GB202113186D0 - GPR52 Modulator compounds - Google Patents

GPR52 Modulator compounds

Info

Publication number
GB202113186D0
GB202113186D0 GBGB2113186.7A GB202113186A GB202113186D0 GB 202113186 D0 GB202113186 D0 GB 202113186D0 GB 202113186 A GB202113186 A GB 202113186A GB 202113186 D0 GB202113186 D0 GB 202113186D0
Authority
GB
United Kingdom
Prior art keywords
gpr52
modulator compounds
modulator
compounds
gpr52 modulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2113186.7A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nxera Pharma UK Ltd
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Priority to GBGB2113186.7A priority Critical patent/GB202113186D0/en
Publication of GB202113186D0 publication Critical patent/GB202113186D0/en
Priority to SI202230201T priority patent/SI4401833T1/sl
Priority to CN202280062419.2A priority patent/CN117999258A/zh
Priority to AU2022348201A priority patent/AU2022348201A1/en
Priority to JP2024516935A priority patent/JP2024535860A/ja
Priority to PL22778038.4T priority patent/PL4401833T3/pl
Priority to SM20250449T priority patent/SMT202500449T1/it
Priority to HRP20251420TT priority patent/HRP20251420T1/hr
Priority to RS20251139A priority patent/RS67399B1/sr
Priority to FIEP22778038.4T priority patent/FI4401833T3/fi
Priority to ES22778038T priority patent/ES3053759T3/es
Priority to MX2024003248A priority patent/MX2024003248A/es
Priority to LTEPPCT/GB2022/052328T priority patent/LT4401833T/lt
Priority to DK22778038.4T priority patent/DK4401833T3/da
Priority to EP22778038.4A priority patent/EP4401833B1/en
Priority to PT227780384T priority patent/PT4401833T/pt
Priority to US18/689,590 priority patent/US20240376070A1/en
Priority to IL311015A priority patent/IL311015A/en
Priority to PCT/GB2022/052328 priority patent/WO2023041909A1/en
Priority to KR1020247006746A priority patent/KR20240058852A/ko
Priority to CA3232606A priority patent/CA3232606A1/en
Priority to CL2024000742A priority patent/CL2024000742A1/es
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GBGB2113186.7A 2021-09-15 2021-09-15 GPR52 Modulator compounds Ceased GB202113186D0 (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
GBGB2113186.7A GB202113186D0 (en) 2021-09-15 2021-09-15 GPR52 Modulator compounds
CA3232606A CA3232606A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
ES22778038T ES3053759T3 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
LTEPPCT/GB2022/052328T LT4401833T (lt) 2021-09-15 2022-09-15 Gpr52 moduliatoriaus junginiai
AU2022348201A AU2022348201A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
JP2024516935A JP2024535860A (ja) 2021-09-15 2022-09-15 Gpr52モジュレーター化合物
PL22778038.4T PL4401833T3 (pl) 2021-09-15 2022-09-15 Związki modulujące receptor gpr52
SM20250449T SMT202500449T1 (it) 2021-09-15 2022-09-15 Composti modulatori di gpr52
HRP20251420TT HRP20251420T1 (hr) 2021-09-15 2022-09-15 Gpr52 modulatorski spojevi
RS20251139A RS67399B1 (sr) 2021-09-15 2022-09-15 Jedinjenja modulatori gpr52
FIEP22778038.4T FI4401833T3 (fi) 2021-09-15 2022-09-15 Gpr52:n muuntajayhdisteitä
SI202230201T SI4401833T1 (sl) 2021-09-15 2022-09-15 Gpr52-modulatorne spojine
MX2024003248A MX2024003248A (es) 2021-09-15 2022-09-15 Compuestos moduladores de gpr52.
CN202280062419.2A CN117999258A (zh) 2021-09-15 2022-09-15 Gpr52调节剂化合物
DK22778038.4T DK4401833T3 (da) 2021-09-15 2022-09-15 Gpr52-modulatorforbindelser
EP22778038.4A EP4401833B1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
PT227780384T PT4401833T (pt) 2021-09-15 2022-09-15 Compostos moduladores do gpr52
US18/689,590 US20240376070A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
IL311015A IL311015A (en) 2021-09-15 2022-09-15 GPR52 modulator compounds
PCT/GB2022/052328 WO2023041909A1 (en) 2021-09-15 2022-09-15 Gpr52 modulator compounds
KR1020247006746A KR20240058852A (ko) 2021-09-15 2022-09-15 Gpr52 조절제 화합물
CL2024000742A CL2024000742A1 (es) 2021-09-15 2024-03-13 Compuestos moduladores de gpr52

