HRP950142A2 - Inhaler - Google Patents

Description

The invention relates to an inhaler for introducing a dosed amount of solids into the air flow, sucked in by the user, according to the introductory part of the 1st patent claim.

Inhalers for hard bodies can be obtained today in large numbers and in many designs. With these inhalers, the user primarily inhales pharmaceutically effective substances, or mixtures of substances, especially dusty substances or mixtures of substances. Such an inhaler is known, for example, from CH-A-666,823. The inhaler described there contains a chamber for supplies for hard bodies as well as an air channel, which connects the inlet air opening for the sucked air with the outlet for the mixture of hard bodies-air, formed in the inhaler. To determine the amount of solids and to introduce that specific amount of solids into the air stream, a cap with a dosing notch is provided. The plug can rotate around its longitudinal axis. The dosing notch of the dosing cap accepts a certain amount of solids in the first position with the volume of the dosing notch. Then the dosing cap is turned 180° around its axis to another position, in which hard bodies can fall out of the dosing notch and thus reach the air channel where they are mixed into the air stream.

The described inhaler has various shortcomings. It is therefore necessary that the hard bodies are capable of good movement, which ensures that the dosing slot is constantly filled quickly, safely and completely. Because granules and some larger hard bodies are not suitable for inhalation; are pharmaceutically effective substances or mixtures of substances, e.g. antiasthmatic effective substances or mixtures of substances are very often available as fine fine powders. These fine-grained powders have, in most cases, a very bad feature, if they are not from are capable of very little movement. This can again result in the dosing slot being incompletely filled, which also changes the dosed amount of solids. Precisely in the case of difficult breathing (e.g. due to an asthmatic attack), which occurs to the patient, the patient must quickly and safely inhale a certain amount of powder for quick relief.

The next shortcoming of the described inhaler is. that the introduction of hard bodies into the air channel is followed by means of a rotating dosing plug. Thus, it can happen that hard bodies get into the cavities (seat) around the rotating dosing cap and cause the dosing cap to be difficult to rotate or even stop completely, which can have noticeable consequences for users, those who are prone to asthma, because in needs, the device is not able to work.

Furthermore, the described inhaler lacks the fact that the fine-grained powder in the storage chamber cannot be stored in a special container, for example in a capsule. This is particularly deficient for those powders where the pharmaceutical effect decreases due to storage in permanent contact with air. In addition, it can happen with the inhaler described above, that with moisture, which penetrates into the inhaler and its chamber with the supply (e.g. when the user accidentally coughs into the inhaler) and which in one way or another mostly additionally affects the poor ability to move the powder from. lumps may form.

For this reason, the task of the invention is to develop an inhaler for hard bodies that will bypass the aforementioned shortcomings, which in addition enables fast, simple and safe dosing of hard bodies, which enables the storage of hard bodies in a special storage, for example in a capsule, and which is also easy to use.

In addition, let the inhaler be designed for a large number of inhalations, so not as the so-called disposable inhaler.

This task will be solved by the invention, as defined in the distinctive part of the 1st patent claim. The dosing plug protrudes through the opening of the supply chamber into it. The supply chamber and the dosing plug can be relatively easily moved relative to each other, so that the recessed notch in the dosing plug is located in the supply chamber in the first relative position, and in the air channel in the second relative position. This achieves that the dosing plug in the first relative position is immersed in a supply of hard bodies. In the following example, powder without or with a very poor ability to move is considered as hard bodies, which is pushed into that notch when filling the dosing notch in the first relative position. In addition, the powder can be stored in a special container in the storage chamber, for example in a capsule. This can be, as already explained, important for such powders, whose pharmaceutical effect decreases due to storage in constant contact with air. In addition, storage of the powder in the capsule provides protection against possible rising moisture, so as to prevent the formation of lumps of powder and thus further influence on the ability to move as well as influence on the pharmaceutical effect due to contact of the powder with moisture.

In the embodiment of the inhaler, according to the invention, the dosing cap is arranged rigidly in relation to the housing of the inhaler device, while the air chamber is flexibly arranged against the dosing cap. This embodiment is distinguished by its simple construction and easy handling, which will be explained in more detail after the detailed description.

A further concept of the inhaler according to the invention comprises a separate member for providing movement of the supply chamber. With extension, this organ moves the supply chamber against the force of the return spring to the first relative position towards the dosing plug. The wall of the storage chamber has an extension on the wall, which closes the air channel in that first relative position. One opening is provided in this extension, which opens the air channel again after returning the storage chamber to another relative position. With this concept of the inhaler, it is possible to inhale and not breathe (e.g. cough) into the air channel when filling the dosing notch, thus preventing moisture from entering the air channel at that relative position of the dosing cap and the supply chamber. After the subsequent subtraction of the amount of powder from the storage chamber from the container placed in it, the storage chamber is put back in another relative position, which allows the filled dosing notch of the dosing plug to reach the air channel. An opening in the wall extension of the supply chamber frees the air channel and inhalation can be performed.

In the next version of the inhaler according to the invention, the delivery organ is also equipped with a shaking element, which can be made, for example, as a shock spring. This element for the cherry causes that when the dosing cap and the storage chamber are in the first relative position, that is, when filling the dosing slot, the storage chamber is shaken, so even in the example that the powder has a poor ability to move, the dosing slot is completely, safely and quickly filled .

In order to make it obvious to the user that he has just taken a dose and also to enable shaking of the supply chamber in the case of powders with poor mobility, while the dosing plug with the dosing notch protrudes into the powder, the following concept of the inhaler according to the invention with a locking device is provided . This arresting device firmly holds the supply chamber from the metering plug of the latter against the latter in the first relative position. At the end of dosing, the arrester can be released again by providing a force-opening element. In this way, inadvertent repeated dosing can also be avoided.

In the preferred embodiment of the invention, it has an inhaler and a special suction extension, in which the cross-section of the air channel increases in the direction of exit.

Such a suction attachment acts inversely to the small opening and causes a complete deagglomeration of the powder, so that it can reach the user's lungs in the air stream. A movable closing cap can be placed on this suction extension, in which a desiccant is provided, to remove any moisture that might penetrate.

In order to prevent the user from washing the powder through the air inlet after a certain amount of powder and after introducing the powder into the air channel by purging (e.g. coughing) into the inhaler, in the following embodiment of the invention, a non-return valve is provided at the air inlet.

The following version of the inhaler according to the invention is equipped with a counter that can be returned to the initial position, and which increases when the first relative position of the supply chamber and the dosing cap is reached. The user can thus recognize how many doses he has already taken. how much he still has left and can refill the supply chamber in the given example.

The inhaler is particularly well suited for the inhalation of substances effective for asthma and a mixture of substances, for example for a mixture of formoterol and lactose, which is explained more precisely later.

The concept according to the invention of special significance foresees an axial conversion of the plug with a relative rotation between the body of the housing, which carries the plug, on the one hand, and the part of the housing, which contains the storage chamber, on the other hand. In this case, the rotational movement across the inclined surfaces is forcibly converted into an axial movement. The inhaler according to the invention is also characterized by the fact that the part of the housing, which contains the supply chamber, and the body of the device, which carries the dosing cap, are movable from the first set of depressed positions to the other to the second, and from the second to the extended position, with the fact that are rotatable relative to each other, at least one inclined surface on the body of the device and/or part of the housing, and the counter piece guided in it, turns the rotational movement into an axial movement.

This results in a significantly more pleasant, dosing movement, because the rotating movement is more reliably feasible than the relatively short axial movement, where two parts have to be pulled out of each other.

