CO6382141A2 - Uso de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1-acetamida como biomarcador de los niveles del receptor perisferico de benzodiazepinas - Google Patents

Uso de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1-acetamida como biomarcador de los niveles del receptor perisferico de benzodiazepinas

Info

Publication number
CO6382141A2
CO6382141A2 CO11051319A CO11051319A CO6382141A2 CO 6382141 A2 CO6382141 A2 CO 6382141A2 CO 11051319 A CO11051319 A CO 11051319A CO 11051319 A CO11051319 A CO 11051319A CO 6382141 A2 CO6382141 A2 CO 6382141A2
Authority
CO
Colombia
Prior art keywords
acetamide
trimethyl
oxo
phenyl
perispheric
Prior art date
Application number
CO11051319A
Other languages
English (en)
Inventor
Jesus Benavides
Herve Boutin
Cyrille Thominiaux
Bertrand Tavitian
Luc Ryvron
Thomas Rooney
Frank Marguet
Philippe Hantraye
Frederic Dolle
Annelaure Damont
Arias Mariela Castellanos
Original Assignee
Sanofi Aventis
Commissariat Energie Atomique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis, Commissariat Energie Atomique filed Critical Sanofi Aventis
Publication of CO6382141A2 publication Critical patent/CO6382141A2/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de una forma radiomarcada de 7-cloro-N,N, 5-trimetil-4-oxo-3-fenil-3,5-dihidro-4H-piridazino[4,5-b]indol-1-acetamida como biomarcador para la detección, en un individuo, de los niveles de PBR asociados con estados normales y patológicos. Método para la detección de los niveles de PBR asociados con estados normales y patológicos. Kit de diagnóstico.
CO11051319A 2008-10-28 2011-04-27 Uso de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1-acetamida como biomarcador de los niveles del receptor perisferico de benzodiazepinas CO6382141A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08291013A EP2181717A1 (en) 2008-10-28 2008-10-28 Use of 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-B]indole-1-acetamide as a biomarker of peripheral benzodiazepine receptor levels

Publications (1)

Publication Number Publication Date
CO6382141A2 true CO6382141A2 (es) 2012-02-15

Family

ID=40262247

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11051319A CO6382141A2 (es) 2008-10-28 2011-04-27 Uso de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1-acetamida como biomarcador de los niveles del receptor perisferico de benzodiazepinas

Country Status (32)

Country Link
US (2) US20120039816A1 (es)
EP (2) EP2181717A1 (es)
JP (1) JP5743894B2 (es)
KR (2) KR20160070846A (es)
CN (1) CN102223899B (es)
AR (1) AR073983A1 (es)
AU (1) AU2009309339C1 (es)
BR (1) BRPI0920412A2 (es)
CA (1) CA2741620C (es)
CL (2) CL2011000954A1 (es)
CO (1) CO6382141A2 (es)
CY (1) CY1115211T1 (es)
DK (1) DK2349352T3 (es)
EA (1) EA020612B1 (es)
ES (1) ES2452665T3 (es)
HK (1) HK1161686A1 (es)
HR (1) HRP20140250T1 (es)
IL (1) IL212473A (es)
MA (1) MA32803B1 (es)
ME (2) ME01128B (es)
MX (1) MX2011004420A (es)
MY (1) MY152968A (es)
NZ (1) NZ592479A (es)
PL (1) PL2349352T3 (es)
PT (1) PT2349352E (es)
RS (1) RS53273B (es)
SI (1) SI2349352T1 (es)
SM (1) SMT201400070B (es)
TW (1) TWI450728B (es)
UY (1) UY32206A (es)
WO (1) WO2010049819A1 (es)
ZA (1) ZA201103082B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201016038D0 (en) * 2010-09-24 2010-11-10 Ge Healthcare Ltd In vivo imaging method
GB201016411D0 (en) * 2010-09-30 2010-11-10 Ge Healthcare Ltd In vivo imaging method for cancer
CA3208480A1 (en) * 2021-01-15 2022-07-21 Minnetronix Neuro, Inc. Systems and methods for managing, monitoring, and treating patient conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2766823B1 (fr) 1997-07-30 1999-10-08 Synthelabo Derives de 4-oxo-3,5-dihydro-4h-pyridazino[4,5-b] indole-1-acetamide, leur preparation et leur application en therapeutique
FR2788696B1 (fr) 1999-01-26 2004-03-05 Synthelabo Utilisation de derives de pyridazino [4,5-b] indole-1-acetamide pour la preparation de medicaments destines aux maladies du systeme nerveux central
JP4362457B2 (ja) * 2005-04-26 2009-11-11 独立行政法人科学技術振興機構 神経因性疼痛治療剤
EP2752415B8 (en) * 2006-08-24 2017-11-15 Australian Nuclear Science & Technology Organisation Fluorinated ligands for targeting peripheral benzodiazepine receptors
US20100055036A1 (en) * 2007-03-12 2010-03-04 National Institute of Radiolotgical Sciences Pet visualization of amyloid-associated neuroinflammation in the brain
EP1997515A1 (en) * 2007-05-30 2008-12-03 Bayer Schering Pharma Aktiengesellschaft Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation

