SI1546322T1 - Vektorji na osnovi transpozona in metode integracije nukleinskih kislin - Google Patents

Vektorji na osnovi transpozona in metode integracije nukleinskih kislin

Info

Publication number
SI1546322T1
SI1546322T1 SI200331963T SI200331963T SI1546322T1 SI 1546322 T1 SI1546322 T1 SI 1546322T1 SI 200331963 T SI200331963 T SI 200331963T SI 200331963 T SI200331963 T SI 200331963T SI 1546322 T1 SI1546322 T1 SI 1546322T1
Authority
SI
Slovenia
Prior art keywords
methods
transposon
nucleic acid
based vectors
acid integration
Prior art date
Application number
SI200331963T
Other languages
English (en)
Inventor
Joseph M Kaminski
Original Assignee
Manoa Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manoa Biosciences Inc filed Critical Manoa Biosciences Inc
Publication of SI1546322T1 publication Critical patent/SI1546322T1/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/90—Vectors containing a transposable element
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/75—Vector systems having a special element relevant for transcription from invertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SI200331963T 2002-07-24 2003-07-24 Vektorji na osnovi transpozona in metode integracije nukleinskih kislin SI1546322T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39862802P 2002-07-24 2002-07-24
PCT/US2003/023090 WO2004009792A2 (en) 2002-07-24 2003-07-24 Transposon-based vectors and methods of nucleic acid integration
EP03748973A EP1546322B1 (en) 2002-07-24 2003-07-24 Transposon-based vectors and methods of nucleic acid integration

Publications (1)

Publication Number Publication Date
SI1546322T1 true SI1546322T1 (sl) 2011-05-31

Family

ID=30771227

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331963T SI1546322T1 (sl) 2002-07-24 2003-07-24 Vektorji na osnovi transpozona in metode integracije nukleinskih kislin

Country Status (9)

Country Link
US (1) US20060210977A1 (sl)
EP (1) EP1546322B1 (sl)
AT (1) ATE494370T1 (sl)
AU (1) AU2003268022B2 (sl)
CA (1) CA2533708C (sl)
DE (1) DE60335637D1 (sl)
ES (1) ES2358994T3 (sl)
SI (1) SI1546322T1 (sl)
WO (1) WO2004009792A2 (sl)

