SI9210252A - Inhaler - Google Patents

Abstract

Inhaler for injecting solid dosage bodies, e.g. pharmaceutically effective powders, in air the flow drawn in by the user comprises a storage chamber (4) into which the dosing pin (5) protrudes. The metering pin (5) is fitted with a metering notch (50) to determine the amount of solids mixed with the air stream. The nozzle chamber (4) and the metering pin (5) are relative so flexible with each other that in the first the relative position of the metering pin (5) and the stock chambers (4) metering notch (50) metering pin (5) located in the storage chamber (4) where it is filled with solids bodies, and in another relative position is located in air duct where solids are mixed with air flow. Axial relative motion is thus achieved by rotating two housing parts (101, 102) via inclined surfaces (103).

Description

CIBA-GEIGYAG

Inhaler

The invention relates to an inhaler for introducing a metered amount of solids into a user-aspirated air stream according to the introductory part of claim 1.

Solid-state inhalers are now available in a large number and many embodiments. With these inhalers, the user is primarily inhaled by a pharmaceutically effective substance or mixture of substances, in particular powders or mixtures of substances. Such an inhaler is known e.g. from CH-A-666,823. The inhaler described therein comprises a storage chamber for the thorn bodies as well as an air duct connecting the inlet air intake port with the outlet for the solid-air mixture formed in the inhaler. To determine the amount of solids and to enter that specified amount of solids into the air stream, a metering pin is provided with a metering notch designed to rotate about its longitudinal axis. The metering notch of the metering pin adopts a certain amount of solids in the first position with the volume of the metering notch. The dosing pin is then rotated 180 ° about its axis to another position in which the solid bodies can fall out of the metering notch and thus reach the air duct where they are mixed with the air stream.

The inhaler described has various drawbacks. It is thus necessary for the solid bodies to be able to flow well, ensuring that the dosing notch is constantly fast, reliable and fully filled. Because granules and other large solids are not suitable for inhalation, pharmaceutically effective substances or mixtures of substances, e.g. anti-asthmatically active substances or mixtures of substances, often available as very fine-grained powders. These fine-grained powders, however, have the very disadvantage that they are not or are not. are capable of very poor flow. This, however, may again be for

22000PP0.1On consequence, the dosage notch is incompletely filled, thereby changing the dosage amount of solids. It is precisely in the case of difficulty breathing (eg conditioned by asthmatic attack) that the user encounters that he or she must inhale a certain amount of powder quickly and reliably for quick relief.

A further disadvantage of the inhaler described is that solids are introduced into the air duct by means of a rotary dosing pin. It may happen that solid bodies can penetrate the cavities (bearings) around the rotating dosing pin and cause the dosing pin to be either very difficult to rotate or even completely clogged ¹ , which may be particularly so for users prone to asthma, important consequences, because the device is therefore incapable of operating when needed.

Furthermore, the inhaler described is also disadvantaged by the fact that the fine-grained powder cannot be stored in a special container, e.g. capsules. This is particularly disadvantageous for those powders whose pharmaceutical effect is compromised by storage in permanent contact with air. In addition, in the inhaler described above, moisture entering the inhaler and its storage chamber (eg by accidentally coughing the user into the inhaler) and which in any case may additionally affect the poor flowability of the powder or the inhaler. clumping may occur.

Therefore, it is an object of the invention to develop a solids inhaler which avoids the aforementioned drawbacks, which enables the rapid, easy and reliable dosing of solids, which enables the storage of solids in a special container, e.g. capsules, and which is easy to use. In addition, the inhaler should be designed for a large number of inhalations, ie not as so. disposable inhaler.

This task is solved by the invention as defined in the characteristic part of claim 1. The metering pin protrudes through the opening of the storage chamber into it. The storage chamber and the metering pin are relatively movable relative to each other such that, in the metering pin, the notch in the first relative position is in the storage chamber and in the second relative position in the air duct. This achieves that the metering pin is immersed in the first solid position in the solid body. As solid

1. Zariba

22000PP0.IV In this case, in the following case, the powder has either no or only poor flowability, which is pushed into this notch when filling the dosing slit in the first relative position. In addition, the powder can also be stored in a special container in the storage chamber, e.g. in the capsule. This may, as explained above, be relevant for such powders whose pharmaceutical effect is impaired by storage in constant contact with air. In addition, the storage of the powder in the capsule also provides protection against possible moisture ingress, so as to avoid clumping and thereby further affect the flowability as well as affect the pharmaceutical effect by contacting the powder with moisture.

In the embodiment of the inhaler according to the invention, the metering pin is firmly disposed relative to the housing of the inhaler device, and the storage chamber is movably arranged against the metering pin. This embodiment is characterized by its simple construction and easy handling, which will be explained in greater detail on the basis of a detailed description.

A further design of the inhaler according to the invention comprises a separate actuator for moving the storage chamber. When actuated, this actuator moves the storage chamber opposite to the force of the return spring in the first relative position to the metering pin. The storage chamber wall is provided with a wall extension that closes the air duct in this first relative position. This wall extension provides an opening which, upon returning the stock chamber to another relative position, releases the air duct again. This design of the inhaler achieves that when filling the metering notch, it cannot be inhaled nor blow (eg coughing) into the air duct, thus preventing moisture from entering the air duct in this relative position of the metering pin and the storage chamber. After that, the next quantity of powder is taken from the storage chamber. from the storage tank therein, the storage chamber is placed back to the second relative position, thereby reaching the filled dosing notch of the metering pin into the air duct. An opening in the wall extension of the storage chamber releases the air duct and inhalation can be done.

In a further embodiment of the inhaler according to the invention, the actuating body is further provided with a shaking element which can be performed e.g. like a shock spring. This shaking element causes the storage chamber to shake when it reaches the first relative position of the metering pin and the storage chamber, thus filling the metering notch, thus filling the metering notch completely, safely and quickly in the case of a powder with particularly poor flowability.

22000PPO.IV

In order to make it obvious to the user that he has just taken the dose and also to allow the storage chamber to shake in a powder with poor flowability, while the dosing pin with the dosage notch protrudes into the powder, a further design of the inhaler according to the invention with the arresting device is provided. This arresting device firmly holds the storage chamber. the dosing pin of each other in the first relative position. Once the dosing is complete, the arrest by releasing the release element can be released again. In this way, inadvertent multiple dosing can also be avoided.

In a preferred embodiment of the invention, the inhaler comprises a special suction nozzle in which the cross section of the air duct is increased in the direction of outlet. Such a suction nozzle acts inversely as a nozzle and causes complete deagglomeration of the powder so that it can reach the user's lungs in the air stream. This suction nozzle is fitted with a closure cap, which provides a desiccant to remove any moisture that may intrude.

In order to prevent the user from blowing the powder through the air inlet after the determination of the amount of powder and after introducing the powder into the air duct by blowing (eg coughing), a non-return valve is provided in the further embodiment of the invention.

A further embodiment of the inhaler according to the invention is provided with a counter ² , which can be reset to its initial position and which, upon reaching the first relative position of the storage chamber and the metering pin, increases. The user can thus recognize how many dosages he or she has already taken. how much dosage he has left and can refill the storage chamber if necessary.

The inhaler is particularly suitable for the inhalation of asthmatically effective substances or mixtures of substances, e.g. for a mixture of formoterol and lactose, which is explained below in the whispers below.

