SI2254890T1 - Postopek za diastereoizomerno ločitev 5-metiltetrahidrofolne kisline - Google Patents

Postopek za diastereoizomerno ločitev 5-metiltetrahidrofolne kisline

Info

Publication number
SI2254890T1
SI2254890T1 SI200831452T SI200831452T SI2254890T1 SI 2254890 T1 SI2254890 T1 SI 2254890T1 SI 200831452 T SI200831452 T SI 200831452T SI 200831452 T SI200831452 T SI 200831452T SI 2254890 T1 SI2254890 T1 SI 2254890T1
Authority
SI
Slovenia
Prior art keywords
methyltetrahydrofolic acid
diastereoisomeric
resolution
diastereoisomeric resolution
methyltetrahydrofolic
Prior art date
Application number
SI200831452T
Other languages
English (en)
Inventor
Ermanno Valoti
Davide Bianchi
Marco Valetti
Original Assignee
Gnosis S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gnosis S.P.A. filed Critical Gnosis S.P.A.
Publication of SI2254890T1 publication Critical patent/SI2254890T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
SI200831452T 2008-02-20 2008-02-20 Postopek za diastereoizomerno ločitev 5-metiltetrahidrofolne kisline SI2254890T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08709117.9A EP2254890B1 (en) 2008-02-20 2008-02-20 Process for the diastereoisomeric resolution of 5-methyltetrahydrofolic acid
PCT/EP2008/052034 WO2009103333A1 (en) 2008-02-20 2008-02-20 Process for the diastereoisomeric resolution of 5-methyltetrahydrofolic acid

Publications (1)

Publication Number Publication Date
SI2254890T1 true SI2254890T1 (sl) 2015-08-31

Family

ID=39938455

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200831452T SI2254890T1 (sl) 2008-02-20 2008-02-20 Postopek za diastereoizomerno ločitev 5-metiltetrahidrofolne kisline

Country Status (10)

Country Link
EP (1) EP2254890B1 (sl)
CY (1) CY1116434T1 (sl)
DK (1) DK2254890T3 (sl)
ES (1) ES2541314T3 (sl)
HR (1) HRP20150747T1 (sl)
HU (1) HUE026535T2 (sl)
PL (1) PL2254890T3 (sl)
PT (1) PT2254890E (sl)
SI (1) SI2254890T1 (sl)
WO (1) WO2009103333A1 (sl)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104530051B (zh) * 2012-01-20 2016-08-24 连云港金康和信药业有限公司 稳定的(6r,s)-5-甲基四氢叶酸晶型及其制备方法
CN102775408B (zh) * 2012-01-20 2015-09-02 连云港金康医药科技有限公司 稳定的5-甲基四氢叶酸晶型及其制备方法
DE202015100275U1 (de) 2015-01-22 2015-03-10 Mibe Gmbh Arzneimittel Nährstoffzubereitung zur Vitalisierung
WO2018172243A1 (en) * 2017-03-20 2018-09-27 Merck Patent Gmbh Isomerically pure 18f-labelled tetrahydrofolates
EP3646873A1 (en) * 2018-10-31 2020-05-06 Aprofol AG Folate salts

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH680731A5 (sl) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
EP0627435A1 (en) 1993-06-01 1994-12-07 ACS DOBFAR S.p.A. Method for the industrial preparation of (6S) folic acid derivatives by chromatographic separation
CN101143863B (zh) * 2006-09-13 2010-08-11 南京莱因医药科技有限公司 5-甲基四氢叶酸的拆分及其成盐方法

Also Published As

Publication number Publication date
PT2254890E (pt) 2015-07-31
WO2009103333A1 (en) 2009-08-27
EP2254890A1 (en) 2010-12-01
HUE026535T2 (en) 2016-06-28
DK2254890T3 (da) 2015-07-13
ES2541314T3 (es) 2015-07-17
HRP20150747T1 (hr) 2015-08-14
EP2254890B1 (en) 2015-04-08
PL2254890T3 (pl) 2015-10-30
CY1116434T1 (el) 2017-02-08

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