SI3347006T1 - Devterirani analogi etifoksina, njihovi derivati in njihova uporaba - Google Patents

Devterirani analogi etifoksina, njihovi derivati in njihova uporaba

Info

Publication number
SI3347006T1
SI3347006T1 SI201631611T SI201631611T SI3347006T1 SI 3347006 T1 SI3347006 T1 SI 3347006T1 SI 201631611 T SI201631611 T SI 201631611T SI 201631611 T SI201631611 T SI 201631611T SI 3347006 T1 SI3347006 T1 SI 3347006T1
Authority
SI
Slovenia
Prior art keywords
etifoxine
derivatives
deuterated analogs
uses therof
therof
Prior art date
Application number
SI201631611T
Other languages
English (en)
Inventor
Olivier Dasse
Original Assignee
Gaba Therapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gaba Therapeutics Inc. filed Critical Gaba Therapeutics Inc.
Publication of SI3347006T1 publication Critical patent/SI3347006T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI201631611T 2015-03-20 2016-03-18 Devterirani analogi etifoksina, njihovi derivati in njihova uporaba SI3347006T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562135979P 2015-03-20 2015-03-20
EP16769437.1A EP3347006B1 (en) 2015-03-20 2016-03-18 Deuterated analogs of etifoxine, their derivatives and uses therof
PCT/US2016/023231 WO2016154039A1 (en) 2015-03-20 2016-03-18 Deuterated analogs of etifoxine, their derivatives and uses therof

Publications (1)

Publication Number Publication Date
SI3347006T1 true SI3347006T1 (sl) 2022-11-30

Family

ID=56977741

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201631611T SI3347006T1 (sl) 2015-03-20 2016-03-18 Devterirani analogi etifoksina, njihovi derivati in njihova uporaba

Country Status (20)

Country Link
US (4) US10080755B2 (sl)
EP (1) EP3347006B1 (sl)
JP (3) JP6762507B2 (sl)
KR (1) KR102290766B1 (sl)
CN (1) CN107530323B (sl)
AU (2) AU2016235495B2 (sl)
BR (1) BR112017020081B1 (sl)
CA (1) CA2979853C (sl)
DK (1) DK3347006T3 (sl)
ES (1) ES2928396T3 (sl)
HR (1) HRP20221240T1 (sl)
HU (1) HUE060240T2 (sl)
IL (2) IL270627B2 (sl)
LT (1) LT3347006T (sl)
MX (1) MX2017011978A (sl)
PL (1) PL3347006T3 (sl)
PT (1) PT3347006T (sl)
RS (1) RS63654B1 (sl)
SI (1) SI3347006T1 (sl)
WO (1) WO2016154039A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3347006T1 (sl) * 2015-03-20 2022-11-30 Gaba Therapeutics Inc. Devterirani analogi etifoksina, njihovi derivati in njihova uporaba
US10420773B2 (en) * 2017-09-26 2019-09-24 Ovid Therapeutics Inc. Methods of treating developmental disorders and/or seizure disorders with etifoxine
WO2019183564A1 (en) * 2018-03-23 2019-09-26 Concert Pharmaceuticals, Inc. DEUTERATED ANALOGS OF D-β-HYDROXYBUTYRIC ACID AND USES THEREOF
AU2019270173A1 (en) * 2018-05-18 2020-12-03 Ovid Therapeutics Inc. Methods of treating attention deficit hyperactivity disorder
CN112125862A (zh) * 2019-06-25 2020-12-25 上海安谱实验科技股份有限公司 一种稳定同位素标记的阿特拉津-d5及其合成方法
US11534434B2 (en) 2019-11-15 2022-12-27 Karuna Therapeutics, Inc. Xanomeline derivatives and methods for treating neurological disorders
WO2023218251A1 (en) * 2022-05-10 2023-11-16 Clearsynth Labs Limied Novel deuterium-enriched nefazodone analogues and method for preparing thereof
US20240189316A1 (en) * 2022-10-24 2024-06-13 Gaba Therapeutics Inc. Deuterated analogs of etifoxine and methods of administration without autoinduction of metabolism

