SI1438960T1 - Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjo - Google Patents
Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjoInfo
- Publication number
- SI1438960T1 SI1438960T1 SI200330739T SI200330739T SI1438960T1 SI 1438960 T1 SI1438960 T1 SI 1438960T1 SI 200330739 T SI200330739 T SI 200330739T SI 200330739 T SI200330739 T SI 200330739T SI 1438960 T1 SI1438960 T1 SI 1438960T1
- Authority
- SI
- Slovenia
- Prior art keywords
- itraconazole
- hydrophilic polymer
- dispersed
- minutes
- composition
- Prior art date
Links
- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 title abstract 7
- 229960004130 itraconazole Drugs 0.000 title abstract 7
- 229920001477 hydrophilic polymer Polymers 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- 238000004090 dissolution Methods 0.000 abstract 1
- 239000012738 dissolution medium Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03290091A EP1438960B2 (en) | 2003-01-14 | 2003-01-14 | Compostion of itraconazole dispersed in a hydrophilic polymer having enhanced bioavailability |
Publications (2)
Publication Number | Publication Date |
---|---|
SI1438960T1 true SI1438960T1 (sl) | 2007-06-30 |
SI1438960T2 SI1438960T2 (sl) | 2013-04-30 |
Family
ID=32524259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200330739T SI1438960T2 (sl) | 2003-01-14 | 2003-01-14 | Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjo |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1438960B2 (sl) |
AT (1) | ATE357234T1 (sl) |
DE (1) | DE60312635T3 (sl) |
DK (1) | DK1438960T4 (sl) |
ES (1) | ES2283724T5 (sl) |
PT (1) | PT1438960E (sl) |
SI (1) | SI1438960T2 (sl) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
FR2758461A1 (fr) † | 1997-01-17 | 1998-07-24 | Pharma Pass | Composition pharmaceutique presentant une biodisponibilite elevee et son procede de preparation |
PT969821E (pt) * | 1997-03-26 | 2003-10-31 | Janssen Pharmaceutica Nv | Pastilhas tendo um nucleo revestido com um antifungico e um polimero |
KR19990001564A (ko) * | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
SI1104291T1 (sl) * | 1998-07-17 | 2006-02-28 | Janssen Pharmaceutica Nv | Pelete, ki imajo jedro oblozeno s fungicidom in polimerom |
ES2157731B1 (es) * | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. |
KR100694667B1 (ko) † | 1999-12-08 | 2007-03-14 | 동아제약주식회사 | 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제 |
FR2803748A1 (fr) * | 2000-01-14 | 2001-07-20 | Ethypharm Lab Prod Ethiques | Composition d'itraconazole et procede de preparation |
US6673373B2 (en) † | 2001-02-01 | 2004-01-06 | Carlsbad Technology Inc. | Antifungal formulation and the methods for manufacturing and using the same |
-
2003
- 2003-01-14 SI SI200330739T patent/SI1438960T2/sl unknown
- 2003-01-14 PT PT03290091T patent/PT1438960E/pt unknown
- 2003-01-14 AT AT03290091T patent/ATE357234T1/de active
- 2003-01-14 ES ES03290091T patent/ES2283724T5/es not_active Expired - Lifetime
- 2003-01-14 DE DE60312635T patent/DE60312635T3/de not_active Expired - Lifetime
- 2003-01-14 EP EP03290091A patent/EP1438960B2/en not_active Expired - Lifetime
- 2003-01-14 DK DK03290091.2T patent/DK1438960T4/da active
Also Published As
Publication number | Publication date |
---|---|
EP1438960B2 (en) | 2012-12-19 |
DE60312635T3 (de) | 2013-05-08 |
DE60312635T2 (de) | 2008-01-03 |
ATE357234T1 (de) | 2007-04-15 |
EP1438960A1 (en) | 2004-07-21 |
DK1438960T4 (da) | 2013-03-25 |
ES2283724T5 (es) | 2013-04-09 |
DE60312635D1 (de) | 2007-05-03 |
SI1438960T2 (sl) | 2013-04-30 |
ES2283724T3 (es) | 2007-11-01 |
DK1438960T3 (da) | 2007-07-23 |
EP1438960B1 (en) | 2007-03-21 |
PT1438960E (pt) | 2007-06-19 |
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