SI2872176T1 - Karboranilporfirin za uporabo pri zdravljenju raka - Google Patents

Karboranilporfirin za uporabo pri zdravljenju raka

Info

Publication number
SI2872176T1
SI2872176T1 SI201330673T SI201330673T SI2872176T1 SI 2872176 T1 SI2872176 T1 SI 2872176T1 SI 201330673 T SI201330673 T SI 201330673T SI 201330673 T SI201330673 T SI 201330673T SI 2872176 T1 SI2872176 T1 SI 2872176T1
Authority
SI
Slovenia
Prior art keywords
carboranylporphyrins
cancer
treatment
Prior art date
Application number
SI201330673T
Other languages
English (en)
Inventor
Christopher Beattie
Anne Wadsworth
James Rennie
Original Assignee
Morex Development Partners Llp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morex Development Partners Llp filed Critical Morex Development Partners Llp
Publication of SI2872176T1 publication Critical patent/SI2872176T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/009—Neutron capture therapy, e.g. using uranium or non-boron material
    • A61K41/0095—Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device
SI201330673T 2012-07-12 2013-07-11 Karboranilporfirin za uporabo pri zdravljenju raka SI2872176T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1212409.5A GB201212409D0 (en) 2012-07-12 2012-07-12 Cancer treatment
PCT/EP2013/064735 WO2014009496A1 (en) 2012-07-12 2013-07-11 Cancer treatment
EP13737828.7A EP2872176B1 (en) 2012-07-12 2013-07-11 Carboranylporphyrins for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
SI2872176T1 true SI2872176T1 (sl) 2017-08-31

Family

ID=46766538

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330673T SI2872176T1 (sl) 2012-07-12 2013-07-11 Karboranilporfirin za uporabo pri zdravljenju raka

Country Status (17)

Country Link
US (1) US9750809B2 (sl)
EP (2) EP2872176B1 (sl)
JP (1) JP6170147B2 (sl)
KR (1) KR20150036574A (sl)
CN (1) CN104602710A (sl)
CA (1) CA2878480A1 (sl)
CY (1) CY1120075T1 (sl)
DK (1) DK2872176T3 (sl)
ES (1) ES2627819T3 (sl)
GB (1) GB201212409D0 (sl)
HK (1) HK1210023A1 (sl)
HU (1) HUE033330T2 (sl)
LT (1) LT2872176T (sl)
PL (1) PL2872176T3 (sl)
PT (1) PT2872176T (sl)
SI (1) SI2872176T1 (sl)
WO (1) WO2014009496A1 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201221125D0 (en) 2012-11-23 2013-01-09 Morex Dev Partners Llp Pharmaceutial formulations
CN105233283B (zh) * 2015-11-11 2021-06-11 广西康健奥鑫生物医药科技有限公司 一种光动力治疗深部肿瘤靶向纳米光敏剂及其制备方法
RU2689623C1 (ru) * 2018-12-18 2019-05-28 Акционерное общество "НИПИгазпереработка" (АО "НИПИГАЗ") Установка подготовки газа
CN112473024B (zh) * 2020-11-30 2021-09-14 南京航空航天大学 一种对bnct过程中的三维硼剂量或硼浓度进行实时监测的方法
CN114344736B (zh) * 2021-12-09 2022-09-13 吉林大学 一种包含体内光核反应的肿瘤治疗系统及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2310447C2 (ru) 2001-06-06 2007-11-20 Брукхейвен Сайенс Ассошиэйтс Новые металлопорфирины и их применение в качестве радиосенсибилизаторов в лучевой терапии
US6566517B2 (en) * 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
US7267990B2 (en) * 2002-11-15 2007-09-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Chelation of charged and uncharged molecules with porphyrin-based compounds
US20070093463A1 (en) * 2004-05-20 2007-04-26 Brookhaven Science Associates, Llc Radiation enhancement agent for X-ray radiation therapy and boron neutron-capture therapy
US6989443B2 (en) 2004-06-28 2006-01-24 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
JP4972929B2 (ja) 2005-03-25 2012-07-11 ニプロ株式会社 放射線増感剤
WO2007050564A2 (en) 2005-10-25 2007-05-03 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Boron-containing porphyrin compounds and their uses
US8287839B2 (en) 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US8444953B2 (en) * 2007-03-22 2013-05-21 Brookhaven Science Associates, Llc Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof
GB201221125D0 (en) * 2012-11-23 2013-01-09 Morex Dev Partners Llp Pharmaceutial formulations

Also Published As

Publication number Publication date
LT2872176T (lt) 2017-07-10
KR20150036574A (ko) 2015-04-07
EP3205354A1 (en) 2017-08-16
JP6170147B2 (ja) 2017-07-26
PT2872176T (pt) 2017-06-21
WO2014009496A1 (en) 2014-01-16
PL2872176T3 (pl) 2017-09-29
US9750809B2 (en) 2017-09-05
GB201212409D0 (en) 2012-08-22
HK1210023A1 (en) 2016-04-15
CN104602710A (zh) 2015-05-06
EP2872176A1 (en) 2015-05-20
EP2872176B1 (en) 2017-03-22
ES2627819T3 (es) 2017-07-31
US20150157712A1 (en) 2015-06-11
CA2878480A1 (en) 2014-01-16
CY1120075T1 (el) 2018-12-12
DK2872176T3 (en) 2017-06-19
HUE033330T2 (en) 2017-11-28
JP2015524795A (ja) 2015-08-27

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