SI2373310T1 - Nove spojine 4- (heterocikloalkil) benzen-1, 3- diola kot inhibitorji tirosinaze, postopek njihove priprave in njihova uporaba v humani medicini in tudi v kozmetiki - Google Patents
Nove spojine 4- (heterocikloalkil) benzen-1, 3- diola kot inhibitorji tirosinaze, postopek njihove priprave in njihova uporaba v humani medicini in tudi v kozmetikiInfo
- Publication number
- SI2373310T1 SI2373310T1 SI200930399T SI200930399T SI2373310T1 SI 2373310 T1 SI2373310 T1 SI 2373310T1 SI 200930399 T SI200930399 T SI 200930399T SI 200930399 T SI200930399 T SI 200930399T SI 2373310 T1 SI2373310 T1 SI 2373310T1
- Authority
- SI
- Slovenia
- Prior art keywords
- heterocycloalkyl
- cosmetics
- benzene
- novel
- preparation
- Prior art date
Links
- 150000005207 1,3-dihydroxybenzenes Chemical class 0.000 title 1
- 102000003425 Tyrosinase Human genes 0.000 title 1
- 108060008724 Tyrosinase Proteins 0.000 title 1
- 239000002537 cosmetic Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D309/06—Radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4986—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with sulfur as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0858206A FR2939136B1 (fr) | 2008-12-02 | 2008-12-02 | Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| US20212809P | 2009-01-30 | 2009-01-30 | |
| PCT/EP2009/066267 WO2010063773A1 (en) | 2008-12-02 | 2009-12-02 | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics |
| EP09796990A EP2373310B1 (en) | 2008-12-02 | 2009-12-02 | Novel 4-(heterocycloalkyl)benzene-1,3-diol compounds as tyrosinase inhibitors, process for the preparation thereof and use thereof in human medicine and also in cosmetics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2373310T1 true SI2373310T1 (sl) | 2013-01-31 |
Family
ID=40845880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200930399T SI2373310T1 (sl) | 2008-12-02 | 2009-12-02 | Nove spojine 4- (heterocikloalkil) benzen-1, 3- diola kot inhibitorji tirosinaze, postopek njihove priprave in njihova uporaba v humani medicini in tudi v kozmetiki |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8372879B2 (sl) |
| EP (2) | EP2373310B1 (sl) |
| JP (1) | JP5395188B2 (sl) |
| KR (1) | KR101290504B1 (sl) |
| CN (1) | CN102238948B (sl) |
| AR (1) | AR074454A1 (sl) |
| AU (1) | AU2009324080B2 (sl) |
| BR (1) | BRPI0916504B8 (sl) |
| CA (1) | CA2742703C (sl) |
| DK (1) | DK2373310T3 (sl) |
| ES (2) | ES2506265T3 (sl) |
| FR (1) | FR2939136B1 (sl) |
| HR (1) | HRP20120954T1 (sl) |
| MX (1) | MX2011005479A (sl) |
| PL (2) | PL2373310T3 (sl) |
| PT (1) | PT2373310E (sl) |
| RU (1) | RU2482116C2 (sl) |
| SI (1) | SI2373310T1 (sl) |
| SM (1) | SMT201200057B (sl) |
| WO (1) | WO2010063773A1 (sl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2939135B1 (fr) * | 2008-12-02 | 2010-12-03 | Galderma Res & Dev | Nouveaux composes 4-(azacycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique |
| ES2857549T3 (es) | 2011-03-23 | 2021-09-29 | Trevena Inc | Ligandos de receptores de opioides y métodos para utilizar y obtener los mismos |
| ES2635290T3 (es) * | 2013-02-14 | 2017-10-03 | Galderma Research & Development | Procedimiento de síntesis de compuestos 4-(heterocicloalquil)-benceno-1,3-diol |
| WO2014139080A1 (en) * | 2013-03-12 | 2014-09-18 | Boehringer Ingelheim International Trading (Shanghai) Co., Ltd. | Novel process for the manufacture of 3-oxo-tetrahydrofuran |
| FR3030249B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un polymere et un glycol |
| FR3030251B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un solvant particulier |
| FR3030250B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol et un hydrotrope |