The design according to the invention substantially provides for axial movement of the metering pin with relative rotation between the housing body carrying the pin, on the one hand, and the housing part containing the storage chamber, on the other, whereby this rotational motion

2. rucksetzbar

220O0PP0.IV Forcibly transforms inclined surfaces into axial motion. The inhaler according to the invention is characterized in that the storage chamber comprising the housing part and the body of the device carrying the metering pin are movable from each other to the other, pushed apart from each other by being rotatable relative to each other. to one another, and at least one inclined surface on the body of the device and / or housing, and the guided counter thereon, converts rotational motion into axial motion. This leads to significantly more comfortable dosing movement because rotary motion is safer to do than a relatively short axial motion in which two parts must be pulled out of the other.

The housing part or body of the device may comprise more of the inclined surfaces distributed along its periphery of the same slope and length, relative to which the rotating bodies or share an appropriate number of projecting projections or proticos. In this way, the rotational motion in several places is simultaneously converted into axial motion, so that during the rotation a symmetrical grip of force and precise axial gearing occurs.

It proved to be advantageous when four inclined, over 90 ° extending, inclining and inclining planes cooperating with projection-like projections were projected each time, and when they were envisaged at the end of inclined planes direction-oriented transitions, grooves or the like for projections, such that the housing part with the stock chamber and the counter-rotation after the rotation and longitudinal slip of the projections on inclined surfaces, thereby resulting in axially adjusting the metering pin, are movable in the axial direction and move back to the starting position. The inclined surfaces serve as guides on the part of the helix and end at the axial passage, so that when rotating, the desired axial movement is followed by transporting the metered material from the storage chamber into the air path, while a simple movement of the metering pin into the storage chamber is sufficient. the axial joint displacement of the body of the device and the housing, since no such displacement of the obstructed inclined surfaces is available at the end of the rotational motion.

By the fact that, on the one hand, the aforementioned axial reverse movement is possible, and on the other hand, at the beginning of the rotational movement a projection, e.g. the thumb, forcibly leading over an inclined surface, may have at least one projection in the course of the axial return guide grooves, a saw-tooth projection (tooth), the steeply descending side of which is arranged coincident with the operatively inclined surface by the thumb, and the thumb may be over the rising one. inclined sides of this tooth adjustable in the axial direction and in the starting position

22000PP0.IV of the next dosing movement arranged for a steeply descending side. When axially moved to the starting position, the projection (thumb) within the axial return guide groove can then slide away over the saw-shaped tooth (tooth), but then, on the other hand, the corresponding opposite movement is impeded, so that the saw tooth as well. the projected projection already belongs to a leading or inclined plane, which helps to rotate the movement of the two housing parts relative to each other in an axial motion.

The sloping surfaces correspond in a sensible manner to the work of the threaded step and are arranged especially on the inside of the wall piece of the housing part. In this case, then, the body of the device with inclined surfaces has a projecting projection. These inclined surfaces may, of course, also be provided on the wall part of the body of the housing, and the housing portion comprises inclined surfaces of the cooperating projection.

The embodiment of the inhaler, in which the introduction of solids is caused by the rotation of the rotary in axial gear movement, permits the implementation of a significant value, in which, on the one hand, the rotation of the housing part is prevented against the metering movement, and at the same time it can be used for this rotational motion to shake the inhaler so that the powder solids can flow well into the dosage notch. Such a reasonable further embodiment may consist in the fact that, at touching points, relative to each other of the rotatable housing parts, there is a lock, a ratchet or the like, which blocks the antisense rotation of the housing parts opposite to the metering movement. On the one hand, this eliminates the wrong connection, since the rotation is only possible for the user in one direction, and on the other, the machine shakes sufficiently during rotation to allow the powder to flow properly into the dosing slit.

In this case, the closure may comprise a locking wheel with saw teeth on the first housing part and with each other in circumferential direction mutually displaced counter-teeth or groups of counter-teeth on the second housing part or body of the device, the offset of each intended counter-teeth in circumferential direction with respect to each other so selected that the ratchet step of the closure is smaller than the tooth splitting. In such a closure, it is sufficient when one tooth of the locking wheel is in the grip with the tooth. As more in the circumferential direction of the displaced counter-teeth, whose displacement deviates from the tooth division, is provided in the inhalatoi, a correspondingly small step in the rotational direction is obtained, which is again followed by blocking. Adequate number of searches occur

22000PPO.IV also during the entire rotational motion.

In this case, it is preferable that the teeth, tooth gaps, and teeth are extended in a straight line in the axial direction. This does not interfere with performing reverse gears at the end of the dosing movement.

In order to accommodate a guide or inclined surface on one side of the leading or inclined surface and a ratchet or lock on the other, the dosing needle may comprise a body of the device or a housing part partially double-sided, the inner wall of which is supported by inclined surfaces on the other housing part. projections projecting radially outward from this inner wall, and the outer wall may extend beyond the circumference of the inclined surface, comprising the wall portion of the second housing portion and comprising counter-teeth for those bearings which exert a locking wheel on the outside of the housing portion containing the storage chamber. The body of the device thus has practically two slots, in which the intermediate space can accommodate a suitable sling of the housing part, which can then carry inclined surfaces on the first side, and a part of the barrier on the other, non-bearing side. Such a space-saving arrangement of the various cooperating components of the whole system is possible in particular by the fact that the parts, due to their relative rotation to each other, are circular, thus permitting the concentric arrangement of the different walls.

While the inner wall of the dosing needle of the enclosing housing part and the guide surface of the enclosing wall of the storage chamber of the enclosing housing part is circular - at least in the area of their cooperation - the outer wall of the first housing part may have a cross-section deviating from this circular shape so that the walls form corner areas, especially in case of rotated and / or axially extracted housing parts, air can be drawn in through these then open corner areas, with tunnels on the inner wall parts as well as with at least one non-return cap leading to the metering channels and the metering needle . This circular shape, which deviates from the cross-section of the outer wall, also allows the inside of each side to be provided with striking countersinks, which are displaced in a circumferential direction so that, after less than one tooth division, the locking wheel finds support in the counter tooth .

Further, these corner areas come out of rotation beyond the entire contour, giving the air easier access.

22000PP0.IV

The metering needle of the enclosing housing part can be pushed against the front surface of the second housing part in a jointly pushed position with the front side of the outer housing and in this position the air path can be crossed and the inhaler can be closed airtightly. This has the advantage that moisture cannot enter as long as the appliance is unused, so that the powder to be dosed is not clogged with moisture the next time it is used.

The rotation according to the invention of the two housing parts relative to each other for axially adjusting the metering pin permits a further advantageous and efficient design such that the first of the housing parts may include a rotating display ring relative to the display window, which is relative to the other housing parts relative to each other in the case of dosing, always move forward by a small value of an angle of the same size and direction. In this way, the user can directly determine the discharge progression directly through this display ring, in a timely manner using a new inhaler or refilling the available inhaler as soon as possible.

