SI22465A - New combination of water soluble forms of coenzyme q10 and l-carnitin, procedure of preparation and application - Google Patents
New combination of water soluble forms of coenzyme q10 and l-carnitin, procedure of preparation and application Download PDFInfo
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- SI22465A SI22465A SI200700060A SI200700060A SI22465A SI 22465 A SI22465 A SI 22465A SI 200700060 A SI200700060 A SI 200700060A SI 200700060 A SI200700060 A SI 200700060A SI 22465 A SI22465 A SI 22465A
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- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims abstract description 89
- 238000002360 preparation method Methods 0.000 title claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 41
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 title abstract description 4
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 92
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 92
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
NOVA KOMBINACIJA VODOTOPIH OBLIK KOENCIMA Q10 IN L-KARNITINA, POSTOPEK PRIPRAVE IN UPORABANEW COMBINATION OF WATER SOLUBLE FORMS Q10 AND L-CARNITINE, PREPARATION AND USE PROCEDURE
Predmet izuma je nova kombinacija oz. zmes vodotopnih oblik koencima Q10 in Lkarnitina, postopek priprave zmesi in izdelkov na osnovi te zmesi in uporaba zmesi in izdelkov na osnovi te zmesi.The subject of the invention is a new combination or. a mixture of water-soluble forms of coenzyme Q10 and Lkarnitine, a process for preparing mixtures and articles based on this mixture, and the use of mixtures and articles based on this mixture.
Izum se nanaša na kombinacije oz. zmesi različnih vodotopnih oblik koencima Q10 in Lkarnitina. Izum se nanaša tudi na postopke priprave teh zmesi in uporabo v obliki samostojnih pripravkov ali kot dodatkov farmacevtskim, kozmetičnim in prehrambenim izdelkom. Izum se nanaša tudi na farmacevtske, kozmetične in prehrambene izdelke, ki vsebujejo vsaj eno od vodotopnih oblik koencima Q10 v kombinaciji z L-karnitinom ter uporabo le-teh.The invention relates to combinations or. mixtures of different water soluble forms of coenzyme Q10 and Lkarnitine. The invention also relates to processes for the preparation of these mixtures and for use in the form of stand-alone preparations or as supplements to pharmaceutical, cosmetic and food products. The invention also relates to pharmaceutical, cosmetic and nutritional products containing at least one of the water-soluble forms of coenzyme Q10 in combination with L-carnitine, and the use thereof.
V nadaljevanju bodo uporabljene naslednje enakopomenke:The following equivalents will be used below:
- za koencim Q10: CoQ10,- for coenzyme Q10: CoQ10,
- za L-karnitin: LC- for L-carnitine: LC
CoQ10 in LC sta snovi, ki sta neobhodni za tvorbo energije v celicah živih organizmov, torej sta neobhodni za življenje. Človek zagotavlja zadostne količine obeh v organizmu s sintezo in prehrano, vendar pa je vse bolj jasno, da je pogosto potreben vnos večjih količin eksogenega CoQ10 in LC, kot jih je mogoče zagotoviti z običajno prehrano. Zlasti je to pomembno pri večjih naporih, v starejših letih, v primeru nekaterih bolezni, neustrezni prehrani ipd. Zato se vse bolj uveljavlja fortificirana hrana in različnimi pripravki s CoQ10 oz. LC, pri čemer se priporočeni dnevni odmerki gibljejo za CoQ10 od ca 10 mg do več sto mg, za LC pa od nekaj sto mg do 2 g in več. Obe snovi se uveljavljata tudi v kozmetiki.CoQ10 and LC are substances that are essential for the production of energy in the cells of living organisms, and therefore are essential for life. Man provides sufficient amounts of both in the body through synthesis and nutrition, but it is increasingly clear that the intake of exogenous CoQ10 and LC is often required than can be assured by a normal diet. This is especially important in the case of increased effort, in older years, in the case of certain diseases, inadequate nutrition, etc. Therefore fortified foods and various preparations with CoQ10 or more are becoming increasingly popular. LC, with recommended daily doses ranging from about 10 mg to several hundred mg for CoQ10 and from several hundred mg to 2 g and above for LC. Both substances are also used in cosmetics.