| FR3030252B1 (fr) * | 2014-12-22 | 2018-11-02 | L'oreal | Composition aqueuse comprenant un compose 4-(heterocycloalkyl)-benzene-1,3-diol, un monoalcool en c2-c4 et un glycol |
| JP6873598B2 (ja) * | 2015-12-22 | 2021-05-19 | ロレアル | 活性成分のための改善された局所送達系 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0651619B2 (ja) | 1988-05-09 | 1994-07-06 | 株式会社クラレ | 美白剤 |
| FR2704428B1 (fr) | 1993-04-29 | 1995-06-09 | Oreal | Utilisation de dérivés de la résorcine substitués en position(s) 4, 4 et 5 ou 4 et 6 dans des compositions cosmétiques ou dermopharmaceutiques à action dépigmentante. |
| US6068834A (en) * | 1994-03-04 | 2000-05-30 | The Procter & Gamble Company | Skin lightening compositions |
| BR9803596A (pt) * | 1997-09-23 | 2000-04-25 | Pfizer Prod Inc | Derivados do resorcinol. |
| JPH11255637A (ja) * | 1998-03-13 | 1999-09-21 | Kansai Kouso Kk | チロシナーゼ活性阻害剤及び化粧料 |
| HN2000000033A (es) * | 1999-03-22 | 2001-02-02 | Pfizer Prod Inc | Composicion de resorcinol |
| US6585953B2 (en) * | 2000-09-07 | 2003-07-01 | Wisconsin Alumni Research Foundation | Synthesis of 17F labeled fluoroalkanes |
| DE60106954T2 (de) * | 2000-09-11 | 2005-12-01 | Pfizer Products Inc., Groton | Resorcin-derivate |
| US6852310B2 (en) | 2002-08-23 | 2005-02-08 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
| US6875425B2 (en) * | 2002-12-12 | 2005-04-05 | Unilever Home & Personal Care Usa | Skin lightening agents, compositions and methods |
| US7300646B2 (en) | 2004-02-27 | 2007-11-27 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Skin lightening agents, compositions and methods |
| US20060210498A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives for skin |
| US20060210497A1 (en) | 2005-03-18 | 2006-09-21 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Novel resorcinol derivatives |
| FR2917087B1 (fr) * | 2007-06-05 | 2012-09-21 | Galderma Res & Dev | Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique. |
-
2008
- 2008-12-02 FR FR0858206A patent/FR2939136B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-02 PL PL09796990T patent/PL2373310T3/pl unknown
- 2009-12-02 ES ES12182351.2T patent/ES2506265T3/es active Active
- 2009-12-02 AU AU2009324080A patent/AU2009324080B2/en not_active Ceased
- 2009-12-02 AR ARP090104649A patent/AR074454A1/es unknown
- 2009-12-02 EP EP09796990A patent/EP2373310B1/en not_active Not-in-force
- 2009-12-02 RU RU2011127120/04A patent/RU2482116C2/ru active
- 2009-12-02 PL PL12182351T patent/PL2529735T3/pl unknown
- 2009-12-02 KR KR1020117015284A patent/KR101290504B1/ko active IP Right Grant
- 2009-12-02 PT PT97969901T patent/PT2373310E/pt unknown
- 2009-12-02 MX MX2011005479A patent/MX2011005479A/es active IP Right Grant
- 2009-12-02 ES ES09796990T patent/ES2393916T3/es active Active
- 2009-12-02 CN CN200980148286.5A patent/CN102238948B/zh not_active Expired - Fee Related
- 2009-12-02 EP EP12182351.2A patent/EP2529735B1/en not_active Not-in-force
- 2009-12-02 DK DK09796990.1T patent/DK2373310T3/da active
- 2009-12-02 SI SI200930399T patent/SI2373310T1/sl unknown
- 2009-12-02 US US13/131,161 patent/US8372879B2/en active Active
- 2009-12-02 CA CA2742703A patent/CA2742703C/en active Active
- 2009-12-02 JP JP2011538010A patent/JP5395188B2/ja not_active Expired - Fee Related
- 2009-12-02 WO PCT/EP2009/066267 patent/WO2010063773A1/en active Application Filing
- 2009-12-02 BR BRPI0916504A patent/BRPI0916504B8/pt not_active IP Right Cessation
-
2012
- 2012-11-21 HR HRP20120954AT patent/HRP20120954T1/hr unknown
- 2012-11-30 SM SM201200057T patent/SMT201200057B/it unknown
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