SI4132909T1 - Organske kisle adicijske soli S-pindolola - Google Patents
Organske kisle adicijske soli S-pindololaInfo
- Publication number
- SI4132909T1 SI4132909T1 SI202130139T SI202130139T SI4132909T1 SI 4132909 T1 SI4132909 T1 SI 4132909T1 SI 202130139 T SI202130139 T SI 202130139T SI 202130139 T SI202130139 T SI 202130139T SI 4132909 T1 SI4132909 T1 SI 4132909T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pindolol
- organic acid
- acid addition
- addition salts
- salts
- Prior art date
Links
- 150000007524 organic acids Chemical class 0.000 title 1
- 229960002508 pindolol Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/43—Indoles; Hydrogenated indoles with an —OCH2CH(OH)CH2NH2 radical, which may be further substituted, attached in positions 4, 5, 6 or 7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/122—Propionic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/08—Malonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/12—Glutaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/14—Adipic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/32—Phenylacetic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C07C63/06—Benzoic acid
- C07C63/08—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/33—Polycyclic acids
- C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
- C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
- C07C63/36—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings containing one carboxyl group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2005112.4A GB2593902B (en) | 2020-04-07 | 2020-04-07 | Salt of a pharmaceutical compound |
| PCT/GB2021/050799 WO2021205144A1 (en) | 2020-04-07 | 2021-03-31 | Organic acid addition salts of s-pindolol |
| EP21717172.7A EP4132909B1 (en) | 2020-04-07 | 2021-03-31 | Organic acid addition salts of s-pindolol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI4132909T1 true SI4132909T1 (sl) | 2024-06-28 |
Family
ID=70768820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI202130139T SI4132909T1 (sl) | 2020-04-07 | 2021-03-31 | Organske kisle adicijske soli S-pindolola |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US12109192B2 (sl) |
| EP (2) | EP4132909B1 (sl) |
| JP (1) | JP2023521985A (sl) |
| KR (1) | KR20220164521A (sl) |
| CN (1) | CN115916751A (sl) |
| AU (1) | AU2021253747A1 (sl) |
| BR (1) | BR112022020198A2 (sl) |
| CA (1) | CA3173878A1 (sl) |
| DK (1) | DK4132909T3 (sl) |
| ES (1) | ES2982095T3 (sl) |
| FI (1) | FI4132909T3 (sl) |
| GB (1) | GB2593902B (sl) |
| HR (1) | HRP20240922T1 (sl) |
| IL (1) | IL297045A (sl) |
| LT (1) | LT4132909T (sl) |
| MX (1) | MX2022012492A (sl) |
| PL (1) | PL4132909T3 (sl) |
| PT (1) | PT4132909T (sl) |
| RS (1) | RS65710B1 (sl) |
| SI (1) | SI4132909T1 (sl) |
| WO (1) | WO2021205144A1 (sl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202114564D0 (en) * | 2021-10-12 | 2021-11-24 | Actimed Therapeutics Ltd | Oral formulation |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| AT336176B (de) * | 1971-12-10 | 1977-04-25 | Sandoz Ag | Verfahren zur herstellung eines pharmazeutischen praparates |
| DE3544172A1 (de) | 1985-12-13 | 1987-06-19 | Lentia Gmbh | Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung |
| US4849224A (en) | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
| JPH01287064A (ja) | 1988-05-13 | 1989-11-17 | Lion Corp | 光学活性アミノプロパノール誘導体の製造方法 |
| HU209251B (en) | 1992-03-13 | 1994-04-28 | Synepos Ag | Process for producing stable, peroral solution drug forms with controlled release of active ingredient and comprising beta-blocking pharmacons |
