SI8810781A - Plaster with an active substance for a controlled application of the active substance to the skin. - Google Patents

Abstract

A plaster containing active ingredients for controlled administration of active ingredients to the skin and possessing a rear side and a skin side, has a rear layer, an active ingredient reservoir containing one or more active ingredients arranged essentially perpendicular to the surface of the plaster in contact with the skin, and an adhesive device on the skin side and possibly a covering layer which is detached before application of the plaster. At least one active ingredient reservoir part (12) can be detached on to the skin while one or more active ingredient reservoir parts remain. For this purpose, the part (13) of the active ingredient reservoir remaining on the skin adheres more strongly to the skin than to the rear side (11).

Description

The invention relates to one patch containing some active substance for the controlled application of the active substance to the basket, which has a back and side facing the skin, with one carrier layer, one reservoir of active substance divided into parts directly on the surface to contact the skin of the patch itself. containing one or more active substances, one layer of contact adhesive on the side facing the skin and, optionally, a removable cover layer prior to plaster placement, which may reduce the size of the plaster active substance release surface by a predetermined value, by removing parts of the active substance reservoir, as well as the application thereof, and the code also refers to the process for the controlled application of the active substance to the skin.

More specifically, the invention relates to those patches used as therapeutic systems acting through the skin for the controlled application of a medically active substance, or a cosmetically active substance, on human or animal skin. A therapeutic system is an agent containing a drug or active substance, or a form of application thereof, which discharges one or more active substances in a continuous manner, at a predetermined rate and amount, and at a predetermined time interval, at one predetermined application point. These systems are therapeutically accurate instruments, the construction of which requires extraordinary measures to ensure the continuous release of the active substance.

Therapeutic systems in the form of patches have already been developed for a variety of purposes, so that in addition to local action, systemic action can also be achieved. The large number of active substances that can be administered in this way, and their different chemical, physical pharmacological characteristics make it impossible to cover all therapeutic problems with a single system.

Numerous therapeutic systems for the application of medicinally active substances on the skin are known, for example, given in the book by Klaus Heilmann's Therapeutische Systeme, Ferdinand Enke Verlag, Suttgart, 1977. Known systems have not been able to achieve a completely satisfactory effect in all cases.

In the conventional structure of a therapeutic system in the form of a patch acting through the skin, one reservoir of active substance, containing the active substance in solid, liquid or dissolved form and one adhesive layer sensitive to pressure (contact adhesive), by means of which the system firmly binds to the skin, is respected. . It is important to ensure that there is contact throughout the area between the release surface of the active substance and the skin throughout the application of the system, in order to provide kinetics of release of the active substance. This can be achieved not only through a single continuous adhesive layer, but also by limited adhesive areas in the patch layer in contact with the skin.

Although patch therapeutic therapeutic systems known so far allow uniform or continuous reduction of active substance release over a predetermined time, they do not allow specific kinetics of active substance release, such as planned reduction of active substance release over a predetermined time, or gradual release of active substance in determines the quantities in unit of time.

This measure is, for example, unnecessary if the dose of the active substance is to be reduced in some planned manner during the period of administration for therapeutic reasons. The same problem arises if, during the administration of a combination product, one of the active substances must be discontinued after a predetermined time. In such cases, it is possible, in principle, to solve the problem by using two patches for action through the skin, one of which is removed at some point. This, however, creates problems for patients, especially if they are old. Therefore, it is easy to forget to apply another patch. For a combination of two patches with discharge surfaces of different active substances, there is a risk of choosing the wrong combination (two identical patches), or of removing the wrong patch. The same complication occurs if patches with different active substances have to be combined, so in this case the problem of double storage also arises. According to Torn, the application of two patches leads to numerous disadvantages and their avoidance is the object of the invention.