CoQ10 in LC delujeta v organizmu sinergistično. CoQ10 je namreč ključni koencim v več stopnjah pretvorbe hrane v celično energijo v mitohondrijih, medtem ko L-karnitin omogoča oz. pospešuje prenos maščob v mitohondrije in odstranjevanje izgorelih ostankov maščob iz notranjosti mitohondrijev. LC torej dovaja energetsko bogate maščobne kisline v mitohondrije, CoQ10 pa omogoča njihovo pretvorbo v energijo in s tem skupaj zagotavljata potrebno energijo organizmu. To je še posebej pomembno za najbolj aktivne organe, kot je npr. srce. Ker se s tem favorizira izraba maščob pred ogljikovimi hidrati, se tudi zmanjša količina maščob v krvi, to pa še dodatno pozitivno vpliva na zdravje človeka. Poleg tega CoQ10 stabilizira celične stene in deluje tudi kot močan antioksidant, kar je posebej pomembno, ker njegova reducirana oblika, ki deluje antioksidativno, nastaja prav na mestu nastajanja prostih radikalov v organizmu. LC pa je pomemben tudi pri odstranjevanju nevrotoksičnega amoniaka iz organizma in s tem preprečuje njegovo kopičenje v krvi ob hujših naporih, ko organizem ne uspe pretvoriti vsega v sečnino; v manjših količinah sicer amonijak povzroča motnje v orientaciji in refleksih, v večjih pa komo ali celo smrt.CoQ10 and LC work synergistically in the body. CoQ10 is a key coenzyme in several stages of food conversion to cellular energy in the mitochondria, while L-carnitine allows or does. accelerates the transfer of fat into the mitochondria and the removal of burned fat residues from inside the mitochondria. LC, therefore, supplies energy-rich fatty acids to mitochondria, and CoQ10 enables them to be converted into energy, thus providing the necessary energy to the body. This is especially important for the most active organs, such as. heart. Because it favors the consumption of fats over carbohydrates, it also reduces the amount of fat in the blood, which has a further positive effect on human health. In addition, CoQ10 stabilizes the cell walls and also acts as a powerful antioxidant, which is especially important because its reduced antioxidant form is generated at the site of free radical formation in the body. LC is also important in the removal of neurotoxic ammonia from the body, thus preventing its accumulation in the blood during a more severe effort when the body fails to convert everything into urea; in smaller amounts, ammonia causes disturbances in orientation and reflexes, and in larger quantities it causes coma or even death.
Zaradi navedenega CoQ10 in LC vsak posebej izjemno pomembno vplivata na delovanje organizma, še posebej srca, krepita organizem, povečujeta psihofizične zmogljivosti, vitalnost in odpornost, preprečujeta oz. lajšata zdravljenje vrste bolezni. Zaradi sinergijskega učinka pa so lahko ob skupni uporabi obeh učinki še bistveno večji oz. se dopolnjujejo, zato je zaželjeno uživanje obeh.Due to the above, CoQ10 and LC each have a particularly important influence on the functioning of the organism, especially the heart, strengthen the organism, increase psychophysical capacities, vitality and resistance, prevent or prevent. facilitate the treatment of a variety of diseases. However, due to the synergistic effect, when combined, the two effects can be significantly larger or larger. they are complementary, so it is desirable to enjoy both.
Vendar pa se CoQ10 in LC bistveno razlikujeta po fizikalnih lastnostih: CoQ10 je lipofilna, torej v vodi netopna snov, medtem ko je LC hidrofilna, torej v vodi dobro topna snov. Zaradi tega je priprava pripravkov, v katerih bi bila oba - CoQ10 in LC skupaj, razmeroma zahtevna, še zlasti v primeru večjih koncentracij. Zato so se uveljavili pripravki, v katerih je ali CoQ10, ali LC, le redki pa so pripravki, v katerih sta prisotna oba hkrati, in še to v razmeroma omejenem koncentracijskem obsegu, to je v malih koncentracijah. Zaradi tega je potrebno ločeno zauživanje oz. uporaba enega in drugega, torej dveh vrst pripravkov oz. več vrst izdelkov, od katerih vsebujejo eni CoQ10, drugi LC, kar obremenjuje uporabnike oz. povzroča vnos večje količine različnih nepotrebnih snovi, ki jih takšni izdelki vsebujejo. Poleg tega uporaba ločenih pripravkov oz. izdelkov, ki temeljijo na različnih osnovah, zmanjšuje sinergistične učinke CoQ10 in LC.However, CoQ10 and LC differ significantly in physical properties: CoQ10 is a lipophilic, ie water-insoluble substance, while LC is hydrophilic, ie a water-soluble substance. This makes the preparation of preparations in which both CoQ10 and LC together would be relatively demanding, especially in the case of higher concentrations. Therefore, preparations containing either CoQ10 or LC have been established, and rarely are preparations in which both are present at a relatively limited concentration range, that is, in low concentrations. Therefore, separate ingestion or administration is required. the use of one or the other, ie two types of preparations, respectively. several types of products, one of which contains CoQ10, the other LC, which puts a heavy burden on users or users. causes the intake of a large amount of the various unnecessary substances contained in such products. In addition, the use of separate preparations or. products based on different bases reduces the synergistic effects of CoQ10 and LC.