The display ring may be designed as a sprocket, which is mounted relative to the hollow sprocket or inner gearing in a dosing needle comprising the housing part, and with its outer gearing fits into the inner gearing of this hollow wheel, leaving so little teeth of this inner gearing. from the number of teeth of the hollow wheel, that the inner gear against the hollow gear is rotatable by about a single revolution or part thereof, when a predetermined number e.g. 200 dosages. Numerous partial-rotational movements at each dosage therefore lead to a very slow folding rotation of the display ring, which, with certain color additives or the like, can signal to the user on the display window the consumption of the solid to be inhaled. Again, it is preferred that the rotational motion of the device is always performed in one direction only, and that the reverse rotation is blocked.

In order to ensure that the user does not attempt to continue inhaling when the intended maximum amount of individual dosage has been reached, the gear wheel may be used as a display ring and thus the dosing movement is blocked after reaching the intended number of dosages. This can be achieved in various ways.

A reasonable option, which also takes advantage of the rotational axial motion at the same time, may be that the gear wheel serves as a display ring, which includes a stop which

22O00PP0.IV mutatis mutandis cooperates with the counter-relative to the rotatable housing part thereof, so that the stops in the initial position are close to each other or touch and move slowly apart in the circumferential direction by the metering movement, whereby the two axles are moved axially at the same time. towards the second plane, which is displaced in height, and again, in a reciprocal motion, they again reach the coincident plane, and that they are designed as projections - the stops, after about one rotation of the display ring and the last dosing step in both planes, so that each other is axially reversed. starting position and thereby blocking the dosing step again.

A further advantageous embodiment of the invention may consist in the fact that in the storage chamber on the side opposite to the metering pin, disposed with a weak spring, the following is plunged into the chamber, or the like, the spring force being so small as to prevent solid compression However, the spring force is still so large that it also pushes the piston against the gravity of the solids and its own weight following the decay of the volume of the chamber. With this arrangement, the inhaler can be used in virtually any position and even at each dosing movement the filling of the metering notch can be ensured. As a result, these measures and the constant light pushing of the powder solid prevents it from sealing it or forming a channel at the point where the metering pin enters or exits. Because the spring that loads the tracer piston causes the complete dosing to follow in every dosing motion, preferably after shaking the inhaler first.

The storage chamber may be arranged freely and interchangeably within the housing portion and / or may have a release lid. In this way, after emptying the storage chamber, either this storage chamber can only be replaced or refilled, instead of using a brand new inhaler and throwing the emptied away.

In the housing part, the interchangeably arranged storage chamber may, in its initial position, comprise a piercing and / or through pre-defined breaking points, a tightly secured passageway passage for the metering pin, which is automatically opened with a metering pin by inserting the stock chamber into its housing part. Therefore, if the emptied storage chamber is replaced by such a new storage chamber, the insertion into the housing portion will at the same time cause the dosing pin to be introduced into that storage chamber without it having to be opened beforehand.

22000PPO.IV

In order to prevent the opening bar from being used later in the dosage notch and disrupting the metering movements with a metering pin, it is advisable to use this mounting to open the locking chamber of the storage chamber inside the storage chamber with a diameter greater than the axial range of the metering slot. However, different technical implementations of this principle are certainly possible.

The following examples are explained in greater detail by means of drawings. In a partly schematic representation, FIG. 1 shows an inhaler according to the invention in a starting position (second relative position) and in longitudinal section; 2 shows the inhaler of FIG. Iv in the first relative position and in the longitudinal section, FIG. 3 is a top view of the inhaler from the front (in the plane of the drawing in FIG.

2), FIG. 4 is a top view of FIG. 3 is a side view in the direction of arrow IV, FIG. 5 is a plan view of the bottom of the inhaler in the direction of arrow V in FIG.

2, FIG. 6 is a longitudinal section through the inhalation chamber of the inhaler (the cross-sectional plane is identical to the cross-sectional plane of FIGS. 1 and 2); FIG. 7 is a cross-sectional view of the storage chamber along the line VTI-VII of FIG. 6, FIG. 8 is a further cross-sectional view of the storage chamber along line VIII-VIII of FIG. 6, FIG. 9 is an external view of the inhaler, FIG. 10 is a section along the line vzd-Χ of FIG. 11 through the arresting device in the starting position (second relative position), FIG. 11 is a plan view of the arresting device in the direction of arrow XI of FIG. 10, FIG. 12 shows the arresting device in the first relative position and in cross-section along the line ΧΙΙ-ΧΙΙ of FIG. 13, fig. 13 is a plan view of the arresting device in the direction of the arrow ΧΙΠ; FIG.

12, FIG. 14 is a longitudinal cross section of a modified inhaler according to the invention in a first relative position in which the metering notch is positioned in the storage chamber, wherein the axial shift is feasible by rotating the body of the device carrying the metering pin opposite the housing

22000PPO.IV of the part containing the storage chamber, FIG. 15 is a schematic cross-sectional view of the inhaler along line D-D of FIG. 14, FIG. 16 view of developed, e.g. about a quarter comprises a projecting, inclined surface of the housing portion, through which the rotational movement is converted by the projection on the body of the device into the required axial movement of the metering pin from its, in FIG. 14 shows the starting positions in the position shown in FIG. 19, FIG. 17 is a cross-sectional view taken along line C-C of FIG. 15 through a non-return flap lying within the airway, FIG. 18 is a partial cross-section along line B-B of FIG. 15 shows a channel through the dosing pin with a view of the entrances to the following channels; FIG. 19 is a longitudinal section inhaler of FIG. 14 after executing the rotational movement converted to axial gearing, FIG. 20 is a cross-section along line E-E of FIG. 19 through the barrier provided between the relatively rotatable housing parts relative to each other, FIG. 21 is a longitudinal section inhaler corresponding to that of FIG. 19, the right side opposite to the arrangement of FIG. 14 to 19 are shown rotated such that the cross-section passes there through the non-return flap and the air ducts, FIG. 22 is a cross-sectional view of the inhaler in the first relative position according to FIG. 14 is rotated 90 °, FIG. 23 is a cross-sectional view taken along line F-F of FIG. 22 through the display device, FIG. 24 to FIG. 28 is a display device according to FIG. 23 in different positions, respectively, in increasing numbers of dosages, with FIG. 28 shows the blocking according to the intended maximum number of dosages, FIG. 29 is a longitudinal cross-section of a modified inhalato in a second relative position, wherein a spring-loaded tracking plunger for solids located in the storage chamber is provided in the storage chamber, FIG. 30 is a longitudinal section through a replaceable storage chamber with a barrier closed with predetermined breaking points or the like, which is automatically openable by insertion into the inhaler with a metering point, in which embodiment is also provided in this embodiment

22000PP0.IV Spring loaded tracking piston.

With the help of FIG. 1 and 2 of the longitudinal sections shown through the inhaler are intended to give a more detailed explanation of its structure and mode of operation. Inhaler I comprises essentially an inlet of 3 air with a non-return non-return valve R (both represented dashed because it does not lie in the cross-section plane) in its detachable upper O, a pushbutton-shaped actuator 2, a solids storage chamber 4 or a separate container , e.g. a capsule K in which the solid bodies are stored, a metering pin 5, which is, in the present case, provided as a groove-shaped metering notch 50, an air duct 6 (shown dashed because it does not lie in the cross-section), as well as a suction nozzle 1 which is equipped with an outlet for a solid-air mixture which is produced in an inhaler in a manner and type that remains to be explained. A suction cap 1 is attached to the suction nozzle 1, by which the outlet 10 is lockable.