The proposal to combine two patches, one part of which can be separated by a predetermined tear line, certainly improves adaptation to requirements, but leads to handling problems. In this way, the detachable part can only be handled in a way that is detached from the skin and in an unsatisfactory way, with at least part of the patch still remaining on the skin and having to be firmly held during separation. This is done by pressing a sensitive system for action through the skin, which can adversely affect the rate of release of the active substance.

U.S. Patent 4,297,995 discloses a single manipulable active patch in which the active substance reservoir is divided into multiple portions but integrated into a single patch. The parts of the reservoir with the active substance are arranged in the form of concentric circles around one central part in the form of a disk, or a round plate. The entire construction of the patch with the mechanical attachment of the reservoir to the support layer, allows only to change the discharge surface of the active substance before applying the patch, ie. Before placing the patch, the doctor / patient can choose which dose to administer, but to release the active substance during the patch application, the patch must be removed from the skin, interrupting therapy, which can also lead to damage and contamination. the supporting surfaces of the patch. So far not found satisfactory

- 4 cuts for the interconnected problems of reinstallation and permanent re-attachment of the system to the skin.

It is therefore a problem of the present invention to provide an improved therapeutic system for action through the skin, which will allow for a more complex change in the release of the active substance than has been possible so far.

This problem is solved by a single patch of the foregoing type, characterized in that it is possible to separate at least one part of the reservoir of active substance while leaving one or more portions of that reservoir on the skin while leaving part of the reservoir of active substance on the skin has better adhesion to the skin than to the worn layer.

Due to the fact that, according to the invention, the active substance reservoir is partially detachable, while the non-detachable active part of the reservoir has a better adhesion to the skin than to the carrier layer, after removing a predetermined portion of the patch with the part of the active substance reservoir adhered to it. the skin remains a predetermined part of the reservoir of active substance, which, for example, can be removed after the desired application period. It is convenient for the reservoir of the active mother to be in two parts.

In the case of given therapies with variable administration of the active substance, or with significant variations in the concentration of the active substance, it may also be appropriate for the reservoir of the active substance to be three-parted. The active substance discharge surfaces of the active substance reservoir portions may be geometrically identical or different. The active substance discharge surfaces may be arranged side by side, or one part of the active substance reservoir may completely comprise one or more other parts of the active substance reservoir, viewed as a flat or surface system. The division into partial areas depends on the therapeutic requirements. Thus, for example, one part of the active substance reservoir may circularly comprise one or more other parts of the active substance reservoir.

The ratio of the size of the discharge surfaces of one part of the active substance reservoir to the other is found, preferably in the range between 1: 1 and 1:10. The same active substance, or the same combination of active substance, may be present in all parts of the active substance reservoir.

- 5: - Particularly suitable products are patches with the following active substances, although it is also possible to treat arbitrary active agents acting through the basket in combinations known to those skilled in the art: asthma / bronchodilators such as clenbuterol, procraterol and salbutamol and vasodilators such as, for example, benzyclan and cinarizine.

Thus, with the aid of the patch according to the invention, in many cases it is possible to reduce the applied dose to the intended and regulated batch during administration.

However, parts of the active substance reservoir may also contain different active substances, or combinations of active substances, so that it is possible to discontinue or stop the administration of one active substance or combination of active substances during administration. Primers of various active substances in parts of the reservoir of active substances with: estrogen / gestagen (contraceptives), dexamethasone / prednisolone (in cases of inflammation, rheumatic stains of muscles and joints), nitroglycerin / blockers (for heart diseases), phenytoin / phenobarbital (for heart diseases) epilepsy) and amitriptyline / chlordiazepoxide (psychopharma product).

All suitable active substances belong to groups that have either local or systemic action. In at least one part of the active substance reservoir there may be different active substances / combinations of active substances in comparison with other part, or parts, of the active substance reservoir.

The preferred application of the patch according to the invention is the local and systemic administration of the active substance through the skin in human or animal medicine or cosmetics.

The invention is described in more detail in the following text by way of one non-limiting embodiment, with reference to the accompanying out-of-scale drawings, and where:

Figure 1 shows a cross-section of the first embodiment of the patch according to the invention with a two-part reservoir of active substance.