A part of the housing or the body of the device can contain several on its circumference divided, arranged inclined surfaces of equal slope and length, relative to it rotating bodies or share with them a corresponding number of protruding parts or counter-parts that cooperate with them. With this, the rotary motion is simultaneously transformed into an axial motion in several places, so that during the rotation, a symmetrical reception of the force and an exact axial transformation occur.

It turned out to be pleasant, when four inclined surfaces, which stretch over approximately 90°, lie at the same height, and rise in the same direction each time. These inclined surfaces cooperate with the counter-elements which are constructed as protrusions, and when at the end of the inclined surfaces oriented passages, grooves or the like are provided in the vertical direction for the protrusions, so that they are part of the housing with the supply chamber and the counter-piece after rotation and after the longitudinal sliding of the protrusions on inclined surfaces with the resulting axial conversion of the dosing plug, the assembly can be converted in the axial direction and can be moved back to the output position. Inclined surfaces serve as guides and they flow on the part of the screw spiral, and end at the axial transition, so that when rotating, the desired axial movement follows first with the transport of the dosing material from the supply chamber to the air path, while for the return movement of the dosing cap to the supply chamber a simple total axial displacement of the body of the device and part of the housing is sufficient, because at the end of the rotating movement there are no more inclined plates available, which would brake such a displacement.

By the fact that, on the one hand, the previously mentioned axial return movement is possible, and on the other hand, already at the beginning of the rotating movement, the projections, for example, the thumb, are guided under force over the inclined surface, it is possible to arrange at least one, a protrusion (tooth) shaped like a saw tooth. The bump has a steeply sloping side, and that side is arranged to match, acting as an inclined surface for the thumb. The thumb, on the other hand, can be turned in the axial direction via the rising oblique side of that tooth and in the initial position of the next dosing movement is arranged behind the steeply falling side. When the axis is converted to the initial position, the protrusion (thumb) can therefore be slid inside the axial return guide groove from, over the protrusion (tooth) constructed like a saw tooth. Then, on the other side, the corresponding opposite movement is braked, so that this protrusion, constructed like a saw tooth, already belongs to the leading or inclined surface, which helps to turn the rotation of both housing parts relative to each other into an axial movement.

The inclined surfaces correspond in an expedient manner to the part of the threaded pitch and are arranged especially on the inner side of the part of the housing rock. In this example, the rear body has devices with inclined surfaces of the protrusion, which cooperate. Admittedly, such inclined surfaces are provided exactly like that on the piece of rock of the body of the casing, while part of the casing contains protrusions that stick out and cooperate with the inclined surfaces.

The embodiment of the inhaler, in which the introduction of hard bodies is caused by the conversion of rotary to axial movement, allows the performance of a special meaning. With this design, the rotation of the part of the housing against the dosing movement is blocked on one side, and this rotation is simultaneously used to shake the inhaler in such a way that hard bodies in the form of dust can easily enter the dosing notch.

An expedient following such design can consist in the fact that at the contact points between relatively different rotating parts of the housing, there is an arrangement of dams, ratchets or the like, which blocks the senseless rotation of the housing parts against the dosing movement. On the one hand, this prevents incorrect connection, because turning for the user is only possible in one direction, and on the other side the device with the ratchet shakes enough to enable good movement of the powder into the dosing slot.

In this case, the dam can also contain a closing wheel with teeth like a saw on the first part of the housing and with counter teeth or groups of counter teeth on the second part of the housing or the body of the device that are moved against each other each time in the circumferential direction. In this case, the displacement of the provided counter teeth each time in the circumferential direction, one against the other, is chosen in such a way that the ratchet step of the dam is smaller than the division of the teeth. With such a dam, it is enough when one tooth of the closing wheel engages with the counter tooth each time. Because on the inhaler, there are more provided in the circumferential direction, one against the other, offset counter teeth, the displacement of which deviates from the division of the teeth, in this way, a correspondingly small step in the direction of rotation is obtained. This is followed by a block every time. Correspondingly many tremors also occur among the overall spin.

In this case, it is preferable that the teeth, tooth gaps and counter teeth extend straight in the axial direction. This does not stop the reverse conversion, which is being performed, at the end of the dosing movement.

In order to make it possible to place in a narrow space leading or inclined surfaces on one side, and a ratchet or a dam on the other side, it can have a partially double formwork and the body of the device, which contains both the dosing needle and part of the housing. In that part of the housing, the internal formwork is supported by inclined surfaces on the other part of the housing, which cooperate and protrude radially outward from the internal formwork. The external formwork, on the other hand, can cover the inclined surfaces outside, which are an integral part of the walls of the second part of the housing, and includes counter teeth. For those counter teeth, which load on the outside of the part of the case, which contains the chamber for the supply, and the closing circuit is arranged there. The body of the device has practically two formwork, where the space between them can accommodate the appropriate formwork of the housing part. That part of the housing can carry inclined surfaces on the first side, and part of the dam on the second, exposed side. Such a very space-saving arrangement of the various cooperating components of the entire system is possible, especially with the fact that the parts are round due to their relative maneuverability, which means they allow concentric arrangement of different formwork.

The inner paneling of the part of the housing that includes both the dosing needle and the guide wall surrounding the storage chamber of the part of the housing - at least in the area of their cooperation - are round. The outer casing of the first part of the housing may have a cross-section that deviates from this round shape. Thus, corner areas are created between the formwork, especially in the case of rotated and/or axially extracted parts of the casing, and the air can be sucked in through these, then open corner areas, with tunnels on the inner parts of the rocks, as well as at least with one non-return cap, and lead it to dosing channels and dosing needle. This, deviating from the round shape of the cross-section of the external formwork, allows for counter teeth to be provided on its inner side every time. These counter teeth are offset against each other in the circumferential direction, so that the closing wheel already finds support on the counter tooth after one tooth division.

Furthermore, those corner areas come when rotated outside the overall outline (contour), so that the air has easier access. The front side of the outer casing of the part of the housing, which contains the dosing needle, can rest in a depressed position with a circular contour, on the support surface of the other part of the housing. In this position, the air path can be cut off, and the inside of the inhaler can be sealed off. This has the advantage that moisture cannot enter as long as the device is unused. In this way, we avoid the possibility that the powder, which would be dosed, would burn due to moisture during the next use.

The possibility of turning according to the invention both parts of the housing against each other to perform the axial conversion of the dosing plug allows the following first and expedient concept so that the first of the parts of the housing can have a rotatable display ring relative to the display window. This ring, which with the relative movement of both housing parts against each other during dosing, can be moved forward each time by a small angle value of the same size and the same direction. With this, the user can determine the discharge progress directly via the display ring. In this way, the user can use a new inhaler in a timely manner - as far as possible - or refill it.

The indicating ring can be constructed as a gear, which is eccentric with respect to the hollow gear or internal toothing embedded in the metering needle, which is located in the housing part. That ring with its outer toothing fits into the inner toothing of that hollow wheel. The number of teeth of the internal gear is so slightly different from the number of teeth of the hollow wheel, that the internal gear against the hollow gear rotates for about only one revolution or only part of it, when a certain number of dosings, for example 200 dosings, have been performed before. Numerous partial turning movements with each dosing lead to a very slow, comfortable rotation of the indicating ring. This ring with certain colored accessories or the like can signal to the user on the window to show the consumption of the hard body, which he inhales. Here again, it is primarily important that the rotational movements on the device are always performed in one direction only, backward rotation is blocked.