Poseben problem, ki doslej ni bil ustrezno rešen, predstavlja priprava takšnih pripravkov na vodni osnovi, ki bi vsebovali hkrati CoQ10 in LC v primernih koncentracijah, oz. takšne rešitve, ki bi omogočale dodajanje obeh v izdelke na vodni osnovi. Zato obstaja stalna potreba po primerni rešitvi problema priprave in uporabe kombinacije CoQ10 in LC, ki bi omogočala enostavno pripravo pripravkov z njima oz. dodajanje obeh v prehranske, farmacevtske in kozmetične izdelke na vodni osnovi.A particular problem that has not been adequately solved so far is the preparation of such water-based preparations containing both CoQ10 and LC at appropriate concentrations, respectively. solutions that would allow both to be added to water-based products. Therefore, there is a continuing need for an adequate solution to the problem of preparation and use of the combination of CoQ10 and LC, which would allow for easy preparation of preparations with them or. adding both to water-based food, pharmaceuticals and cosmetics.
Naloga in cilj izuma je kombinacija oz. zmes CoQ10 in LC, ki bi omogočala pripravo pripravkov, ki bi istočasno vsebovali tako CoQ10 kot LC v primernih koncentracijah oz. ki bi omogočala dodajanje tako Q10 kot LC v prehranske in druge izdelke na vodni osnovi. Naloga in cilj izuma so tudi pripravki, ki vsebujejo CoQ10 in LC ter izdelki na vodni osnovi z dodanim CoQ10 in LC ter postopki priprave. Naloga in cilj izuma je tudi uporaba teh pripravkov in izdelkov.The object and object of the invention is a combination or. a mixture of CoQ10 and LC that would allow the preparation of preparations which simultaneously contain both CoQ10 and LC at appropriate concentrations or concentrations. which would allow for the addition of both Q10 and LC in food and other water based products. The object and object of the invention are also compositions containing CoQ10 and LC and water-based products with added CoQ10 and LC and preparation processes. It is also an object of the invention to use these preparations and products.
Po izumu je naloga rešena s pripravo kombinacij LC in CoQ10 na način, da se LC kombinira s posebnimi oblikami CoQ10, t.j. z oblikami z izboljšano topnostjo v vodi oz. vodotopnimi oblikami. Po izumu je naloga rešena tudi z uporabo takšnih kombinacij za pripravo pripravkov ter dodajanjem obeh komponent v različne izdelke na vodni osnovi ter uporabo kombinacije in izdelkov z njo po neodvisnih patentnih zahtevkih.According to the invention, the task is solved by preparing the combinations of LC and CoQ10 in such a way that the LC is combined with specific forms of CoQ10, i.e. with forms with improved water solubility water-soluble forms. According to the invention, the problem is also solved by the use of such combinations for the preparation of preparations and the addition of both components to different water-based products and the use of the combination and the products thereof according to independent claims.
Izum bo opisan s pomočjo izvedbenih primerov in slik, ki prikazujejo:The invention will be described by way of embodiments and illustrations showing:
Slika 1. Povprečni padec telesne teže skupine prostovoljcev v poskusu.Figure 1. Average weight loss of the volunteer group in the experiment.
Slika 2. Padec vsebnosti maščob (%) in naraščanje procenta vode v organizmu med izvedbo poskusa. Prikazana je srednja vrednost vseh meritev.Figure 2. Decrease in fat content (%) and increase in percentage of water in the body during the experiment. The mean of all measurements is shown.
Slika 3. Spremembe posameznih parametrov med izvajanjem poskusa.Figure 3. Changes in individual parameters during the run of the experiment.
