SI3031910T1 - Mn/ca ix-specifična monoklonska protitelesa generirana iz mn/ca- pomanjkljive miši in metode uporabe - Google Patents

Mn/ca ix-specifična monoklonska protitelesa generirana iz mn/ca- pomanjkljive miši in metode uporabe Download PDF

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Publication number
SI3031910T1
SI3031910T1 SI200332554T SI200332554T SI3031910T1 SI 3031910 T1 SI3031910 T1 SI 3031910T1 SI 200332554 T SI200332554 T SI 200332554T SI 200332554 T SI200332554 T SI 200332554T SI 3031910 T1 SI3031910 T1 SI 3031910T1
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Slovenia
Prior art keywords
antibody
amino acid
acid sequence
domain
seq
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SI200332554T
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English (en)
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Jaromir Pastorek
Silvia Pastorekova
Miriam Zatovicova
Jan Zavada
Gut Marta Ortova
Zuzanna Zavadova
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Institute Of Virology Slovak Academy Of Sciences
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Application filed by Institute Of Virology Slovak Academy Of Sciences filed Critical Institute Of Virology Slovak Academy Of Sciences
Publication of SI3031910T1 publication Critical patent/SI3031910T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B3/00—Measuring instruments characterised by the use of mechanical techniques
    • G01B3/10—Measuring tapes
    • G01B3/1084—Tapes combined with arrangements for functions other than measuring lengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B3/00—Measuring instruments characterised by the use of mechanical techniques
    • G01B3/10—Measuring tapes
    • G01B3/1084—Tapes combined with arrangements for functions other than measuring lengths
    • G01B3/1089—Tapes combined with arrangements for functions other than measuring lengths for marking, drawing or cutting
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B3/00—Measuring instruments characterised by the use of mechanical techniques
    • G01B3/10—Measuring tapes
    • G01B3/1061—Means for displaying or assisting reading of length measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82—Translation products from oncogenes

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (8)

  1. MN/CA IX-SPECIFIČNA MONOKLONSKA PROTITELESA GENERIRANA IZ MN/CA- POMANJKLJIVE MIŠI IN METODE UPORABE PATENTNI ZAHTEVKI
    1. Rekombinantno-proizvedeno monoklonsko protitelo ali njegov antigen-vezavni fragment, ki se specifično veže na neimunodominanten epitop topnega proteina MN/CA IX ali MN/CA IX polipeptid, kjer omenjeno protitelo ne konkurira za vezavo na MN/CA IX z monoklonskimi protitelesi MN7, M75 ali MN12, pod pogojem, da se protitelo ne veže na proteoglikan-podobno (PG) domeno MN/CA IX, in pri čemer je navedeni epitop izbran izmed epitopov (a) znotraj karbo anhidraza (CA) domene, ki ima aminokislinsko sekvenco od SEQ ID NO:9, (b) znotraj CA domene, ki ima aminokislinsko sekvenco od SEQ ID NO:101, (c) znotraj CA domene, ki ima aminokislinsko zaporedje SEQ ID NO:67, (d) znotraj CA domene, ki ima aminokislinsko zaporedje SEQ ID NO:69, (e) znotraj transmembranske domene (TM), ki ima aminokislinsko sekvenco SEQ ID NO:6 in (f) znotraj intracelulame domene (IC), ki ima aminokislinsko sekvenco SEQ ID NO:7
  2. 2. Protitelo po zahtevku 1, kjer omenjeno protitelo komplementarno determinirajoče regije (CDR), ki imajo aminokislinsko sekvenco protitelesa, pridobljenega iz MN/CA IX-pomanjkljivih miši.
  3. 3. Protitelo po zahtevku 1, kjer protitelo vsebuje spremenljive domene težkih- in lahkih-verig, ki imajo amino kislinsko sekvenco protitelesa, pridobljenega iz MN/CA IX-pomanjkljivih miši.
  4. 4. Protitelo po zahtevku 1, kjer je protitelo humano ali humanizirano.
  5. 5. Uporaba monoklonskega protitelesa po enem ali več predhodnih zahtevkih za presejanje, odkrivanje, diagnozo in prognoze raka.
  6. 6. Rekombinantno-proizvedeno monoklonsko protitelo po enem ali več predhodnih zahtevkov za uporabo v postopku zdravljenja tumorjev.
  7. 7. Uporaba monoklonskega protitelesa po zahtevku 5, kjer navedeno protitelo nastane iz MN/CA IX-pomanjkljivih miši.
  8. 8. Rekombinantno-proizvedeno monoklonsko protitelo po zahtevku 6 za uporabo pri postopku zdravljenja tumorjev, kjer je navedeno protitelo proizvedeno iz MN/CA IX-pomanjkljivih miši.
SI200332554T 2002-02-21 2003-02-21 Mn/ca ix-specifična monoklonska protitelesa generirana iz mn/ca- pomanjkljive miši in metode uporabe SI3031910T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US35882402P 2002-02-21 2002-02-21
US38306802P 2002-05-23 2002-05-23
US43149902P 2002-12-05 2002-12-05
EP15180634.6A EP3031910B1 (en) 2002-02-21 2003-02-21 Mn/ca ix-specific monoclonal antibodies generated from mn/ca ix-deficient mice and methods of use

Publications (1)

Publication Number Publication Date
SI3031910T1 true SI3031910T1 (sl) 2018-05-31

Family

ID=27737296

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200332453T SI1487972T1 (sl) 2002-02-21 2003-02-21 Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe
SI200332554T SI3031910T1 (sl) 2002-02-21 2003-02-21 Mn/ca ix-specifična monoklonska protitelesa generirana iz mn/ca- pomanjkljive miši in metode uporabe
SI200332452T SI2508596T1 (sl) 2002-02-21 2003-02-21 Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe

Family Applications Before (1)

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SI200332453T SI1487972T1 (sl) 2002-02-21 2003-02-21 Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe

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SI200332452T SI2508596T1 (sl) 2002-02-21 2003-02-21 Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe

Country Status (4)

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EP (2) EP2508596B1 (sl)
CA (1) CA2704273C (sl)
DK (1) DK2508596T3 (sl)
SI (3) SI1487972T1 (sl)

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Also Published As

Publication number Publication date
EP3031910A1 (en) 2016-06-15
EP2508596A3 (en) 2013-04-24
EP2508596B1 (en) 2015-08-12
CA2704273C (en) 2016-01-05
EP3031910B1 (en) 2017-08-16
SI2508596T1 (sl) 2016-01-29
SI1487972T1 (sl) 2016-03-31
CA2704273A1 (en) 2003-12-04
EP2508596A2 (en) 2012-10-10
DK2508596T3 (en) 2015-10-19

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