SI2981520T1 - Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina - Google Patents

Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina

Info

Publication number
SI2981520T1
SI2981520T1 SI201431188T SI201431188T SI2981520T1 SI 2981520 T1 SI2981520 T1 SI 2981520T1 SI 201431188 T SI201431188 T SI 201431188T SI 201431188 T SI201431188 T SI 201431188T SI 2981520 T1 SI2981520 T1 SI 2981520T1
Authority
SI
Slovenia
Prior art keywords
dimethylphenyl
thio
piperazine
phenyl
synthesis
Prior art date
Application number
SI201431188T
Other languages
English (en)
Inventor
Borut Zupancic
Original Assignee
Lek Pharmaceuticals D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48040094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2981520(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceuticals D.D. filed Critical Lek Pharmaceuticals D.D.
Publication of SI2981520T1 publication Critical patent/SI2981520T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI201431188T 2013-04-04 2014-04-04 Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina SI2981520T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13162296 2013-04-04
EP14715016.3A EP2981520B1 (en) 2013-04-04 2014-04-04 New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
PCT/EP2014/056769 WO2014161976A1 (en) 2013-04-04 2014-04-04 New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine

Publications (1)

Publication Number Publication Date
SI2981520T1 true SI2981520T1 (sl) 2019-07-31

Family

ID=48040094

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431188T SI2981520T1 (sl) 2013-04-04 2014-04-04 Novi proces za sintezo 1-(2-((2,4-dimetilfenil)tio)fenil)piperazina

Country Status (8)

Country Link
US (1) US9493409B2 (sl)
EP (2) EP2981520B1 (sl)
CN (1) CN105283442B (sl)
ES (1) ES2724246T3 (sl)
PL (1) PL2981520T3 (sl)
SI (1) SI2981520T1 (sl)
TR (1) TR201906691T4 (sl)
WO (1) WO2014161976A1 (sl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2981520B1 (en) 2013-04-04 2019-03-06 LEK Pharmaceuticals d.d. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
CZ2014471A3 (cs) * 2014-07-08 2016-01-20 Zentiva, K.S. Způsob přípravy vortioxetinu
WO2016079751A2 (en) * 2014-11-17 2016-05-26 Megafine Pharma (P) Ltd. A process for preparation of vortioxetine and polymorphs thereof
EP3023417B1 (en) 2014-11-21 2017-06-28 Dipharma Francis S.r.l. Process for the preparation of an antidepressant and the intermediates thereof
CN104356092B (zh) * 2014-11-27 2017-03-22 合肥创新医药技术有限公司 沃替西汀的制备方法
WO2016125191A2 (en) * 2015-02-04 2016-08-11 Mylan Laboratories Limited Processes for the preparation of vortioxetine hydrobromide
WO2016135636A1 (en) 2015-02-25 2016-09-01 Lupin Limited Process for the preparation of vortioxetine
EP3274330A1 (en) 2015-03-26 2018-01-31 Cipla Limited Method for making serotonin reuptake inhibitors
CN104829557B (zh) * 2015-04-23 2017-06-27 山东百诺医药股份有限公司 一种新化合物1‑[2‑（2,4‑二甲基苯基硫基）苯基]‑2‑氧哌嗪及其制备方法和在沃替西汀合成中的应用
CN105153066B (zh) * 2015-09-07 2018-01-09 浙江大学 盐酸沃替西汀的结晶型物及其制备方法
CN105541759A (zh) * 2016-01-07 2016-05-04 美吉斯制药（厦门）有限公司 一种制备沃替西汀的新方法
WO2018065348A1 (en) 2016-10-05 2018-04-12 Hexal Ag Novel enteric-coated tablet comprising vortioxetine
US10428033B2 (en) 2017-02-15 2019-10-01 Piramal Enterprises Limited Process for the preparation of vortioxetine and salts thereof
GB2564887A (en) * 2017-07-26 2019-01-30 Azad Pharmaceutical Ingredients Ag New route of synthesis to vortioxetine salts
CN107266390A (zh) * 2017-08-07 2017-10-20 山东鲁宁药业有限公司 一种氢溴酸沃替西汀的合成新工艺
PL3810582T3 (pl) 2018-06-20 2024-05-13 Vio Ag Pharmaceuticals S.A. Jednonaczyniowy sposób organopseudokatalitycznej aktywacji c-h do wytwarzania wortioksetyny i związku pośredniego wortioksetyny
CN111320592A (zh) * 2018-12-17 2020-06-23 天津理工大学 一种1-[2-(2,4-二甲基苯硫基)-苯基]哌嗪的制备方法
CN113185485B (zh) 2021-05-10 2022-03-04 合肥立方制药股份有限公司 一种二氢槲皮素的半合成方法
CN113214210B (zh) * 2021-05-10 2022-03-04 合肥立方制药股份有限公司 一种二氢槲皮素的制备方法
EP4247802A1 (en) * 2021-05-31 2023-09-27 R L Fine Chem Private Limited A method for preparation of 1-(2-((2,4-dimethylphenyl)thio)phenyl) piperazine and its salts
CN115181077B (zh) * 2022-07-27 2024-03-29 安徽峆一药业股份有限公司 一种低杂质含量的沃替西汀合成方法
CN115894314A (zh) * 2022-12-20 2023-04-04 苏州敬业医药化工有限公司 一种2'-氨基-(2,4-二甲基)二苯硫醚的制备工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20022319A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Substituovaná fenylpiperazinová sloučenina a farmaceutický prostředek, který ji obsahuje
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
RS52205B2 (sr) 2006-06-16 2021-05-31 H Lundbeck A/S 1-[2-(2,4-dimetilfenilsulfanil)-fenil]piperazin kao jedinjenje sa kombinovanom aktivnošću ponovnog uzimanja serotonina, 5-ht3 i 5-ht1a, za tretman kognitivnih oštećenja
EP2981520B1 (en) 2013-04-04 2019-03-06 LEK Pharmaceuticals d.d. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine

Also Published As

Publication number Publication date
PL2981520T3 (pl) 2019-09-30
ES2724246T3 (es) 2019-09-09
EP3495347A1 (en) 2019-06-12
TR201906691T4 (tr) 2019-05-21
WO2014161976A1 (en) 2014-10-09
US20160060215A1 (en) 2016-03-03
US9493409B2 (en) 2016-11-15
CN105283442A (zh) 2016-01-27
CN105283442B (zh) 2018-04-13
EP2981520B1 (en) 2019-03-06
EP2981520A1 (en) 2016-02-10

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