In order to ensure that the user does not try to inhale further, when the predicted maximum amount of single dosing has been reached, the toothed wheel, which serves as an indicator ring, and thus the dosing movement after reaching the predicted number of dosing can be blocked. This can be achieved in different ways.

A purposeful possibility, which simultaneously utilizes the axial motion caused by rotation, can consist in the fact that the gear, which serves as a ring for showing, also includes a screen that cooperates with the counter-screen of the rotating part of the case relative to it. The screens are close to each other or touching in the output position. With the dosing movement, they slowly move away from each other in the circumferential direction. At the same time, they come with a simultaneous axial conversion of both screens each time to the other against the other displaced plane. With the return movement, they again come to the matching plane, and that - purposefully constructed as protrusions, the screens are designed after approximately one turn of the indicating ring and after the last dosing step in both planes, they are placed on top of each other, so that the return axis is transformed into the output position and thus I block the repeated dosing step.

The following embodiment of the invention with a considerable advantage can consist in the fact that in the supply chamber on the side opposite the dosing cap, a piston loaded with a weak spring is arranged, which follows the reduction of the amount in the chamber or the like, where the spring force is so small that it is prevented compression of hard bodies, and the spring force is still so great that it pushes the piston against the gravity of the hard bodies and its own weight, which follows the reduction of the chamber volume. With such a comparison, it is possible to use the inhaler in practically any position and to ensure that the dosing notch is filled with each dosing movement. Therefore, with these actions and the continuous pushing of the dusty hard bodies, they are prevented from sealing them or creating channels at the place where the dosing plug enters or exits. Because the spring, which loads the piston, causes that with each dosing movement, and especially after shaking the inhaler, complete dosing truly follows.

The storage chamber may be arranged within the housing portion so that it can be removed and replaced and/or have a removable cover. With this, it is possible that after emptying the supply chamber or that supply chamber itself can be replaced or refilled, instead of having to use a completely new inhaler and discard the empty one.

The replaceable supply chamber arranged in the part of the housing can have a penetrating and/or by means of predetermined breakable points tightly attached dam, transition channel for the dosing plug in the output position before assembly. The dam with the placement of the storage chamber and its housing part is self-acting and can be opened with a dosing plug. If, therefore, an empty supply chamber is replaced by such a new supply chamber, it causes the insertion of a portion of the housing at the same time and the introduction of the dispensing cap into that supply chamber, not that it must have been opened before.

So that the dam that opens with the dosing cap does not fall into the dosing notch during later use and disrupts the dosing movement, it is expedient, if with this balance the dam of the stock chamber, which can normally be opened, is twisted into the inside of the stock chamber, its the diameter is larger than the axial distance of the dosing notch. Different technical versions of this example are certainly possible.

In the extension, the implementation examples are explained in more detail with the help of drawings. In a partially schematic representation it shows

drawing no. 1 inhaler according to the invention in the output position (second relative position) and in longitudinal section,

design no. 2 inhaler with design no. 1 in the first relative position and in longitudinal section,

drawing no. 3 upper part of the inhaler in the front view (in the plane of drawing no. 2)

drawing no. 4 upper part from drawing no. 3 in the side view in the direction of arrow IV,

drawing no. 5 lower part of the inhaler in the floor plan in the direction of arrow V from drawing no. 2

drawing no. 6 longitudinal section through the inhaler supply chamber (the plane of the section is identical to the plane of the section on the drawing no. 1 and 2),

drawing no. 7 of storage chambers in section along line VII-VII from drawing no. 6,

drawing no. 8 of storage chambers in the following section along line VIII-VIII from drawing no. 6,

design no. 9 external appearance of the inhaler,

drawing no. 10 section along line X-X from drawing no. 11 through the arresting device in the exit position (second relative position),

drawing no. 11 of the arresting device in the floor plan in the direction of arrow XI from drawing no. 10,

drawing no. 12 of the device for arresting in the first relative position and in a section along the line XII-XII from drawing no. 13,

drawing no. 13 of the arresting device in the floor plan in the direction of arrow XIII from drawing no. 12,

drawing no. 14 longitudinal section of the modified inhaler according to the invention in the first relative position, in which the dosing notch is positioned in the supply chamber, in which the axial conversion is feasible with the rotation of the body of the device, which carries the dosing cap, opposite the part of the housing, which contains the chamber for stock,

drawing no. 15 partially schematic cross-section of the inhaler along line D-D from drawing no. 14,

drawing no. 16 a view of the developed, over, for example, about a quarter of the circumference, located, the inclined surface of the part of the housing, through which, by means of a protrusion on the body of the cap, the rotary movement is converted into the required axial transformation of the dosing cap from its, on drawing no. 14 of the shown, output position to the position shown on drawing no. 19,

drawing no. 17 section along the line C-C from drawing no. 15 through the irreversible dam, which lies inside the airway,

drawing no. 18 partial cross-section along line B-B from drawing no. 15 through the channel leading to the dosing plug with a view of the entrances to the following channels,

design no. 19 inhaler in a longitudinal section according to design no. 14 after the completion of the rotary rotation, converted into an axial rotation,

drawing no. 20 cross section along line E-E from drawing no. 19 through the fence, provided between the relatively side-by-side rotating parts of the housing,

drawing no. 21 inhaler in longitudinal section, corresponding to that of drawing no. 19, where the right part opposite to the arrangement from drawings no. 14 to 19 is shown rotated, so that the section passes there through the non-return dam and air channels,

drawing no. 22 inhaler in the first relative position in the section, which is rotated by 90° with respect to drawing no. 14,

drawing no. 23 cross section along line F-F from drawing no. 22 through the pointing device,

draft no. 24 do

drawing no. 28 of the device for indicating according to drawing no. 23 in different positions each time after an increased number of dosing, in which drawing no. 28 shows blocking for the predicted maximum number of dosing,

drawing no. 29 longitudinal section of a modified inhaler in another relative position, where a spring-loaded piston is provided in the supply chamber, which follows the hard bodies located in the supply chamber,

drawing no. 30 longitudinal section through the supply chamber which can be replaced with a dam closed with predetermined points for breakthrough or similar, which opens automatically when assembled into an inhaler with a dosing cap, where in this embodiment it is also provided with a spring loaded piston, which follows hard bodies.

Using the longitudinal sections through the inhaler shown in drawings no. 1 and 2, its construction and mode of action should be clarified more precisely. The inhaler I comprises essentially an air inlet 3 with a non-return valve R shown (both dashed, as it does not lie in the plane of the section), in its removable upper part 0, a delivery organ in the form of a push button 2, a supply chamber 4 for hard bodies or for a separate storage chamber, e.g. capsule K, in which hard bodies are stored, dosing plug 5, which in the given example has a dosing notch 50 designed as a slot, air channel 6 (shown dashed, because it does not lie in a plane cross-section) as well as the suction extension 1, which is equipped with an outlet for the mixture of hard bodies - air, which is produced in the inhaler in a way and type that needs to be explained. A protective cap 1 is placed on the suction extension 1, which can be used to close the outlet.

In the following explanation of the mode of action of the inhaler, an example is taken into account, that hard bodies are stored in a capsule K, which contains, for example, 200 dosages, and that this capsule K is already placed in the supply chamber 4. Dimensions of the capsule K and the chamber for stock 4 are aligned one after the other. If the push button 2 is now pressed and the upper part 0 is fitted and the push button 2 is pressed to its exit position, the dosing plug 5 penetrates through the opening 400 through the supply chamber 4 into the capsule K and protrudes into the hard bodies, stored in the capsule K. Inhaler is then in its output - starting position (picture 1), from which the dosage of the amount of hard bodies can follow first, and then inhalation.

