SI2032134T1 - Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida - Google Patents
Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipidaInfo
- Publication number
- SI2032134T1 SI2032134T1 SI200731687T SI200731687T SI2032134T1 SI 2032134 T1 SI2032134 T1 SI 2032134T1 SI 200731687 T SI200731687 T SI 200731687T SI 200731687 T SI200731687 T SI 200731687T SI 2032134 T1 SI2032134 T1 SI 2032134T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibiting
- methods
- liver disease
- fatty liver
- treating fatty
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74681106P | 2006-05-09 | 2006-05-09 | |
EP07762033.4A EP2032134B1 (fr) | 2006-05-09 | 2007-05-09 | Methodes pour traiter la steatose hepatique par inhibition de la synthese des glucosphingolipides |
PCT/US2007/068521 WO2007134086A2 (fr) | 2006-05-09 | 2007-05-09 | Méthodes pour traiter une maladie de foie adipeux |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2032134T1 true SI2032134T1 (sl) | 2015-10-30 |
Family
ID=38621025
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200731687T SI2032134T1 (sl) | 2006-05-09 | 2007-05-09 | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
Country Status (10)
Country | Link |
---|---|
US (3) | US8716327B2 (fr) |
EP (2) | EP2032134B1 (fr) |
DK (1) | DK2032134T3 (fr) |
ES (1) | ES2546181T3 (fr) |
HK (1) | HK1215533A1 (fr) |
HU (1) | HUE026057T2 (fr) |
PL (1) | PL2032134T3 (fr) |
PT (1) | PT2032134E (fr) |
SI (1) | SI2032134T1 (fr) |
WO (1) | WO2007134086A2 (fr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT2266968E (pt) * | 2001-07-16 | 2013-02-25 | Genzyme Corp | Síntese de udp-glucose: inibidores de n-acil esfingosinaglucosiltransferase |
US8003617B2 (en) | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
JP5645360B2 (ja) * | 2006-04-21 | 2014-12-24 | 株式会社明治 | ジペプチドを有効成分として含有する組成物 |
SI2032134T1 (sl) | 2006-05-09 | 2015-10-30 | Genzyme Corporation | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
ES2527438T3 (es) * | 2006-08-08 | 2015-01-26 | Metabolon, Inc. | Marcadores de la hepatopatía grasa no alcohólica (NAFLD) y de la esteatohepatitis no alcohólica (NASH) y métodos de uso de los mismos |
WO2008150486A2 (fr) * | 2007-05-31 | 2008-12-11 | Genzyme Corporation | Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol |
KR101640263B1 (ko) | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
AU2008318291A1 (en) * | 2007-10-31 | 2009-05-07 | The University Of Sydney | Treatment of metabolic disease |
BRPI0819434A2 (pt) * | 2007-11-08 | 2019-09-24 | Univ Utah Res Found | método de tratamento ou prevenção de doenças hepáticas e uso de antagonistas á angiogênese em condições de proliferação venosa anormal |
WO2010014554A1 (fr) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Inhibition de synthase de glucosylcéramide pour le traitement du glomérulopathie avec collapsus, et d'un autre trouble glomérulaire |
US20100049265A1 (en) * | 2008-08-22 | 2010-02-25 | Dymedix Corporation | EMI/ESD hardened sensor interface for a closed loop neuromodulator |
WO2010030909A1 (fr) * | 2008-09-12 | 2010-03-18 | Dymedix Corporation | Système de détecteur pyro/piézo sans fil |
JP2012504608A (ja) | 2008-10-03 | 2012-02-23 | ジェンザイム コーポレーション | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
LT2796457T (lt) | 2009-11-27 | 2016-09-12 | Genzyme Corporation | Genz 112638, skirtas gošė arba fabri ligos gydymui kombinuota terapija |
WO2011133923A1 (fr) * | 2010-04-23 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Modulation de l'expression de la lactosylcéramide synthase (lcs) |
WO2011133915A1 (fr) * | 2010-04-23 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Modulation de l'expression de la glucosylcéramide synthase (gcs) |
US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
US10245288B2 (en) | 2011-02-04 | 2019-04-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease |
US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
US10512661B2 (en) | 2011-02-04 | 2019-12-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
US10086018B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