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2113186.7A GB202113186D0 (en) 2021-09-15 2021-09-15 GPR52 Modulator compounds

Publications (1)

Publication Number Publication Date
GB202113186D0 true GB202113186D0 (en) 2021-10-27

Family

ID=78149263

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2113186.7A Ceased GB202113186D0 (en) 2021-09-15 2021-09-15 GPR52 Modulator compounds

Country Status (22)

Country Link
US (1) US20240376070A1 (enExample)
EP (1) EP4401833B1 (enExample)
JP (1) JP2024535860A (enExample)
KR (1) KR20240058852A (enExample)
CN (1) CN117999258A (enExample)
AU (1) AU2022348201A1 (enExample)
CA (1) CA3232606A1 (enExample)
CL (1) CL2024000742A1 (enExample)
DK (1) DK4401833T3 (enExample)
ES (1) ES3053759T3 (enExample)
FI (1) FI4401833T3 (enExample)
GB (1) GB202113186D0 (enExample)
HR (1) HRP20251420T1 (enExample)
IL (1) IL311015A (enExample)
LT (1) LT4401833T (enExample)
MX (1) MX2024003248A (enExample)
PL (1) PL4401833T3 (enExample)
PT (1) PT4401833T (enExample)
RS (1) RS67399B1 (enExample)
SI (1) SI4401833T1 (enExample)
SM (1) SMT202500449T1 (enExample)
WO (1) WO2023041909A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139284A1 (en) 2020-04-22 2023-03-01 Neurocrine Biosciences, Inc. Gpr52 modulators and methods of use
WO2025252061A1 (zh) * 2024-06-04 2025-12-11 海思科医药集团股份有限公司 一种gpr52激动剂及其在医药上的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2009107391A1 (ja) * 2008-02-27 2011-06-30 武田薬品工業株式会社 6員芳香環含有化合物
MX373876B (es) 2015-04-29 2020-03-26 Arena Pharm Inc 1-heteroaril-indolin-4-carboxamidas como moduladores de gpr52 útiles para el tratamiento o prevención de trastornos relacionados a las mismas.
CN111094278B (zh) * 2017-09-13 2023-07-14 诺华股份有限公司 二苯基衍生物及其用途
CN114650992A (zh) * 2019-11-08 2022-06-21 赫普泰雅治疗有限公司 Gpr52调节剂化合物
GB202003668D0 (en) 2020-03-13 2020-04-29 Heptares Therapeutics Ltd GPR52 Modulator compounds

Also Published As

Publication number Publication date
WO2023041909A1 (en) 2023-03-23
IL311015A (en) 2024-04-01
SMT202500449T1 (it) 2026-01-12
CL2024000742A1 (es) 2024-09-27
US20240376070A1 (en) 2024-11-14
JP2024535860A (ja) 2024-10-02
PL4401833T3 (pl) 2026-02-16
LT4401833T (lt) 2025-12-10
MX2024003248A (es) 2024-04-02
DK4401833T3 (da) 2025-11-17
RS67399B1 (sr) 2025-11-28
ES3053759T3 (en) 2026-01-26
KR20240058852A (ko) 2024-05-07
HRP20251420T1 (hr) 2026-01-02
AU2022348201A1 (en) 2024-03-28
EP4401833B1 (en) 2025-10-22
EP4401833A1 (en) 2024-07-24
PT4401833T (pt) 2025-11-14
SI4401833T1 (sl) 2026-01-30
CA3232606A1 (en) 2023-03-23
FI4401833T3 (fi) 2025-11-25
CN117999258A (zh) 2024-05-07

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)