Figure 2 shows a horizontal projection of the side facing the skin of the second embodiment of the patch according to the invention with the protective layer removed.

Figure 3 shows a cross-section along line I-I of Figure 2.

Figure 4 shows a horizontal projection of the side facing the skin of the third embodiment of the invention, without a protective layer.

Figure 5 shows, in an introduced scale, a cross-section along the line II-II of the embodiment of Figure 4.

Figure 6 shows a horizontal projection of the side of the lazy skin of the fourth embodiment of the invention, without a protective layer.

Figure 7 shows a cross-section of the embodiment of Figure 6 along line III.

Figure 8 shows a cross-section of a fifth embodiment of the invention.

Figure 9 shows a cross-section of a sixth embodiment of the invention.

Figure 10 shows the side facing the skin of another embodiment of the patch according to the invention, with a three-part reservoir of active substance and no protective layer.

Figure 11 shows, in an introduced scale, a cross-section along line IV-IV of Figure 10.

A preferred embodiment of the invention shown in the individual drawings will be described. The part of the active mass reservoir that last remains on the skin is called the first ded of the reservoir ?. active substances, while the second and third parts of the active substance reservoir are those which separate from the carrier layer.

Figure 1 shows one preferred embodiment, one optionally circular or angular patch with a two-part reservoir of active substance with contact adhesive, in cross-section. The second part 12 of the reservoir of active substance directly adheres to the carrier layer 11 and is separated from the first part 13 of the reservoir of active substance by a adhesive layer 14 which can also be formed as a gap or space, a cavity between the parts of the reservoir of active substance, or can be filled some inert separation material. Part 13 of the reservoir of active substance adherence to the carrier layer 11 by means of a detachable layer 15, which leads to the gradual adherence of two parts 12, 13 of the reservoir of active substance to the carrier layer. The detachable layer 15 may be, for example, some polymer, or metal layer or foil, some fabric or their laminate, and after removing the carrier layer 11, with the second part 12 of the active substance reservoir forms a protective layer for the first part 13 of the active substance reservoir remained on the skin to protect it. The adhesion of the first part 13 of the active substance reservoir for skin must be greater than the adhesion between the detachable layer 15 and the carrier layer 11. The protective layer 16 is removed before applying the patch. Using the same point marking system representing the parts 12, 13 of the active substance reservoir in Figure 1, it is clear that in both parts 12, 13 of the active substance reservoir the same active substance or combination of active substances is obtained, so that the patch of Figure 1 can be derived a gradual decrease in the release of the active substance into the skin.

Figure 2 shows a horizontal projection of the side facing the skin of another angular patch according to the invention, with a two-part reservoir of active substance with a layer of non-contact adhesive from which the protective layer has already been removed. Thus, on the side to the skin, the patch has layers 21, 22 of contact adhesive, which are separated from one another by a separation layer 23, which again may be a simple gap or some inert material.

Figure 3 shows a cross-sectional view through the embodiment shown in Figure 2, and along line II in Figure 2. The non-sticky parts 24, 25 of the active substance reservoir are attached from the rear sides by contact adhesive layer 27 to the support layer 28, wherein the first part 24 of the active substance reservoir it adheres to the support layer by means of a detachable layer 26 placed between the first contact adhesive layer 27 and the first part 24 of the active substance reservoir. The detachable layer 26 is designed such that its adhesion to the first portion 24 of the active substance reservoir is greater than its adhesion to the contact adhesive layer 27. Thus, when removing the carrier layer 28 and the second part 25 of the active substance reservoir attached to the adhesive layer 27 of the contact adhesive for the carrier layer 28, the detachable layer 26 with the first part 24 of the active substance reservoir remains on the skin and assumes the protective function for said remaining part 24. a layer that protects the reservoir material from contamination and damage from the environment, or against the eruption, for example, of volatile active ingredient constituents.

