SI4401833T1 - Gpr52-modulatorne spojine - Google Patents

Gpr52-modulatorne spojine

Info

Publication number
SI4401833T1
SI4401833T1 SI202230201T SI202230201T SI4401833T1 SI 4401833 T1 SI4401833 T1 SI 4401833T1 SI 202230201 T SI202230201 T SI 202230201T SI 202230201 T SI202230201 T SI 202230201T SI 4401833 T1 SI4401833 T1 SI 4401833T1
Authority
SI
Slovenia
Prior art keywords
gpr52
modulator compounds
modulator
compounds
gpr52 modulator
Prior art date
Application number
SI202230201T
Other languages
English (en)
Slovenian (sl)
Inventor
Stephen Paul Watson
Nigel Alan Swain
Michael Alistair O'brien
Original Assignee
Nxera Pharma Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nxera Pharma Uk Limited filed Critical Nxera Pharma Uk Limited
Publication of SI4401833T1 publication Critical patent/SI4401833T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI202230201T 2021-09-15 2022-09-15 Gpr52-modulatorne spojine SI4401833T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2113186.7A GB202113186D0 (en) 2021-09-15 2021-09-15 GPR52 Modulator compounds
EP22778038.4A EP4401833B1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
PCT/GB2022/052328 WO2023041909A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds

Publications (1)

Publication Number Publication Date
SI4401833T1 true SI4401833T1 (sl) 2026-01-30

Family

ID=78149263

Family Applications (1)

Application Number Title Priority Date Filing Date
SI202230201T SI4401833T1 (sl) 2021-09-15 2022-09-15 Gpr52-modulatorne spojine

Country Status (22)

Country Link
US (1) US20240376070A1 (enExample)
EP (1) EP4401833B1 (enExample)
JP (1) JP2024535860A (enExample)
KR (1) KR20240058852A (enExample)
CN (1) CN117999258A (enExample)
AU (1) AU2022348201A1 (enExample)
CA (1) CA3232606A1 (enExample)
CL (1) CL2024000742A1 (enExample)
DK (1) DK4401833T3 (enExample)
ES (1) ES3053759T3 (enExample)
FI (1) FI4401833T3 (enExample)
GB (1) GB202113186D0 (enExample)
HR (1) HRP20251420T1 (enExample)
IL (1) IL311015A (enExample)
LT (1) LT4401833T (enExample)
MX (1) MX2024003248A (enExample)
PL (1) PL4401833T3 (enExample)
PT (1) PT4401833T (enExample)
RS (1) RS67399B1 (enExample)
SI (1) SI4401833T1 (enExample)
SM (1) SMT202500449T1 (enExample)
WO (1) WO2023041909A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139284A1 (en) 2020-04-22 2023-03-01 Neurocrine Biosciences, Inc. Gpr52 modulators and methods of use
WO2025252061A1 (zh) * 2024-06-04 2025-12-11 海思科医药集团股份有限公司 一种gpr52激动剂及其在医药上的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009107391A1 (ja) * 2008-02-27 2011-06-30 武田薬品工業株式会社 6員芳香環含有化合物
MX373876B (es) 2015-04-29 2020-03-26 Arena Pharm Inc 1-heteroaril-indolin-4-carboxamidas como moduladores de gpr52 útiles para el tratamiento o prevención de trastornos relacionados a las mismas.
CN111094278B (zh) * 2017-09-13 2023-07-14 诺华股份有限公司 二苯基衍生物及其用途
CN114650992A (zh) * 2019-11-08 2022-06-21 赫普泰雅治疗有限公司 Gpr52调节剂化合物
GB202003668D0 (en) 2020-03-13 2020-04-29 Heptares Therapeutics Ltd GPR52 Modulator compounds

Also Published As

Publication number Publication date
WO2023041909A1 (en) 2023-03-23
IL311015A (en) 2024-04-01
SMT202500449T1 (it) 2026-01-12
CL2024000742A1 (es) 2024-09-27
US20240376070A1 (en) 2024-11-14
JP2024535860A (ja) 2024-10-02
PL4401833T3 (pl) 2026-02-16
LT4401833T (lt) 2025-12-10
MX2024003248A (es) 2024-04-02
DK4401833T3 (da) 2025-11-17
RS67399B1 (sr) 2025-11-28
ES3053759T3 (en) 2026-01-26
KR20240058852A (ko) 2024-05-07
HRP20251420T1 (hr) 2026-01-02
AU2022348201A1 (en) 2024-03-28
EP4401833B1 (en) 2025-10-22
EP4401833A1 (en) 2024-07-24
GB202113186D0 (en) 2021-10-27
PT4401833T (pt) 2025-11-14
CA3232606A1 (en) 2023-03-23
FI4401833T3 (fi) 2025-11-25
CN117999258A (zh) 2024-05-07

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