cross-sectional view taken along line F-F of FIG. 22 through the display device, FIG. 24 to FIG. 28 is a display device according to FIG. 23 in different positions, respectively, in increasing numbers of dosages, with FIG. 28 shows the blocking according to the intended maximum number of dosages, FIG. 29 is a longitudinal cross-section of a modified inhalato in a second relative position, wherein a spring-loaded tracking plunger for solids located in the storage chamber is provided in the storage chamber, FIG. 30 is a longitudinal section through a replaceable storage chamber with a barrier closed with predetermined breaking points or the like, which is automatically openable by insertion into the inhaler with a metering point, in which embodiment is also provided in this embodiment
22000PP0.IV vzmetno obremenjen sledilni bat.22000PP0.IV Spring loaded tracking piston.
S pomočjo na sl. 1 in 2 prikazanih vzdolžnih prerezov skozi 'inhalator naj bi se natančneje pojasnilo njegovo zgradbo in način delovanja. Inhalator I obsega v bistvu vstop 3 zraka z nakazanim protipovratnim ventilom R (oboje predstavljeno črtkano, ker ne leži v prerezni ravnini) v svojem snemljivem zgornjem delu O, prožilni organ v obliki pritisnega gumba 2, zalogovno komoro 4 za trdna telesa ali za ločen zalogovnik, npr. kapsulo K, v kateri so uskladiščena trdna telesa, dozirni zatič 5, ki je opremljen z v danem primeru kot utor zasnovano dozirno zarezo 50, zračni kanal 6 (prikazan Črtkano, ker ne leži v prerezni ravnini), kot tudi sesalni nastavek 1, ki je opremljen z izstopom za zmes trdna telesa-zrak, katera se proizvaja v inhalatorju na način in vrsto, ki ju je še potrebno pojasniti. Na sesalni nastavek 1 je nataknjena zaščitna kapa 1, s pomočjo katere je izstop 10 zapirljiv.With the help of FIG. 1 and 2 of the longitudinal sections shown through the inhaler are intended to give a more detailed explanation of its structure and mode of operation. Inhaler I comprises essentially an inlet of 3 air with a non-return non-return valve R (both represented dashed because it does not lie in the cross-section plane) in its detachable upper O, a pushbutton-shaped actuator 2, a solids storage chamber 4 or a separate container , e.g. a capsule K in which the solid bodies are stored, a metering pin 5, which is, in the present case, provided as a groove-shaped metering notch 50, an air duct 6 (shown dashed because it does not lie in the cross-section), as well as a suction nozzle 1 which is equipped with an outlet for a solid-air mixture which is produced in an inhaler in a manner and type that remains to be explained. A suction cap 1 is attached to the suction nozzle 1, by which the outlet 10 is lockable.
Pri temu sledečem pojasnjevanju načina delovanja inhalatorja se upošteva primer, da so trdna telesa uskladiščena v kapsuli K, ki vsebuje npr. 100 doziranj, in da je ta kapsula K že vnešena v zalogovno komoro 4. Izmere kapsule K in zalogovne komore 4 so pri tem usklajene druga z drugo. Če se sedaj napne pritisni gumb 2 in nasadi zgornji del O ter pritisne pritisni gumb 2 v njegov izhodiščni položaj, predre tako dozirni zatič 5 skozi odprtino. 400 skozi zalogovno komoro 4 v kapsulo K in štrli v trdna telesa, uskladiščena v kapsuli K. Inhalator je tedaj v svojem izhodiščnem položaju (sl. 1), iz katerega lahko sledi najprej doziranje količine trdnih teles, zatem pa inhalacija.In the following explanation of the mode of operation of the inhaler, the case is taken into account that the solids are stored in a capsule K containing e.g. 100 dosages, and that this capsule K has already been inserted into the storage chamber 4. The dimensions of the capsule K and the storage chamber 4 are aligned with each other. If the pushbutton 2 is now tensioned and the upper part O is planted and the pushbutton 2 is pressed to its starting position, it thus penetrates the metering pin 5 through the opening. 400 through the storage chamber 4 into capsule K and protruding into solids stored in capsule K. The inhaler is then in its starting position (Fig. 1), from which the dosage of the amount of solids can be followed first, followed by inhalation.
Zalogovna komora 4 z uležiščeno kapsulo K se znajde v mirovnem položaju, kot je predstavljeno na sl. 1. Zalogovna komora 4 in dozirni zatič 5 sta v tem mirovnem položaju relativno drug k drugemu tako razporejena, da dozirni zatič 5 sicer štrli v notranjost kapsule K in zapira odprtino 400 zalogovne komore 4, kot utor zasnovana dozirna zareza 50 pa se nahaja še v zračni poti med vstopom 3 in izstopom 10. Ta relativni položaj (izhodiščni položaj) dozirnega zatiča 5 in zalogovne komore 4 je v nadaljevanju označen kot drugi relativni položaj. Stena 40 zalogovne komore 4 je opremljena s stenskim podaljškom 41, v katerem je predvidena odprtina 410. V tem relativnem položaju zalogovne komore 4 in dozirnega zatiča 5 sprosti ta odprtina 410 zračno pot vstopa 3 zraka in izstopa 10 preko zračnega kanala 6. Stenski podaljšek 41 zalogovne komore 4 udari na svojem spodnjem koncu proti povratni vzmeti 43, ki jeThe storage chamber 4 with the restrained capsule K is in the rest position as shown in FIG. 1. In this stationary position, the storage chamber 4 and the metering pin 5 are relative to one another so that the metering pin 5 protrudes into the capsule K inside and closes the opening 400 of the storage chamber 4, while the groove-shaped metering notch 50 is still in the air paths between inlet 3 and outlet 10. This relative position (starting position) of metering pin 5 and stock chamber 4 is hereinafter referred to as the second relative position. The wall 40 of the storage chamber 4 is provided with a wall extension 41, which provides an opening 410. In this relative position of the storage chamber 4 and the metering pin 5, this opening 410 releases an air path through 3 air and outlet 10 via an air duct 6. The wall extension 41 stock chamber 4 strikes at its lower end against the return spring 43 which is
22000PP0.IV v tem drugem relativnem položaju napeta, ne glede na potrebno prednapetje mehanizma.22000PP0.IV in this second relative position is tensioned regardless of the required prestressing mechanism.
Za izvedbo doziranja pritisne sedaj uporabnik od zgoraj na pritisni gumb 2 v smeri puščice P. Ta pritisni gumb 2 je v tu pojasnjenem izvedbenem primeru opremljen s stresalnim elementom, ki je zasnovan kot udarna vzmet 20. Udarna vzmet 20 je pritrjena na pritisnem gumbu 2, npr. prilepljena. Na delovanje te udarne vzmeti se bomo še povrnili kasneje. V tem trenutku je pomembno, da je vzmetna togost te udarne vzmeti 20 večja kakor srednja togost povratne vzmeti 43. S pritiskom od zgoraj na pritisni gumb 2 v smeri puščice P se zalogovna komora 4 premakne navzdol, povratna vzmet 43 pa se stisne. Udarna vzmet 20 ostane zaradi večje togosti še v svojem mirovnem stanju. Dozirni zatič 5, ki je glede na telo naprave razporejen fiksno (npr. je vpet v izvrtini), se zaradi navzdoljnjega gibanja zalogovne komore 4 zabode globlje v trdna telesa, ki so uskladiščena v kapsuli K. Koje povratna vzmet 43 približno popolnoma stisnjena, se dozirna zareza 50 dozirnega zatiča 5 znajde že v notranjosti kapsule K in s tem v trdnih telesih.To perform the dosage, the user now presses the pushbutton 2 in the direction of the arrow P. from above. This pushbutton 2 is provided in this embodiment with a shaking element designed as a shock spring 20. The shock spring 20 is attached to the pushbutton 2, e.g. pasted. We will come back to this shock spring later. At this point, it is important that the spring stiffness of this shock spring 20 is greater than the mean stiffness of the return spring 43. By pressing the pushbutton 2 in the direction of arrow P from above, the stock chamber 4 moves down and the return spring 43 is compressed. The shock spring 20 remains in its quiescent state for greater rigidity. The metering pin 5, which is fixed with respect to the body of the device (eg, is fixed in the bore), is driven deeper into the solids stored in capsule K. Due to the downward movement of the storage chamber 4, the return spring 43 is approximately fully compressed, The metering notch 50 of the metering pin 5 is already present inside the capsule K and thus in the solids.