Problem kombiniranja CoQ10 in LC je po izumu rešen tako, da je uporabljena primerna oblika CoQ10 s povečano vodotopnostjo. Bistvo izuma je torej uporaba CoQ10 v primerni obliki s povečano vodotopnostjo, kar omogoča poljubne kombinacije z LC, ki je sam v vodi dobro topen, dodatno pa še z drugimi vodotopnimi snovmi. Uporabimo lahko poljubno obliko CoQ10 s povečano vodotopnostjo, kot so npr. kompleksi CoQ10 z nesubstituiranimi ali substituiranimi beta- in gama-ciklodekstrini, mikro in nano-kapsulirani CoQ10, liposomske oblike ipd., pa tudi oblike, ki tvorijo navidezne raztopine, npr. disperzije oz. emulzije. Tako lahko pripravimo stabilne trdne mešanice CoQ10 in LC v željenem razmerju ali pa mešanice v obliki vodnih raztopin ali suspenzij, ki jih lahko na enostaven način dodajamo v različne prehrambene izdelke na vodni osnovi, kot so mleko, jogurti, skuta, sir in drugi mlečni izdelki, marmelade in džemi, sadni in zelenjavni sokovi in nektarji ter različne pijače, kompoti, kaše, žitni izdelki, čokoladni izdelki, čaji, izdelki iz medu, mesni izdelki in podobno. Podobno jih lahko dodajamo v farmacevtske in kozmetične izdelke na vodni osnovi. Prav tako pa lahko na enostaven način dodajamo CoQ10 z izboljšano vodotopnostjo in LC v te izdelke vsakega posebej, tako da tvorimo zmes obeh šele v samem izdelku. Tako je mogoče na primer v mleko, jogurt, sokove ali kak drug izdelek na vodni osnovi primešati zadostno količino CoQ10 s povečano vodotopnostjo in LC, da odrasel človek v enem obroku zaužije dnevni ali celo večkratni dnevni odmerek CoQ10 in LC. Na analogen način lahko pripravimo tudi različne farmacevtske in kozmetične pripravke in prehranska dopolnila v obliki kapsul, sirupov, raztopin, kapljic, past, gelov, krem, tablet, praškov in drugih oblikah oz. dostavnih sistemih. Poleg kombinacije CoQ10 in LC pa lahko ti izdelki vsebujejo še druge pomožne snovi, zlasti pa biološko pomembne oz. aktivne snovi, kot so vitamini, minerali, antioksidanti, poživila, npr. kofein, idr. Pomožne snovi lahko uporabimo po potrebi za pripravo ustreznih farmacevtskih, kozmetičnih in drugih oblik formuliranih izdelkov, pa tudi kot nosilce pri pripravi trdne oz. prašne oblike kombinacije CoQ10 in LC iz raztopine. Tak primer je uporaba npr. maltodekstrina za pripravo kombinacije CoQ10 in LC v prašni obliki iz raztopine s sušenjem z razpršilnim sušilnikom. Dobljeni prah je zlasti primeren npr. za pripravo kapsul, šumenk, tablet ipd.The problem of combining CoQ10 and LC according to the invention is solved by using a suitable form of CoQ10 with increased water solubility. The essence of the invention is therefore the use of CoQ10 in a suitable form with increased water solubility, which allows any combination with LC, which is well soluble in water itself, and additionally with other water soluble substances. Any form of CoQ10 with increased water solubility such as e.g. CoQ10 complexes with unsubstituted or substituted beta- and gamma-cyclodextrins, micro- and nano-encapsulated CoQ10, liposomal forms, etc., as well as forms forming virtual solutions, e.g. dispersion or. emulsions. In this way, stable solid mixtures of CoQ10 and LC can be prepared in the desired ratio, or mixtures in the form of aqueous solutions or suspensions, which can be easily added to various water-based food products such as milk, yoghurts, curds, cheese and other dairy products. , jams and jams, fruit and vegetable juices and nectars and various beverages, compotes, cashews, cereals, chocolate products, teas, honey products, meat products and the like. Similarly, they can be added to water-based pharmaceuticals and cosmetics. We can also easily add CoQ10 with improved water solubility and LC to these products individually, forming a mixture of both only within the product itself. For example, a sufficient amount of CoQ10 may be mixed into milk, yogurt, juices or other water-based product with increased water solubility and LC to allow an adult to consume daily or even multiple daily doses of CoQ10 and LC in one meal. Different pharmaceutical and cosmetic preparations and nutritional supplements in the form of capsules, syrups, solutions, drops, traps, gels, creams, tablets, powders and other forms or forms can also be prepared in an analogous manner. delivery systems. In addition to the combination of CoQ10 and LC, these products may contain other excipients, and in particular, biologically important ones. active substances such as vitamins, minerals, antioxidants, stimulants, e.g. caffeine, etc. Excipients can be used as needed to prepare suitable pharmaceutical, cosmetic and other formulated formulations, as well as as carriers in the preparation of solid or powder forms of a combination of CoQ10 and LC from solution. An example is the use of e.g. maltodextrin for the preparation of a combination of CoQ10 and LC in powder form from a spray-dried solution. The resulting powder is particularly suitable e.g. for the preparation of capsules, irises, tablets and the like.