The adhesive layers 21, 22 on the side to the skin of the non-adhesive parts 24, 25 of the active substance reservoir are adjusted such that the adhesion of the adhesive layer 22 is

- 8 of the first part 24 of the reservoir of active substance on the skin leads to adhesion between the detachable layer 26 and the contact adhesive layer 27. The different surfaces shown in the drawing should indicate that there are different active substances or combinations of active substances in both parts 24, 25 of the active substance reservoir.

Figure 4 shows another preferred embodiment of the patch according to the invention in horizontal projection so that its side facing the skin is seen. The oval patch has a two-part active agent reservoir and a contact adhesive layer 41 that secures the active substance reservoir parts 42, 43 to the support layer 45, which also secures the therapeutic system to the skin.

Figure 5 is an enlarged cross-sectional view along line II-II of Figure 4. Parts 42, 43 of the reservoir of active substance with contact adhesive, which are separated from one another by an inert barrier layer 46 of the tank, in this case as one slits, are covered by a carrier layer 45, in the form of a bag, on which is a layer 41 of contact adhesive. Here again, the partition layer 46 ensures that the adhesion of the active substance reservoir portion 42 is greater than the adhesion between the detachable layer 44 and the contact adhesive layer 41, and also ensures that the first active substance reservoir portion 42 remains on the skin after the second reservoir portion 43 is separated. of the active substance and the carrier layer 45, is protected by a single layer. The two portions 42, 43 of the reservoir of active substance contain different active substances, or combinations of active substances, as is evident from the arrangement of the surfaces.

Figure 6 shows another patch according to the invention with a two-part reservoir of active substance, in which one part 61 of the reservoir of active substance concentrically surrounds the other part 63 of the reservoir of active substance, with the view from the side of the skin, with the protective layer removed. The first circular reservoir 63 of the active substance with contact adhesive is separated from the second circular reservoir 61 of the active substance by a single inert barrier layer 62 of the reservoir, which may also be in the form of a single gap. This embodiment has the advantage that by reducing the release surface of the active substance by removing a portion of the patch with the other portion 61 of the active substance reservoir and together with the carrier layer 65, the direction of removal of the patch is freely available.

Figure 7 shows a section through an embodiment of Figure 6, along line III-III. The circular second portion 61 of the active substance reservoir is positioned adjacent to the carrier layer 65, while the detachable layer 64 is positioned between the circular first portion 63 of the active substance and the carrier layer 65. The adhesion of the first portion of the active substance reservoir to the skin and between the detachable layer and the carrier layer 65 , is greater than the adhesion between detachable layer 64 and part 63 of the active substance reservoir, so that when separating the carrier layer 65, the second part 61 of the active substance reservoir is separated, while on the skin, the first part 63 of the active substance reservoir remains covered by the detachable layer 64. Inert barrier layer 62 tanks separate the parts 61, 63 of the active substance reservoir. In this embodiment, the active substance is the same in both parts 61, 63 of the active agent reservoir.

Figure 8 shows another preferred embodiment of the invention in cross section, in which two parts of the non-sticky active agent reservoir are again made as a circular disk 82 around which a circular ring 81 is separated from each other by an inert barrier layer 83 of the reservoir. The carrier layer 88 is covered with a layer 87 of contact adhesive, which is directly in contact with the other part 81 of the active substance reservoir.

Between the contact adhesive layer 87 and the first part 82 of the active substance reservoir, an inert detachable layer 86 is constructed, so constructed that its adhesion to the contact adhesive layer 87 is less than that between the contact adhesive layer 85 and the skin. Other adhesion values at the boundary layers of this part of the patch must, of course, be higher than the skin adhesion values. Layers 84, 85 of the contact adhesive on the skin side of parts 81, 82 of the active substance reservoir provide contact with the skin, and prior to application of the patch according to the invention, it is advantageous for these layers to be covered with a protective layer 89.

In this embodiment, the parts 81, 82 of the active substance reservoir have different active substances, or combinations of active substances.