The supply chamber 4 with the inserted capsule K is in a stationary position, as shown in Figure 1. The supply chamber 4 and the dosing plug 5 are in this stationary position so relatively arranged against each other that the dosing plug 5 otherwise protrudes into the interior capsule K and closes the opening 400 of the supply chamber 4. the dosing notch 50 constructed as a groove is already in the air path between the inlet 3 and the outlet 10. That relative position (initial position) of the dosing plug 5 and the supply chamber 4 is marked in the extension as another relative position. The wall 40 of the supply chamber 4 is equipped with an extension of the wall 41, in which an opening 410 is provided. In this relative position of the supply chamber 4 and the dosing cap 5, this opening 410 releases the air path of the air inlet 3 and the air outlet 10 via the air channel 6. Extension the rock 41 of the supply chamber 4 strikes at its lower end against the return spring 43, which is tensioned in that second relative position, regardless of the required preload of the mechanism.

To perform dosing, the user now presses from above the button 2 for pressing in the direction of the arrow P. This button 2 for pressing is equipped in the embodiment explained here with a cherry element, which is designed as a shock spring 20. The shock spring 20 is attached to the button for pressing 2 eg stuck. We will return to the action of that shock spring later. At that moment, it is important that the spring stiffness of that shock spring 20 is greater than the average stiffness of the return spring 43. By pressing the push button 2 from above in the direction of arrow P, the storage chamber 4 moves down, and the return spring 43 is compressed. Due to its greater stiffness, the impact spring 20 remains in its stationary position. The dosing cap 5, which is arranged fixedly with respect to the body of the device (e.g. it is stuck in the well), due to the downward movement of the supply chamber 4, is stuck deeper into the hard bodies, which are stored in the capsule K.

When the return spring 43 is almost completely compressed, the dosing notch 50 of the dosing plug 5 is already inside the capsule K and thus in the hard bodies.

As soon as the dosing notch 50 of the dosing cap 5 penetrates into the supply chamber 4, especially when reaching the position in which the return spring 43 is fully compressed and is marked as the first relative position in the extension, the dosing notch 50 of the dosing cap 5, designed as a groove, is filled with hard bodies. In order to achieve that, even with extremely weak movement capabilities and very fine-grained powders that were already mentioned at the beginning, the dosing notch 50 is filled quickly, safely and completely, the shock and spring 20, depending on the increasing spring stiffness at the end of the path quickly compressed return spring 43, jerkily reverses the position, shown in Figure 2. With this jerky jump of the shock spring 20, the storage chamber 4 is shaken and the capsule K and the powder are embedded with it, so that even the powder with extremely poor mobility reaches the dosing notch 50. Alternatively, the impact spring 20 could be arrested, in which case the user would have to shake the inhaler violently, in order to achieve the described effect.

If now the supply chamber 4 and the dosing plug 5 are in the first relative position, shown in Figure 2, it closes the extension of the wall 41 to the air flow. With this, it is achieved that, with purging into the suction extension 1, e.g. with inadvertent coughing during dosing, no powder is washed out of the inhaler through the air inlet 3. In addition, by closing the airway, it is achieved that during dosing, i.e. during of filling the dosing notch 50, moisture cannot get into the inhaler, which is otherwise possible all the time with the user's inadvertent coughing.

After the jump of the shock spring 20, the dosing notch 50 is filled with powder. If the push button 2 is now released, the return spring 43 moves the supply chamber 4 backwards to another relative position, that is, to the starting position. In this second relative position (exit position) release the opening 410 and in the extension of the wall 41 of the chamber. for the supply 4 the air path, as already described. If the user now sucks in air on the suction extension 1, an air flow develops in the air channel 6 through the air inlet 3 and through the non-return valve R, which is symbolically sketched with the flap R in Figure 1. This air flow washes the dosed amount of powder out of the dosing notch 50. In this way, a mixture of hard bodies - air is created, which the user then inhales through the outlet 10 on the suction extension 1 and this mixture can thus reach his airways. In order to achieve the most efficient possible blow-out of the dosed amount of powder from the dosing notch 50 and to reduce the flow rate of the mixture of hard bodies - air at the entrance to the user's respiratory tract, in the suction extension 1 the cross-section of the air channel, which is normally kept small, is increased according to exit 10.

How the air channel 6 is constructed in detail in the embodiment explained here, i.e. how the air flow is guided in the inhaler, will be more precisely explained in the extension using figures 3 to 9. Figures 3 and 4 show the upper part 0 of the inhaler, where in from the side view in Fig. 4, I can recognize the entrances of 3 rays (long cuts). Through these air inlets 3 and through the non-return valve R (shown in dashed lines in fig. 1 and in its rest position as well as in the position during inhalation) the sucked air reaches the interior of the inhaler.

How the air flow is further guided inside the inhaler can be seen from fig.5, which shows the floor plan of the lower part of the inhaler U. Three embedded air channels 6a, 6b, 6c are recognized, which are arranged in the body of the lower part U of the inhaler in such a way that they lead downwards (see also the dashed line in Fig. 1) and through which the air flow is directed forward.

In Figure 6, the flexible supply chamber 4 is shown by pressing the button 2, here clearly without the inserted capsule K. At the end of the dosing step, when the dosing plug 5 and the supply chamber 4 are in the output position (second relative position), the powder is washed by air from the dosing notch 50 of the dosing cap 5. That is why the air flow must clearly reach from the air channels 6 to the dosing notch 50.

How this can be realized is shown in figure no. 7 and 8, which each time show a section along lines VII-VII and VIII-VIII, respectively.

The VII-VII cross-section plane passes through it exactly at the height of the dosing notch, so that it stands optimally in the air flow. Using fig.7 it can be seen that the inlet openings 44a and 44b for air flow are arranged at the same angle with respect to the plane of intersection of the longitudinal section from fig.1 as well as the corresponding air ducts 6a, 6b from fig.6.

A third air inlet 44c is arranged at the same angle β with respect to that plane of intersection as the corresponding air channel 62, as can be seen in FIG. 8, below both air inlets 44a and 44b in the plane of intersection VII-VII. This inlet opening 44c for air is used so that any grains of hard bodies or powder that may have fallen out of the dosing notch are washed together and thereby mixed into the air flow. Through the opening 410 in the extension of the wall 41 of the supply chamber 4, the thus established mixture of hard bodies - air can then reach the respiratory tract of the user through the outlet 10 in the suction extension 1.

In order to avoid unintended repeated dosing, the supply chamber 4 and the dosing cap 5 (see Fig. 2) with the arresting device are tightly held together in the first relative position. This arresting device is shown in Fig. 1 as an example with latch 21, the mode of operation of which is further explained using Figs. 9 to 13.

In order to be able to understand the mode of operation of the arresting device, Fig. 9 first shows the external construction of the inhaler once again, in which, as can be seen from Fig. 3, an opening 212 is provided in the upper part 0.

Fig. 10 shows the push button 2 in a side view in a longitudinal section. Under its "head" it has a slot 22, which is already shown as a dashed line in fig.1. The latch 21, which is also shown in Fig. 1, can enter this slot, in an even better explained manner and type.

In its output position (the second relative position of the supply chamber 4 and the dosing cap 5), the inhaler is shown in plan in Fig. 11.

