SI1270562T1 - Cyclic alpha-amino-gamma-hydroxy-amides, process for their preparation and pharmaceutical compositions thereof - Google Patents

Cyclic alpha-amino-gamma-hydroxy-amides, process for their preparation and pharmaceutical compositions thereof

Info

Publication number
SI1270562T1
SI1270562T1 SI200230031T SI200230031T SI1270562T1 SI 1270562 T1 SI1270562 T1 SI 1270562T1 SI 200230031 T SI200230031 T SI 200230031T SI 200230031 T SI200230031 T SI 200230031T SI 1270562 T1 SI1270562 T1 SI 1270562T1
Authority
SI
Slovenia
Prior art keywords
amides
gamma
hydroxy
amino
preparation
Prior art date
Application number
SI200230031T
Other languages
English (en)
Slovenian (sl)
Inventor
Michel Wierzbicki
Jean-Marie Fourquez
Nigel Levens
Bernadette Husson-Robert
Olivier Nosjean
Michelle Boulanger
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1270562T1 publication Critical patent/SI1270562T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200230031T 2001-06-18 2002-06-17 Cyclic alpha-amino-gamma-hydroxy-amides, process for their preparation and pharmaceutical compositions thereof SI1270562T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0107934A FR2826003B1 (fr) 2001-06-18 2001-06-18 Nouveaux derives cycliques d'alpha-amino-gamma-hydroxy- amides, leur procede de preparation et les compositions pharmaceutiques que les contiennent

Publications (1)

Publication Number Publication Date
SI1270562T1 true SI1270562T1 (en) 2004-12-31

Family

ID=8864417

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200230031T SI1270562T1 (en) 2001-06-18 2002-06-17 Cyclic alpha-amino-gamma-hydroxy-amides, process for their preparation and pharmaceutical compositions thereof

Country Status (25)

Country Link
US (1) US6593312B2 (hu)
EP (1) EP1270562B1 (hu)
JP (1) JP2003012642A (hu)
CN (1) CN1178901C (hu)
AR (1) AR034516A1 (hu)
AT (1) ATE277027T1 (hu)
AU (1) AU781822B2 (hu)
BR (1) BR0202313A (hu)
CA (1) CA2389858C (hu)
CZ (1) CZ20022119A3 (hu)
DE (1) DE60201296T2 (hu)
DK (1) DK1270562T3 (hu)
EA (1) EA004955B1 (hu)
ES (1) ES2229063T3 (hu)
FR (1) FR2826003B1 (hu)
HK (1) HK1050186A1 (hu)
HU (1) HUP0202011A3 (hu)
MX (1) MXPA02005997A (hu)
NO (1) NO322155B1 (hu)
NZ (1) NZ519610A (hu)
PL (1) PL354565A1 (hu)
PT (1) PT1270562E (hu)
SI (1) SI1270562T1 (hu)
SK (1) SK285989B6 (hu)
ZA (1) ZA200204865B (hu)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002306823B2 (en) * 2001-03-27 2006-05-11 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122010000020I1 (de) * 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern

Also Published As

Publication number Publication date
EA004955B1 (ru) 2004-10-28
EP1270562A3 (fr) 2003-05-07
CN1392137A (zh) 2003-01-22
AU4882202A (en) 2002-12-19
CZ20022119A3 (cs) 2003-02-12
PT1270562E (pt) 2004-11-30
PL354565A1 (en) 2002-12-30
DE60201296T2 (de) 2006-02-23
JP2003012642A (ja) 2003-01-15
CN1178901C (zh) 2004-12-08
DE60201296D1 (de) 2004-10-28
DK1270562T3 (da) 2005-01-24
EP1270562A2 (fr) 2003-01-02
NO20022891L (no) 2002-12-19
US6593312B2 (en) 2003-07-15
FR2826003A1 (fr) 2002-12-20
EA200200574A1 (ru) 2002-12-26
HK1050186A1 (en) 2003-06-13
NZ519610A (en) 2003-05-30
FR2826003B1 (fr) 2003-08-15
HUP0202011A3 (en) 2005-07-28
BR0202313A (pt) 2003-04-29
NO20022891D0 (no) 2002-06-17
CA2389858A1 (fr) 2002-12-18
SK285989B6 (sk) 2008-01-07
ATE277027T1 (de) 2004-10-15
ZA200204865B (en) 2003-02-20
SK8772002A3 (en) 2003-01-09
CA2389858C (fr) 2007-08-28
HU0202011D0 (hu) 2002-08-28
US20030004138A1 (en) 2003-01-02
AU781822B2 (en) 2005-06-16
EP1270562B1 (fr) 2004-09-22
ES2229063T3 (es) 2005-04-16
NO322155B1 (no) 2006-08-21
HUP0202011A2 (hu) 2003-01-28
MXPA02005997A (es) 2005-02-17
AR034516A1 (es) 2004-02-25

Similar Documents

Publication Publication Date Title
HUP0402225A3 (en) Macrolide-compounds, process for their preparation and pharmaceutical compositions containing them
HUP0402264A3 (en) Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines process for preparing them, pharmaceutical compositions containing them and use thereof
HUP0402063A3 (en) Indole-2-carboxamides process for producing them, pharmaceutical compositions containing them and use thereof
HUP0301187A3 (en) Novel benzyl-piperidine-derivatives, process for their preparation and pharmaceutical compositions containing them
IL165977A (en) Substituted pyrimidinylaminobenzamides , process for the preparation thereof and pharmaceutical compositions comprising the same
HU229604B1 (en) 6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
HUP0301069A3 (en) Novel biarylcarboxamides, process for their preparation, pharmaceutical compositions containing them and their use
HUP0401619A3 (en) Phenethanolamine derivatives, process for their preparation and pharmaceutical composition containing them
HUP0303078A3 (en) Cyclic peptidies process for their preparation pharmaceutical compositions containing them and their use
IL162185A0 (en) Phenylpropionate derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
HUP0400246A3 (en) 1,2,4-trioxolane antimalarial pharmaceutical compositions and process for their preparation and use
HUP0400040A2 (hu) Szulfonamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0401107A3 (en) Novel benzo-fused heterocycles, their use process for their preparation and pharmaceutical compositions containing them
HUP0302515A3 (en) Sulfanidothienopyrimidines, process for their preparation and pharmaceutical compositions containing them
HUP0401082A3 (en) Substituted 4-aminocyclohexanols, process for their preparation and pharmaceutical compositions containing them
HUP0303270A3 (en) Isoxazoline derivatives as anti-depressants, process for their preparation and pharmaceutical compositions containing them
HUP0204394A3 (en) Tetrahydropyridines, process for their preparation, pharmaceutical compositions containing them and use thereof
AU2003231920A8 (en) Antiinfectve compounds, process for their preparation and pharmaceutical compositions containing them
HUP0302429A3 (en) 4-amino-quinazolines, process for producing them, pharmaceutical compositions containing them and their use
HUP0303105A3 (en) Novel aminocyclohexane derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0301254A3 (en) Novel compounds, process fo their preparation and pharmaceutical compositions containing them
HUP0204001A3 (en) Substituted aminomethyl-phenyl-cyclohexane derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0303361A3 (en) Substituted 1-aminobutan-3-ol derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0401713A3 (en) Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same
SI1245565T1 (en) Indenoindolone derivatives, process for their preparation and pharmaceutical compositions containing them