SI2349352T1 - Uporaba 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5-dihidro-4H-piridazino(4,5-b) indol-1-acetamida kot biomarkerja nivojev perifernega benzodiazepinskega receptorja - Google Patents

Uporaba 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5-dihidro-4H-piridazino(4,5-b) indol-1-acetamida kot biomarkerja nivojev perifernega benzodiazepinskega receptorja

Info

Publication number
SI2349352T1
SI2349352T1 SI200930891T SI200930891T SI2349352T1 SI 2349352 T1 SI2349352 T1 SI 2349352T1 SI 200930891 T SI200930891 T SI 200930891T SI 200930891 T SI200930891 T SI 200930891T SI 2349352 T1 SI2349352 T1 SI 2349352T1
Authority
SI
Slovenia
Prior art keywords
bćindole
biomarker
acetamide
dihydro
trimethyl
Prior art date
Application number
SI200930891T
Other languages
English (en)
Inventor
Jesus Benavides
Herve Boutin
Marie-Noelle Castel
Annelaure Damont
Frederic Dolle
Philippe Hantraye
Frank Marguet
Thomas Rooney
Luc Rivron
Bertrand Tavitian
Cyrille Thominiaux
Original Assignee
Sanofi, 54 Rue La Boetie
Commissariat A L'energie Atomique Et Aux Energies Alternatives
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi, 54 Rue La Boetie, Commissariat A L'energie Atomique Et Aux Energies Alternatives filed Critical Sanofi, 54 Rue La Boetie
Publication of SI2349352T1 publication Critical patent/SI2349352T1/sl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI200930891T 2008-10-28 2009-10-27 Uporaba 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5-dihidro-4H-piridazino(4,5-b) indol-1-acetamida kot biomarkerja nivojev perifernega benzodiazepinskega receptorja SI2349352T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08291013A EP2181717A1 (en) 2008-10-28 2008-10-28 Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
PCT/IB2009/007562 WO2010049819A1 (en) 2008-10-28 2009-10-27 Use of 7-chloro-n,n,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4h-pyridazino[4,5-b]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels
EP09760593.5A EP2349352B1 (en) 2008-10-28 2009-10-27 Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Publications (1)

Publication Number Publication Date
SI2349352T1 true SI2349352T1 (sl) 2014-07-31

Family

ID=40262247

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930891T SI2349352T1 (sl) 2008-10-28 2009-10-27 Uporaba 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5-dihidro-4H-piridazino(4,5-b) indol-1-acetamida kot biomarkerja nivojev perifernega benzodiazepinskega receptorja

Country Status (32)

Country Link
US (2) US20120039816A1 (sl)
EP (2) EP2181717A1 (sl)
JP (1) JP5743894B2 (sl)
KR (2) KR20110098711A (sl)
CN (1) CN102223899B (sl)
AR (1) AR073983A1 (sl)
AU (1) AU2009309339C1 (sl)
BR (1) BRPI0920412A2 (sl)
CA (1) CA2741620C (sl)
CL (2) CL2011000954A1 (sl)
CO (1) CO6382141A2 (sl)
CY (1) CY1115211T1 (sl)
DK (1) DK2349352T3 (sl)
EA (1) EA020612B1 (sl)
ES (1) ES2452665T3 (sl)
HK (1) HK1161686A1 (sl)
HR (1) HRP20140250T1 (sl)
IL (1) IL212473A (sl)
MA (1) MA32803B1 (sl)
ME (2) ME01128B (sl)
MX (1) MX2011004420A (sl)
MY (1) MY152968A (sl)
NZ (1) NZ592479A (sl)
PL (1) PL2349352T3 (sl)
PT (1) PT2349352E (sl)
RS (1) RS53273B (sl)
SI (1) SI2349352T1 (sl)
SM (1) SMT201400070B (sl)
TW (1) TWI450728B (sl)
UY (1) UY32206A (sl)
WO (1) WO2010049819A1 (sl)
ZA (1) ZA201103082B (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
WO2022155473A1 (en) * 2021-01-15 2022-07-21 Minnetronix Neuro, Inc. Systems and methods for managing, monitoring, and treating patient conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
JP4362457B2 (ja) * 2005-04-26 2009-11-11 独立行政法人科学技術振興機構 神経因性疼痛治療剤
EP2752415B8 (en) * 2006-08-24 2017-11-15 Australian Nuclear Science & Technology Organisation Fluorinated ligands for targeting peripheral benzodiazepine receptors
EP2120717A1 (en) * 2007-03-12 2009-11-25 National Institute of Radiological Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
EP1997515A1 (en) * 2007-05-30 2008-12-03 Bayer Schering Pharma Aktiengesellschaft Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation

Also Published As

Publication number Publication date
KR20110098711A (ko) 2011-09-01
CA2741620A1 (en) 2010-05-06
ES2452665T3 (es) 2014-04-02
MX2011004420A (es) 2011-11-18
AU2009309339B2 (en) 2015-08-27
AU2009309339C1 (en) 2016-01-14
HK1161686A1 (en) 2012-08-03
BRPI0920412A2 (pt) 2015-12-22
MY152968A (en) 2014-12-15
EP2181717A1 (en) 2010-05-05
CY1115211T1 (el) 2017-01-04
CN102223899A (zh) 2011-10-19
HRP20140250T1 (hr) 2014-06-20
TWI450728B (zh) 2014-09-01
RS53273B (en) 2014-08-29
ME01819B (me) 2014-09-20
JP5743894B2 (ja) 2015-07-01
CO6382141A2 (es) 2012-02-15
AU2009309339A1 (en) 2010-05-06
UY32206A (es) 2010-05-31
IL212473A0 (en) 2011-06-30
MA32803B1 (fr) 2011-11-01
WO2010049819A1 (en) 2010-05-06
US20170160287A1 (en) 2017-06-08
EA020612B1 (ru) 2014-12-30
IL212473A (en) 2015-01-29
CN102223899B (zh) 2014-08-27
WO2010049819A8 (en) 2011-05-26
AR073983A1 (es) 2010-12-15
SMT201400070B (it) 2014-07-07
CL2011000954A1 (es) 2012-01-20
ME01128B (me) 2013-03-20
PL2349352T3 (pl) 2014-05-30
KR20160070846A (ko) 2016-06-20
CA2741620C (en) 2016-08-16
DK2349352T3 (da) 2014-03-31
CL2013001041A1 (es) 2014-01-24
ZA201103082B (en) 2013-01-30
EA201170613A1 (ru) 2011-12-30
NZ592479A (en) 2013-03-28
PT2349352E (pt) 2014-04-03
US20120039816A1 (en) 2012-02-16
EP2349352A1 (en) 2011-08-03
TW201029671A (en) 2010-08-16
JP2012507031A (ja) 2012-03-22
EP2349352B1 (en) 2013-12-25

Similar Documents

Publication Publication Date Title
EP2309333A4 (en) TONER
EP2287673A4 (en) TONER
EP2249208A4 (en) TONER
EP2249207A4 (en) TONER POWDER
EP2262719A4 (en) CELL CUSHION
IL212551A0 (en) Cxcr4 receptor compounds
EP2345935A4 (en) TONER
EP2309334A4 (en) TONER CYAN
EP2256557A4 (en) TONER
EP2312947A4 (en) TRPV4 Antagonist
HK1163063A1 (en) Novel pyrazole-3-carboxamide derivate having 5-ht2b receptor antagonist activity 5-ht2b -3-
EP2319000A4 (en) DISCOVERING ALTERNATIVE USER EXPERIENCES FOR WEBSITES
EP2259925A4 (en) IMPROVED FLEXO CUSHIONS
ZA201105184B (en) Biomarker
SI2349352T1 (sl) Uporaba 7-kloro-N,N,5-trimetil-4-okso-3-fenil-3,5-dihidro-4H-piridazino(4,5-b) indol-1-acetamida kot biomarkerja nivojev perifernega benzodiazepinskega receptorja
IL207700A0 (en) 3-aminoalkyl-1,4-diazepan-2-one melanocortin -5 receptor antagonists
IL207701A0 (en) 3-substituted-1,4-diazepan-2-one melanocortin-5 receptor antagonists
IL209007A0 (en) Allosteric enhancers of the a1 adenosine receptor
GB0712805D0 (en) Pils ring
GB0712954D0 (en) Pils ring
GB0713023D0 (en) Pils ring
GB0820777D0 (en) Tint bowl
GB0817414D0 (en) Sutassist-suture ring
HU0800231V0 (en) Biceps pad
AU323932S (en) Key ring