US9987224B2 (en) | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
US11273187B2 (en) | 2015-11-30 | 2022-03-15 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing depression in an individual |
US10842834B2 (en) | 2016-01-06 | 2020-11-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
US11419903B2 (en) | 2015-11-30 | 2022-08-23 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
US10548761B2 (en) | 2011-02-04 | 2020-02-04 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
US20130040953A1 (en) * | 2011-08-10 | 2013-02-14 | Amy S. Paller | Promotion of wound healing |
WO2014152207A1 (fr) | 2013-03-15 | 2014-09-25 | Mylan Laboratories, Inc. | Formulations de granulation par fusion de principes actifs faiblement hydrosolubles |
JP6537500B2 (ja) | 2013-09-20 | 2019-07-03 | ビオマリン プハルマセウトイカル インコーポレイテッド | 疾患治療用のグルコシルセラミドシンターゼ阻害剤 |
JP6526652B2 (ja) | 2013-10-29 | 2019-06-05 | ビオマリン プハルマセウトイカル インコーポレイテッド | グルコシルセラミドシンターゼ阻害剤としてのn−(1−ヒドロキシ−3−(ピロリジニル)プロパン−2−イル)ピロリジン−3−カルボキサミド誘導体 |
US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
SG11201703024VA (en) | 2014-10-15 | 2017-05-30 | Corcept Therapeutics Inc | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists |
SG10202103552XA (en) | 2015-03-09 | 2021-05-28 | Intekrin Therapeutics Inc | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
AU2018249822A1 (en) | 2017-04-03 | 2019-10-31 | Coherus Biosciences Inc. | PPArgamma agonist for treatment of progressive supranuclear palsy |
JP7055429B2 (ja) * | 2017-10-27 | 2022-04-18 | 学校法人北里研究所 | 慢性腎臓病の予防又は治療剤 |
KR20220010708A (ko) * | 2019-06-18 | 2022-01-26 | 주식회사 스탠다임 | 대사성 간질환의 예방 또는 치료용 조성물 |
MX2023006075A (es) * | 2020-12-03 | 2023-06-06 | Nestle Sa | Metodos de restriccion calorica interna para impartir beneficios de salud a un animal. |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8309A (en) * | 1851-08-26 | Washing-machine | ||
GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
JPS568318A (en) | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
EP0144290A3 (fr) | 1983-12-01 | 1987-05-27 | Ciba-Geigy Ag | Dérivés éthylènediamine substitués |
US5206347A (en) | 1985-08-06 | 1993-04-27 | La Jolla Cancer Research Foundation | Isolation and use of receptors binding to a peptide column |
US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
JPH0416856A (ja) | 1990-05-10 | 1992-01-21 | Canon Inc | 正帯電性非磁性トナー |
US5264563A (en) | 1990-08-24 | 1993-11-23 | Ixsys Inc. | Process for synthesizing oligonucleotides with random codons |
US5302609A (en) | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
HUT73527A (en) * | 1993-08-13 | 1996-08-28 | Seikagaku Kogyo Co Ltd | Remedy for nervous diseases |
US5631394A (en) * | 1994-02-02 | 1997-05-20 | The Liposome Company, Inc. | Pharmaceutically active ceramide-related compounds |
CA2192555C (fr) | 1994-06-10 | 2005-01-11 | Jinichi Inokuchi | Compose de 2-acylaminopropanol et composition medicinale |
US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
WO2001004108A1 (fr) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Composes de type amino-ceramide et procedes therapeutiques d'utilisation |
WO1997010817A1 (fr) * | 1995-09-20 | 1997-03-27 | The Regents Of The University Of Michigan | Composes de type amino ceramide et leurs methodes d'utilisation therapeutiques |
US6890949B1 (en) * | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20030073680A1 (en) * | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US6255336B1 (en) | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
NO965193L (no) * | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
JP3993908B2 (ja) | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
US6096529A (en) | 1996-06-10 | 2000-08-01 | National Research Council Of Canada | Recombinant α-2,3-sialyltransferases and their uses |
US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
US6555371B1 (en) | 1997-07-09 | 2003-04-29 | Seikagaku Kogyo Kabushiki Kaisha | Sialyltransferase and DNA encoding the same |
US6465488B1 (en) | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
AU756008B2 (en) * | 1998-07-27 | 2003-01-02 | Johns Hopkins University, The | Methods for treating conditions modulated by lactosylceramide |
