SI3250563T1 - Substituirani triazoli in z njimi povezani postopki - Google Patents

Substituirani triazoli in z njimi povezani postopki

Info

Publication number
SI3250563T1
SI3250563T1 SI201631489T SI201631489T SI3250563T1 SI 3250563 T1 SI3250563 T1 SI 3250563T1 SI 201631489 T SI201631489 T SI 201631489T SI 201631489 T SI201631489 T SI 201631489T SI 3250563 T1 SI3250563 T1 SI 3250563T1
Authority
SI
Slovenia
Prior art keywords
methods relating
substituted triazoles
triazoles
substituted
relating
Prior art date
Application number
SI201631489T
Other languages
English (en)
Inventor
John P. Williams
Deborah Slee
Manisha Moorjani
Neil J. Ashweek
Original Assignee
Neurocrine Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences, Inc. filed Critical Neurocrine Biosciences, Inc.
Publication of SI3250563T1 publication Critical patent/SI3250563T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41921,2,3-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201631489T 2015-01-30 2016-01-29 Substituirani triazoli in z njimi povezani postopki SI3250563T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562110415P 2015-01-30 2015-01-30
US201562259314P 2015-11-24 2015-11-24
PCT/US2016/015740 WO2016123533A1 (en) 2015-01-30 2016-01-29 Substituted triazoles and methods relating thereto
EP16703250.7A EP3250563B1 (en) 2015-01-30 2016-01-29 Substituted triazoles and methods relating thereto

Publications (1)

Publication Number Publication Date
SI3250563T1 true SI3250563T1 (sl) 2022-04-29

Family

ID=55305123

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201631489T SI3250563T1 (sl) 2015-01-30 2016-01-29 Substituirani triazoli in z njimi povezani postopki

Country Status (23)

Country Link
US (4) US9718789B2 (sl)
EP (1) EP3250563B1 (sl)
JP (1) JP6728198B2 (sl)
KR (1) KR102575601B1 (sl)
CN (1) CN107406420B (sl)
AU (1) AU2016211292B2 (sl)
BR (1) BR112017016488A2 (sl)
CA (1) CA2975474C (sl)
CY (1) CY1125082T1 (sl)
DK (1) DK3250563T3 (sl)
ES (1) ES2905878T3 (sl)
HR (1) HRP20220327T1 (sl)
HU (1) HUE058156T2 (sl)
IL (1) IL253705B (sl)
LT (1) LT3250563T (sl)
MX (1) MX2017009824A (sl)
NZ (1) NZ734260A (sl)
PL (1) PL3250563T3 (sl)
PT (1) PT3250563T (sl)
RS (1) RS62862B1 (sl)
RU (1) RU2718049C2 (sl)
SI (1) SI3250563T1 (sl)
WO (1) WO2016123533A1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR201816624T4 (tr) 2014-06-03 2018-11-21 Idorsia Pharmaceuticals Ltd Pirazol bileşikleri ve t tipi kalsiyum kanalı bloke edicileri olarak kullanımları.
SG11201701998XA (en) 2014-09-15 2017-04-27 Actelion Pharmaceuticals Ltd Triazole compounds as t-type calcium channel blockers
SI3250563T1 (sl) 2015-01-30 2022-04-29 Neurocrine Biosciences, Inc. Substituirani triazoli in z njimi povezani postopki
BR112019011208A2 (pt) 2016-12-16 2019-10-15 Idorsia Pharmaceuticals Ltd combinação farmacêutica, composição farmacêutica, e, kit de partes.
CN110234622B (zh) 2017-02-06 2023-07-04 爱杜西亚药品有限公司 用于合成1-芳基-1-三氟甲基环丙烷的新颖方法
KR102298546B1 (ko) * 2018-10-18 2021-09-08 에이치케이이노엔 주식회사 신규한 n-(이소프로필-트리아졸릴)피리디닐)-헤테로아릴-카르복사미드 유도체 및 이의 용도
CN110669017B (zh) * 2019-10-11 2023-08-04 成都麻沸散医药科技有限公司 多取代三唑甲酸酯类衍生物及其用途
CN115974799A (zh) * 2021-10-14 2023-04-18 成都百裕制药股份有限公司 氨基甲酸酯取代的醇衍生物及其在医药上的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL50699A0 (en) 1975-10-28 1976-12-31 Ici America Inc Triazole derivatives
TW513301B (en) * 1999-03-01 2002-12-11 Novartis Ag Pharmaceutical composition for treatment of neuropathic pain and affective and attention disorders
US7319110B2 (en) * 2002-09-19 2008-01-15 Solvay Pharmaceuticals B.V. 1H-1,2,4-triazole-3-carboxamide derivatives having cannabinoid-CB1 receptor agonistic, partial agonistic, inverse agonistic or antagonistic activity
EP1829867A1 (en) * 2006-03-03 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Imidazole compounds having pharmaceutical activity towards the sigma receptor
EP1921071A1 (en) * 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,3- triazole derivatives as sigma receptor inhibitors
EP1921073A1 (en) * 2006-11-10 2008-05-14 Laboratorios del Dr. Esteve S.A. 1,2,4-Triazole derivatives as sigma receptor inhibitors
GB0722077D0 (en) * 2007-11-09 2007-12-19 Smithkline Beecham Corp Compounds
US8742097B2 (en) 2010-11-09 2014-06-03 Hoffmann-La Roche Inc. Triazole compounds I
EP2752411A1 (en) * 2013-01-07 2014-07-09 Laboratorios Del Dr. Esteve, S.A. 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
SI3250563T1 (sl) 2015-01-30 2022-04-29 Neurocrine Biosciences, Inc. Substituirani triazoli in z njimi povezani postopki

Also Published As

Publication number Publication date
RU2017130474A (ru) 2019-02-28
IL253705A0 (en) 2017-09-28
EP3250563A1 (en) 2017-12-06
AU2016211292A1 (en) 2017-08-24
JP6728198B2 (ja) 2020-07-22
US20170349558A1 (en) 2017-12-07
CA2975474A1 (en) 2016-08-04
AU2016211292B2 (en) 2020-05-07
US11021449B2 (en) 2021-06-01
US9718789B2 (en) 2017-08-01
US20160221968A1 (en) 2016-08-04
US10138214B2 (en) 2018-11-27
CA2975474C (en) 2023-06-13
JP2018503661A (ja) 2018-02-08
RS62862B1 (sr) 2022-02-28
CY1125082T1 (el) 2023-06-09
RU2718049C2 (ru) 2020-03-30
US10738017B2 (en) 2020-08-11
MX2017009824A (es) 2017-11-02
WO2016123533A1 (en) 2016-08-04
PT3250563T (pt) 2022-02-09
HUE058156T2 (hu) 2022-07-28
IL253705B (en) 2020-09-30
KR102575601B1 (ko) 2023-09-05
CN107406420A (zh) 2017-11-28
ES2905878T3 (es) 2022-04-12
EP3250563B1 (en) 2022-01-12
US20200399229A1 (en) 2020-12-24
CN107406420B (zh) 2020-11-06
RU2017130474A3 (sl) 2019-06-11
BR112017016488A2 (pt) 2018-04-10
US20190169137A1 (en) 2019-06-06
HRP20220327T1 (hr) 2022-05-13
DK3250563T3 (da) 2022-01-31
LT3250563T (lt) 2022-04-11
PL3250563T3 (pl) 2022-05-02
NZ734260A (en) 2024-01-26
KR20170106470A (ko) 2017-09-20

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