SI2350093T1 - Substituirani tetrahidrotienopiridini kotKCNQ modulatorji za zdravljenje bolečine epilepsije in urinske inkotinence - Google Patents
Substituirani tetrahidrotienopiridini kotKCNQ modulatorji za zdravljenje bolečine epilepsije in urinske inkotinenceInfo
- Publication number
- SI2350093T1 SI2350093T1 SI200930353T SI200930353T SI2350093T1 SI 2350093 T1 SI2350093 T1 SI 2350093T1 SI 200930353 T SI200930353 T SI 200930353T SI 200930353 T SI200930353 T SI 200930353T SI 2350093 T1 SI2350093 T1 SI 2350093T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetrahydrothienopyridines
- kcnq2
- epilepsy
- modulators
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08018617 | 2008-10-24 | ||
PCT/EP2009/007567 WO2010046108A1 (de) | 2008-10-24 | 2009-10-22 | Substituierte 4,5,6,7-tetrahydrothienopyridine als kcnq2/3 modulatoren zur behandlung von schmerz, epilepsie und harninkontinenz |
EP09747793A EP2350093B1 (de) | 2008-10-24 | 2009-10-22 | Substituierte 4,5,6,7-tetrahydrothienopyridine als kcnq2/3 modulatoren zur behandlung von schmerz, epilepsie und harninkontinenz |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2350093T1 true SI2350093T1 (sl) | 2012-11-30 |
Family
ID=40383750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200930353T SI2350093T1 (sl) | 2008-10-24 | 2009-10-22 | Substituirani tetrahidrotienopiridini kotKCNQ modulatorji za zdravljenje bolečine epilepsije in urinske inkotinence |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100105722A1 (sl) |
EP (1) | EP2350093B1 (sl) |
JP (1) | JP2012506395A (sl) |
AU (1) | AU2009306722A1 (sl) |
BR (1) | BRPI0919898A2 (sl) |
CA (1) | CA2739740A1 (sl) |
CY (1) | CY1113373T1 (sl) |
DK (1) | DK2350093T3 (sl) |
ES (1) | ES2392758T3 (sl) |
HR (1) | HRP20120822T1 (sl) |
MX (1) | MX2011003849A (sl) |
PL (1) | PL2350093T3 (sl) |
PT (1) | PT2350093E (sl) |
SI (1) | SI2350093T1 (sl) |
WO (1) | WO2010046108A1 (sl) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2537628T3 (es) | 2010-08-27 | 2015-06-10 | Grünenthal GmbH | 2-Oxiquinolin-3-carboxamidas sustituidas como moduladores de KCNQ2/3 |
TWI552750B (zh) | 2010-08-27 | 2016-10-11 | 歌林達股份有限公司 | 作為kcnq2/3鉀離子通道調節劑之經取代之2-氧基-及2-硫基-二氫喹啉-3-羧醯胺 |
EP2609084A1 (en) * | 2010-08-27 | 2013-07-03 | Grünenthal GmbH | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
TWI565465B (zh) * | 2010-08-27 | 2017-01-11 | 歌林達股份有限公司 | 作為kcnq2/3調節劑之被取代之喹啉-3-甲醯胺 |
BR112013005056A2 (pt) | 2010-09-01 | 2016-05-31 | Gruenenthal Gmbh | 1-oxo-di-hidroisoquinolina-3-carboxamidas substituídas como moduladores kcnq2/3 |
US9168259B2 (en) | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
BR112013010957A2 (pt) | 2010-10-20 | 2016-08-30 | Gruenenthal Gmbh | 6-amino-nicotinamidas substituídas como moduladores kcnq2/3 |
JP6117334B2 (ja) * | 2012-03-23 | 2017-04-19 | メモリアル スローン−ケタリング キャンサー センター | 膵臓癌および関連するがんの5−アシル−6,7−ジヒドロチエノ[3,2−c]ピリジンでの処置 |
CN104428287A (zh) | 2012-04-18 | 2015-03-18 | 格吕伦塔尔有限公司 | 作为kcnq2/3调节剂的取代的含有oh基团的6-氨基-烟酰胺 |
EP2844645A1 (en) | 2012-04-18 | 2015-03-11 | Grünenthal GmbH | Substituted 4-aminobenzamides as kcnq2/3 modulators |
MX2015006689A (es) | 2012-11-28 | 2015-08-20 | Grünenthal GmbH | Carboxamidas especificas como moduladores de kcnq2/3. |
WO2014082738A1 (en) | 2012-11-28 | 2014-06-05 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as kcnq2/3 modulators |
US9248122B2 (en) | 2012-11-28 | 2016-02-02 | Grünenthal GmbH | Heteroquinoline-3-carboxamides as KCNQ2/3 modulators |
WO2021212010A2 (en) * | 2020-04-17 | 2021-10-21 | The Trustees Of Indiana University | Small molecule antiviral drug treatment for human papillomavirus infections |
US11931356B1 (en) | 2022-11-30 | 2024-03-19 | The Trustees Of Indiana University | Compositions and methods for treating human papilloma virus infections |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2733750B1 (fr) * | 1995-05-03 | 1997-06-13 | Synthelabo | Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique |
MXPA03007397A (es) * | 2001-02-20 | 2003-12-04 | Bristol Myers Squibb Co | Moduladores de canales de potasio kcnq y uso de los mismos en tratamiento de migrana y enfermedades mecanicamente relacionadas. |