In the following explanation of the mode of operation of the inhaler, the case is taken into account that the solids are stored in a capsule K containing e.g. 100 dosages, and that this capsule K has already been inserted into the storage chamber 4. The dimensions of the capsule K and the storage chamber 4 are aligned with each other. If the pushbutton 2 is now tensioned and the upper part O is planted and the pushbutton 2 is pressed to its starting position, it thus penetrates the metering pin 5 through the opening. 400 through the storage chamber 4 into capsule K and protruding into solids stored in capsule K. The inhaler is then in its starting position (Fig. 1), from which the dosage of the amount of solids can be followed first, followed by inhalation.

The storage chamber 4 with the restrained capsule K is in the rest position as shown in FIG. 1. In this stationary position, the storage chamber 4 and the metering pin 5 are relative to one another so that the metering pin 5 protrudes into the capsule K inside and closes the opening 400 of the storage chamber 4, while the groove-shaped metering notch 50 is still in the air paths between inlet 3 and outlet 10. This relative position (starting position) of metering pin 5 and stock chamber 4 is hereinafter referred to as the second relative position. The wall 40 of the storage chamber 4 is provided with a wall extension 41, which provides an opening 410. In this relative position of the storage chamber 4 and the metering pin 5, this opening 410 releases an air path through 3 air and outlet 10 via an air duct 6. The wall extension 41 stock chamber 4 strikes at its lower end against the return spring 43 which is

22000PP0.IV in this second relative position is tensioned regardless of the required prestressing mechanism.

To perform the dosage, the user now presses the pushbutton 2 in the direction of the arrow P. from above. This pushbutton 2 is provided in this embodiment with a shaking element designed as a shock spring 20. The shock spring 20 is attached to the pushbutton 2, e.g. pasted. We will come back to this shock spring later. At this point, it is important that the spring stiffness of this shock spring 20 is greater than the mean stiffness of the return spring 43. By pressing the pushbutton 2 in the direction of arrow P from above, the stock chamber 4 moves down and the return spring 43 is compressed. The shock spring 20 remains in its quiescent state for greater rigidity. The metering pin 5, which is fixed with respect to the body of the device (eg, is fixed in the bore), is driven deeper into the solids stored in capsule K. Due to the downward movement of the storage chamber 4, the return spring 43 is approximately fully compressed, The metering notch 50 of the metering pin 5 is already present inside the capsule K and thus in the solids.

As soon as the dosing notch 50 of the dosing pin 5 is penetrated into the storage chamber 4, and especially when reaching the position in which the return spring 43 is fully compressed and hereinafter referred to as the first relative position, the dosing notch 50 of the dosing pin 5 is filled as a groove. with solid bodies. In order to achieve that, even with the extremely poor flow capability and the very fine-grained powders mentioned above, the dosage notch 50 is filled quickly, reliably and completely, depending on the rear of the increasing spring stiffness, the shock spring 20 compressed return springs 43, jerked to the position shown in FIG. 2. With this shock leap of shock spring 20, the storage chamber 4 and the capsule bearing therewith are shaken, so that the powder with extremely poor flow capability reaches the dosage notch 50. Alternatively, of course, the shock spring 20 could also be canceled, by the user however, the inhaler would shake violently to achieve the described effect.

If the storage chamber 4 and the metering pin 5 are now in the first relative position shown in FIG. 2, closes wall extension 41 air flow path. This is achieved by blowing into the suction nozzle 1, e.g. by accidental coughing, no powder is expelled from the inhaler through the inlet of 3 air during dosing. In addition, this closure of the air route ensures that during the dosing, ie during filling 22000PP0.IV of the metering notch 50, no moisture can enter the inhaler, which is always possible by accidental coughing of the user.

After skipping the shock spring 20, the metering notch 50 is filled with powder. If the pushbutton 2 is released now, it moves the return spring 43 of the storage chamber 4 back to the second relative position, ie to the starting position. In this second relative position (starting position), the opening 410 in the wall extension 41 of the storage chamber 4 releases the air path as described above. If the user now draws in air at suction port 1, the air inlet 3 and the non-return valve R in FIG. 1 is shown dashed symbolically by flap R, an air stream develops in the air channel 6. This air stream blows a metered amount of powder out of the dosage notch 50. This creates a solid-air mixture, which is then inhaled by the user through the outlet 10 at the suction port 1 and which can enter his airways. In order to maximize the effective blowing out of the dosage amount of the powder from the notch 50 and to reduce the flow rate of the solid-air mixture upon entry into the airways of the user, the intersection section 1, which is otherwise kept small, is enlarged toward the outlet. 10.

How is the air duct 6 designed in detail in the embodiment illustrated herein, or. how the air flow is guided in the inhaler should be explained in more detail below by means of FIG. 3 to 9. FIG. 3 and 4 show the upper portion of the O inhaler, with the side views of FIG. 4 distinct air intakes 3 (elongate slots). Through these air intakes 3 and through the non-return valve R (shown in Fig. 1 dashed in both its resting position and in the inhalation position), the intake air enters the inhaler.

How the air flow is further guided inside the inhaler can be seen in FIG. 5 showing a plan view of the lower portion of the U inhaler. Three recessed air ducts 6a, 6b, 6c, which are disposed in the body of the lower portion of the inhaler in such a way that they are directed downwards (see also the dashed line 6 in Fig. 1), and through which the air flow is guided, are recognized.

In FIG. 6 is shown by means of a pushbutton 2 a moving storage chamber 4, of course without a capsule K. Inserted after the dosing step is completed, when the dosing pin 5 and the storage chamber 4 are in the starting position (second relative

22000PP0.IV position), the powder is blown out of the dosage notch 50 of the dosing pin by means of air 5. Therefore, naturally, the air flow must flow from the air ducts 6 to the dosing notch 50.

How to realize this is shown in fig. 7 and 8, each showing cross-sections along lines VII-VII and FIGS. VHI-Vin. The cross-sectional plane of the VH-VII runs exactly at the height of the metering notch, so that it stands optimally in the air flow. By means of FIG. 7 it is seen that the inlet openings 44a and 44b for the air flow are arranged at the same angle a with respect to the cross-sectional plane of the longitudinal section of FIG. 1 as the corresponding air ducts 6a and 6b of FIG. 6.

The third air inlet 44c is arranged at the same angle β with respect to this cross-sectional plane as the corresponding air duct 62, as can be seen from FIG. 8, below both air intakes 44a and 44b in the cross-sectional plane VII-VII. This inlet 44c for air is used to prevent the removal of solids from the dosage notch. it blows the powder together to mix with the air flow. Through the opening 410 in the wall extension 41 of the storage chamber 4, a solid body air mixture through the outlet 10 in the suction port 1 can then be introduced into the airways of the user.

In order to avoid unintentional multiple dosing, the storage chamber 4 and the metering pin 5 (see Fig. 2) are held firmly in the first relative position by the arresting device. This arresting device is in FIG. 1 is exemplified by latch 21, the operation of which is further explained by FIG. 9 to 13.

In order to be able to understand how the aretime device works, in FIG. 9, the exterior structure of the inhaler is shown again, with the upper part O being shown in FIG. 3, intended opening 212.

In FIG. 10 is a side view of the push button 2 in longitudinal section. Under its head, it is provided with a groove 22, which is already shown in Fig. 1. A latch 21, which is also shown in FIG. 1, in an even more elaborate manner and type.