Figure 9 shows a cross-section of another embodiment, wherein the support layer 95 comprises a concentric stack of parts 91, 92 of the active substance reservoir with contact adhesive on the side facing the skin. To attach the entire patch and parts of the active substance reservoir to the skin, the entire surface of the carrier layer 95 is covered with a layer 93 of contact adhesive. For this immediate adherence, the second part 91 of the active substance reservoir, while the first part 92 of the active substance reservoir is attached via the detachable layer 94. The adhesion of the detachable layer 94 to the part 92 of the active substance reservoir is greater, and the adhesion of the layer 94 to the contact adhesive layer 93 is less from adhesion between the first portion 92 of the active substance and skin reservoir. This allows selective separation of the carrier layer 95 together with the other part 91 of the reservoir of active substance. By appropriately altering the structure, it is also possible to perform the selective separation of the first part 92 of the active substance reservoir. The reference numeral 96 indicates the inert barrier layer of the reservoir or the gap between the parts 91, 92 of the active substance reservoir. By application, the entire syllable is covered by detachable layer 97. In this embodiment, different active substances, or combinations of active substances, are found in parts 91, 92 of the reservoir.

One preferred embodiment of the invention with a three-part reservoir of active substance is shown in Figure 10.

The figure shows a horizontal projection of the side facing the patch skin according to the invention without a protective layer. The first circular portion 105 of the active substance reservoir with contact adhesive is surrounded by a second circular portion 103 of the active substance reservoir with contact adhesive, and are separated from each other by an inert barrier layer 104 of the reservoir. The third part 101 of the active substance reservoir with contact adhesive surrounds the second part 103 of the active substance reservoir in the form of a concentric ring. Between the second and third portions 101, 103, a second inert barrier layer 102 is installed. Figure 11 shows, in magnified scale, a cross-section along line IV-IV.

Part 101 of the active substance reservoir adheres directly to the carrier layer 108. The first detachable layer 106 mounted on the carrier layer 108 covers parts 103, 105 of the reservoir of active substance 11.11. Their adhesion to the carrier layer 108 is less than the adhesion of the active substance reservoir parts 103, 105, so that the active substance reservoir parts 103, 105 remain on the skin after removal of the carrier layer 108 with the active agent reservoir portion 101. In this way, the first detachable layer 106 forms a protective, new layer for the remainder of the patch. Part 103 of the reservoir of active substance with contact adhesive adheres directly to the first detachable layer 106, and can be removed with it at some subsequent removal stage, leaving the skin of the first portion 105 of the active substance, which is made possible by the second detachable layer 107 between the first part 105 of the active substance reservoir and the first detachable layer 106. The adhesion of the second detachable layer 107 to the first layer 106 is less than the adhesion of the first part 105 of the active substance reservoir to the skin. Inert bulkheads 102, 104 of the reservoir, which may also be formed in the form of a gap, are arranged between the parts 101, 103 or 103, 105 of the active substance reservoir. The selected example shows that parts 103, 105 of the active substance reservoirs contain the same active substance or combination of active substances, as indicated by the identical screwing in Figure 11, while part 101 of the active substance reservoirs has a different active substance, or combination of active substances.

The drawings, which only show the invention in the form of one example, are not intended to limit the invention, either in terms of geometric shape, linking of specific individual components, or in view of the size of the active substance release surface. As is known to those skilled in the art, all of these sizes can be adapted to the therapeutic requirements and rational production must certainly be considered. The portion of the active substance reservoir to be separated may also have a detachable layer, which then has a stronger adhesion to the carrier layer than the detachable layer of the portion of the reservoir that remains on the skin.

This construction has advantages if the parts of the active substance tank are the same thickness. Contact adhesive layers, especially those on the side facing the skin, may have areas without contact adhesive for improved conductivity of the active substance, or may be constructed solely as single contact adhesive surfaces, for example, may be incorporated into the material of the active substance reservoir. The release of the active substance from the parts of the active substance reservoir may, if desired, be regulated by control membranes which are incorporated, in a known manner, into the mass of the reservoirs in one or more parts of the active substance reservoir, or may be placed between the active substance reservoir and the contact adhesive layer at side facing the skin, or inside the layer of contact glue facing the skin.