US6610703B1 (en) | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
US6255366B1 (en) | 1999-10-01 | 2001-07-03 | Eastman Chemical Company | Sulfopolymers as emulsion stabilizers with improved coagulum level |
JP5009459B2 (ja) | 1999-12-06 | 2012-08-22 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
US6407064B2 (en) * | 1999-12-06 | 2002-06-18 | Seikagaku Corporation | Aminoalcohol derivative and medicament comprising the same |
US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
US20040009961A1 (en) * | 2000-04-19 | 2004-01-15 | Borody Thomas Julius | Composition and therapies for hyperlipidaemia-associated disorders |
CA2432908A1 (fr) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Company | Diamines servant de modulateurs de l'activite recepteur des chimiokines |
MXPA03005855A (es) | 2000-12-29 | 2003-09-10 | Wyeth Corp | Metodo para preparacion regioselectiva de benzo[g]quinolin-3-carbonitrilos sustituidos y benzo[g]quinazolinas sustituidas. |
JP2004531478A (ja) * | 2001-01-10 | 2004-10-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | アミノセラミド様化合物および治療目的での使用方法 |
US7148251B2 (en) * | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20040260099A1 (en) * | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
US20020198240A1 (en) * | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
PT2266968E (pt) | 2001-07-16 | 2013-02-25 | Genzyme Corp | Síntese de udp-glucose: inibidores de n-acil esfingosinaglucosiltransferase |
US6835831B2 (en) * | 2001-11-26 | 2004-12-28 | Genzyme Corporation | Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors |
GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
AU2002367266A1 (en) | 2001-12-28 | 2003-07-24 | Sumitomo Pharmaceuticals Company, Limited | Disease markers for renal diseaes and utilization thereof |
WO2003062236A1 (fr) | 2002-01-22 | 2003-07-31 | Warner-Lambert Company Llc | 2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
EP1336411A1 (fr) | 2002-02-14 | 2003-08-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Compositions et méthodes pour améliorer la thérapie de remplacement d'enzymes des maladies lysosomales |
JP2003238410A (ja) | 2002-02-21 | 2003-08-27 | Seibutsu Yuki Kagaku Kenkyusho:Kk | インスリン抵抗性解除剤 |
US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20060217560A1 (en) * | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
NZ538217A (en) | 2002-07-17 | 2007-04-27 | Biogen Idec Inc | Beta interferon when used to treat proteinuria, glomerular cell proliferation and inflammation |
CA2492404C (fr) * | 2002-07-17 | 2012-02-07 | Oxford Glycosciences (Uk) Ltd | Utilisation de derives du piperidinetriol en tant qu'inhibiteurs de la glycosylceramide synthase |
AU2003225670A1 (en) | 2003-02-28 | 2004-09-28 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
US6919802B2 (en) * | 2003-07-08 | 2005-07-19 | Rf Saw Components, Inc. | Multi-layer method of accommodating code collisions from multiple surface acoustic wave identification tags |
US7423851B2 (en) | 2003-09-30 | 2008-09-09 | Tdk Corporation | Magneto-resistive element and device being provided with magneto-resistive element having magnetic nano-contact |
DE602004030604D1 (de) | 2003-10-29 | 2011-01-27 | Genzyme Corp | N-(5-adamantane-1-yl-methoxy-pentyl)desoxynojirimycin oder eines pharmazeutischen salzes davon zur verwendung bei der behandlung der insulinresistenz |
EP1528056A1 (fr) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Dérives de desoxynojirimycine et leurs utilisations en tant qu'inhibiteurs de glucosylceramidase |
CA2548313A1 (fr) | 2003-12-23 | 2005-07-14 | Musc Foundation For Research Development | Methodes et compositions pour la prevention et le traitement de maladies ou de troubles inflammatoires |
GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
US20070207983A1 (en) | 2004-03-16 | 2007-09-06 | Nieuwenhuizen Willem F | Use of Sphingolipids in the Treatment and Prevention of Type 2 Diabetes Mellitus, Insulin Resistance and Metabolic Syndrome |