In its starting position (the second relative position of the storage chamber 4 and the metering pin 5), the inhaler of FIG. 11 is shown in plan view. In this plan view, the latch 21 is provided with a leaf spring 210 and a holding button

22000PPO.IV

211. The leaf spring 210 is supported by a groove in the inner wall of the inhaler (see also Fig. 10) and tries to move the latch 21 in the direction of arrow V, and push the holding button 211 further out through the opening 212 shown already in FIG. 9 and 10. ·

This further pushing out of the holding knob 211 through the opening 212 is prevented by the latch 21 striking the body of the pushbutton 2 (actuator) in the starting position. This is particularly well illustrated by the cross-sectional view of FIG. 10.

If the pushbutton 2 is now triggered (arrow P in Fig. 1), so that the metering notch 50 of the metering pin 5 is moved to the storage chamber 4, the latch 21 thus remains first in the position described, since the holding button 211 is firmly held in the opening 212. In contrast, push button 2 moves downwards. Upon reaching the first relative position (Fig. 2), the latch 21 can slide into the groove 22 of the pushbutton 2, and thus the leaf spring 210 can move the latch 21 in the direction of arrow V (Fig. 11). In this way, the holding button 211 with the leaf spring 210 is pushed further out through the opening 212. In this state (Fig. 12, Fig. 13), the return spring 43 (Fig. 2) of the storage chamber 4 can no longer be repositioned. (second relative position), because the pushbutton 2 is firmly locked over the latch 21.

Only when the user presses outwardly from the holding button 211 in the direction of arrow E from the outside does the latch 21 move out of the groove 22 in the pushbutton 2 and thus out of its locked position and release the arrest. Now the stock chamber with the return spring 43 can be reverted back to the starting position (the second relative position of the metering pin 5 and the stock chamber 4). This type of arrest prevents multiple dosing.

The inhalers described so far, as mentioned above, can be fitted with a non-return valve at the inlet of 3 air. Alternatively, a non-return valve R could also be provided in the suction line. This non-return valve R may be implemented e.g. as a flap as shown in FIG. 1, and causes it to blow through the outlet 10 when blowing into the inhaler, e.g. accidentally when coughing the user into exit 10, air intake 3 closed. This is particularly preferred, such as e.g. after dosing the powder and returning the storage chamber 4 to a second relative position so that the powder cannot be blown through the inlet of 3 inhalers. Therefore, if the user accidentally coughs up the inhaler after successful dosing, nothing can be lost and it can be sucked in again without the need for

22000PP0.IV newly dosed.

Further, the inhaler may also be designed with a counter 7 which can be reset to its initial position (Fig. 1), which is incremented at each dosing step. The counter 7 is e.g. incrementing in downward movement of the storage chamber 4. Such counter 7 is particularly preferred, since in the storage chamber 4, the capsule K contained contains a certain number of dosages of powder. When inserting a new capsule K, the user can then place the counter 7 in the starting position ³ , so that he / she can recognize how many dosages he / she has already taken from the capsule K, and can insert a new capsule K in the storage chamber 4 or in time. if necessary replace the inhaler.

In order to keep the inhaler or air way dried or the holder is dry, a drying agent 12 is provided in the protective cap 11, which may e.g. designed as silica gel.

Such an inhaler is, as explained above, particularly suited to a solid-based substance or mixture of a substance having an anti-asthmatic effect, especially for the inhalation of a mixture of lactose and formoterol available e.g. in the form of a salt of formoterol fumarate, whose IUPAC nomenclature code reads as follows:

'' (±) -2'-hydroxy-5 '- [(RS) -l-hydroxy-2 - [[(RS) -p-inethoxy-a-methylphenyl] -amino] ethyl-formanilide-fumarate-dihydrate.

Many variants can be thought of for the inhaler described. In principle, it is not absolutely necessary for the inventor to have the storage chamber arranged in a movable manner and the metering pin locally fixed, and a reverse case is also possible. It must only be ensured that the storage chamber and the metering pin with the metering notch are relatively movable. Further, it is also intended to be a powder or a. solids stored directly in the storage chamber and not in a separate capsule inserted into that storage chamber. The stress element (shock spring) can, of course, be done differently, as can the arresting device. The drying agent may also be slightly different from the silica gel mentioned.

In FIG. 14 to 30 show modified embodiments of inhaler I in which

3. Resets

22000PP0.IV is designed in a particularly prudent manner, the foregoing relative movement between the storage chamber 4 and the metering pin 5. The portions of this modified inhaler I are substantially provided with the same reference numbers as in the embodiment described above. A comparison of e.g. between FIG. 1 and 14, that in the embodiment described below, the inhaler may also be converted into two housing portions, but the division is performed below the air outlet or mouthpiece 10.

In order to perform relative movement between the stock chamber 4 and the metering pin 5, it is contemplated in the embodiments described below that the stock chamber 4 comprising a housing part 101 and a body of the device or a housing part 102 carrying a metering pin 5 is thus relatively movable. to the second from the first compressed position, e.g. according to FIG. 14, to another extracted position, e.g. according to FIG. 19 to be rotatable relative to one another, the inclined guide surfaces or the inclined surfaces 103 on the housing portion 101 and the guided counter guides 104 disposed on the body 102 of the device shift the said rotational motion in axial motion. Here again, it should be noted that the sloping surfaces 103 may also be provided on the outside of the socket 109, i.e. on the body 102 of the device, and the counter-tiles 104 correspondingly on the housing portion 101. The sloping surface 103 is in FIG. 16 is an advanced view in the direction of arrow A in FIG. 14.

In this case, the housing part 101 comprises, in the embodiment, four, namely, each of the four inclined planes 103 arranged at its periphery, of the same inclination and length, and the relatively rotatable pivot portion 102 thereof, the corresponding number of projecting projections or proticos 104 thereof.

The four inclined surfaces 103, which are cleverly designed as grooves to allow the protruding proticoles 104 to be well-guided, extend about 90 ° in circumference, lie at the same height and rise in the same direction. At the end of the inclined surfaces 103, the transverse groove 105 is projected in a vertical direction in each case in the vertical direction, ie parallel to the longitudinal center of the inhaler I, so that after one rotation and longitudinal sliding of the proticos 104 or projections on the inclined surfaces 103 there is an outgoing axis by repositioning the metering pin 5, the housing portion 101 with the storage chamber 4 and, as a guide pin, the housing housing piece 104 are re-pushed together in the axial direction, thus adjustable back to the starting position according to FIG. 14. From this starting position, the following dosing and rotation movement can then be performed in the same direction as

22000PP0.1V previous. Therefore, simple handling is provided for the user, in which he can advantageously carry out relatively easy and safe rotary movement, which can also be for the elderly and children, when a relatively short axial shift is required against the initial friction resistance.

In the course of the axial return grooves 105, FIG. 14,16,19, 22 and 29 at least one saw-shaped projection is arranged, the steeply descending side of which is arranged in accordance with the respective inclined surface 103 for protrusion or protrusion 104. Proticos 104 can be moved in the circumferential direction with the rising outer side 107 of protrusion 106. , so that in the starting position of the next dosing movement it is arranged for the steeply descending side of the projection 106 and transported through this steeply descending side into the sloping surface 103. This ensures that the user can and must always perform the dosing only with the rotational movement and not by axial movement by moving the proticos 104 along the groove 105. Further, a smaller projection or thumb 105a is provided in the course of the axial return groove 105, which prevents poor or unwanted compression of the inhaler.