Že med vdiranjem dozirne zareze 50 dozirnega zatiča 5 v zalogovno komoro 4, zlasti pa tudi pri dosegu položaja, v katerem je povratna vzmet 43 popolnoma stisnjena in je v nadaljevanju označen kot prvi relativni položaj, se kot utor zasnovana dozirna zareza 50 dozirnega zatiča 5 napolni s trdnimi telesi. Da bi se doseglo, da se tudi pri izjemno slabi sposobnosti tečenja in zelo finozrnatih praških, ki so bili omenjeni že uvodoma, dozirno zarezo 50 napolni hitro, zanesljivo in popolnoma, se udarna vzmet 20, odvisno od na zadnjem kosu poti naraščajoče vzmetne togosti hitro stisnjene povratne vzmeti 43, sunkovito prevrže v položaj, prikazan na sl. 2. S tem sunkovitim preskokom udarne vzmeti 20 se strese zalogovna komora 4 in z njo uležiščena kapsula K ter prašek, tako da tudi prašek z izjemno slabo sposobnostjo tečenja dospe v dozirno zarezo 50. Alternativno bi se dalo seveda udarni vzmeti 20 tudi odpovedati, uporabnik pa bi inhalator sunkovito stresel, da bi dosegel opisani učinek.As soon as the dosing notch 50 of the dosing pin 5 is penetrated into the storage chamber 4, and especially when reaching the position in which the return spring 43 is fully compressed and hereinafter referred to as the first relative position, the dosing notch 50 of the dosing pin 5 is filled as a groove. with solid bodies. In order to achieve that, even with the extremely poor flow capability and the very fine-grained powders mentioned above, the dosage notch 50 is filled quickly, reliably and completely, depending on the rear of the increasing spring stiffness, the shock spring 20 compressed return springs 43, jerked to the position shown in FIG. 2. With this shock leap of shock spring 20, the storage chamber 4 and the capsule bearing therewith are shaken, so that the powder with extremely poor flow capability reaches the dosage notch 50. Alternatively, of course, the shock spring 20 could also be canceled, by the user however, the inhaler would shake violently to achieve the described effect.
Če se sedaj zalogovna komora 4 in dozirni zatič 5 znajdeta v prvem relativnem položaju, prikazanem na sl. 2, zapre stenski podaljšek 41 pot zračnega toka. S tem se doseže, da se z vpihavanjem v sesalni nastavek 1, npr. z nenamernim kašljanjem, med doziranjem nikakršen prašek ne izpihne iz inhalatorja skozi vstop 3 zraka. Razen tega se s tem zapiranjem zračne poti doseže, da med doziranjem, torej med polnje22000PP0.IV njem dozirne zareze 50, v inhalator ne more dospeti niti vlaga, kar je z nenamernim kašljanjem uporabnika sicer vseskozi mogoče.If the storage chamber 4 and the metering pin 5 are now in the first relative position shown in FIG. 2, closes wall extension 41 air flow path. This is achieved by blowing into the suction nozzle 1, e.g. by accidental coughing, no powder is expelled from the inhaler through the inlet of 3 air during dosing. In addition, this closure of the air route ensures that during the dosing, ie during filling 22000PP0.IV of the metering notch 50, no moisture can enter the inhaler, which is always possible by accidental coughing of the user.
Po preskoku udarne vzmeti 20 je dozirna zareza 50 napolnjena s praškom. Če se sedaj sprosti pritisni gumb 2, premakne povratna vzmet 43 zalogovno komoro 4 nazaj v drugi relativni položaj, torej v izhodiščni položaj. V tem drugem relativnem položaju (izhodiščni postavitvi) sprosti odprtina 410 v stenskem podaljšku 41 zalogovne komore 4 zračno pot, kot je že opisano. Če sedaj uporabnik vsesa zrak na sesalnem nastavku 1, se s tem skozi vstop 3 zraka in skozi protipovratni ventil R, ki je na sl. 1 simbolično črtkano prikazan z loputo R, v zračnem kanalu 6 razvije zračni tok. Ta zračni tok izpiha dozirano količino praška ven iz dozirne zareze 50. Na ta način nastane zmes trdna telesa-zrak, katero zatem uporabnik inhalira skozi izstop 10 na sesalnem nastavku 1 in katera lahko dospe v njegove dihalne poti. Da bi se doseglo karseda učinkovito izpihovanje dozirane količine praška iz dozirne zareze 50 in zmanjšalo hitrost toka zmesi trdna telesa-zrak ob vstopu v dihalne poti uporabnika, se v sesalnem nastavku 1 prečni presek zračnega kanala, ki se ga sicer drži majhnega, poveča proti izstopu 10.After skipping the shock spring 20, the metering notch 50 is filled with powder. If the pushbutton 2 is released now, it moves the return spring 43 of the storage chamber 4 back to the second relative position, ie to the starting position. In this second relative position (starting position), the opening 410 in the wall extension 41 of the storage chamber 4 releases the air path as described above. If the user now draws in air at suction port 1, the air inlet 3 and the non-return valve R in FIG. 1 is shown dashed symbolically by flap R, an air stream develops in the air channel 6. This air stream blows a metered amount of powder out of the dosage notch 50. This creates a solid-air mixture, which is then inhaled by the user through the outlet 10 at the suction port 1 and which can enter his airways. In order to maximize the effective blowing out of the dosage amount of the powder from the notch 50 and to reduce the flow rate of the solid-air mixture upon entry into the airways of the user, the intersection section 1, which is otherwise kept small, is enlarged toward the outlet. 10.
Kako je zračni kanal 6 detajlno zasnovan v tu pojsnjenem izvedbenem primeru, oz. kako je zračni tok voden v inhalatorju, naj bi se natančneje pojasnilo v nadaljevanju s pomočjo sl. 3 do 9. Na sl. 3 in 4 je prikazan zgornji del O inhalatorja, pri čemer so v pogledu s strani na sl. 4 razpoznavni vstopi 3 zraka (podolgovate reže). Skozi te zračne vstope 3 in skozi protipovratni ventil R (na sl. 1 prikazan črtkano tako v svoji mirovni postavitvi kot tudi v postavitvi pri vdihu) prispe vsesani zrak v notranjost inhalatorja.How is the air duct 6 designed in detail in the embodiment illustrated herein, or. how the air flow is guided in the inhaler should be explained in more detail below by means of FIG. 3 to 9. FIG. 3 and 4 show the upper portion of the O inhaler, with the side views of FIG. 4 distinct air intakes 3 (elongate slots). Through these air intakes 3 and through the non-return valve R (shown in Fig. 1 dashed in both its resting position and in the inhalation position), the intake air enters the inhaler.
Kako je zračni tok nadalje voden v notranjosti inhalatorja je razvidno s sl. 5, na kateri je prikazan tlorisni pogled na spodnji del U inhalatorja. Razpozna se tri uležiščene zračne kanale 6a, 6b, 6c, ki so v telesu spodnjega dela U inhalatorja razporejeni tako, da vodijo navzdol (glej tudi črtkano črto 6 na sl. 1), in skozi katere je naprej voden zračni tok.How the air flow is further guided inside the inhaler can be seen in FIG. 5 showing a plan view of the lower portion of the U inhaler. Three recessed air ducts 6a, 6b, 6c, which are disposed in the body of the lower portion of the inhaler in such a way that they are directed downwards (see also the dashed line 6 in Fig. 1), and through which the air flow is guided, are recognized.
Na sl. 6 je prikazana s pomočjo pritisnega gumba 2 gibljiva zalogovna komora 4, tu seveda brez vstavljene kapsule K. Po končanju dozirnega koraka, ko se torej dozirni zatič 5 in zalogovna komora 4 nahajata v izhodiščni postavitvi (drugi relativniIn FIG. 6 is shown by means of a pushbutton 2 a moving storage chamber 4, of course without a capsule K. Inserted after the dosing step is completed, when the dosing pin 5 and the storage chamber 4 are in the starting position (second relative
22000PP0.IV položaj), se prašek s pomočjo zraka izpihne iz dozirne zareze 50 dozirnega zatiča 5. Zato mora seveda zračni tok dospeti iz zračnih kanalov 6 k dozirni zarezi 50.22000PP0.IV position), the powder is blown out of the dosage notch 50 of the dosing pin by means of air 5. Therefore, naturally, the air flow must flow from the air ducts 6 to the dosing notch 50.