In this floor plan, it can be seen that the latch 21 is equipped with a leaf spring 210 and a holding button 211. The leaf spring 210 is open on the groove in the inner wall of the inhaler (see also fig. 10) and try to move the latch 21 in the direction of arrow V, holding push the button 211 even further out through the opening 212, already shown in fig. 9 and 10.

This further outward pushing of the holding button 211 through the opening 212 is prevented by the fact that the latch 21 in the exit position hits the body of the push button 2 (providing organ). This is particularly well visible from the cross-sectional view in Figure 10!

If the push button 2 (arrow P in fig.1) is now activated, it means that the dosing notch 50 of the dosing cap 5 moves into the supply chamber 4, thus the latch 21 remains forward in the described position, because the holding button 211 is firmly fixed in opening 212. Opposite that, the push button moves downwards. When it reaches the first relative position (fig. 2), the latch 21 can slide into the groove 22 of the push button 2 and thus the leaf spring 210 can move the latch 21 in the direction of arrow V (fig. 11). With this, the holding button 211 with the leaf spring 210 is pushed even further out through the opening 212. In this condition (fig. 12, fig. 13) the return spring 43 (fig. 2) cannot set the supply chamber 4 back to the exit position because push button 2 is firmly locked by latch 21.

Only when the user externally presses against the holding button 211 in the direction of arrow E, does the latch 21 move from the slot 22 in the push button 2 and thus out of its locked position and release the arrest. Now the supply chamber with the return spring 43 can be returned back to the output position (second relative position of the dosing plug 5 and the supply chamber 4). This type of arresting prevents multiple dosing.

The inhaler described so far can be, as already mentioned, equipped with a non-return valve at the 3-air inlet. Alternatively, a non-return valve R could also be provided in the intake manifold. This valve R can be made, for example, as a valve, as shown in the drawing in Fig. 1, and cause that when breathing into the inhaler through outlet 10, for example by mistake when the user coughs into outlet 10, the air inlet 3 is closed. This is especially important, as, for example, after dosing the powder and after returning the supply chamber 4 to another relative position, that the powder cannot be washed out through the inlet 3 of the air from the inhaler. If, after successful dosing, the user accidentally coughs into the inhaler, none of the powder is lost and he can suck in a new one, not that it would be necessary to dose again sooner.

Furthermore, the inhaler can be constructed with a counter 7, which can be returned to the initial position (fig. 1), which is incremented with each dosing step. The counter is, for example, incremented when the supply chamber 4 moves downwards. Such a counter 7 is particularly suitable, because in the supply chamber 4 there is a capsule K, which contains a certain amount of powder dosing. When inserting a new capsule K, the user can then set the counter 7 to the initial position, so that each time he can determine how many doses he has already taken of the capsule K, and he can timely place a new capsule K in the supply chamber 4, i.e. replace the inhaler in the given example.

To keep the inside of the inhaler from. airway dried up from. kept dry, a drying agent 12 is provided in the protective drop U, which can be thought of as silica gel.

As already explained, such an inhaler is particularly suitable for substances that are conceived as a hard body or as mixtures of substances with an antiasthmatic effect, especially for inhalations of mixtures of lactose and formoterol, which is available, for example, in the form of the formoterol fumarate salt. Its designation according to the IUPAC nomenclature reads: "(±)-2',-hydroxy-5',-/(RS)-1-hydroxy-2-//(RS)-p-methoxy-a-methyl-phenethyl/- amino/-ethyl/-formanilide'fumarate'dihydrate".

It is possible to design many variants for the inhaler described. In principle, according to the inventor's idea, it is not necessarily necessary that the supply chamber is arranged flexibly, while the dosing cap is locally hard, just like that, the reverse example is also possible. It must only be ensured that the supply chamber and the dosing plug with the dosing notch are relatively movable. Furthermore, it was thought that the powder, that is, hard objects, were stored directly in the storage chamber and not in a separate capsule, which was brought into that storage chamber. The element for the cherry (shock spring) can be clearly designed differently, just like the arresting device. And the drying agent can be something different than the specified silica gel.

Figures no. 14 to 30 show modified examples of inhaler I, in which the previously mentioned relative motion between the supply chamber 4 and the dosing plug 5 is constructed in a particularly expedient manner. The parts of this modified inhaler I are equipped with with the same reference figures, as in the previously described implementation example. A comparison between Fig. 1 and Fig. 14 shows that in the following embodiment the inhaler is actually divided into two housing parts, although the division is made under the air outlet or through the mouthpiece 10.

In order to perform a relative movement between the supply chamber 4 and the dosing plug 5, in the following embodiments it is provided that the part of the housing 101, which includes the supply chamber 4 and the body of the device or the part of the housing 102 that carries the dosing plug 5, are so relatively convertable mate to other from the first compressed position, for example according to Fig. 14 to the second extended position, for example according to Fig. 19, that they are rotatable relatively mate against the other, inclined leading surfaces or inclined surfaces 103 on the part of the housing 101, and the counter pieces guided on them 104, which are arranged on the body 102 of the device, turn the aforementioned rotational movement into an axial movement. At this point, it should be noted once again that inclined surfaces 103 can also be provided on the outer side of the rocks 109, that is, on the body 102 of the device, corresponding counterpieces 104 on the part of the housing 101. The inclined surface 103 is represented in Fig. 16 developed in the direction of arrow A from Figure 14.

In this case, the part of the housing 101 includes more in the embodiment, namely four inclined surfaces 103 of equal slope and length arranged on its circumference, a rotating part of the ore 102 relative to them and a corresponding number of protrusions or counter pieces 104 cooperating with them.

The four inclined surfaces 103, which are expediently constructed as grooves, so that the protrusions of the counter piece 104 could be forced to be well guided, stretch for a fairly 90° circumference, lie at the same height and rise in the same direction. At the end of the inclined surfaces 103 each time is provided in the vertical direction, that is, parallel to the longitudinal center of the inhaler, and a through slot 105 for the protruding counter pieces 104, so that after one revolution and longitudinal sliding of the counter pieces 104 or protrusions on the inclined surfaces 103 are with it; by the outgoing axial conversion of the dosing plug 5, part of the housing 101 with the supply chamber 4 and the housing piece 104 serving as a guide plug can be pressed together again in the axial direction, so it can be placed back in the exit position according to fig. 14. From this exit position, the following can be performed afterwards dosing - rotating motion in the same direction as the previous one. It means that the user is given a simple handling, in which he can preferentially perform a relatively easy and safely feasible circular motion, which is easy for both elderly people and children, when it is necessary to perform a relatively short axial rotation against the initial frictional resistance.

According to Fig. 14 16, 19, 22 and 29, in the course of the axial return grooves 105, at least one toothed projection is arranged, the steeply falling side of which is arranged in accordance with the inclined surface 103 acting each time for the counter piece or projection 104. The counter piece 104 can be turn the outer side 107 of the protrusion 106 in the axial direction so that in the output position of the next dosing movement it is arranged behind the steeply falling side of the protrusion 106, and during the turning movement, the steeply falling side is transported to the inclined surface 103. This ensures that the user can must always perform dosing only with a rotary motion and not with an axial motion with the conversion of the counterpiece 104- along the groove 105. Furthermore, in the course of the axial return groove 105, an even smaller projection or thumb 105a is provided, which prevents bad or unwanted compression of the inhaler.