Also Published As

Publication number Publication date
RS53273B (en) 2014-08-29
CY1115211T1 (el) 2017-01-04
KR20110098711A (ko) 2011-09-01
MA32803B1 (fr) 2011-11-01
PL2349352T3 (pl) 2014-05-30
DK2349352T3 (da) 2014-03-31
ME01128B (me) 2013-03-20
CL2013001041A1 (es) 2014-01-24
JP2012507031A (ja) 2012-03-22
TW201029671A (en) 2010-08-16
AU2009309339B2 (en) 2015-08-27
EP2181717A1 (en) 2010-05-05
WO2010049819A1 (en) 2010-05-06
SI2349352T1 (sl) 2014-07-31
NZ592479A (en) 2013-03-28
JP5743894B2 (ja) 2015-07-01
UY32206A (es) 2010-05-31
PT2349352E (pt) 2014-04-03
MX2011004420A (es) 2011-11-18
CA2741620C (en) 2016-08-16
MY152968A (en) 2014-12-15
SMT201400070B (it) 2014-07-07
AU2009309339C1 (en) 2016-01-14
US20170160287A1 (en) 2017-06-08
ZA201103082B (en) 2013-01-30
EA020612B1 (ru) 2014-12-30
CN102223899A (zh) 2011-10-19
KR20160070846A (ko) 2016-06-20
US20120039816A1 (en) 2012-02-16
EP2349352A1 (en) 2011-08-03
TWI450728B (zh) 2014-09-01
CN102223899B (zh) 2014-08-27
IL212473A0 (en) 2011-06-30
HRP20140250T1 (hr) 2014-06-20
IL212473A (en) 2015-01-29
ME01819B (me) 2014-09-20
EA201170613A1 (ru) 2011-12-30
AU2009309339A1 (en) 2010-05-06
CA2741620A1 (en) 2010-05-06
EP2349352B1 (en) 2013-12-25
AR073983A1 (es) 2010-12-15
BRPI0920412A2 (pt) 2015-12-22
HK1161686A1 (en) 2012-08-03
CL2011000954A1 (es) 2012-01-20
WO2010049819A8 (en) 2011-05-26
ES2452665T3 (es) 2014-04-02

Similar Documents

Publication Publication Date Title
WO2009037572A3 (en) Biomarker combinations for colorectal cancer
IL254062B (en) Kits containing ptk7 antibody and their use in the treatment, detection, diagnosis or monitoring of cancer
MX2019015159A (es) Composiciones, metodos y usos para asistir en el diagnostico, pronostico y tratamiento de la fibrosis pulmonar idiopatica.
CR20110069A (es) Agentes de fijacion al receptor notch1 y metodos para el uso de los mismos
PL2341341T3 (pl) Elektrochemiczny pasek testowy, elektrochemiczny układ testowy i sposób przeprowadzania pomiarów z ich wykorzystaniem
ZA201004112B (en) Non-destructive testing,in particular for tubes during manufacture or in the finished state
BRPI0914632A2 (pt) métodos e aparelhos para uso com rádio e navegação de modo comutável
HK1154052A1 (en) Kits for diagnosing prostate conditions
BR112012033231A2 (pt) peças revestidas e seu uso
GB201305388D0 (en) Benchmarks for normal cell identification
MY160945A (en) Use of accommodative error measurements in providing ophthalmic lenses
AR087363A1 (es) Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
WO2012122374A3 (en) Non-invasive methods for diagnosing chronic organ transplant rejection
BRPI1015927A2 (pt) Kit e método para diagnosticar uma doença de tireoide e método para diagnosticar o hipotireoidismo, bem como célula e seu uso
CO6382141A2 (es) Uso de 7-cloro-n,n,5-trimetil-4-oxo-3-fenil-3,5-dihidro-4h-piridazino[4,5-b]indol-1-acetamida como biomarcador de los niveles del receptor perisferico de benzodiazepinas
GB201114909D0 (en) Biomarkers for lysosomal storage disorders
AU324728S (en) Automobile tyre
BRPI0924560A2 (pt) Métodos e kits para detectar, diagnosticar e monitorar doenças
EP2384440A4 (en) SYNTHETIC PEPTIDES, METHODS AND KITS FOR THE DIAGNOSIS OF AUTOIMMUNE DISEASES
EA201071203A1 (ru) Комбинациия дронедарона по меньшей мере с одним диуретиком, её применение в терапии
WO2012030738A3 (en) Complex phosphoprotein activation profiles
AU324729S (en) Automobile tyre
AU324730S (en) Automobile tyre
AU324731S (en) Automobile tyre
GB0700425D0 (en) High discriminating power biomarker diagnosing

Legal Events

Date Code Title Description
FG Application granted