US7723523B2 (en) * | 2004-05-28 | 2010-05-25 | 4Sc Ag | Tetrahydropyridothiophenes |
AU2005251485A1 (en) * | 2004-06-11 | 2005-12-22 | 4Sc Ag | Tetrahydropyridothiophenes for treating hyperproliferative disorders |
DE102006049452A1 (de) * | 2006-10-17 | 2008-05-08 | Grünenthal GmbH | Substituierte Tetrahydropyrolopiperazin-Verbindungen und deren Verwendung in Arzneimitteln |
WO2009001128A1 (en) * | 2007-06-26 | 2008-12-31 | Astrazeneca Ab | 1,2-cycl0hexane dicarboxamides as cathepsin inhibitors |
-
2009
- 2009-10-22 DK DK09747793.9T patent/DK2350093T3/da active
- 2009-10-22 BR BRPI0919898A patent/BRPI0919898A2/pt not_active IP Right Cessation
- 2009-10-22 SI SI200930353T patent/SI2350093T1/sl unknown
- 2009-10-22 EP EP09747793A patent/EP2350093B1/de not_active Not-in-force
- 2009-10-22 WO PCT/EP2009/007567 patent/WO2010046108A1/de active Application Filing
- 2009-10-22 PL PL09747793T patent/PL2350093T3/pl unknown
- 2009-10-22 PT PT09747793T patent/PT2350093E/pt unknown
- 2009-10-22 ES ES09747793T patent/ES2392758T3/es active Active
- 2009-10-22 JP JP2011532538A patent/JP2012506395A/ja active Pending
- 2009-10-22 MX MX2011003849A patent/MX2011003849A/es active IP Right Grant
- 2009-10-22 CA CA2739740A patent/CA2739740A1/en not_active Abandoned
- 2009-10-22 AU AU2009306722A patent/AU2009306722A1/en not_active Abandoned
- 2009-10-23 US US12/604,534 patent/US20100105722A1/en not_active Abandoned
-
2012
- 2012-10-12 HR HRP20120822AT patent/HRP20120822T1/hr unknown
- 2012-11-05 CY CY20121101053T patent/CY1113373T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
BRPI0919898A2 (pt) | 2016-02-16 |
HRP20120822T1 (hr) | 2012-11-30 |
PL2350093T3 (pl) | 2013-01-31 |
PT2350093E (pt) | 2012-11-02 |
AU2009306722A1 (en) | 2010-04-29 |
CY1113373T1 (el) | 2016-06-22 |
MX2011003849A (es) | 2011-05-23 |
US20100105722A1 (en) | 2010-04-29 |
CA2739740A1 (en) | 2010-04-29 |
WO2010046108A1 (de) | 2010-04-29 |
DK2350093T3 (da) | 2012-11-12 |
EP2350093A1 (de) | 2011-08-03 |
JP2012506395A (ja) | 2012-03-15 |
ES2392758T3 (es) | 2012-12-13 |
EP2350093B1 (de) | 2012-10-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL2350093T3 (pl) | Podstawione 4,5,6,7-tetrahydrotienopirydyny jako modulatory KCNQ2/3 do leczenia bólu, padaczki i nietrzymania moczu | |
EP2173275A4 (en) | APPARATUS AND METHOD FOR TREATING INCONTINENCE TO EFFORT | |
EP2346416A4 (en) | METHOD AND DEVICES FOR TREATING SPINAL STENOSIS | |
IL202015A0 (en) | Methods and compositions for treating skin conditions | |
EP2170309A4 (en) | METHOD AND COMPOSITIONS FOR THE TREATMENT OF DISEASES | |
IL209032A0 (en) | Compositions and methods for treating digestive disorders | |
EP2094180A4 (en) | METHODS AND SYSTEMS FOR TREATING TISSUE SITES USING ELECTROCORPORATION | |
EP2260109A4 (en) | METHODS AND COMPOSITIONS BASED ON MICRO-RNA FOR DIAGNOSING, PROGNOSING AND TREATING PROSTATE-RELATED DISORDERS | |
EP2088952A4 (en) | METHODS AND DEVICES FOR PROCESSING FABRICS | |
EP2229171A4 (en) | METHOD AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN WITH A LOCAL ANESTHETIC | |
EP2176283A4 (en) | METHOD AND COMPOSITIONS FOR TREATING BRAIN DISEASES | |
EP2068999A4 (en) | IMPLANTABLE DEVICE AND METHOD FOR THE TREATMENT OF STERILE CURVES AND OTHER DISEASES | |
EP2083857A4 (en) | METHOD FOR TREATING INTERFERENCE IN CONNECTION WITH MICA | |
EP2073752A4 (en) | IMPLANTABLE DEVICES FOR THE TREATMENT OF INCONTINENCE, AND METHODS OF USE | |
ZA200902213B (en) | Urinary incontinence device applicator | |
HK1162366A1 (en) | Devices and methods for treating and or preventing diseases | |
IL207132A0 (en) | Composition and method for seed treatment use | |
IL202424A (en) | Telomerase activator compounds for use in the treatment of disorders and related conditions | |
GB0718523D0 (en) | Agricultural treatment | |
PL2106774T3 (pl) | Regulowany aplikator dla urządzeń stosowanych przy nietrzymaniu moczu | |
EP2244690A4 (en) | METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND DRESSES | |
EP2272472A4 (en) | Excrement treating apparatus | |
HK1232162A1 (zh) | 治療疼痛症狀及其它失調的化合物 | |
EP2051727A4 (en) | METHOD FOR THE TREATMENT OF FIBROTIC DISEASES AND KELOIDS | |
HK1139856A1 (en) | Methods for treating acute pain |