Inclined surfaces 103 oz. the grooves comprising the latter correspond to each part of the threaded step and, in the embodiment, are arranged on the inside of the wall piece 108 of the housing part 101, which housing part 108 extends from the housing part 101 approximately axially to the side facing away from the storage chamber 4 , if necessary downwards. On the corresponding wall parallel to this wall 108, the wall 109 of the device 102, the wall 109 of which in the embodiment is arranged inside the wall piece 108, protruses 104 radially outwards and grips into grooved sloping surfaces 103.

To replace the shock spring 20 of the embodiment of FIG. 1 to 13, however, in the case of the dosing movement, shaking for solid body shaking would develop, while at the same time preventing the dosing movement in the opposite rotating manner, it is arranged at a junction between relatively mutually rotating housing parts 101 and 102 as a ratchet acting imprisonment 110. This can be seen in particular from FIG. 20, which also shows the recess grooves 105 for the countercurrents 104.

In addition, in FIG. 20 with a horizontal cross-section of this view along cross-section E-E of FIG.

inclined surfaces 103 partly cut and thus each ^ at visible as a segment.

22000PPO.IV

The shutter 110 comprises, in a customary manner, a locking wheel 111 with saw teeth 112 on the housing portion 101, namely, a wall piece 108, and cooperates with each other in circumferentially mutually displaced counter-teeth 113 or groups of such counter-teeth 113 provided on another housing unit or to the body 102 of the device on the inside of the outer wall 114, which according to FIG. 20 has no circular contour, but leaves the corner spaces 115 empty opposite the circular shape of the locking wheel 111 each time, so that said groups of counter-teeth can be displaced against each other in such a way that rotation of the locking wheel 111 already leads to locking in less than one tooth division. rotate in the opposite direction. These corner spaces 115 will be mentioned later in connection with the air supply.

Particularly when observing FIG. 20 and 19 it is seen that the locking wheel 111 is essentially a part of the housing 108 of the housing portion 101, which has, after a short axial region, saw teeth 112 projecting outward and gripping into the counter teeth 113 of the outer wall 114, which has a larger axial length, in order to account for the axial relative movement between the housing portion 101 and the body 102 of the device. In this case, the teeth 112, the dental gaps and the antidotes extend in a straight line in the axial direction in order to enable and also guide said axial relative motion in which rotational motion is to be converted.

The metering pin 5 comprising the device body 102 or the housing part therefore has, by area, a partially double wall, the inner wall 109 of which is supported by inclined surfaces 103 on the second housing portion 101 of the counter-projecting radially outward protruding 104, while the outer wall 114 extends from the outside of the inclined surface. 103 comprising a wall piece 108 of the second housing portion 101 and comprising counter-teeth 113 for a locking wheel 111 disposed on the outside of the storage chamber 4 of the housing housing 101 or. 108. gives this in FIG. 14, 19, 22 and 29 recognizable compact construction methods and connection of the housing part 101 to the body 102 of the device, even though the two parts are not only movable in the axial direction but also in relation to each other in the direction of rotation.

In order that said rotational movement can be performed smoothly, the inner wall 109 of the dosing needle 5 of the enclosing housing part 102 and the inclined guide surface 103 of the enclosing wall 108 of the storage chamber 4 of the enclosing housing part 101 are circularly shaped while the outer wall 114 of the first housing part 102 - as already mentioned - deviates from this circular shape at least in part by creating corner spaces or corner areas 115. Particularly at

22000PPO.IV by rotating and / or axially extending the housing parts 101 and 102 according to FIG. 21, in which some parts of the VG are represented in a rotated, intake air by the arrows Pf 1 and Pf 2 in FIG.

through these then open corner areas 115, and through holes 116 near the bottom

117 of the device body 102 as well as at least through the non-return flap 118 of FIG. 15 two non-return flaps 118 - leads to air ducts 6a, 6b and 6c and dosing pin 5.

It is at the same time possible for the metering needle end face 114 of the containment body 102 to be pressed in a compressed position with a contiguous contour contiguous against the abutment surface 119 of the second housing portion 101, and in this position the airway is closed and the interior of the inhaler I is closed airtightly. The closure of the air to the air ducts 6a, 6b and 6c and the dosing range is therefore no longer solely dependent on the return force of the non-return flap or non-return valve R, but in the compressed position the air path is closed further.

The invention permits the rotary movement to be moved in axial motion, in addition to controlling and displaying dosages already performed, instead of using a counter 7. In embodiments of FIG. 14 to 30, one of the housing portions relative to the display window 120 comprises a rotatable display ring 121 which, by relative rotation of both housing portions 101 and 102 to each other, is in each case moving forward for a small amount of angle of the same size and - relative to always in the same directional dosing rotary motion - in the same direction. The exact design and arrangement of such a display device is shown in FIG. 22 to 28.

It is apparent from these figures that the display ring 121 is designed as a sprocket, which, with respect to the hollow sprocket 122, is mounted in a metering needle with the inner casing or body 102 of the device and fits with its outer casing into the inner cog of this hollow wheel. 122, which is firmly connected to said housing part 102. The number of teeth of this internal, such as the display ring 121 of the serving gear, thus deviates so little from the number of teeth of the hollow wheel 122, so that it is smaller by only a small number that the gear with internal gear is opposite the hollow sprocket 122 is rotatable by about a single rotation or part thereof when a predetermined number e.g. 100 to 200 dosages. In FIG. 23 to 28, it is explained that the outer coats of the display ring 121 are visible at all times or outside the display window 120, especially if the display window is transparent or transparent and the display ring 121 is painted with a priming color. The color may change around the perimeter

22000PP0.IV of the display ring 121 to emphasize the progress of the dosage or advancement of storage chamber emptying 4.

The type of display by repeatedly rotating the body 102 of the device against the housing part 101 by a quarter turn and the further movement of the display ring 121 is explained in FIG. 24 to 28, with one of the teeth of the display ring 121 being marked. At the same time, it is shown in these figures that the display ring 121 and thus the metering movement can be blocked after reaching the intended number of dosages.

While in FIG. 24 shows the inhaler in the delivery state and the marked tooth is located on one side of the display window 120, in FIG. 25 shows a first dosage in which the display window 120 of the enclosing body 102 of the device rotates 90 °. The ring 121 through the toothed was properly matched. Thereafter, the axial reverse motion and subsequent dosing are followed, with FIG. 26 shows the position according to e.g. the fourth dosage. The marked tooth has now passed approximately the width of the display window 120.

At the same time, the preparatory blocking of the dosing movement according to the intended number of dosages, in this case e.g. 200 dosages.

This blocking is then accomplished by means of the display ring 121 as follows: The gear, which serves as the display ring 121, comprises on its away from the teeth an inner 123, which cooperates in this sense with the counter-member 124 relative to the rotatable housing 101 thereof. , that both stops 123 and 124 are in the starting position according to FIG. 24, or even touching each other, with the metering movement of FIG. 25 to 27, however, are slowly moving in the circumferential direction, first from each other and then back into each other, with the two axes 123 and 124 respectively moving in a direction that is offset each time by the axial axis, and in return they return to resting in a coincident plane or at almost the same height. At the same time, care is taken to ensure that both stops even after a relatively large number of dosages, e.g. after 197 doses (at last dosage), according to FIG. 27 do not yet collide with each other.