Kako se da to realizirati je prikazano na sl. 7 in 8, ki vsakokrat prikazujeta prereza vzdolž črt VII-VII oz. VHI-Vin. Prerezna ravnina VH-VII poteka pri tem natanko na višini dozirne zareze, tako da le-ta stoji optimalno v zračnem toku. S pomočjo sl. 7 se vidi, da sta vstopni odprtini 44a in 44b za zračni tok razporejeni pod enakim kotom a glede na prerezno ravnino vzdolžnega prereza s sl. 1 kakor ustrezna zračna kanala 6a in 6b s sl. 6.How to realize this is shown in fig. 7 and 8, each showing cross-sections along lines VII-VII and FIGS. VHI-Vin. The cross-sectional plane of the VH-VII runs exactly at the height of the metering notch, so that it stands optimally in the air flow. By means of FIG. 7 it is seen that the inlet openings 44a and 44b for the air flow are arranged at the same angle a with respect to the cross-sectional plane of the longitudinal section of FIG. 1 as the corresponding air ducts 6a and 6b of FIG. 6.
Tretja vstopna odprtina 44c za zrak je razporejena pod enakim kotom β glede na to prerezno ravnino kakor ustrezni zračni kanal 62, kot se seveda vidi s sl. 8, pod obema vstopnima odprtinama 44a in 44b za zrak v prerezni ravnini VII-VII. Ta vstopna odprtina 44c za zrak služi za to, da se morebitna iz dozirne zareze izpadla zrna trdnih teles oz. praška izpihne skupaj in s tem primeša zračnemu toku. Skozi odprtino 410 v stenskem podaljšku 41 zalogovne komore 4 lahko vzpostavljena zmes trdna telesazrak skozi izstop 10 v sesalnem nastavku 1 zatem dospe v dihalne poti uporabnika.The third air inlet 44c is arranged at the same angle β with respect to this cross-sectional plane as the corresponding air duct 62, as can be seen from FIG. 8, below both air intakes 44a and 44b in the cross-sectional plane VII-VII. This inlet 44c for air is used to prevent the removal of solids from the dosage notch. it blows the powder together to mix with the air flow. Through the opening 410 in the wall extension 41 of the storage chamber 4, a solid body air mixture through the outlet 10 in the suction port 1 can then be introduced into the airways of the user.
Da bi se izognilo nenamernemu večkratnemu doziranju, se zalogovno komoro 4 in dozirni zatič 5 (glej sl. 2) z aretimo napravo medsebojno trdno drži v prvem relativnem položaju. Ta aretirna naprava je na sl. 1 kot primer prikazana z zapahom 21, katerega način delovanja je v nadaljevanju pojasnjen s pomočjo sl. 9 do 13.In order to avoid unintentional multiple dosing, the storage chamber 4 and the metering pin 5 (see Fig. 2) are held firmly in the first relative position by the arresting device. This arresting device is in FIG. 1 is exemplified by latch 21, the operation of which is further explained by FIG. 9 to 13.
Da bi lahko razumeli način delovanja aretime naprave, je na sl. 9 najprej še enkrat prikazana zunanja zgradba inhalatorja, pri čemer je v zgornjem delu O, kotje že razvidno tudi s sl. 3, predvidena odprtina 212.In order to be able to understand how the aretime device works, in FIG. 9, the exterior structure of the inhaler is shown again, with the upper part O being shown in FIG. 3, intended opening 212.
Na sl. 10 je pritisni gumb 2 predstavljen v stranskem pogledu v vzdolžnem prerezu. Pod svojo glavo je opremljen z utorom 22, ki je že črtkano prikazan na sl. 1. V ta utor je prijemljiv zapah 21, kije prav tako prikazan na sl. 1, na še bolj pojasnjen način in vrsto.In FIG. 10 is a side view of the push button 2 in longitudinal section. Under its head, it is provided with a groove 22, which is already shown in Fig. 1. A latch 21, which is also shown in FIG. 1, in an even more elaborate manner and type.
V svojem izhodiščnem položaju (drugi relativni položaj zalogovne komore 4 in dozirnega zatiča 5) je inhalator na sl. 11 prikazan v tlorisnem pogledu. V tem tlorisnem pogledu se vidi, daje zapah 21 opremljen z listnato vzmetjo 210 in držalnim gumbomIn its starting position (the second relative position of the storage chamber 4 and the metering pin 5), the inhaler of FIG. 11 is shown in plan view. In this plan view, the latch 21 is provided with a leaf spring 210 and a holding button
22000PPO.IV22000PPO.IV
211. Listnata vzmet 210 je podprta na utoru v notranji steni inhalatorja (glej tudi sl. 10) in poizkuša pomakniti zapah 21 v smeri puščice V, držalni gumb 211 pa potisniti še dlje ven skozi odprtino 212, prikazano že na sl. 9 in 10. ·211. The leaf spring 210 is supported by a groove in the inner wall of the inhaler (see also Fig. 10) and tries to move the latch 21 in the direction of arrow V, and push the holding button 211 further out through the opening 212 shown already in FIG. 9 and 10. ·
To nadaljnje potiskanje ven držalnega gumba 211 skozi odprtino 212 se prepreči s tem, da zapah 21 v izhodiščnem položaju udari proti telesu pritisnega gumba 2 (prožilni organ). To je zlasti dobro razvidno iz prikaza v prerezu na sl. 10.This further pushing out of the holding knob 211 through the opening 212 is prevented by the latch 21 striking the body of the pushbutton 2 (actuator) in the starting position. This is particularly well illustrated by the cross-sectional view of FIG. 10.
Če se sedaj Sproži pritisni gumb 2 (puščica P na sl. 1), torej se dozirna zareza 50 dozirnega zatiča 5 premakne v zalogovno komoro 4, ostane tako zapah 21 najprej v opisanem položaju, kajti držalni gumb 211 je trdno držan v odprtini 212. Temu nasprotno se pritisni gumb 2 giblje navzdol. Ob dosegu prvega relativnega položaja (sl. 2)lahko zapah 21 zdrsne v utor 22 pritisnega gumba 2 in tako lahko listnata vzmet 210 pomakne zapah 21 v smeri puščice V (sl. 11). S tem se držalni gumb 211 z listnato vzmetjo 210 potisne še dlje ven skozi odprtino 212. V tem stanju (sl. 12, sl. 13) ne more povratna vzmet 43 (sl. 2) zalogovne komore 4 nič več postaviti nazaj v izhodiščni položaj (drugi relativni položaj), kajti pritisni gumb 2 je trdno zaskočen preko zapaha 21.If the pushbutton 2 is now triggered (arrow P in Fig. 1), so that the metering notch 50 of the metering pin 5 is moved to the storage chamber 4, the latch 21 thus remains first in the position described, since the holding button 211 is firmly held in the opening 212. In contrast, push button 2 moves downwards. Upon reaching the first relative position (Fig. 2), the latch 21 can slide into the groove 22 of the pushbutton 2, and thus the leaf spring 210 can move the latch 21 in the direction of arrow V (Fig. 11). In this way, the holding button 211 with the leaf spring 210 is pushed further out through the opening 212. In this state (Fig. 12, Fig. 13), the return spring 43 (Fig. 2) of the storage chamber 4 can no longer be repositioned. (second relative position), because the pushbutton 2 is firmly locked over the latch 21.
Šele ko uporabnik od zunaj pritisne proti držalnemu gumbu 211 v smeri puščice E, se zapah 21 pomakne iz utora 22 v pritisnem gumbu 2 in s tem ven iz svojega zaskočenega položaja ter sprosti aretiranje. Sedaj se lahko zalogovno komoro s povratno vzmetjo 43 ponovno povrne nazaj v izhodiščni položaj (drugi relativni položaj dozirnega zatiča 5 in zalogovne komore 4). S to vrsto aretiranja se prepreči večkratno doziranje.Only when the user presses outwardly from the holding button 211 in the direction of arrow E from the outside does the latch 21 move out of the groove 22 in the pushbutton 2 and thus out of its locked position and release the arrest. Now the stock chamber with the return spring 43 can be reverted back to the starting position (the second relative position of the metering pin 5 and the stock chamber 4). This type of arrest prevents multiple dosing.