Inclined surfaces 103 of. the grooves, which include them, each time correspond to a part of the threaded pitch and in the embodiment are arranged on the inner side of the piece of rock 108 of the housing part 101. That piece of housing 108 extends from the housing part 101 approximately axially to the side, which faces away from the chamber for stock 4, in the given example below. On the appropriate formwork 109 arranged parallel to that rock 108, the body 102 of the device, which formwork 109 is in the embodiment arranged inside a piece of rock 108, the counterpieces 104 protrude radially outward and engage in inclined surfaces 103 with grooves.

In order to replace the impact spring 20 from the embodiment according to fig. 1 to 13, despite this, during the dosing movement, a shaking for the cherry of hard bodies would develop, at the same time, in a advantageous manner, the rotating movement opposite to the dosing movement would be excluded, at the contact point between relatively against the other rotating parts of the housing 101 and 102 arranged as a ratchet-acting dam 110. This can be especially seen from fig.20, from which the return slots 105 for counter pieces 104 are also visible.

In addition, in Fig. 20 with a horizontal cross-section of that view along the line of intersection E-E from Fig. 19, the inclined surfaces 103 are partially cut and thus visible each time as a segment.

The dam 110 includes in its own way a closing wheel 111 with teeth like a saw 112 on part of the housing 101 and a piece of rock 108 and participates with counter teeth 113 or groups of such counter teeth 113, which are provided on the other part, each time in the circumferential direction moved against each other the housing or body 102 is made on the inner side of the outer formwork 114, which according to Fig. 20 does not have a circular contour, but opposite the circular shape of the closing wheel 111, each time it leaves the spaces 115 in the corners empty, so that the designated group of counter teeth can be shifted to another in the mentioned manner against the other, so that the oscillation of the closed circle 111 already code. less than one tooth division leads to blocking of rotation in the opposite direction. The mentioned corner spaces 115 will be processed later in connection with the air supply.

20 and 19, it can be seen that the shutter wheel 111 is basically a part of the formwork 108 of the housing part 101, which has saw-like teeth 112 on the short axial area, which protrude outward and engage the counter teeth 113 of the outer formwork 114 , which has a longer axial length, in order to take into account the axial relative motion between the part of the housing 101 and the body 102 of the device. In this case, the teeth 112, the gap between the teeth and the counter teeth are stretched straight in the axial direction, in order to enable and at the same time guide the indicated axial relative motion, into which it is necessary to transform the rotary motion.

The body of the device 102 or the part of the housing that also includes the dosing plug has a partially double paneling in areas, which the internal paneling 109 carries with the inclined surfaces 103 on the second part of the housing 101 cooperating radially with the outwardly protruding counterpieces 104, while the external paneling 114 surrounds the inclined surfaces from the outside 103 encompassing a piece of rock 108 of the second part of the housing 101 and contains counter teeth 113 for the closing wheel 111. This wheel is arranged on the outside of the part of the housing 101, i.e. the formwork 108, and contains a storage chamber 4. This is shown in Fig. 14, 19, 22 and 29 recognizable compact construction methods and the connection of the part of the housing 101 with the body of the device 102, although these two parts can be turned not only in the axial direction, but also against each other and in the direction of rotation.

In order for the above-mentioned rotating motion to be carried out without interference, the inner casing 109 of the part of the housing 102, which also contains the dosing needle, and the inclined guides 103, which are in the rock 108, the part of the housing 101 that includes the supply chamber 4, all of this is in cross-section constructed circular, while however the outer walls 114 of the first part of the housing 102 - as already mentioned - deviate at least partially in certain parts from this circular shape, so that corner spaces or corner areas 115 are created. Especially when rotating and/or axis after extracting the housing parts 101 and 102, according to Fig. 21, in which some parts of the VG are drawn in a rotated manner, the sucked air according to the arrows Pf1 and Pf2 in Fig. 21 can be sucked through the then open corner areas 115 and through the tunnels 116 near the floor 117 of the body 102 device as well as the bar through the non-return valve 118 - coatings 15 two non-return valves 118 - lead to the air channels 6a, 6b and 6c and the dosing plug 5.

At the same time, it is possible that the front side of the outer casing 114 of the body of the device 102, which includes the dosing needle, in a compressed position and with a matching contour rests on the support surface 119 of the second part of the housing 101 and in this position the airway is closed, the inside of the inhaler and again tightly closed for air. Closing the air towards the air channels 6a, 6b and 6c and the dosing area means that it no longer shuts off depending on the return force of the non-return valve or the non-return valve R, but in the compressed position the airway is additionally tightly closed.

The invention allows the conversion of the rotary motion into an axial motion in addition to the control and display of already performed dosing, instead of using the counter 7. In the embodiments according to Fig. 14 to 30, one of the housing parts has a rotating indicating ring 121 relative to the indicating window 120. , which with the relative rotation of both parts of the housing 101 and 102 towards each other during dosing is moved forward each time by a small amount of an angle of equal size and - since the dosed rotating motion is always performed in the same direction - in the same direction. The exact design and layout of such an indicating device is shown in fig. 22 to 28.

From these pictures it can be seen that the indicating ring 121 is constructed as a gear, which is eccentrically seated with respect to the hollow gear 122 with internal toothing and that is seated in the part of the housing or body of the device 102, which also carries the dosing needle and with its external the toothing fits into the inner toothing of that hollow wheel 122, as it is otherwise rigidly connected to the mentioned part of the housing 102. The number of teeth of that inner gear, which serves as an indicator ring 121, deviates so slightly from the number of teeth of the hollow wheel 122, which means it is less only for a small number, that the gear on the internal toothing opposite the hollow gear 122 is rotatable for approx. only one revolution or part of a revolution, and that when a predetermined number of e.g. 100 to 200 dosages has been performed. In Fig. 23 to 28 it is clarified that the outer layers of the display ring 121 are always visible from the outside on the display window 120, especially if the display window is translucent or transparent, the display ring is painted with the appropriate color. In this case, the color can be changed around the circumference of the indicating ring 121, in order to emphasize the progress of the dosing from. progress of emptying the storage chamber 4.

The type of indicating with repeated turning of the body of the device 102 against the part of the housing 101 for a quarter turn and further movement of the indicating ring 121 is explained in fig. 24 to 28 with the fact that one of the teeth of the indicating ring 121 is marked. At the same time, it is also shown in these pictures that by showing the ring 121 and thus the dosing motion can be blocked after reaching a certain number of dosings.

While in picture no. 24 shows the inhaler in a condition where delivery can start, and the marked tooth is on one side of the indicating window 120, Fig. 25 shows the first dosing, in which the body of the device 102, which has the indicating window 120, is turned by 90° . The display ring also turned accordingly using the serrations. Then follows the axial return movement and the next dosing, where Fig. 26 shows the position after, for example, the fourth dosing. The highlighted tooth has now passed the approximate width of the display window 120.

At the same time, the previously mentioned preparatory blocking of the dosing movement after the predicted number of dosings, in this example, for example, 200 dosings, is important.

This blocking is done as follows by means of the indicating ring 121 in the following way: The gear, which serves as the indicating ring 121, includes on its inner side facing away from the teeth a support 123, which with the counter support 124 of the rotating part of the housing 101 relative to it cooperates in such a sense that both backrests 123 and 124 in the output position according to fig. 24 are close to each other or even touch each other, with the dosing movement according to fig. 25 to 27 they are slowly movable in the circumferential direction first one behind the other, and then again next to each other, where with a simultaneous axial transformation these supports 123 and 124 each time reach each other in height against the other shifted plane, and with the return motion they come again so that. lie in matching planes or soon at the same height. At the same time, the eccentricity enables both backrests to not collide with each other even after a relatively large number of dosing, for example 197 (for the last dosing), according to Fig. 27.