For the construction of the active substance reservoir, and according to the present invention, standard measures and materials may be used. The base materials may consist of natural and / or synthetic substances, of low or high molecular weight, the choice of which is a function of the characteristics of the active substance being applied and the therapeutic requirements. In addition to the basic materials, the reservoir of the active substance may contain other suitable additives known or apparent to the person skilled in the art, such as, for example, solvents, softeners, plasticizers, adhesive reagents, stabilizers, fillers and enhancers. The composition in the parts of the tank may be the same or different, which again depends on the active substance being applied and the desired discharge rates or kinetics. In the case of an identical composition of the tank, and only one active substance to be transmitted to the patient, it may be appropriate to have a graded concentration of the active substance in the various parts of the tank. Suitable active ingredients for the patch according to the invention are those that can penetrate the skin by themselves or with pharmaceutical preparations that enhance their action.

The carrier layer that covers the active substance reservoir on the side opposite to the one that contacts the skin may be permeable or impermeable. It must be flexible and, due to the mechanical stabilization of the patch, serves to remove part of the active mass reservoir. If the components of the reservoirs or active substances are volatile, then the support layer must be impermeable to those substances. It can be in the form of single or multiple layers. Suitable materials for its manufacture are, for example, polymeric substances, such as polyethylene, polypropylene, polyesters and polyamides. Other materials may be metallic

- 13 foils, such as aluminum foil, either alone or coated with some polymer substrate. Conductive carrier layers are, for example, textile fabrics such as non-wovens and the like, but also porous polymeric materials. The carrier layer may, for example, have some marking to indicate the optimum direction of removal of the patch. Optionally, detachable layers are placed between the parts of the active substance reservoir instead of a gap or gap. They may be made of the same materials previously mentioned in connection with the barrier layer between the parts of the active substance reservoir and the carrier layer. The protective layer that is removed before use and covers the surfaces of the contact adhesive on the side facing the skin may be made of the same material used to make the carrier layer, provided that it can be made detachable, for example by applying a single silicone layer. Other detachable protective layers are, as is well known to those skilled in the art of plaster, in particular terrains of patch systems such as polytetrafluoroethylene, treated paper, cellophane, polyvinyl chloride, etc. In order to facilitate separation, a protective layer may be provided with separation agents, which are otherwise known. The protective layer may also be larger than the patch, for example if several patches are placed on a single continuous strip of protective layer material.

The layers of contact adhesive used on the patches of the invention may consist of all physically acceptable contact adhesives that are inert to the active substances and other components of the active substance reservoir, and may, for example, be based on rubber, rubber synthetic homopolymers. , copolymers or block polymers, · polyacrylates and their copolymers, polyurethanes and silicones.

The patch according to the invention can be manufactured by all known methods of patch technology. This is shown in the following example of manufacturing a patch with a two-part reservoir of active substance.

- 14 Production example

In the process of application by rollers, a solution or material of a reservoir of active substance is applied to a layer or foil covered with a coating which repels by the application of silicone and which, after drying at 65 ° C, forms a layer of contact glue of 55 g / m and has the following composition:

1. Acrylate copolymer I

2. Acrylate copolymer II

3. POE- (10) -oleyl alcohol.

4. active substance

68.86 parts by weight 10.39 parts by weight 5.20 parts by weight 15.56 parts by weight.

Acrylate copolymer I is Durotac 280-2516 by National Starch & Chemical B.V., The Netherlands. Acrylic Copolymer II is Eudragit E100 by Rohm Pharma, GermanyO; The POE- (10) -oleyl alcohol is Brij 97 from Atlas Chemicals Industries, United Kingdom.