Do sedaj opisani inhalatorje lahko, kot že omenjeno, na vstopu 3 zraka opremljen s protipovratnim ventilom. Alternativno bi lahko protipovratni ventil R bil predviden tudi v sesalnem nastavku. Ta protipovratni ventil R je lahko izveden npr. kot loputa, kot je Črtkano prikazano na sl. 1, in povzroča, da je pri pihanju v inhalator skozi izstop 10, npr. pomotoma pri kašljanju uporabnika v izstop 10, vstop 3 zraka zaprt. To je zlasti prednostno, kot npr. po doziranju praška in po povratku zalogovne komore 4 v drugi relativni položaj, da se praška ne da izpihati skozi vstop 3 zraka iz inhalatorja. Če torej uporabnik po uspešnem doziranju pomotoma zakašlja v inhalator, se nič praška ne igubi in lahko posesa novega, ne da bi bilo poprej potrebnoThe inhalers described so far, as mentioned above, can be fitted with a non-return valve at the inlet of 3 air. Alternatively, a non-return valve R could also be provided in the suction line. This non-return valve R may be implemented e.g. as a flap as shown in FIG. 1, and causes it to blow through the outlet 10 when blowing into the inhaler, e.g. accidentally when coughing the user into exit 10, air intake 3 closed. This is particularly preferred, such as e.g. after dosing the powder and returning the storage chamber 4 to a second relative position so that the powder cannot be blown through the inlet of 3 inhalers. Therefore, if the user accidentally coughs up the inhaler after successful dosing, nothing can be lost and it can be sucked in again without the need for
22000PP0.IV na novo dozirati.22000PP0.IV newly dosed.
Nadalje je lahko inhalator zasnovan še s števcem 7, ki se ga da vrniti v začetni položaj (sl. 1), ki se pri vsakem dozirnem koraku inkrementira. Števec 7 se npr. inkrementira pri navzdoljnjem gibanju zalogovne komore 4. Takšen števec 7 je zlasti prednosten, kajti v zalogovni komori 4 nahajajoča se kapsula K vsebuje določeno število doziranj praška. Pri vnosu nove kapsule K lahko nato uporabnik števec 7 postavi v začetni položaj3, tako da lahko vsakokrat razpozna, koliko doziranj je že odvzel kapsuli K, in lahko pravočasno vstavi novo kapsulo K v zalogovno komoro 4 oz. v danem primeru zamenja inhalator.Further, the inhaler may also be designed with a counter 7 which can be reset to its initial position (Fig. 1), which is incremented at each dosing step. The counter 7 is e.g. incrementing in downward movement of the storage chamber 4. Such counter 7 is particularly preferred, since in the storage chamber 4, the capsule K contained contains a certain number of dosages of powder. When inserting a new capsule K, the user can then place the counter 7 in the starting position 3 , so that he / she can recognize how many dosages he / she has already taken from the capsule K, and can insert a new capsule K in the storage chamber 4 or in time. if necessary replace the inhaler.
Da bi se notranjost inhalatorja oz. zračno pot osušilo oz. držalo suho, je v zaščitni kapi 11 predvideno sušilno sredstvo 12, kije lahko npr. zasnovano kot silika-gel.In order to keep the inhaler or air way dried or the holder is dry, a drying agent 12 is provided in the protective cap 11, which may e.g. designed as silica gel.
Takšen inhalator je, kot že pojasnjeno, zlasti primeren za kot trdno telo zasnovane snovi ali zmesi snovi z antiastmatičnim učinkom, posebno tudi za inhalacijo mešanice iz laktoze in formoterola, ki je na razpolago npr. v obliki soli formoterola fumarata, katerega oznaka po IUPAC nomenklaturi se glasi:Such an inhaler is, as explained above, particularly suited to a solid-based substance or mixture of a substance having an anti-asthmatic effect, especially for the inhalation of a mixture of lactose and formoterol available e.g. in the form of a salt of formoterol fumarate, whose IUPAC nomenclature code reads as follows:
’’(±)-2’-hidroksi-5’-[(RS)-l-hidroksi-2-[[(RS)-p-inetoksi-a-metilfenetil]-amino]etilj-formanilid-fumarat-dihidrat.'' (±) -2'-hydroxy-5 '- [(RS) -l-hydroxy-2 - [[(RS) -p-inethoxy-a-methylphenyl] -amino] ethyl-formanilide-fumarate-dihydrate.
Za opisani inhalator si je mogoče misliti mnogo variant. V principu ni po izumiteljski zamisli nujno potrebno, daje zalogovna komora razporejena gibljivo, dozirni zatič pa lokalno trdno, prav tako je mogoč obraten primer. Zagotovljeno mora le biti, da sta zalogovna komora in dozirni zatič z dozirno zarezo medsebojno relativno premakljiva. Nadalje je tudi mišljeno, da so prašek oz. trdna telesa uskladiščena neposredno v zalogovni komori in ne v ločeni kapsuli, ki je vnešena v to zalogovno komoro. Stresalni element (udarna vzmet) je seveda lahko izvedena drugače, prav tako tudi aretirna naprava. Tudi sušilno sredstvo je lahko nekoliko drugačno kot omenjen silika-gel.Many variants can be thought of for the inhaler described. In principle, it is not absolutely necessary for the inventor to have the storage chamber arranged in a movable manner and the metering pin locally fixed, and a reverse case is also possible. It must only be ensured that the storage chamber and the metering pin with the metering notch are relatively movable. Further, it is also intended to be a powder or a. solids stored directly in the storage chamber and not in a separate capsule inserted into that storage chamber. The stress element (shock spring) can, of course, be done differently, as can the arresting device. The drying agent may also be slightly different from the silica gel mentioned.
Na sl. 14 do 30 so prikazani modificirani izvedbeni primeri inhalatorja I, pri katerih jeIn FIG. 14 to 30 show modified embodiments of inhaler I in which
3. resetira (op. prev.)3. Resets
22000PP0.IV na zlasti smotrn način zasnovano predvsem poprej omenjeno relativno gibanje med zalogovno komoro 4 in dozirnim zatičem 5. Deli tega modificiranega inhalatorja I so pri tem v znatnem obsegu opremljeni z istimi referenčnimi številkami kot pri poprej opisanem izvedbenem primeru. Pri tem kaže primerjava npr. med sl. 1 in 14, da je pri nadaljnje opisanem izvedbenem primeru inhalator sicer prav tako predeljen v dva ohišna dela, vendar je delitev izvedena pod izstopom zraka ali ustnikom 10.22000PP0.IV is designed in a particularly prudent manner, the foregoing relative movement between the storage chamber 4 and the metering pin 5. The portions of this modified inhaler I are substantially provided with the same reference numbers as in the embodiment described above. A comparison of e.g. between FIG. 1 and 14, that in the embodiment described below, the inhaler may also be converted into two housing portions, but the division is performed below the air outlet or mouthpiece 10.
Da bi se izvedlo relativno gibanje med zalogovno komoro 4 in dozirnim zatičem 5, je pri nadalje opisanih izvedbenih primerih predvideno, da sta zalogovno komoro 4 obsegajoč ohišni del 101 in telo naprave ali ohišni del 102, ki nosi dozirni zatič 5, tako relativno prestavljiva drug k drugemu iz prvega stisnjenega položaja, npr. po sl. 14, v drugi izvlečeni položaj, npr. po sl. 19, da sta zavrtljiva relativno drug proti drugemu, nagnjene vodilne ploskve ali nagnjene ploskve 103 na ohišnem delu 101 in na njih vodeni protikosi 104, ki so razporejeni na telesu 102 naprave, pa omenjeno vrtilno gibanje prestavijo v osno gibanje. Na tem mestu pa se naj še enkrat opozori na to, da so lahko nagnjene ploskve 103 prav tako predvidene na zunanji strani ostenja 109, torej na telesu 102 naprave, protikosi 104 pa temu ustrezno na ohišnem delu 101. Nagnjena ploskev 103 je na sl. 16 predstavljena razvito v pogledu v smeri puščice A s sl. 14.In order to perform relative movement between the stock chamber 4 and the metering pin 5, it is contemplated in the embodiments described below that the stock chamber 4 comprising a housing part 101 and a body of the device or a housing part 102 carrying a metering pin 5 is thus relatively movable. to the second from the first compressed position, e.g. according to FIG. 14, to another extracted position, e.g. according to FIG. 19 to be rotatable relative to one another, the inclined guide surfaces or the inclined surfaces 103 on the housing portion 101 and the guided counter guides 104 disposed on the body 102 of the device shift the said rotational motion in axial motion. Here again, it should be noted that the sloping surfaces 103 may also be provided on the outside of the socket 109, i.e. on the body 102 of the device, and the counter-tiles 104 correspondingly on the housing portion 101. The sloping surface 103 is in FIG. 16 is an advanced view in the direction of arrow A in FIG. 14.
