JP2024535860A - Ｇｐｒ５２モジュレーター化合物 - Google Patents

Ｇｐｒ５２モジュレーター化合物 Download PDF

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Publication number
JP2024535860A
JP2024535860A JP2024516935A JP2024516935A JP2024535860A JP 2024535860 A JP2024535860 A JP 2024535860A JP 2024516935 A JP2024516935 A JP 2024516935A JP 2024516935 A JP2024516935 A JP 2024516935A JP 2024535860 A JP2024535860 A JP 2024535860A
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JP
Japan
Prior art keywords
disorder
optionally substituted
compound
acid
methyl
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Pending
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JP2024516935A
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English (en)
Japanese (ja)
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JP2024535860A5 (enExample
Inventor
ワトソン，スティーブン・ポール
スウェイン，ナイジェル・アラン
オブライエン，マイケル・アリステア
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Nxera Pharma UK Ltd
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Nxera Pharma UK Ltd
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Publication date
Application filed by Nxera Pharma UK Ltd filed Critical Nxera Pharma UK Ltd
Publication of JP2024535860A publication Critical patent/JP2024535860A/ja
Publication of JP2024535860A5 publication Critical patent/JP2024535860A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2024516935A 2021-09-15 2022-09-15 Ｇｐｒ５２モジュレーター化合物 Pending JP2024535860A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2113186.7 2021-09-15
GBGB2113186.7A GB202113186D0 (en) 2021-09-15 2021-09-15 GPR52 Modulator compounds
PCT/GB2022/052328 WO2023041909A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds

Publications (2)

Publication Number Publication Date
JP2024535860A true JP2024535860A (ja) 2024-10-02
JP2024535860A5 JP2024535860A5 (enExample) 2025-09-25

Family

ID=78149263

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024516935A Pending JP2024535860A (ja) 2021-09-15 2022-09-15 Ｇｐｒ５２モジュレーター化合物

Country Status (22)

Country Link
US (1) US20240376070A1 (enExample)
EP (1) EP4401833B1 (enExample)
JP (1) JP2024535860A (enExample)
KR (1) KR20240058852A (enExample)
CN (1) CN117999258A (enExample)
AU (1) AU2022348201A1 (enExample)
CA (1) CA3232606A1 (enExample)
CL (1) CL2024000742A1 (enExample)
DK (1) DK4401833T3 (enExample)
ES (1) ES3053759T3 (enExample)
FI (1) FI4401833T3 (enExample)
GB (1) GB202113186D0 (enExample)
HR (1) HRP20251420T1 (enExample)
IL (1) IL311015A (enExample)
LT (1) LT4401833T (enExample)
MX (1) MX2024003248A (enExample)
PL (1) PL4401833T3 (enExample)
PT (1) PT4401833T (enExample)
RS (1) RS67399B1 (enExample)
SI (1) SI4401833T1 (enExample)
SM (1) SMT202500449T1 (enExample)
WO (1) WO2023041909A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139284A1 (en) 2020-04-22 2023-03-01 Neurocrine Biosciences, Inc. Gpr52 modulators and methods of use
WO2025252061A1 (zh) * 2024-06-04 2025-12-11 海思科医药集团股份有限公司 一种gpr52激动剂及其在医药上的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009107391A1 (ja) * 2008-02-27 2009-09-03 武田薬品工業株式会社 ６員芳香環含有化合物
JP2018519253A (ja) * 2015-04-29 2018-07-19 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド
WO2019053090A1 (en) * 2017-09-13 2019-03-21 Novartis Ag DIPHENYL DERIVATIVES AND USES THEREOF

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114650992A (zh) * 2019-11-08 2022-06-21 赫普泰雅治疗有限公司 Gpr52调节剂化合物
GB202003668D0 (en) 2020-03-13 2020-04-29 Heptares Therapeutics Ltd GPR52 Modulator compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009107391A1 (ja) * 2008-02-27 2009-09-03 武田薬品工業株式会社 ６員芳香環含有化合物
JP2018519253A (ja) * 2015-04-29 2018-07-19 アリーナ ファーマシューティカルズ， インコーポレイテッド Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド
WO2019053090A1 (en) * 2017-09-13 2019-03-21 Novartis Ag DIPHENYL DERIVATIVES AND USES THEREOF

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NAKAHATA, T. ET AL.: "Design and synthesis of 1-(1-benzothiophen-7-yl)-1H-pyrazole, a novel series of G protein-coupled re", BIOORGANIC AND MEDICINAL CHEMISTRY, vol. 26, JPN6024014948, 10 February 2018 (2018-02-10), pages 1598 - 1608, ISSN: 0005911730 *
SETOH, M. ET AL.: "Discovery of the First Potent and Orally Available Agonist of the Orphan G-Protein-Coupled Receptor", JOURNAL OF MEDICINAL CHMEISTRY, vol. 57, JPN6024014949, 2 June 2014 (2014-06-02), pages 5226 - 5237, ISSN: 0005911729 *

Also Published As

Publication number Publication date
WO2023041909A1 (en) 2023-03-23
IL311015A (en) 2024-04-01
SMT202500449T1 (it) 2026-01-12
CL2024000742A1 (es) 2024-09-27
US20240376070A1 (en) 2024-11-14
PL4401833T3 (pl) 2026-02-16
LT4401833T (lt) 2025-12-10
MX2024003248A (es) 2024-04-02
DK4401833T3 (da) 2025-11-17
RS67399B1 (sr) 2025-11-28
ES3053759T3 (en) 2026-01-26
KR20240058852A (ko) 2024-05-07
HRP20251420T1 (hr) 2026-01-02
AU2022348201A1 (en) 2024-03-28
EP4401833B1 (en) 2025-10-22
EP4401833A1 (en) 2024-07-24
GB202113186D0 (en) 2021-10-27
PT4401833T (pt) 2025-11-14
SI4401833T1 (sl) 2026-01-30
CA3232606A1 (en) 2023-03-23
FI4401833T3 (fi) 2025-11-25
CN117999258A (zh) 2024-05-07

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