In FIG. 28, it is shown that both the stops 123 and 124, after approximately one rotation of the display ring 121 and the last dosing step, thus lie differently.

22000PPO.IV above the other in both planes, provides a closed axial return shift to the inhaler starting position according to FIG. 14 and thus repeated, a dosing step (blocking effect) is initiated from this position. The dosing rotary motion can be used simultaneously in a preferred manner, not only to rotate the display ring, but it can also have an additional function by means of stops 123 and 124 to close the inhaler I after a predetermined number of dosing steps. . This prevents the user from performing further dosing steps with a sufficiently emptied inhaler I, but no longer obtains sufficient solids.

In FIG. 29 and 30 illustrate embodiments of the inhaler I according to the invention, in which the above mentioned characteristics and measures are also fulfilled, and in addition, in the storage chamber 4, on the side facing away from the metering pin 5, is arranged with a weak spring 125, in in the present case, the spring spring is loaded and the contents of the storage chamber 4 are removed, following piston 126. The spring force is so small that no solid bodies are compressed, while the spring force is so large that it can also move the piston 126 against the gravity force. of solids and its own weight, following the decay of the volume of the chamber. In this way, the entire inhaler I can be used practically in any position, i.e. the user can also use it in the supine position without having to take a difficult position. However, it is always ensured that any dosing movement causes the dosage notch 50 to be inhaled with an adequate amount of solids.

At the same time, he becomes involved with these images, and especially with FIG. 30, it is clear that the storage chamber 4 within the housing portion 101 is arranged releasably and interchangeably and / or may have a releasable cover 127. Thus, after the storage chamber 4 is emptied, it is not necessary to replace the entire inhaler I, but only the storage chamber or even to reload it. fill up. The tendency to eject is also relatively small.

Herein, FIG. 30 it is further explained that the storage chamber 4 disposed in the housing portion 101 in the initial arrangement before mounting, which can be punctured, punctured and / or tightly fixed by predetermined breaking points, has a passage channel 400 for the metering pin 5 which the closure 129 is automatically imprinted and opened by inserting the storage chamber 4 into its housing part 101 with the metering pin 5. This makes it very easy to replace a fairly emptied dosing chamber 4 with a filled dosing chamber 4, since at the same time it is pushed into the usable position already in place

22000PPO.IV airway connection and dosing pin 5 reaches the first dosing position.

By mounting, the opening closure 129 of the storage chamber 4 may in this case be removable into the interior of the storage chamber 4, thus remaining in connection with the remainder of the storage chamber 4, its diameter being in this manner being substantially larger than the axial course of the metering slot 50, so that it can be easily monitored at the shutter 129, which is turned inwards.

According to the invention, the inhaler according to the invention has several advantages. Safe, fast, reliable and complete filling of the dosing slit is ensured in such a way that the dosed amount of solids has a good constant, so that a difficult-to-breathe user can quickly and reliably inhale a certain amount of buffer powder. Furthermore, the inhaler is particularly suited for the inhalation of fine-grained and therefore poor-flowing powders. In addition, moisture is prevented from entering the inhaler and thus clotting. Furthermore, in the inhaler according to the invention, the powder, as described above, can be stored in a capsule so that such powders whose pharmaceutical effect is diminished (see, e.g., construction according to FIG. 30) with permanent contact with air (direct storage in stock) may also be used chamber). The inhaler is easy to disassemble, clean, maintain, and is not designed as a disposable inhaler. It is particularly suitable for the inhalation of anti-asthmatically active substances and mixtures of substances, and in particular for mixtures of formoterol and lactose substances. Particularly light handling is reflected in the increased mass when the axial dosing movement is caused by the partial rotation of the two housing parts 101 and 102 against each other, since such rotation is significantly safer for the user than a relatively short friction force, which impedes pure axial displacement.

Inhaler I for administration of a dosage amount of solids, e.g. of pharmaceutically effective powders, injected into the air by the user, comprises a storage chamber 4 into which the metering pin protrudes. 5. The metering pin 5 is provided with a metering notch 50 which determines the amount of solids to be mixed with the air flow. The stock chamber 4 and the metering pin 5 are relatively movable relative to each other such that in the first relative position of the metering pin 5 and the metering chamber 4, the metering notch 50 of the metering pin 5 is located in the stock chamber 4, which is filled with solids, in the second relative The position is located in the air duct where the solids are mixed with the air stream. Axial relative movement may be caused by the rotation of two

22000PPO.IV housing work 101,102 over inclined surfaces 103.

CIBA-GEIGY / AG: z;

PATEKm / lSAMA

I-JUe / jaMA

22000PP0.IV

Claims (31)