Pri tem ohišni del 101 obsega v izvedbenem primeru več, namreč vsakokrat štiri na svojem obodu razporejene nagnjene ploskve 103 enake strmine in dolžine, relativno k njim zavrtljiv ojišni del 102 pa ustrezno število z njimi sodelujočih štrlin ali protikosov 104.In this case, the housing part 101 comprises, in the embodiment, four, namely, each of the four inclined planes 103 arranged at its periphery, of the same inclination and length, and the relatively rotatable pivot portion 102 thereof, the corresponding number of projecting projections or proticos 104 thereof.
Štiri nagnjene ploskve 103, ki so na smotrn način zasnovane kot utori, da bi se štrlinaste protikose 104 lahko dobro prisilno vodilo, se pri tem raztezajo po približno 90° obsega, ležijo na enaki višini in se dvigajo v isti smeri. Na koncu nagnjenih ploskev 103 je vsakokrat predviden v navpični smeri, torej vzporedno z vzdolžno središčnico inhalatorja I orientiran prehodni utor 105 za štrlinaste protikose 104, tako da sta po enem vrtljaju in vzdolžnem zdrsu protikosov 104 ali štrlin na nagnjenih ploskvah 103 z iz tega izhajajočo osno prestavitvijo dozirnega zatiča 5 ohišni del 101 z zalogovno komoro 4 in kot vodilni zatič služeči ohišni kos 104 ponovno potisljiva skupaj v osni smeri, torej postavljiva nazaj v izhodiščno lego po sl. 14. Iz te izhodiščne lege se lahko potem izvaja naslednje dozirno-vrtilno gibanje v isti smeri kotThe four inclined surfaces 103, which are cleverly designed as grooves to allow the protruding proticoles 104 to be well-guided, extend about 90 ° in circumference, lie at the same height and rise in the same direction. At the end of the inclined surfaces 103, the transverse groove 105 is projected in a vertical direction in each case in the vertical direction, ie parallel to the longitudinal center of the inhaler I, so that after one rotation and longitudinal sliding of the proticos 104 or projections on the inclined surfaces 103 there is an outgoing axis by repositioning the metering pin 5, the housing portion 101 with the storage chamber 4 and, as a guide pin, the housing housing piece 104 are re-pushed together in the axial direction, thus adjustable back to the starting position according to FIG. 14. From this starting position, the following dosing and rotation movement can then be performed in the same direction as
22000PP0.1V poprejšnje. Za uporabnika je torej podano enostavno rokovanje, pri čemer lahko na prednosten način opravi sorazmerno lahko in varno izvedljivo vrtilno gibanje, ki je lahko tudi za starejše ljudi in otroke, kadar je potrebno izvesti sorazmerno kratko osno prestavitev proti začetnemu tornemu odporu.22000PP0.1V previous. Therefore, simple handling is provided for the user, in which he can advantageously carry out relatively easy and safe rotary movement, which can also be for the elderly and children, when a relatively short axial shift is required against the initial friction resistance.
V poteku osnih povratnih utorov 105 je po sl. 14,16,19, 22 in 29 razporejena vsaj ena žagasto zasnovana štrlina, katere strmo padajoča stran je razporejena skladno z vsakokratno delujočo nagnjeno ploskvijo 103 za protikos ali štrlino 104. Protikos 104 se da z naraščajočo zunanjo stranjo 107 štrline 106 prestaviti v opni smeri, tako da se v izhodoščni legi naslednjega dozirnega gibanja razporedi za strmo padajočo stranjo štrline 106 in med vrtilnim gibanjem preko te strmo padajoče strani prepelje v nagnjeno ploskev 103. S tem je zagotovljeno, da uporabnik lahko in mora izvajati doziranje vedno le z vrtilnim gibanjem in ne z osnim gibanjem s prestavitvijo protikosa 104 vzdolž utora 105. Nadalje je v poteku osnega povratnega utora 105 predvidena še manjša štrlina ali palec 105a, ki prepreči slabo ali neželeno stisnitev inhalatorja.In the course of the axial return grooves 105, FIG. 14,16,19, 22 and 29 at least one saw-shaped projection is arranged, the steeply descending side of which is arranged in accordance with the respective inclined surface 103 for protrusion or protrusion 104. Proticos 104 can be moved in the circumferential direction with the rising outer side 107 of protrusion 106. , so that in the starting position of the next dosing movement it is arranged for the steeply descending side of the projection 106 and transported through this steeply descending side into the sloping surface 103. This ensures that the user can and must always perform the dosing only with the rotational movement and not by axial movement by moving the proticos 104 along the groove 105. Further, a smaller projection or thumb 105a is provided in the course of the axial return groove 105, which prevents poor or unwanted compression of the inhaler.
Nagnjene ploskve 103 oz. utori, ki obsegajo slednje, ustrezajo vsakokrat delu navojnega koraka in so v izvedbenem primeru razporejene na notranji strani stenskega kosa 108 ohišnega dela 101, kateri ohišni kos 108 se razteza od ohišnega dela 101 približno osno v stran, ki je obrnjena proč od zalogovne komore 4, v danem primeru navzdol. Na ustreznem, vzporedno k tej steni 108 razporejenem ostenju 109 telesa 102 naprave, katero ostenje 109 je v izvedbenem primeru razporejeno znotraj stenskega kosa 108, štrlijo protikosi 104 radialno navzven in prijemljejo v utoraste nagnjene ploskve 103.Inclined surfaces 103 oz. the grooves comprising the latter correspond to each part of the threaded step and, in the embodiment, are arranged on the inside of the wall piece 108 of the housing part 101, which housing part 108 extends from the housing part 101 approximately axially to the side facing away from the storage chamber 4 , if necessary downwards. On the corresponding wall parallel to this wall 108, the wall 109 of the device 102, the wall 109 of which in the embodiment is arranged inside the wall piece 108, protruses 104 radially outwards and grips into grooved sloping surfaces 103.
Da bi se nadomestilo udarno vzmet 20 iz izvedbenega primera po sl. 1 do 13, kljub temu pa bi se pri dozirnem gibanju razvilo stresanje za tresenje trdnih teles, istočasno pa na prednosten način izključilo dozirnemu gibanju nasprotno vrtilno gibanje, je na stičnem mestu med relativno drug proti drugemu zavrtljivima ohišnima deloma 101 in 102 razporejena kot raglja delujoča zapora 110. To se zlasti vidi iz sl. 20, iz katere so razen tega razvidni tudi povratni utori 105 za protikose 104.To replace the shock spring 20 of the embodiment of FIG. 1 to 13, however, in the case of the dosing movement, shaking for solid body shaking would develop, while at the same time preventing the dosing movement in the opposite rotating manner, it is arranged at a junction between relatively mutually rotating housing parts 101 and 102 as a ratchet acting imprisonment 110. This can be seen in particular from FIG. 20, which also shows the recess grooves 105 for the countercurrents 104.
Razen tega so na sl. 20 z vodoravnim prerezom tega prikaza po prerezni Črti E-E s sl.In addition, in FIG. 20 with a horizontal cross-section of this view along cross-section E-E of FIG.
nagnjene ploskve 103 delno prerezane in s tem vsako^at vidne kot segment.inclined surfaces 103 partly cut and thus each ^ at visible as a segment.
22000PPO.IV22000PPO.IV
Zapora 110 obsega na po sebi običajen način zaporno kolo 111 z žagastimi zobmi 112 na ohišnem delu 101 in sicer stenskem kosu 108 in sodeluje z vsakokrat v obodni smeri drug proti drugemu zamaknjenimi protizobmi 113 ali skupinami takih protizob 113, ki so predvideni na drugem ohišnemcdelu ali telesu 102 naprave na notranji strani zunanjega ostenja 114, ki po sl. 20 nima krožne konture, temveč nasproti krožni obliki zapornega kolesa 111 vsakokrat pusti vogalne prostore 115 prazne, tako da se omenjene skupine protizob na omenjeni način da zamakniti druge proti drugim, tako da zavrtitev zapornega kolesa 111 že pri manj kot eni zobni delitvi vodi k blokiranju vrtenja v nasprotni smeri. Omenjene vogalne prostore 115 se bo kasneje omenilo Še v zvezi z dovodom zraka.The shutter 110 comprises, in a customary manner, a locking wheel 111 with saw teeth 112 on the housing portion 101, namely, a wall piece 108, and cooperates with each other in circumferentially mutually displaced counter-teeth 113 or groups of such counter-teeth 113 provided on another housing unit or to the body 102 of the device on the inside of the outer wall 114, which according to FIG. 20 has no circular contour, but leaves the corner spaces 115 empty opposite the circular shape of the locking wheel 111 each time, so that said groups of counter-teeth can be displaced against each other in such a way that rotation of the locking wheel 111 already leads to locking in less than one tooth division. rotate in the opposite direction. These corner spaces 115 will be mentioned later in connection with the air supply.