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670772C3 (de) 1966-11-24 1978-04-20 Hoechst Ag, 6000 Frankfurt 4H-3,1-Benzoxazin-Derivate, deren Salze und pharmazeutische Präparate
FR2888748B1 (fr) * 2005-07-19 2007-10-12 Biocodex Composes neuroprotecteurs et compositions pharmaceutiques les comprenant
US20080039453A1 (en) * 2006-03-20 2008-02-14 David Putman Enantiomerically pure R-etifoxine, pharmaceutical compositions thereof and methods of their use
US8110569B2 (en) * 2006-03-20 2012-02-07 The Regents Of The University Of California Enantiomerically pure S-etifoxine, pharmaceutical compositions thereof and methods of their use
JP2011001308A (ja) * 2009-06-19 2011-01-06 Research Foundation Itsuu Laboratory 重水素化カルボスチリル化合物
BR112013000599A2 (pt) * 2010-07-09 2016-07-05 Teva Pharma deuterado n-etil-n-fenil-1,2-di-hidro-4-hidroxi-5-cloro-1-metil-2-oxoquinolino-3-carboxamida, os seus sais e suas utilizações
EP2730559A4 (en) 2011-07-05 2015-03-04 Kemphys Ltd DEUTERATED PHENYLPROPIONIC ACID DERIVATIVE
FR3016881B1 (fr) 2014-01-29 2016-03-04 Biocodex Traitement des degenerescences et des lesions photo-induites de la retine
SI3347006T1 (sl) * 2015-03-20 2022-11-30 Gaba Therapeutics Inc. Devterirani analogi etifoksina, njihovi derivati in njihova uporaba

Also Published As

Publication number Publication date
CA2979853C (en) 2021-05-11
AU2020201728A1 (en) 2020-03-26
BR112017020081A2 (pt) 2018-06-05
LT3347006T (lt) 2022-10-25
JP7376668B2 (ja) 2023-11-08
US11672805B2 (en) 2023-06-13
JP2018508592A (ja) 2018-03-29
ES2928396T3 (es) 2022-11-17
KR102290766B1 (ko) 2021-08-19
US20180064717A1 (en) 2018-03-08
WO2016154039A1 (en) 2016-09-29
RS63654B1 (sr) 2022-11-30
PL3347006T3 (pl) 2022-11-14
EP3347006B1 (en) 2022-07-27
JP6762507B2 (ja) 2020-09-30
HRP20221240T1 (hr) 2022-12-09
BR112017020081B1 (pt) 2021-11-30
IL254567B (en) 2020-03-31
EP3347006A4 (en) 2019-04-24
JP2021001174A (ja) 2021-01-07
PT3347006T (pt) 2022-10-17
IL270627B (en) 2022-11-01
HUE060240T2 (hu) 2023-02-28
IL270627A (sl) 2019-12-31
US10080755B2 (en) 2018-09-25
CN107530323A (zh) 2018-01-02
US20200405726A1 (en) 2020-12-31
AU2016235495A1 (en) 2017-10-05
IL270627B2 (en) 2023-03-01
IL254567A0 (en) 2017-11-30
AU2020201728B2 (en) 2021-12-23
CN107530323B (zh) 2021-05-04
US20190015419A1 (en) 2019-01-17
JP2023009114A (ja) 2023-01-19
DK3347006T3 (da) 2022-10-17
US20230263805A1 (en) 2023-08-24
MX2017011978A (es) 2018-02-09
KR20170137085A (ko) 2017-12-12
EP3347006A1 (en) 2018-07-18
CA2979853A1 (en) 2016-09-29
AU2016235495B2 (en) 2020-05-14
US10736901B2 (en) 2020-08-11

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