Patent claims An inhaler for introducing a dosage amount of solids, - in particular pharmaceutically effective solids or mixtures of substances, preferably in powder form, an intake air flow from the user side, which enters the airways of the user as a solids-air mixture, after the solids are introduced, intake air intake (3), with an air duct (6) connecting the air inlet (3) to the outlet (10) or. a mouthpiece, with a storage chamber (4) for solids and with a metering pin (5), which, by means of a metering slit (50) provided thereon, determines and injects into the air flow a quantity of solids, characterized in that the metering pin (5) protrude through the opening (400) of the storage chamber (4) in the direction of its longitudinal axis into the storage chamber (4), so that the storage chamber (4) and the metering pin (5) are so movable to each other in the direction of the longitudinal axis of the metering pin (5). , that the metering notch (50) of the metering pin is in the first relative position in the storage chamber (4) and in the second relative position in the air duct. An inhaler according to claim 1, characterized in that the metering pin (5) is positioned locally firmly with respect to the body of the device and that the storage chamber (4) is movable against the metering pin (5). An inhaler according to claim 2, characterized in that it comprises a separate actuator (2) for movement of the storage chamber (4), designed to move the storage chamber (4) opposite to the force of the return spring (43) in the first motion relative position to the metering pin (5), and that the wall of the storage chamber (4) is provided with a wall extension (41) that closes the air duct in this first relative position and provides an opening (410) provided in the wall extension which, upon return the storage chambers (4) release the air duct again to another relative position. An inhaler according to claim 3, characterized in that the actuating body (2) is provided with a shaking element (20) which, upon reaching the first relative position of the metering pin (5) and the storage chamber (4), shakes the storage chamber (4). An inhaler according to claim 4, characterized in that the shaking element is designed as a shock spring (20). 22000PPO.IV Inhaler according to one of Claims 1 to 5, characterized in that it is provided with an arresting device (21, 210, 211, 212) which holds the storage chamber (4) or. the metering pin (5) is firmly held in the first relative position · and that a release element (211) is provided to release the arrest. An inhaler according to any one of claims 1 to 6, characterized in that it comprises a special suction nozzle (1) in which the cross section of the air duct is increased in the direction of the outlet (10). Inhaler according to claim 7, characterized in that it comprises a separate closure cap (11) that can be seated onto the suction nozzle (1). An inhaler according to claim 8, characterized in that a drying agent (12) is provided in the closure cap (11). An inhaler according to any one of claims 1 to 9, characterized in that a non-return valve is provided at the air inlet (3). Inhaler according to one of Claims 1 to 10, characterized in that it is provided with a counter (7) which can be reset to its initial position and which, when reaching the first relative position of the storage chamber (4) and the metering pin (5) ) increase. An inhaler according to any one of claims 1 to 11, characterized in that the solids are an antiasthmatically effective substance or an antiasthmatically effective mixture of substances. An inhaler according to claim 12, characterized in that it is an anti-asthmatically effective substance or substance. an antiasthmatically effective mixture of substances a mixture of formoterol and lactose. An inhaler, in particular according to one of the preceding claims, characterized in that the storage chamber (4) comprises a housing part (101) and a body (102) of the device, which carries the metering pin (5,) from the first jointly pushed position to each other moveable to one another, extending from one another by being rotatable relative to one another, and at least one inclined surface (103) on the body (102) of the device and / or housing part (101) and a guided counter (104) thereon. convert 22000PP0.IV rotary motion in axial motion. An inhaler according to claim 14, characterized in that the housing part · or body (102) of the device may comprise, at its circumference, distributed inclined planes (103) of the same inclination and length, and relative to it, rotating bodies or dividing by an appropriate number with the projections or countersinks involved (104). An inhaler according to claim 14 or 15, characterized in that in each case there are provided four extending over 90 ° extending at the same altitude and inclining planes in the same direction, which cooperate with protrusions designed as projections (104), and that at the end of the inclined surfaces (103) are provided in the vertical direction oriented aisles, grooves (105) or the like for countersinks (104) such that the housing part (101) with the stock chamber (4) and the countersink (104) are rotated and the longitudinal sliding of the countersinks (104) on the inclined surfaces (103) with which the resulting axial movement of the metering pin (5) is jointly adjustable in the axial direction and is movable back to the starting position. Inhaler according to one of Claims 14 to 15, characterized in that at least one annular projection (105a) is provided in the course of the axial return guide grooves (105a), through which a lateral proticose (104) is moved so that the axis at least one of the reverse guide grooves (105) is further disposed as a saw blade • a projecting projection (106), the steeply sloping side of which is arranged coincident with the operatively inclined surface (103) for the counter (104), and the counter (104) is via the rising the sloping sides (107) of this projection (106) adjustable in the axial direction and arranged for the steeply descending side in the initial position of the next dosing movement. Inhaler according to one of Claims 14 to 17, characterized in that the inclined surfaces (103) are preferably designed as grooves and correspond to the parts of the threaded step and are arranged in particular on the inside of the wall part (108) of the housing part (101). An inhaler according to one of Claims 14 to 18, characterized in that a stop (110), a ratchet or the like, which blocks antisense rotation, are disposed at contact points between relatively rotatable housing parts (101, 102) 22000PP0.IV housing parts opposite to the metering movement. 20. Inhaler according to one of Claims 14 to 19, characterized in that the stopper (110) comprises a locking wheel (111) with saw teeth (112) on the first housing part (101) and in each case circumferentially displaced counter teeth. (113) or groups of counter-teeth (113) on the second housing part (102) or body of the device, the offset of the respective projected counter-teeth (113) in a circumferential direction relative to each other so that the angle of the closure is smaller than the division of the teeth. 21. Inhaler according to claim 19 or 20, characterized in that the teeth (112), dental gaps and counter teeth (113) extend in a straight line in the axial direction. Inhaler according to one of Claims 14 to 21, characterized in that the metering pin (5) comprises the device body (102) or the housing part partially double wall, the inner wall (109) of which is supported by inclined surfaces (103) on the other the housing part (101) of the counter protrusion (104) projecting from this inner wall radially outwards, and that the outer wall (114) outside the embrace of the inclined surface (103) comprises the wall portion (108) of the second housing part (101) and the circumference ( 113) for the outside of the housing part (101) comprising the storage chamber (4), a locking wheel (111) arranged. Inhaler according to one of Claims 14 to 22, characterized in that the inner wall (109) is a metering needle (5) of the enclosing housing part (102) and the guide surface (103) of the enclosing wall (108) of the storage chamber (4) the housing part (101) is circular, and that the outer wall (114) of the first housing part (102) has a cross-section at least in area from that circular shape, so that corner areas (115) are formed between the walls, and that in particular in rotated and / or axially extracted housing parts (101, 102) drawn in from these, then open corner areas (115), with tunnels (116) near the bottom (117) of the body (102) of the device as well as with at least one non-return cap the metering channels (6a, 6b, 6c) and the metering pin (5). Inhaler according to one of Claims 14 to 23, characterized in that the front side of the outer wall (114) is a metering needle of the enclosing body (102) of the device in 22000PPO.IV together with the depressed position with a coherent circular contour, it rests against the resting surface (119) of the second housing part (101) and in this position the air path is crossed and the interior of the inhaler closed airtight. Inhaler according to one of Claims 14 to 24, characterized in that the first of the housing parts comprises a rotating display ring (121) relative to the display window (120), which is each time movable by relative rotation of the two housing parts against each other forward for the smallest value of an angle of the same size and direction. 26. Inhaler according to one of Claims 14 to 25, characterized in that the display ring (121) is designed as a gear, which is, relative to the hollow gear (122) or the inner gearing, mounted in a dosing needle (5) comprising a housing part (5). 102) and with its outer gearing it fits into the inner gearing of this hollow wheel (122), with the number of teeth of this inner gearing deviating so little from the number of teeth of the hollow wheel that the inner gearing against the hollow gear is rotatable by about a single revolution or its part when a predetermined number is executed e.g. 100 to 200 dosages. 27. An inhaler according to claim 25 or 26, characterized in that the display ring (121) and thus the dosage movement 'can be blocked after reaching the intended number of dosages. 28. An inhaler according to one of Claims 14 to 27, characterized in that, as a display ring (121), the toothed wheel comprises a stop (123) which cooperates with the counter (124) relative to the rotatable housing portion (101) thereto. the backrests are in the initial position close to each other or touching and are slowly moving apart in a circumferential direction by the metering movement, whereby the backrests (123, 124) are axially displaced each time by a displaced plane, and, in the reverse motion, they again reach the coinciding plane, and that the stops (123,124), after about one revolution of the display ring (121) and the last dosing step in both planes, are so aligned that the axial reversing is in the starting position and thus the dosing step blocked. 29. An inhaler according to any one of claims 1 to 28, characterized in that it is in stock 22000PP0.IV of the chamber (4) on the side opposite to the metering pin (5), arranged with a weak spring (125) loaded, decelerating the contents of the chamber following piston (126) or the like, the spring force being so small that compression of the solid is prevented However, the spring force is still so large that it also pushes the piston (126) against the force of gravity of the solids and its own weight following the reduction of the volume of the chamber. Inhaler according to one of Claims 1 to 29, characterized in that the storage chamber (4) is arranged in a spatially and interchangeably manner within the housing part (101) and / or has a releasable lid (127). 31. Inhaler according to one of Claims 1 to 30, characterized in that the storage chamber (4), which is interchangeable in the housing part (101), has a breakable, punctured and / or penetrating barrier (129) in the initial arrangement. with predefined breaking points tightly fastened, the passage duct (400) for the metering pin (5), which closure (129) is automatically imprinted and opened by inserting the stock chamber (4) into its housing part (101) with the metering pin (5). .