Predvsem pri istočasnem opazovanju sl. 20 in 19 se vidi, da je zaporno kolo 111 v osnovi del ostenja 108 ohišnega dela 101, ki ima po kratkem osnem območju žagaste zobe 112, ki štrlijo navzven in prijemljejo v protizobe 113 zunanjega ostenja 114, katero ima pri tem večjo osno dolžino, da bi se upoštevalo osno relativno gibanje med ohišnim delom 101 in telesom 102 naprave. Pri tem se zobje 112, zobne vrzeli in protizobje raztezajo premočrtno v osni smeri, da bi omogočili in tudi vodili omenjeno osno relativno gibanje, v katerega je potrebno pretvoriti vrtilno gibanje.Particularly when observing FIG. 20 and 19 it is seen that the locking wheel 111 is essentially a part of the housing 108 of the housing portion 101, which has, after a short axial region, saw teeth 112 projecting outward and gripping into the counter teeth 113 of the outer wall 114, which has a larger axial length, in order to account for the axial relative movement between the housing portion 101 and the body 102 of the device. In this case, the teeth 112, the dental gaps and the antidotes extend in a straight line in the axial direction in order to enable and also guide said axial relative motion in which rotational motion is to be converted.
Dozirni zatič 5 obsegajoče telo 102 naprave ali ohišni del ima torej po območjih deloma dvojno ostenje, katerega notranje ostenje 109 nosi z nagnjenimi ploskvami 103 na drugem ohišnem delu 101 sodelujoče, radialno navzven štrleče protikose 104, medtem ko zunanje ostenje 114 od zunaj objema nagnjene ploskve 103 obsegajoč stenski kos 108 drugega ohišnega dela 101 in vsebuje protizobe 113 za zaporno kolo 111, razporejeno na zunanji strani zalogovno komoro 4 vsebujočega ohišnega dela 101 oz. ostenja 108. To podaja na sl. 14, 19, 22 in 29 razpoznavne kompaktne gradbene načine in povezavo ohišnega dela 101 s telesom 102 naprave, četudi ta dva dela nista prestavljiva le v osni smeri, temveč tudi drug proti drugemu v smeri vrtenja.The metering pin 5 comprising the device body 102 or the housing part therefore has, by area, a partially double wall, the inner wall 109 of which is supported by inclined surfaces 103 on the second housing portion 101 of the counter-projecting radially outward protruding 104, while the outer wall 114 extends from the outside of the inclined surface. 103 comprising a wall piece 108 of the second housing portion 101 and comprising counter-teeth 113 for a locking wheel 111 disposed on the outside of the storage chamber 4 of the housing housing 101 or. 108. gives this in FIG. 14, 19, 22 and 29 recognizable compact construction methods and connection of the housing part 101 to the body 102 of the device, even though the two parts are not only movable in the axial direction but also in relation to each other in the direction of rotation.
Da bi se omenjeno vrtilno gibanje lahko neovirano izvajalo, sta notranje ostenje 109 dozirno iglo 5 obsegajočega ohišnega dela 102 in nagnjene vodilne ploskve 103 obsegajoča stena 108 zalogovno komoro 4 obsegajočega ohišnega dela 101 v prečnem prerezu zasnovana krožno, medtem ko zunanje ostenje 114 prvega ohišnega dela 102 - kot že omenjeno - vsaj deloma območno odstopa od te krožne oblike, tako da se ustvari vogalne prostore ali vogalna območja 115. Zlasti priIn order that said rotational movement can be performed smoothly, the inner wall 109 of the dosing needle 5 of the enclosing housing part 102 and the inclined guide surface 103 of the enclosing wall 108 of the storage chamber 4 of the enclosing housing part 101 are circularly shaped while the outer wall 114 of the first housing part 102 - as already mentioned - deviates from this circular shape at least in part by creating corner spaces or corner areas 115. Particularly at
22000PPO.IV zavrtitvi in/ali osnem izvlečenju ohišnih delov 101 in 102 se lahko po sl. 21, na kateri so nekateri deli VG predstavljeni zavrteno, vsesani zrak po puščicah Pf 1 in Pf 2 na sl.22000PPO.IV by rotating and / or axially extending the housing parts 101 and 102 according to FIG. 21, in which some parts of the VG are represented in a rotated, intake air by the arrows Pf 1 and Pf 2 in FIG.
preko teh tedaj odprtih vogalnih območij 115 vsesa in skozi preboje 116 blizu dnathrough these then open corner areas 115, and through holes 116 near the bottom
117 telesa 102 naprave kot tudi vsaj skozi protipovratno loputo 118 - po sl. 15 dve protipovratni loputi 118 - vodi k zračnim kanalom 6a, 6b in 6c ter dozirnemu zatiču 5.117 of the device body 102 as well as at least through the non-return flap 118 of FIG. 15 two non-return flaps 118 - leads to air ducts 6a, 6b and 6c and dosing pin 5.
S tem je istočasno mogoče, da čelna stran zunanjega ostenja 114 dozirno iglo vsebujočega telesa 102 naprave v stisnjenem položaju s sovpadajoče potekajočo konturo nalega proti prislonski ploskvi 119 drugega ohišnega dela 101 in v tem položaju je zračna pot zaprta, notranjost inhalatorja I pa zrakotesno zaprta. Zapiranje zraka proti zračnim kanalom 6a, 6b in 6c ter dozirnemu območju torej ni več izključno odvisna od povratne sile protipovratne lopute ali protipovratnega ventila R, temveč se v stisnjenem položaju zračna pot dodatno tesno zapre.It is at the same time possible for the metering needle end face 114 of the containment body 102 to be pressed in a compressed position with a contiguous contour contiguous against the abutment surface 119 of the second housing portion 101, and in this position the airway is closed and the interior of the inhaler I is closed airtightly. The closure of the air to the air ducts 6a, 6b and 6c and the dosing range is therefore no longer solely dependent on the return force of the non-return flap or non-return valve R, but in the compressed position the air path is closed further.
izumu dovoljuje v osno gibanje prestavljivo vrtilno gibanje razen tega kontrolo in prikaz že izvedenih doziranj, namesto da bi se uporabilo števec 7. Pri izvedbenih primerih po sl. 14 do 30 vsebuje eden od ohišnih delov relativno k prikazovalnemu oknu 120 zavrtljiv prikazovalni obroč 121, ki je z relativnim vrtenjem obeh ohišnih delov 101 in 102 drugega k drugemu pri doziranju vsakokrat gibljiv naprej za majhen znesek kota enake velikosti in - glede na vedno v isti smeri izvajajoče dozirno vrtilno gibanje - v isto smer. Natančna zasnova in razporeditev tovrstne prikazovalne priprave je prikazana na sl. 22 do 28.The invention permits the rotary movement to be moved in axial motion, in addition to controlling and displaying dosages already performed, instead of using a counter 7. In embodiments of FIG. 14 to 30, one of the housing portions relative to the display window 120 comprises a rotatable display ring 121 which, by relative rotation of both housing portions 101 and 102 to each other, is in each case moving forward for a small amount of angle of the same size and - relative to always in the same directional dosing rotary motion - in the same direction. The exact design and arrangement of such a display device is shown in FIG. 22 to 28.