Fig. 28 shows that both supports 123 and 124 after approximately one turn of the indicating ring 121 and the last dosing step lie one above the other in both planes, that the closed axial return to the initial position of the inhaler according to Fig. 14 and thus repeated, start the dosing step from that position (blocking takes effect). The rotary movement, which is used for dosing, can be used simultaneously in a preferred way not only to rotate the display ring, but it can have an additional function by means of the rests 123 and 124 and otherwise serves to close the inhaler I after a predetermined number of dosing steps. This prevents the user, with a heavily emptied inhaler I, from performing further dosing steps, but no longer receiving sufficient amounts of solids.

Figures 29 and 30 show examples of the inhaler I according to the invention, in which the mentioned characteristics of contact and measurements are also fulfilled, and in addition, in the supply chamber 4 on the side, which is turned back from the dosing cap 5, it is arranged with a weak spring 125, in the given example with a screw spring loaded take away the contents of the storage chamber 4 piston 126, which follows this change. The force of the spring is so small that it does not compress the hard bodies, and at the same time the spring force is simultaneously so great that it can move the piston 126 against the force of gravity of the hard bodies and its own weight, which of course results in a reduction of the volume of the chamber. In this way, the entire inhaler I can be used in practically any position, i.e. the user can also use it in a lying position, without having to take a difficult position. Despite this, it is always ensured that each dosing movement leads to the fact that an appropriate amount of solids can be inhaled through the dosing notch 50.

At the same time, it becomes clear with these pictures and above all with fig.30, that the supply chamber 4 inside the part of the housing 101 is arranged so that it can be released and replaced and/or it can have a cover 127, which can be released. In this way, after emptying the supply chamber 4, it is not necessary to replace the entire inhaler I, but only the supply chamber, or it can even be refilled. The inclination towards excrement is correspondingly small.

It is further clarified in fig.30 that the storage chamber 4, which is arranged in the part of the housing 101 and can be replaced, has in the initial position before assembly a dam 129, which can be pierced, punched out and/or with predetermined points to break tightly to fasten, the passage channel 400 for the dosing plug, which dam 129 can be automatically pressed and opened with the placement of the supply chamber 4 in its part of the housing 101 with the dosing plug 5. This makes changing the rather empty dosing chamber 4 with the filled dosing chamber 4 very simple, because at the same time as it is pushed into the position for use, it also establishes a connection with the airway, and the dosing plug reaches the first dosing position.

In this case, the opening dam 129 of the supply chamber 4 can be mounted, in the given example, twisted inside the supply chamber 4. So it still remains in connection with the casing of the supply chamber 4, its diameter is in a purposeful way larger than the axial flow of the dosing notch 50, so that it can easily follow the same on the dam 129, which is turned downwards.

As mentioned before, the inhaler according to the invention has several advantages. Safe, fast, reliable and complete filling of the dosing notch is ensured so that the dosed amount of solids is well constant, and thus a user who breathes hard can quickly and reliably inhale a certain amount of softening powder. Furthermore, the inhaler is especially suitable for inhaling fine-grained and therefore powders with poor mobility. In addition, the penetration of moisture into the inhaler and thus the formation of lumps is prevented. Furthermore, in the inhaler according to the invention, the powder, as already described, can be stored in a capsule, so that such powders can also be used, the pharmaceutical effect of which decreases (see, for example, the construction according to Fig. 30) with permanent contact with air ( immediate storage in the stock chamber). The inhaler can be easily disassembled, cleaned, easily supplied, and it is not designed as a single-use inhaler. It is especially useful for inhaling antiasthmatic effective substances and mixtures of substances and especially for the mixture of substances from formoterol and lactose. Easy serving is maintained in increased mass. when the axial dosing movement is caused by partial rotation of both parts of the housing 101 and 102 against each other, because such a rotation is significantly safer for the user, as a relatively short, purely axial rotation loaded with frictional forces.

Inhaler I for introducing a dosed amount of solids, eg pharmaceutical effective powders, into the air stream. sucked in by the user, it comprises a supply chamber 4 into which the dosing plug 5 protrudes. The dosing plug 5 is equipped with a dosing notch 50, which determines the amount of solids, which are mixed with the air flow. The supply chamber 4 and the dosing plug 5 can be moved relative to each other in such a way that in the first relative position of the dosing plug 5 and the dosing chamber 4, the dosing notch 50 of the dosing plug is located in the supply chamber 4, where it is filled with hard bodies, in the other relative position is in the air channel, where hard bodies are mixed into the air stream.

Axial relative motion can be caused by rotating both parts of the housing 101, 102 over the inclined surfaces 103.

Claims (31)