| US5985317A (en) | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
| WO2000024386A1 (en) | 1998-09-08 | 2000-05-04 | Theratech, Inc. | Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs |
| US7417038B1 (en) | 1998-10-15 | 2008-08-26 | Imperial Innovations Limited | Methods of treating cachexia |
| GB0624282D0 (en) * | 2006-12-05 | 2007-01-10 | Cavalla David | Treatment of cachexia |
| GB0907350D0 (en) | 2009-04-29 | 2009-06-10 | Myotec Therapeutics Ltd | Methods |
| BR112015001712A2 (pt) * | 2012-07-25 | 2017-07-04 | Psioxus Therapeutics Ltd | uso de s-pindolol para o tratamento da caquexia e sarcopenia |
| CN105338975B (zh) | 2013-03-14 | 2019-07-16 | 艾可迪迈治疗有限公司 | 用于治疗癌症的氧烯洛尔组合物 |
| CN105358140A (zh) | 2013-03-14 | 2016-02-24 | 安德鲁·J·S·科茨 | 一种用于治疗肌萎缩性侧索硬化症的β受体阻滞剂的S-对映体富集组合物 |
| WO2017144977A1 (en) | 2016-02-26 | 2017-08-31 | Act Ventures Ltd. | S-enantiomerically enriched compositions of beta blockers for treating muscle weakness |
-
2020
- 2020-04-07 GB GB2005112.4A patent/GB2593902B/en active Active
-
2021
- 2021-03-31 MX MX2022012492A patent/MX2022012492A/es unknown
- 2021-03-31 ES ES21717172T patent/ES2982095T3/es active Active
- 2021-03-31 CN CN202180040441.2A patent/CN115916751A/zh active Pending
- 2021-03-31 US US17/995,621 patent/US12109192B2/en active Active
- 2021-03-31 AU AU2021253747A patent/AU2021253747A1/en active Pending
- 2021-03-31 JP JP2022561648A patent/JP2023521985A/ja active Pending
- 2021-03-31 PT PT217171727T patent/PT4132909T/pt unknown
- 2021-03-31 BR BR112022020198A patent/BR112022020198A2/pt unknown
- 2021-03-31 CA CA3173878A patent/CA3173878A1/en active Pending
- 2021-03-31 DK DK21717172.7T patent/DK4132909T3/da active
- 2021-03-31 IL IL297045A patent/IL297045A/en unknown
- 2021-03-31 SI SI202130139T patent/SI4132909T1/sl unknown
- 2021-03-31 WO PCT/GB2021/050799 patent/WO2021205144A1/en active Application Filing
- 2021-03-31 FI FIEP21717172.7T patent/FI4132909T3/fi active
- 2021-03-31 HR HRP20240922TT patent/HRP20240922T1/hr unknown
- 2021-03-31 EP EP21717172.7A patent/EP4132909B1/en active Active
- 2021-03-31 RS RS20240763A patent/RS65710B1/sr unknown
- 2021-03-31 LT LTEPPCT/GB2021/050799T patent/LT4132909T/lt unknown
- 2021-03-31 PL PL21717172.7T patent/PL4132909T3/pl unknown
- 2021-03-31 EP EP24160044.4A patent/EP4385566A3/en active Pending
- 2021-03-31 KR KR1020227037233A patent/KR20220164521A/ko unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230190706A1 (en) | 2023-06-22 |
| DK4132909T3 (da) | 2024-05-13 |
| ES2982095T3 (es) | 2024-10-14 |
| AU2021253747A1 (en) | 2022-11-10 |
| PL4132909T3 (pl) | 2024-08-05 |
| US12109192B2 (en) | 2024-10-08 |
| EP4132909B1 (en) | 2024-04-10 |
| KR20220164521A (ko) | 2022-12-13 |
| CN115916751A (zh) | 2023-04-04 |
| LT4132909T (lt) | 2024-05-27 |
| JP2023521985A (ja) | 2023-05-26 |
| GB2593902B (en) | 2022-04-13 |
| GB202005112D0 (en) | 2020-05-20 |
| EP4132909A1 (en) | 2023-02-15 |
| EP4385566A3 (en) | 2024-09-18 |
| CA3173878A1 (en) | 2021-10-14 |
| MX2022012492A (es) | 2023-01-11 |
| RS65710B1 (sr) | 2024-08-30 |
| IL297045A (en) | 2022-12-01 |
| PT4132909T (pt) | 2024-05-02 |
| FI4132909T3 (fi) | 2024-05-23 |
| HRP20240922T1 (hr) | 2024-10-11 |
| GB2593902A (en) | 2021-10-13 |
| WO2021205144A1 (en) | 2021-10-14 |
| BR112022020198A2 (pt) | 2022-11-22 |
| EP4385566A2 (en) | 2024-06-19 |
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