Iz teh slik je razvidno, da je prikazovalni obroč 121 zasnovan kot zobnik, ki je izsredno glede na votli zobnik 122 z notranjim ozobljenjem uležajen v dozirno iglo obsegajočem ohišnem delu ali telesu 102 naprave in se s svojim zunanjim ozobljenjem prilega v notranje ozobljenje tega votlega kolesa 122, katero je trdno povezano z omenjenim ohišnim delom 102. Število zob tega notranjega, kot prikazovalni obroč 121 služečega zobnika pri tem tako malo odstopa od števila zob votlega kolesa 122, torej je manjše le za majhno število, da je zobnik z notranjim ozobljenjem nasproti votlemu zobniku 122 zavrtljiv za približno en sam vrtljaj ali del le-tega, kadar je izvedeno preddoločeno število npr. 100 do 200 doziranj. Na sl. 23 do 28 je pojasnjeno, da so na prikazovalnem oknu 120 vsakokrat oz zunaj vidni zunanji plašči prikazovalnega obroča 121, zlasti če je prikazovalno okno prosojno ali prozorno, prikazovalni obroč 121 pa pobarvan s primemo barvo. Pri tem se barva lahko menja po oboduIt is apparent from these figures that the display ring 121 is designed as a sprocket, which, with respect to the hollow sprocket 122, is mounted in a metering needle with the inner casing or body 102 of the device and fits with its outer casing into the inner cog of this hollow wheel. 122, which is firmly connected to said housing part 102. The number of teeth of this internal, such as the display ring 121 of the serving gear, thus deviates so little from the number of teeth of the hollow wheel 122, so that it is smaller by only a small number that the gear with internal gear is opposite the hollow sprocket 122 is rotatable by about a single rotation or part thereof when a predetermined number e.g. 100 to 200 dosages. In FIG. 23 to 28, it is explained that the outer coats of the display ring 121 are visible at all times or outside the display window 120, especially if the display window is transparent or transparent and the display ring 121 is painted with a priming color. The color may change around the perimeter
22000PP0.IV prikazovalnega obroča 121, da bi se poudarilo napredovanje doziranja oz. napredovanje praznjenja zalogovne komore 4.22000PP0.IV of the display ring 121 to emphasize the progress of the dosage or advancement of storage chamber emptying 4.
Vrsta prikazovanja z večkratnim vrtenjem telesa 102 naprave nasproti ohišnemu delu 101 za četrtino zavrtljaja in nadaljnje gibanje prikazovalnega obroča 121 je pri tem pojasnjeno na sl. 24 do 28 s tem, da je eden od zob prikazovalnega obroča 121 označen. Istočasno je na teh slikah še prikazano, da se prikazovalni obroč 121 in s tem dozirno gibanje po dosegu predvidenega števila doziranj da blokirati.The type of display by repeatedly rotating the body 102 of the device against the housing part 101 by a quarter turn and the further movement of the display ring 121 is explained in FIG. 24 to 28, with one of the teeth of the display ring 121 being marked. At the same time, it is shown in these figures that the display ring 121 and thus the metering movement can be blocked after reaching the intended number of dosages.
Medtem ko je na sl. 24 prikazan inhalator v stanju dobave in se označen zob nahaja na eni strani prikazovalnega okna 120, je na sl. 25 prikazano prvo doziranje, pri katerem se je prikazovalno okno 120 obsegajoče telo 102 naprave zavrtelo za 90°. Ustrezno se je sojemalo prikazovalni obroč 121 preko ozobljenja. Zatem sledi osno povratno gibanje in nadaljnje doziranje, pri čemer je na sl. 26 prikazan položaj po npr. četrtem doziranju. Označen zob je sedaj prešel približno širino prikazovalnega okna 120.While in FIG. 24 shows the inhaler in the delivery state and the marked tooth is located on one side of the display window 120, in FIG. 25 shows a first dosage in which the display window 120 of the enclosing body 102 of the device rotates 90 °. The ring 121 through the toothed was properly matched. Thereafter, the axial reverse motion and subsequent dosing are followed, with FIG. 26 shows the position according to e.g. the fourth dosage. The marked tooth has now passed approximately the width of the display window 120.
Pri tem je bistveno istočasno že omenjeno pripravljalno blokiranje dozirnega gibanja po predvidenem številu doziranj, v tem primeru npr. 200 doziranj.At the same time, the preparatory blocking of the dosing movement according to the intended number of dosages, in this case e.g. 200 dosages.
To blokiranje pri tem sledi s pomočjo prikazovalnega obroča 121 na naslednji način: Zobnik, ki služi kot prikazovalni obroč 121, obsega na svoji proč od zob obrnjeni notranji strani prislon 123, ki s protiprislonom 124 relativno k njemu zavrtljivega ohišnega dela 101 sodeluje v takem smislu, da sta oba prislona 123 in 124 v izhodiščni legi po sl. 24 blizu drug drugemu ali se celo dotikata, z dozirnim gibanjem po sl. 25 do 27 pa sta počasi gibljiva v obodni smeri najprej drug iz drugega nato pa zopet drug v drugega, pri čemer z istočasno osno prestavitvijo dospeta tadva prislona 123 in 124 vsakokrat v druga proti drugi po višini zamaknjeni ravnini, s povratnim gibanjem pa ponovno prideta v naleganje v sovpadajoči ravnini ali skoraj na isti višini. Izsrednost skrbi pri tem istočasno za to, da oba prislona tudi po sorazmerno velikem številu doziranj, npr. po 197 doziranjih (pri zadnjem doziranju), po sl. 27 medsebojno še ne kolidirata.This blocking is then accomplished by means of the display ring 121 as follows: The gear, which serves as the display ring 121, comprises on its away from the teeth an inner 123, which cooperates in this sense with the counter-member 124 relative to the rotatable housing 101 thereof. , that both stops 123 and 124 are in the starting position according to FIG. 24, or even touching each other, with the metering movement of FIG. 25 to 27, however, are slowly moving in the circumferential direction, first from each other and then back into each other, with the two axes 123 and 124 respectively moving in a direction that is offset each time by the axial axis, and in return they return to resting in a coincident plane or at almost the same height. At the same time, care is taken to ensure that both stops even after a relatively large number of dosages, e.g. after 197 doses (at last dosage), according to FIG. 27 do not yet collide with each other.
Na sl. 28 je prikazano, da oba prislona 123 in 124 po približno enem zavrtljaju prikazovalnega obroča 121 in zadnjem dozirnem koraku na takšen način ležita drugIn FIG. 28, it is shown that both the stops 123 and 124, after approximately one rotation of the display ring 121 and the last dosing step, thus lie differently.
22000PPO.IV nad drugim v obeh ravninah, daje zaprto osno povratno prestavljanje v začetno lego inhalatorja po sl. 14 in s tem ponovljen, iz te lege začet dozirni korak (učinkuje blokiranje). Vrtilno gibanje, ki služi doziranju, je lahko uporabljivo istočasno na prednosten način ne le za zavrtitev prikazovalnega obroča, temveč ima ta lahko s pomočjo prislonov 123 in 124 dodatno funkcijo in sicer služi za to, da se po vnaprej podanem številu dozirnih korakov inhalator I zapre. S tem se prepreči, da bi uporabnik pri dokaj izpraznjenem inhalatorju I izvajal nadaljnje dozirne korake, ne bi pa več dobil zadostne količine trdnih teles.22000PPO.IV above the other in both planes, provides a closed axial return shift to the inhaler starting position according to FIG. 14 and thus repeated, a dosing step (blocking effect) is initiated from this position. The dosing rotary motion can be used simultaneously in a preferred manner, not only to rotate the display ring, but it can also have an additional function by means of stops 123 and 124 to close the inhaler I after a predetermined number of dosing steps. . This prevents the user from performing further dosing steps with a sufficiently emptied inhaler I, but no longer obtains sufficient solids.
Na sl. 29 in 30 sta predstavljena izvedbena primera inhalatorja I po izumu, pri katerih so prav tako izpolnjene poprej omenjene značilnosti in ukrepi, dodatno pa je v zalogovni komori 4 na strani, ki je obrnjena proč od dozirnega zatiča 5, razporejen s šibko vzmetjo 125, v danem primeru vijačno vzmetjo obremenjen, odvzemu vsebije zalogovne komore 4 sledeč bat 126. Vzmetna sila je pri tem tako majhna, da ne pride do stiskanja trdnih teles, pri čemer pa je vzmetna sila istočasno tako velika, da lahko prestavi bat 126 tudi proti težnostni sili trdnih teles in njegovi lastni teži, pri čemer sledi pojemanju volumna komore. S tem se da celotni inhalator I uporabiti praktično v poljubni legi, t.j. uporabnik ga lahko uporabi tudi v ležečem položaju, ne da bi moral zavzeti težak položaj. Kljub temu ostane vedno zagotovljeno, da vsako dozirno gibanje vodi k temu, da se lahko inhalira dozirni zarezi 50 ustrezno količino trdnih teles.In FIG. 29 and 30 illustrate embodiments of the inhaler I according to the invention, in which the above mentioned characteristics and measures are also fulfilled, and in addition, in the storage chamber 4, on the side facing away from the metering pin 5, is arranged with a weak spring 125, in in the present case, the spring spring is loaded and the contents of the storage chamber 4 are removed, following piston 126. The spring force is so small that no solid bodies are compressed, while the spring force is so large that it can also move the piston 126 against the gravity force. of solids and its own weight, following the decay of the volume of the chamber. In this way, the entire inhaler I can be used practically in any position, i.e. the user can also use it in the supine position without having to take a difficult position. However, it is always ensured that any dosing movement causes the dosage notch 50 to be inhaled with an adequate amount of solids.