S kombinacijo obeh snovi je dosežena enostavnejša aplikacija oz. uporaba, saj je mogoče zaužiti zadostne količine obeh hkrati. Kombinacija oz. izdelki s kombinacijo CoQ10 in LC omogočajo povečane oz. sinergijske učinke obeh komponent, ki jih je mogoče kombinirati še z učinki drugih snovi. Ker izkazujejo oblike CoQ10 s povečano vodotopnostjo praviloma večjo biorazpoložljivost, je kombinacija takšnih oblik z LC še toliko učinkovitejša, kot bi bila sicer. Zato se predmetna kombinacija lahko uporablja za doseganje povečanja različnih sistemskih in lokalnih učinkov, med drugim v preventivi in terapiji kardiovaskularnih bolezni, zvišanega holesterola, diabetesa, raka, imunskih bolezni, mitohondrijskih bolezni, distrofije mišic, bolezni ustne votline, izboljšanje psihofizičnih zmogljivosti idr., pa tudi za hujšanje, odpravljanje celulita ipd. Zaradi uporabe vodotopnih oblik, za katere je v splošnem znana boljša biorazpoložljivost, so ti učinki dodatno povečani glede na ločeno uporabo obeh snovi.The combination of both substances results in a simpler application or application. use as sufficient amounts of both can be consumed at the same time. The combination or. products with the combination of CoQ10 and LC allow increased or synergistic effects of both components, which can be combined with the effects of other substances. As CoQ10 forms with increased water solubility generally exhibit greater bioavailability, the combination of such forms with LC is even more effective than it would otherwise be. Therefore, the subject combination can be used to achieve an increase in various systemic and local effects, including in the prevention and therapy of cardiovascular disease, high cholesterol, diabetes, cancer, immune diseases, mitochondrial diseases, muscular dystrophy, oral cavity disease, improvement of psychophysical capacities, etc., as well as for weight loss, eliminating cellulite and the like. Due to the use of water-soluble forms, which are generally known to have better bioavailability, these effects are further enhanced by the separate use of the two substances.
Zato se izum nanaša na kombinacije vodotopnih oblik CoQ10 oz. oblik CoQ10 s povečano vodotopnostjo in LC, pripravo in uporabo kombinacije za dodajanje v izdelke oz. pripravo in uporabo prehrambenih, farmacevtskih in kozmetičnih izdelkov s kombinacijo oz. zmesjo po izumu samo oz. z dodanimi pomožnimi oz. drugimi aktivnimi snovmi.Therefore, the invention relates to combinations of water-soluble forms of CoQ10 or. forms of CoQ10 with increased water solubility and LC, preparation and use of the combination for addition to products or preparation and use of food, pharmaceutical and cosmetic products with a combination of the mixture according to the invention only or. with the added auxiliary respectively. other active substances.
Izum se nanaša tudi na uporabo kombinacije in izdelkov z njo v zvezi s funkcijami človekovega organizma, ki so povezane s koencimom Q10 in LC.The invention also relates to the use of the combination and its products in relation to the functions of the human organism that are related to the coenzyme Q10 and LC.
Izum pojasnjujejo, vendar ne omejujejo izvedbeni primeri.The invention is explained but not limited to the embodiments.
Uporabljen je bil CoQ10 z izboljšano topnostjo v vodi Q10Vital (Valens Int., Slovenija), AllQ (DSM, Nizozemska), ProQusan (Nemčija), NanoQ (Kitajska), Novasol (Italija), kofein brezvodni (Fluka, Švica), ribezovi antociani (Kemijski inštitut, Slovenija), sadni sirupi in sokovi Fructal (Slovenija), Alpsko mleko (Ljubljanske mlekarne, Slovenija), probiotični jogurti Ego (Celjske Mlekarne, Slovenija) in Actimel (Danone, Francija).CoQ10 with improved water solubility Q10Vital (Valens Int., Slovenia), AllQ (DSM, Netherlands), ProQusan (Germany), NanoQ (China), Novasol (Italy), caffeine anhydrous (Fluka, Switzerland), currant anthocyanins was used (Chemical Institute, Slovenia), Fructal fruit juices and juices, Alpine milk (Ljubljanske mlekarne, Slovenia), Ego probiotic yoghurts (Celje dairies, Slovenia) and Actimel (Danone, France).