EP1576894A1 (fr) | 2004-03-16 | 2005-09-21 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | Utilisation de sphingolipides pour la prevention et le traitement diabete deType 2, la resistance a l'insuline et syndrome metabolique |
AU2005240714B2 (en) | 2004-05-07 | 2011-07-07 | Merck Patent Gmbh | GM3 synthase as a therapeutic target in microvascular complications of diabetes |
US20090111812A1 (en) | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
AU2005277186A1 (en) | 2004-08-20 | 2006-03-02 | The Johns Hopkins University | Methods for treatment of angiogenesis |
US8003617B2 (en) | 2004-11-10 | 2011-08-23 | Genzyme Corporation | Methods of treating diabetes mellitus |
CA2595519C (fr) | 2005-01-26 | 2013-10-29 | Allergan, Inc. | Methodes d'utilisation comme analgesique les amines 1 benzyl 1 hydroxy 2,3 diamino propyl, les acides amines 3 benzyl 3 hydroxy 2 amino propionique et les composes lies |
WO2007022518A2 (fr) * | 2005-08-19 | 2007-02-22 | Amylin Pharmaceuticals, Inc. | Nouvelles utilisations de proteines glucoregulatoires |
SI2032134T1 (sl) | 2006-05-09 | 2015-10-30 | Genzyme Corporation | Postopki zdravljenja bolezni zamaščenih jeter, ki obsegajo inhibicijo sintezo glukosfingolipida |
WO2008011487A2 (fr) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Procédés pour le traitement de la douleur chronique à l'aide de 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, d'amides d'acide 3-benzyl-3-hydroxy-2-amino-propioniques et de composés apparentés |
WO2008011478A2 (fr) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Procédés de traitement de douleur chronique utilisant des amides d'acide 3-aryl-3-hydroxy-2-amino-propioniques, amides d'acide 3-hétéroaryl-3-hydroxy-2-amino-propionique et composés connexes |
GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制bcl蛋白質與結合夥伴間之交互作用的化合物及方法 |
MX2009008493A (es) | 2007-02-09 | 2009-08-20 | Irm Llc | Compuestos y composiciones como inhibidores de la proteasa activadora de canal. |
WO2008150486A2 (fr) | 2007-05-31 | 2008-12-11 | Genzyme Corporation | Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol |
KR101640263B1 (ko) * | 2007-10-05 | 2016-07-15 | 젠자임 코포레이션 | 세라마이드 유도체로 다낭성 신장질환을 치료하는 방법 |
WO2009117150A2 (fr) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Méthode de traitement d’un lupus avec des dérivés de céramide |
WO2010014554A1 (fr) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Inhibition de synthase de glucosylcéramide pour le traitement du glomérulopathie avec collapsus, et d'un autre trouble glomérulaire |
JP2012504608A (ja) * | 2008-10-03 | 2012-02-23 | ジェンザイム コーポレーション | 2−アシルアミノプロパノール−タイプグルコシルセラミドシンターゼ抑制剤 |
-
2007
- 2007-05-09 SI SI200731687T patent/SI2032134T1/sl unknown
- 2007-05-09 EP EP07762033.4A patent/EP2032134B1/fr active Active
- 2007-05-09 EP EP15162842.7A patent/EP2923699B1/fr not_active Not-in-force
- 2007-05-09 HU HUE07762033A patent/HUE026057T2/en unknown
- 2007-05-09 PT PT77620334T patent/PT2032134E/pt unknown
- 2007-05-09 US US12/227,076 patent/US8716327B2/en not_active Expired - Fee Related
- 2007-05-09 ES ES07762033.4T patent/ES2546181T3/es active Active
- 2007-05-09 PL PL07762033T patent/PL2032134T3/pl unknown
- 2007-05-09 DK DK07762033.4T patent/DK2032134T3/en active
- 2007-05-09 WO PCT/US2007/068521 patent/WO2007134086A2/fr active Application Filing
-
2014
- 2014-04-08 US US14/247,732 patent/US9556155B2/en active Active
-
2016
- 2016-03-24 HK HK16103499.2A patent/HK1215533A1/zh unknown
- 2016-12-19 US US15/383,602 patent/US20170281593A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2546181T3 (es) | 2015-09-21 |
EP2923699A1 (fr) | 2015-09-30 |
US20170281593A1 (en) | 2017-10-05 |
HUE026057T2 (en) | 2016-05-30 |
PT2032134E (pt) | 2015-10-07 |
US20090105125A1 (en) | 2009-04-23 |
US9556155B2 (en) | 2017-01-31 |
EP2032134B1 (fr) | 2015-06-24 |
WO2007134086A2 (fr) | 2007-11-22 |
EP2032134A2 (fr) | 2009-03-11 |
EP2923699B1 (fr) | 2018-06-20 |
US8716327B2 (en) | 2014-05-06 |
HK1215533A1 (zh) | 2016-09-02 |
WO2007134086A3 (fr) | 2008-01-17 |
PL2032134T3 (pl) | 2015-11-30 |
US20150051261A1 (en) | 2015-02-19 |
DK2032134T3 (en) | 2015-09-28 |
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