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US7527966B2 (en) * 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US20040172667A1 (en) 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
DK1594972T3 (da) * 2003-02-10 2011-04-18 Max Delbrueck Centrum Transposon-baseret målretningssystem
DE602004031284D1 (de) * 2003-02-10 2011-03-17 Max Delbrueck Centrum Transposon-system zur gezielten integration
ATE536419T1 (de) * 2003-02-10 2011-12-15 Max Delbrueck Centrum Transposon basiertes targeting- system
WO2005062881A2 (en) 2003-12-24 2005-07-14 Transgenrx, Inc. Gene therapy using transposon-based vectors
WO2005089123A2 (en) * 2004-03-04 2005-09-29 Massachusetts Institute Of Technology Therapeutic anti-cancer dna
EP1755640A4 (en) * 2004-04-30 2009-10-28 Poetic Genetics Llc HYBRID RECOMBINATIONS FOR GENOMIC MANIPULATION
US7470777B2 (en) 2004-12-22 2008-12-30 Iowa State University Research Foundation, Inc. Compositions and methods related to modified retroviral vectors for restricted, site specific integration
US7919583B2 (en) 2005-08-08 2011-04-05 Discovery Genomics, Inc. Integration-site directed vector systems
WO2008100424A2 (en) * 2007-02-09 2008-08-21 University Of Hawaii Animals and cells with genomic target sites for transposase-mediated transgenesis
WO2008137114A1 (en) * 2007-05-04 2008-11-13 University Of Hawai'i Methods and compositions for targeted delivery of gene therapeutic vectors
US20090042297A1 (en) * 2007-06-01 2009-02-12 George Jr Alfred L Piggybac transposon-based vectors and methods of nucleic acid integration
EP2167519A4 (en) * 2007-06-16 2011-04-13 Scarab Genomics Llc NUCLEIC ACID ENCAPSIDATION SYSTEM
CN101503670B (zh) * 2008-02-04 2011-12-14 复旦大学附属华山医院 一种含有整合子的工程菌株
WO2010008562A2 (en) * 2008-07-16 2010-01-21 Recombinetics Methods and materials for producing transgenic animals
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010085699A2 (en) * 2009-01-23 2010-07-29 The Johns Hopkins University Mammalian piggybac transposon and methods of use
GB2467167B (en) 2009-01-26 2013-09-11 Algentech Sas Gene targeting in plants
EP2417263B1 (en) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Production of proteins using transposon-based vectors
JP6087148B2 (ja) * 2010-12-15 2017-03-01 大学共同利用機関法人情報・システム研究機構 タンパク質の生産方法
CA2919503C (en) 2013-07-12 2019-06-25 University Of South Alabama Minimal piggybac vectors for genome integration
EP3352798A1 (en) * 2015-09-22 2018-08-01 Julius-Maximilians-Universität Würzburg A method for high level and stable gene transfer in lymphocytes
CN105154473B (zh) * 2015-09-30 2019-03-01 上海细胞治疗研究院 一种高效安全的转座子整合系统及其用途
CN105481984B (zh) * 2015-12-03 2020-09-22 上海细胞治疗研究院 一种高效介导外源基因整合的转座酶及其用途
AU2019245243A1 (en) 2018-03-29 2020-09-03 Genentech, Inc Modulating lactogenic activity in mammalian cells
US20220090142A1 (en) 2019-02-13 2022-03-24 Probiogen Ag Transposase with enhanced insertion site selection properties
CA3141422A1 (en) * 2019-06-11 2020-12-17 Avencia Sanchez-mejias Garcia Targeted gene editing constructs and methods of using the same
EP3835421A1 (en) * 2019-12-11 2021-06-16 Consejo Superior de Investigaciones Científicas (CSIC) Vectors for tissue specific transcriptomics
CA3169908A1 (en) 2020-03-26 2021-09-30 Genentech, Inc. Modified mammalian cells having reduced host cell proteins
WO2021226141A1 (en) 2020-05-04 2021-11-11 Saliogen Therapeutics, Inc. Transposition-based therapies
KR20230026491A (ko) 2020-06-24 2023-02-24 제넨테크, 인크. 아폽토시스 내성 세포주
CN117015600A (zh) 2020-07-17 2023-11-07 普罗拜奥根股份公司 高活性转座子和转座酶
CA3215965A1 (en) 2021-04-19 2022-10-27 Amy Shen Modified mammalian cells
CN117396599A (zh) 2021-05-21 2024-01-12 基因泰克公司 用于生产目的重组产物的经修饰的细胞
WO2023039434A1 (en) * 2021-09-08 2023-03-16 Metagenomi, Inc. Systems and methods for transposing cargo nucleotide sequences
TW202342755A (zh) 2021-12-22 2023-11-01 美商建南德克公司 多載體重組酶介導的匣式交換
WO2024068845A1 (en) * 2022-09-29 2024-04-04 Vib Vzw New loxpsym sites for large-scale orthogonal cre-mediated recombination

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US6150511A (en) * 1995-05-09 2000-11-21 Fox Chase Cancer Center Chimeric enzyme for promoting targeted integration of foreign DNA into a host genome
JPH11505128A (ja) * 1995-05-22 1999-05-18 カイロン コーポレイション キメラインテグラーゼタンパク質に媒介される真核生物ゲノム中へのベクター構築物の位置特異的組み込み
EP0871711A1 (en) * 1995-12-01 1998-10-21 The Regents Of The University Of California Compositions and methods for site-directed integration into dna
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Also Published As

Publication number Publication date
DE60335637D1 (de) 2011-02-17
CA2533708C (en) 2013-05-14
ES2358994T3 (es) 2011-05-17
EP1546322B1 (en) 2011-01-05
ATE494370T1 (de) 2011-01-15
EP1546322A2 (en) 2005-06-29
AU2003268022B2 (en) 2009-02-05
EP1546322A4 (en) 2006-07-19
US20060210977A1 (en) 2006-09-21
WO2004009792A2 (en) 2004-01-29
AU2003268022A1 (en) 2004-02-09
WO2004009792A3 (en) 2004-05-13
CA2533708A1 (en) 2004-01-29

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