PRIMER 1 - Priprava tekoče zmesi CoQ10 in LCEXAMPLE 1 - Preparation of CoQ10 and LC liquid mixture
V vodne raztopine CoQ10 s povečano vodotopnostjo (Q10Vital, 7,3%, 100 g) med mešanjem pri sobni temperaturi dodamo po 73, 146 oz. 365 g LC. Dobimo stabilne vodne zmesi CoQ10 in LC v utežnih razmerjih 1:10, 1:20 in 1:50. Po potrebi pasteriziramo pri temperaturi 80-85°C 15 min. Zmesi hranimo v hladilniku; HPLC analiza pokaže, da se koncentracije v 4 mesecih praktično ne spremenijo. Na analogen način pripravimo tudi zmesi v drugih razmerjih, po potrebi dodamo vodo.To CoQ10 aqueous solutions with increased water solubility (Q10Vital, 7.3%, 100 g) were added 73, 146, respectively, while stirring at room temperature. 365 g LC. Stable aqueous mixtures of CoQ10 and LC are obtained in weight ratios of 1:10, 1:20 and 1:50. If necessary, pasteurize at 80-85 ° C for 15 min. The mixtures are refrigerated; HPLC analysis showed that concentrations did not change practically within 4 months. Mixtures in other proportions are prepared in an analogous manner, and water is added as needed.
Dobljene zmesi uporabimo za pripravo razredčenih vodnih raztopin, dodajanje v različne izdelke oz. za pripravo različnih izdelkov.The resulting mixtures are used for the preparation of dilute aqueous solutions, for addition to various products, respectively. to prepare different products.
PRIMER 2 - Priprava vodne raztopine CoQ10 in LCEXAMPLE 2 - Preparation of CoQ10 and LC aqueous solution
V vodi (100 mL) med mešanjem raztopimo najprej LC (201 mg) in nato pa še CoQ10 (AllQ, 10%, 20,6 mg), tako da dobimo stabilno raztopino CoQ10 in LC v razmerju ca 1:100. Raztopino hranimo v hladilniku.Dissolve LC (201 mg) and then CoQ10 (AllQ, 10%, 20.6 mg) in water (100 mL) while stirring to obtain a stable solution of CoQ10 and LC at a ratio of ca 1: 100. Store the solution in the refrigerator.
PRIMER 3 - Priprava sadnega napitka s CoQ10, LC in kofeinomEXAMPLE 3 Preparation of Fruit Drink with CoQ10, LC and Caffeine
LC (20 g), kofein (2 g) in CoQ10 z izboljšano vodotopnostjo (560 mg) vmešamo v 500 mL sadnega malinovega sirupa (33% z dodatkom citronske kisline). Nato v dobljeno zmes dodamo med mešanjem še 500 mL sirupa ter mešamo do homogenosti. Tako dobimo sirup s ca 20 mg LC/mL, 2 mg kofeina/mL in 0,56 mg CoQ10/mL. Sirup hranimo v temni steklenici hladilniku. Uporabimo ga samega ali razredčenega z vodo v razmerju ca 1:10.LC (20 g), caffeine (2 g) and CoQ10 were mixed with improved water solubility (560 mg) in 500 mL of raspberry fruit syrup (33% with citric acid). Then another 500 mL of syrup was added to the resulting mixture while stirring until homogeneous. Syrup is thus obtained with ca 20 mg LC / mL, 2 mg caffeine / mL and 0.56 mg CoQ10 / mL. Keep the syrup in a dark bottle in the refrigerator. It is used alone or diluted with water in a ratio of ca 1:10.
PRIMER 4 - Testiranje napitka s CoQ10, LC in kofeinomEXAMPLE 4 - Testing a beverage with CoQ10, LC and caffeine
Naključno izbrani prostovoljci (5 moških in 15 žensk, 29-61 let) so 5 tednov uživali napitek iz primera 3 dvakrat dnevno po 40-50 mL. Spremljana je bila telesna teža, krvni tlak ter razmerje maščob in vode v telesu ter ocena splošne vitalnosti ter požitvitve. Prostovoljci so v 81% opazili povečanje splošne vitalnosti in v 74% poživitev do nekaj ur po zaužitju napitka. Ostali rezultati so prikazani na slikah 1-3.The randomly selected volunteers (5 males and 15 females, 29-61 years) consumed 40-50 mL of Case 3 twice daily for 5 weeks. Body weight, blood pressure and the ratio of fat to water in the body were monitored, along with an assessment of overall vitality and recovery. Volunteers observed an increase in general vitality in 81% and a recovery rate of up to a few hours after ingestion in 74%. Other results are shown in Figures 1-3.