1. An inhaler for introducing a dosage amount of solids, especially pharmaceutical effective solids or mixtures of substances, preferably in the form of powder, into the air flow sucked in by the user, which after the introduction of the solids reaches the user's airways as a mixture of solids - air, with with the air inlet (3) for the intake air, with the air channel (6), which connects the air inlet (3) with the outlet (10), i.e. the whistle, with the supply chamber (4) for hard objects and with the dosing plug (5), which of the dosing notch (50) provided on it determines and introduces into the air stream the amount of solids, it is significant in that the dosing plug (5) protrudes through the opening (400) of the supply chamber (4) and that the supply chamber (4) and the dosing cap (5) side by side in the direction of the longitudinal axis of the dosing cap (S) so flexible that the dosing notch (50) of the dosing cap (5) is in the first relative position in the supply chamber (4) and in the second relative position in the air duct. 2. An inhaler according to claim 1, significant in that the dosing plug (5) is arranged locally hard with respect to the body of the device and that the supply chamber (4) is designed flexibly against the dosing plug (5). 3. An inhaler according to claim 2, characterized in that it comprises a separate supply member (2) for the movement of the supply chamber (4), which is designed to move the supply chamber (4) against the force of the return spring (43) in the first relative position to the dosing plug (5) and that the wall of the storage chamber (4) is equipped with an extension (41), which in this first relative position closes the air channel, and that the extension of the wall has an opening (410) which, after the return of the chamber for stock (4) to another relative position, release the air channel again, 4. An inhaler according to claim 3, significant in that the supply organ (2) is equipped with a cherry element (20), which after reaching the first relative position of the dosing cap (5) and the supply chamber (4) shakes the supply chamber ( 4). 5. Inhaler according to claim 4, characterized in that the shaking element is designed as a shock spring (20). 6. An inhaler according to one of the claims 1 to 5, significant in that it is equipped with an arresting device (21,210,211,212) that the supply chamber (4) of. the dosing plug (5) holds tightly to each other in the first relative position and that a pushing element (211) is provided to release the locking. 7. An inhaler according to one of claims 1 to 6, significant in that it includes a special suction extension (1) in which the cross-section of the air channel increases in the direction towards the outlet (10). 8. The inhaler according to claim 7, significant in that it includes a separate closing cap (11) that can be put on the suction nozzle (1). 9. An inhaler according to claim 8, significant in that a drying agent (12) is provided in the closing cap (11). 10. An inhaler according to one of claims 1 to 9, significant in that a non-return valve is provided at the air inlet (3). 11. Inhaler according to one of claims 1 to 10, significant in that it is equipped with a counter (7) which can be returned to the initial position and which, upon reaching the first relative position of the supply chamber (4) and the dosing cap (5). grows. 12. An inhaler according to one of claims 1 to 11, characterized in that the hard bodies are an antiasthmatically effective substance or an antiasthmatically effective mixture of substances. 13. Inhaler according to claim 12, significant in that it is an antiasthmatic effective substance of. antiasthmatic effective mixture of substances, a mixture of formoterol and lactose. 14. An inhaler in particular according to one of the preceding claims, significant in that the part of the housing (101) that includes the supply chamber (4) and the body of the device (102), which carries the dosage plug (5) from the first set of depressed position moved towards each other, one pulled out from the other, in that they are rotatable relatively towards each other, at least one inclined surface (103) on the body of the device (102) and/or part of the housing (101) and on it guided counter pieces (104) and convert circular motion into axial motion. 15. The inhaler according to claim 14, significant in that the part of the housing or the body of the device (102) can include on its circumference a number of evenly spaced inclined surfaces (103) of equal slope and length, relatively rotating bodies or dividing the corresponding number cooperating with them protrusion or counter-compartment (104). 16. An inhaler according to claim 14 or 15, significant in that each time four inclined surfaces are provided, extending over approximately 90°, lying at the same height and rising in the same direction, which cooperate with counter-pieces (104) constructed as protrusions, and that at the end of the inclined surfaces (103) vertically oriented passages, grooves (105) or the like are provided on the counter pieces (104), so that the part of the housing (101) with the storage chamber (4) and the counter pieces (104) are after turning and the longitudinal sliding of the counter parts (104) on the inclined surfaces (103) with the resulting axial conversion of the dosing plug (5), which can be converted in the axial direction and moved back to the output position. 17. An inhaler according to one of claims 14 to 15, significant in that at least one projection in the form of fingers (105a) is provided in the axis of the return guide grooves (105) over which the counter pieces (104) can be moved to the side, that during of the axial return guide grooves (105) further arranged at least one projection, designed like a saw tooth, which protrudes (106) and which steeply falling side is arranged coincident with the effective inclined surface (103) for the counter pieces (104), the counter piece (104) is on the other hand, the rising inclined side (107) and protrusions (106) can be turned in the axial direction and in the initial position of the next dosing movement it is arranged behind the steeply falling side. 18. An inhaler according to one of claims 14 to 17, characterized by the fact that the inclined surfaces (103) are preferably constructed as grooves and correspond to parts of the thread pitch, and are arranged especially on the inner side of the rock part (108) of the housing part (101), 19. Inhaler according to one of the claims 14 to 18, significant in that a dam (110), ratchet or similar is arranged at the contact points between the relative rotating parts of the housing (101,102), which blocks the counterproductive rotation of the housing parts against the dosing movement . 20. An inhaler according to one of claims 14 to 19, characterized in that the dam (110) includes a stop wheel (111) with. teeth as in a saw (112) on the first part of the housing (101) and each time in the circumferential direction the other counter teeth (113) or groups of counter teeth (113) are moved against the other on the second part of the housing (102) or the body of the device, where the displacement is each time of the provided counter teeth (113) in the circumferential direction one against the other is chosen in such a way that the ratcheting step from the dam is smaller than the division of the teeth, 21. Inhaler according to claims 19 and 20, significant in that the teeth (112), the clearance between the teeth and the counter teeth (113) stretch straight in the axial direction. 22. An inhaler according to one of the claims 14 to 21, significant in that it has a body of the device (102), which also includes a dosing cap (5), or a part of the housing partially double-walled, which the inner wall (109) carries with inclined surfaces (103) ) on the second part of the housing (101) cooperating counter pieces (104) that protrude radially outwards from that inner formwork, and that the outer formwork (114) outside includes the inclined surfaces (103) encompassing part of the rock (108) of the second part of the housing (101), and includes counter teeth (113) for the shutter wheel (111) arranged on the outside of the housing part (101), which also includes the storage chamber (4). 23. An inhaler according to one of claims 14 to 22, significant in that the inner paneling (109) of the part of the housing (102), which also includes the dosing needle (5), and the guide surfaces (103) are the wall (108) and the chamber for the stock (4) comprising the part of the housing (101) is circular and that the outer paneling (114) of the first part of the housing (102) has a cross-section deviating at least in segments from that circular shape, so that angular areas (115) are created between the panels and that is especially in the case of rotated and/or axially pulled out parts of the housing (101, 102), the air is sucked in through those then open corner areas (115), with tunnels (116) near the floor (117) of the body of the device (1C2) as well as at least with with one non-return cap guided to the dosing channels (6a, 6b and 6c) and the dosing plug (5). 24. An inhaler according to one of the claims 14 to 23, significant in that the front side of the outer casing (114) of the body (102) enclosing the dosing needle in a compressed position with a correspondingly rotating contour rests against the support surface (119) of the second part of the housing (101) and in this position, the air path is cut off, and the inside of the inhaler is sealed off. 25. An inhaler according to one of claims 14 to 24, characterized in that the first of the housing parts has a rotatable display ring (121) relative to the display window (120), which with the relative rotation of both housing parts of the second one against the other during dosing each times moved forward by a small angle value of equal size and same direction. 26. An inhaler according to one of the claims from 14 to 25, characterized in that the indicating ring (121) is designed as a gear which is eccentric with respect to the hollow gear (122) or inserted into the dosing needle (5) by means of internal toothing in the housing part. (102) and with its external toothing lies in the internal toothing of that hollow wheel (122), where the number of teeth of that internal gear is so slightly different from the number of teeth of the hollow wheel, that the internal gear can be turned against the hollow gear by only about one turnover or part thereof, when a certain number of e.g. 100 to 200 dosings have been performed. 27. The inhaler according to claims 25 and 26, significant in that the indicating ring (121) and thus the dosing movement can be blocked after reaching the intended number of dosing. 28. An inhaler according to one of the claims from 14 to 27, significant in that the gear that serves as an indicating ring (121) includes a screen (123), which in terms of cooperation with the counter screen (124) of the rotating part of the housing relative to it ( 101), that the screens in the output position are close to each other or touch each other and with the dosing motion they are slightly movable each in the circumferential direction, whereupon they come with simultaneous axial transformation of these two screens (123,124) into abutment each time against each other by to the shifted plane, with a return motion, they reach the matching plane again, and that the screens (123,124) after approximately one revolution of the indicating ring (121) and after the last dosing step in both planes are placed on top of each other, that the axial return conversion in exit position and thus the re-dosing step blocked. 29. An inhaler according to one of the claims from 1 to 28, significant in that, in the supply chamber (4) on the side opposite the dosing plug (5), arranged with a weak spring (125) loaded, the piston (126) which otherwise follows the reduction of the amount, or similar in which the spring force is so small that the compression of hard bodies is prevented, in this case the spring force is nevertheless so great that it pushes the piston (126) against the force of the heavier hard bodies and against its own weight , which follows the reduction of the chamber volume. 30. An inhaler according to one of claims 1 to 29, characterized in that the supply chamber (4) within the housing part (101) is arranged so that it can be released and replaced and/or has a cover (127) that can also be rid. 31. An inhaler according to one of the claims from 1 to 30, significant in that it has a replaceable supply chamber (4) arranged in the housing part (101) and a barrier (129) that can be broken in the exit position before assembly , punch out and/or hard-fasten the passage channel (400) for the dosing plug (5) with predetermined breaking points. That fence (129) is with the insertion of the supply chamber (4) in its part of the housing (101) with the dosing plug (5) can be pressed and opened automatically.