One half of the contact adhesive layer containing the active substance is coated with an unsiliconized polyester film (0.036 mm thick) and on the other half an uniliconized one-sided, siliconized film (0.036 mm thick). Upon removal of the middle cover, the annular parts of the active substance reservoir are cut from the first half and transferred side by side with a contact adhesive to a single, silicone coated, polyester layer (protective layer) to which an aluminum layer is applied. From the other half, disc pieces of the active substance reservoir portion, slightly smaller than the inner diameter of the rings into which they are centered, are cut, with the contact adhesive side facing the protective layer. The open side of the assembly thus obtained is covered with a polyester support layer coated with contact adhesive, 0.015 mm thick (Durotac 280-2516, 30 g / m dry), with the outside facing without adhesive. The distance between the units of the active substance tank is approximately 14 mm, so that the support layer is in contact with the protective layer between the units. The laminate thus obtained is then discharged into the production process, in which circular cuts at a distance of about 7 mm from the outer edge of the rings give completely round, closed and disc-shaped patches, which are individually or in several pieces packed in sealed bags.

Claims (12)

Patent claims An active substance patch for the controlled application of the active substance to the skin, comprising the carrier side and the skin facing side, with the carrier layer, the reservoir of the active substance being 5 vertically processed to the skin-contact surface, comprising one or more active substances, a layer of contact adhesive on the skin side and, if necessary, a cover layer removed before applying the patch, whereby by removing a portion of the reservoir of the active substance may reduce the surface area of release of the active substance of the patch by a predetermined amount, characterized in that at least one portion (12, 25, 43, 61, 81, 10 91, 101, 103) remove the active substance reservoir from the skin, leaving on the skin parts (13, 24, 42, 63, 82, 92) of the reservoir with one or more active substances, and having a portion of the reservoir of active substance which remains on the skin, better adhesion to the skin than the carrier layer (11, 28, 45, 65, 88, 95, 108). 15 The active substance patch layer according to claim 1, characterized in that the reservoir of the active substance is multi-particle. An active substance patch layer according to claim 1, characterized in that the reservoir of the active substance is tripartite. Active substance patch according to one of the preceding claims, characterized in that the discharge surfaces of the active substance tank parts are geometrically identical or different. An active substance patch according to any one of the preceding claims, characterized in that a part 25 (61, 81, 91, 101, 103) of the active substance reservoir completely surrounds one or more other portions (63, 82, 92, 103, 105), either planar or surface. Active substance patch according to claims 4 and 5, characterized in that a portion (61, 81, 91, 101, 103) of the active substance reservoir is annularly surrounded by one or more other parts 30 (63, 82, 92, 103, 105) of the active substance reservoir. Active substance patch according to one or more of Claims 1 to 5, characterized in that the ratio of the size of the discharge surfaces of one part of the active substance reservoir to / Ib over the other lies between about 1: 1 and 1:10. Active substance patch according to one of the preceding claims, characterized in that the same active substance or the same combination of active substances is present in all parts of the tank 5 active substances. Active substance patch according to one of claims 1 and 7, characterized in that at least one of the parts of the active substance reservoir is a different active substance / combination of active substances compared to the other part of the active substance reservoir. Active substance patch according to one of the preceding claims, characterized in that the active substance is acting either locally or systemically. 11. Process for the controlled application of one or more active ingredients to the skin by means of 15 patch according to one of the preceding claims, characterized in that a patch is applied to the skin, comprising, if necessary, several active substances and / or the same active substance in different or equal concentrations in different parts of the reservoir of the active substance which can be separated from each other, and in each case, one or more parts of the patch are removed with one or more parts of the reservoir of the active substance after a predetermined time, 20 remains the remainder of the patch with at least one portion of the reservoir of active substance on the skin and, if necessary, repeats the last phase in a predetermined time sequence. Use of an active substance patch according to one of the preceding claims, for topical and systemic application of the active substance through the skin in human medicine or veterinary medicine, or 25 cosmetics.