PRIMER 5 - Testiranje učinkov na zmanjševanje celulitaEXAMPLE 5 Testing Effects on Cellulite Reduction
Učinki zmesi iz primera 1 (razmerje CoQ10:LC 1:20) na zmanjševanje celulita so bili primerjani z učinki raztopine samega LC v vodi v enaki koncentraciji po dvakrat dnevni aplikciji 4 tedne na kožo stegen z vtiranjem z masažo. Spremljan je bil izgled in obseg stegen. Primerjava začetnih in končnih rezultatov je pokazala v obeh primerih izboljšanje izgleda, vendar v primeru uporabe zmesi bistveno večje. Debelina kožne gube na stegnih se je zmanjšala v primeru LC z 32 mm na 31 mm, v primeru zmesi pa z 32 na 28 mm.The effects of the mixture of Example 1 (CoQ10 ratio: LC 1:20) on cellulite reduction were compared with the effects of the LC solution alone in water at the same concentration after a twice daily application for 4 weeks to the thighs by massage with rubbing. The appearance and circumference of the thighs were monitored. The comparison of the initial and final results showed in both cases an improvement in appearance, but significantly more in the case of the mixture. The thickness of the skin fold on the thighs decreased in the case of LC from 32 mm to 31 mm, and in the case of mixtures from 32 to 28 mm.
PRIMER 6 - Priprava sirupa s CoQ10 in LCEXAMPLE 6 Preparation of CoQ10 and LC Syrup
Tekočo zmes 750 g CoQ10 in 3,75 kg LC v vodi, pripravljeno po analogiji iz Primera 1 dodamo med intenzivnim mešanjem pri temperaturi 30-40° v 33 L naravnega sadnega sirupa gozdnih sadežev. Mešamo še ca 0,5 h, da dobimo homogeni sirup, nato mešanje upočasnimo in mešamo še ca 0,5 h. Dobimo ca 50 L sirupa s koncentracijo ca 15 mg CoQ10/mL in ca 75 mg LC/mL. Sirup je posebej primeren za višje doziranje obeh komponent.A liquid mixture of 750 g CoQ10 and 3.75 kg LC in water, prepared by analogy to Example 1, was added during vigorous stirring at 30-40 ° C in 33 L of natural fruit syrup of forest fruits. Stir for another 0.5 h to obtain a homogeneous syrup, then slow the stirring and stir for another 0.5 h. About 50 L of syrup with a concentration of ca 15 mg CoQ10 / mL and ca 75 mg LC / mL are obtained. The syrup is especially suitable for higher dosage of both components.
Nova kombinacija koencima Q10 in L-karnitina po izumu je značilna po tem, da koencim Q10 v primerni obliki s povečano vodotopnostjo tvori zmes z L-karnitinom. Koencim Q10 in L-karnitin sta v poljubnem razmerju, prednostno v utežnem razmeiju v območju 1:200 do 10:1, še prednostno v razmerju med 1:1 in 1:100. Kombinacija koencima Q10 in Lkarnitina je trdna ali v obliki raztopine oz. suspenzije v vodi ali vodnem mediju in je čista ali z dodatkom drugih pomožnih in/ali biološko aktivnih snovi.The new combination of coenzyme Q10 and L-carnitine according to the invention is characterized in that coenzyme Q10 in a suitable form with increased water solubility forms a mixture with L-carnitine. Coenzyme Q10 and L-carnitine are in any ratio, preferably in a weight ratio in the range of 1: 200 to 10: 1, more preferably in the ratio of 1: 1 to 1: 100. The combination of coenzyme Q10 and lcarnitine is either solid or in solution or form. suspensions in water or aqueous medium and is pure or with the addition of other excipients and / or biologically active substances.
Kombinacija koencima Q10 in L-karnitina po izumu se uporablja za pripravo farmacevtskih, prehranskih in kozmetičnih pripravkov tako, da se ju dodaja ali v predhodno pripravljeni zmesi ali ločeno.The combination of the Q10 and L-carnitine coenzyme of the invention is used for the preparation of pharmaceutical, nutritional and cosmetic preparations by adding them either in a premix or separately.
Priprava izdelkov, ki vsebujejo koencim Q10 in L-karnitin je značilna po tem, da se koencim Q10 in L-karnitin po predhodnih zahtevkih dodaja v primerni fazi priprave izdelkov skupaj ali vsakega posebej.Preparation of products containing coenzyme Q10 and L-carnitine is characterized by the fact that coenzyme Q10 and L-carnitine according to the preceding claims are added at an appropriate stage of preparation of the products together or individually.