Istočasno postane pri tem s temi slikami in predvsem s sl. 30 jasno, da je zalogovna komora 4 znotraj ohišnega dela 101 razporejena sprostljivo in izmenljivo in/ali lahko ima sprostljiv pokrov 127. S tem po izpraznitvi zalogovne komore 4 ni potrebno zamenjati celotnega inhalatorja I, temveč le zalogovno komoro ali pa se jo da celo ponovno napolniti. Ustrezno majhna je tudi nagnjenost k izmetu.At the same time, he becomes involved with these images, and especially with FIG. 30, it is clear that the storage chamber 4 within the housing portion 101 is arranged releasably and interchangeably and / or may have a releasable cover 127. Thus, after the storage chamber 4 is emptied, it is not necessary to replace the entire inhaler I, but only the storage chamber or even to reload it. fill up. The tendency to eject is also relatively small.
Pri tem je na sl. 30 še pojasnjeno, da ima izmenljivo v ohišnem delu 101 razporejena zalogovna komora 4 v izhodiščni postavitvi pred montažo zaporo 129, ki se jo da prebiti, izbiti in/ali z vnaprej določenimi lomnimi točkami tesno pritrditi, prehodnega kanala 400 za dozirni zatič 5, katera zapora 129 je z vstavitvijo zalogovne komore 4 v njen ohišni del 101 z dozirnim zatičem 5 samodejno vtisljiva in odpirljiva. S tem je zamenjava dokaj izpraznjene dozirne komore 4 z napolnjeno dozirno komoro 4 zelo enostavna, ker istočasno s potisnjenjem le-te v uporabni položaj vzpostavi tudi žeHerein, FIG. 30 it is further explained that the storage chamber 4 disposed in the housing portion 101 in the initial arrangement before mounting, which can be punctured, punctured and / or tightly fixed by predetermined breaking points, has a passage channel 400 for the metering pin 5 which the closure 129 is automatically imprinted and opened by inserting the storage chamber 4 into its housing part 101 with the metering pin 5. This makes it very easy to replace a fairly emptied dosing chamber 4 with a filled dosing chamber 4, since at the same time it is pushed into the usable position already in place
22000PPO.IV povezavo z zračno potjo, dozirni zatič 5 pa dospe v prvi dozirni položaj.22000PPO.IV airway connection and dosing pin 5 reaches the first dosing position.
Pri tem je lahko z montažo odpirljiva zapora 129 zalogovne komore 4 v danem primeru izvihtljiva v notranjost zalogovne komore 4, torej ostane še v povezavi z ostenjem zalogovne komore 4, njen premer pa je pri tem na smotrn način večji kakor osni potek dozirne zareze 50, tako da le-to lahko brez težav spremlja na zapori 129, ki je zavihtena navznot.By mounting, the opening closure 129 of the storage chamber 4 may in this case be removable into the interior of the storage chamber 4, thus remaining in connection with the remainder of the storage chamber 4, its diameter being in this manner being substantially larger than the axial course of the metering slot 50, so that it can be easily monitored at the shutter 129, which is turned inwards.
Kot že poprej omenjeno ima inhalator po izumu več prednosti. Varno, hitro, zanesljivo in popolno polnjenje dozirne zareze je zagotovljeno tako, da dozirana količina trdnih teles obsega dobro konstanto in tako lahko uporabnik, ki težko diha, hitro in zanesljivo inhalira določeno količino blažilnega praška. Nadalje je inhalator primeren posebej tudi za inhaliranje drobnozrnatih in zato praškov s slabo sposobnostjo tečenja. Razen tega je preprečen vdor vlage v inhalator in s tem grudičenje. Nadalje se da pri inhalatorju po izumu prašek, kot že opisano, uskladiščiti v kapsulo, tako da se lahko uporabi tudi takšne praške, katerih farmacevtski učinek pojenjuje (glej npr. konstrukcijo po sl. 30) s trajnim stikom z zrakom (neposredno skladiščenje v zalogovni komori). Inhalator se da enostavno demontirati, čistiti, lahko oskrbovati, poleg tega pa ni zasnovan kot inhalator za enkratno uporabo. Zlasti primeren je za inhaliranje antiastmatično učinkovitih snovi in zmesi snovi ter zlasti posebej za zmes snovi iz formoterola in laktoze. Predvsem lahka posluževalnost se odraža v povišani masi, kadar je osno dozirno gibanje povzročeno z delno zavrtitvijo obeh ohišnih delov 101 in 102 drugega proti drugemu, ker je takšna zavrtitev za uporabnika bistveno varneje izvedljiva, kot sorazmerno kratka, s tornimi silami otežena čista osna prestavitev.According to the invention, the inhaler according to the invention has several advantages. Safe, fast, reliable and complete filling of the dosing slit is ensured in such a way that the dosed amount of solids has a good constant, so that a difficult-to-breathe user can quickly and reliably inhale a certain amount of buffer powder. Furthermore, the inhaler is particularly suited for the inhalation of fine-grained and therefore poor-flowing powders. In addition, moisture is prevented from entering the inhaler and thus clotting. Furthermore, in the inhaler according to the invention, the powder, as described above, can be stored in a capsule so that such powders whose pharmaceutical effect is diminished (see, e.g., construction according to FIG. 30) with permanent contact with air (direct storage in stock) may also be used chamber). The inhaler is easy to disassemble, clean, maintain, and is not designed as a disposable inhaler. It is particularly suitable for the inhalation of anti-asthmatically active substances and mixtures of substances, and in particular for mixtures of formoterol and lactose substances. Particularly light handling is reflected in the increased mass when the axial dosing movement is caused by the partial rotation of the two housing parts 101 and 102 against each other, since such rotation is significantly safer for the user than a relatively short friction force, which impedes pure axial displacement.
Inhalator I za vnos dozirane količine trdnih teles, npr. farmacevtsko učinkovitih praškov, v zračni tok, vsesan s strani uporabnika, obsega zalogovno komoro 4, v katero štrli dozirni zatič 5. Dozirni zatič 5 je opremljen z dozirno zarezo 50, katera določa količino trdnih teles, ki se jo primeša zračnemu toku. Zalogovna komora 4 in dozirni zatič 5 sta drug proti drugemu relativno tako premakljiva, da se v prvem relativnem položaju dozirnega zatiča 5 in dozirne komore 4 dozirna zareza 50 dozirnega zatiča 5 nahaja v zalogovni komori 4, kjer se napolni s trdnimi telesi, v drugem relativnem položaju pa se nahaja v zračnem kanalu, kjer se trdna telesa primešajo zračnemu toku. Osno relativno gibanje se lahko pri tem povzroči z zavrtitvijo dvehInhaler I for administration of a dosage amount of solids, e.g. of pharmaceutically effective powders, injected into the air by the user, comprises a storage chamber 4 into which the metering pin protrudes. 5. The metering pin 5 is provided with a metering notch 50 which determines the amount of solids to be mixed with the air flow. The stock chamber 4 and the metering pin 5 are relatively movable relative to each other such that in the first relative position of the metering pin 5 and the metering chamber 4, the metering notch 50 of the metering pin 5 is located in the stock chamber 4, which is filled with solids, in the second relative The position is located in the air duct where the solids are mixed with the air stream. Axial relative movement may be caused by the rotation of two
22000PPO.IV ohišnih delo 101,102 preko nagnjenih ploskev 103.22000PPO.IV housing work 101,102 over inclined surfaces 103.
CIBA-GEIGY/AG: z;CIBA-GEIGY / AG: z;
PATEKm/lSAMAPATEKm / lSAMA
I-JUe/jaMAI-JUe / jaMA
22000PP0.IV22000PP0.IV
Claims (31)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91810195 | 1991-03-21 | ||
CH251591 | 1991-08-28 | ||
YU25292 | 1992-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
SI9210252A true SI9210252A (en) | 1995-02-28 |
Family
ID=27173747
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9210252A SI9210252A (en) | 1991-03-21 | 1992-03-13 | Inhaler |
Country Status (2)
Country | Link |
---|---|
HR (1) | HRP950142A2 (en) |
SI (1) | SI9210252A (en) |
-
1992
- 1992-03-13 SI SI9210252A patent/SI9210252A/en unknown
-
1995
- 1995-03-23 HR HRP-252/92A patent/HRP950142A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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HRP950142A2 (en) | 1997-04-30 |
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