Izdelki po izumu vsebujejo kombinacijo koencima Q10 in L-karnitina po izumu. Izdelki lahko vsebujejo poleg koencima Q10 in L-karnitina še druge biološko aktivne in pomožne snovi, kot so vitamini, antioksidanti, poživila ipd.The products of the invention contain a combination of the coenzyme Q10 and the L-carnitine of the invention. The products may contain, in addition to the Q10 and L-carnitine coenzyme, other biologically active and auxiliary substances such as vitamins, antioxidants, stimulants and the like.
Uporaba kombinacije in izdelkov po izumu je značilna po tem, da se uporabljajo za zagotavljanje sinergijskih učinkov koencima Q10 in L-karnitina, predvsem za povečanje psihofizičnih zmogljivosti, zniževanje holesterola in maščob v krvi, zniževanje telesne teže, povečevanje odpornosti, upočasnjevanje procesov staranja, lajšanje znakov mitohondrijskih bolezni, zmanjševanje znakov utrujenosti, in drugih pozitivnih preventivnih in kurativnih učinkov, ki izvirajo iz skupnih učinkov koencima Q10 in L-karnitina. Uporaba kombinacije po izumu se nanaša na hujšanje, odpravljanje celulita, učvrščevanje in pomlajevanje videza kože in druge učinke, povezane z videzom. Izdelki po izumu se uporabljajo kot energetski napitki za poživljanje, zmanjševanje utrujenosti, povečanje vitalnosti ipd.The use of the combination and the products according to the invention is characterized in that they are used to provide synergistic effects of Q10 and L-carnitine coenzymes, in particular for increasing psychophysical capacities, lowering cholesterol and fat in the blood, reducing weight, increasing resistance, slowing down the aging process, alleviating signs of mitochondrial disease, reduction of signs of fatigue, and other positive preventative and curative effects arising from the combined effects of coenzyme Q10 and L-carnitine. The use of the combination according to the invention relates to weight loss, cellulite elimination, firming and rejuvenation of the appearance of the skin and other appearance related effects. The products according to the invention are used as energy drinks for invigorating, reducing fatigue, increasing vitality, etc.
Claims (13)
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| PCT/SI2008/000012 WO2008111919A2 (en) | 2007-03-15 | 2008-02-27 | A novel combination of water-soluble forms of coenzyme q10 and l-carnitine, process of production and use |
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Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI22465A true SI22465A (en) | 2008-10-31 |
| SI22465B SI22465B (en) | 2010-10-29 |
Family
ID=39760234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200700060A SI22465B (en) | 2007-03-15 | 2007-03-15 | New combination of water soluble forms of coenzyme q10 and l-carnitin, procedure of preparation and application |
Country Status (2)
| Country | Link |
|---|---|
| SI (1) | SI22465B (en) |
| WO (1) | WO2008111919A2 (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1317008B1 (en) * | 2000-04-04 | 2003-05-26 | Sigma Tau Healthscience Spa | ENERGIZING FOOD SUPPLEMENT ON SKELETON MUSCULATION AND PROTECTIVE ON THE CARDIOVASCULAR APPARATUS. |
| EP1681053B1 (en) * | 2003-10-31 | 2014-10-08 | Kaneka Corporation | Composition containing clathrated reduced coenzyme Q |
| US7780873B2 (en) * | 2004-02-23 | 2010-08-24 | Texas A&M University System | Bioactive complexes compositions and methods of use thereof |
| AU2006235633A1 (en) * | 2005-04-14 | 2006-10-19 | Jarrow Formulas, Inc. | Dietary supplement formulations for improved delivery of coenzyme Q10 and methods of administration |
| US7956031B2 (en) * | 2005-05-31 | 2011-06-07 | Naidu Lp | Metallo-lactoferrin-coenzyme compositions for trigger and release of bioenergy |
| US7645742B2 (en) * | 2005-06-22 | 2010-01-12 | Advocare International, L.P. | Composition for enhancing cellular energy |
-
2007
- 2007-03-15 SI SI200700060A patent/SI22465B/en not_active IP Right Cessation
-
2008
- 2008-02-27 WO PCT/SI2008/000012 patent/WO2008111919A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| SI22465B (en) | 2010-10-29 |
| WO2008111919A2 (en) | 2008-09-18 |
| WO2008111919A3 (en) | 2009-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OO00 | Grant of patent |
Effective date: 20070521 |
|
| OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20100908 |
|
| KO00 | Lapse of patent |
Effective date: 20231122 |