SI1205484T1 - Process for producing 4-amino-1-hidroxybutylidene-1,1-bisphosphonic acid and its trihydrated monosodic salt - Google Patents

Process for producing 4-amino-1-hidroxybutylidene-1,1-bisphosphonic acid and its trihydrated monosodic salt

Info

Publication number
SI1205484T1
SI1205484T1 SI200030140T SI200030140T SI1205484T1 SI 1205484 T1 SI1205484 T1 SI 1205484T1 SI 200030140 T SI200030140 T SI 200030140T SI 200030140 T SI200030140 T SI 200030140T SI 1205484 T1 SI1205484 T1 SI 1205484T1
Authority
SI
Slovenia
Prior art keywords
amino
trihydrated
hidroxybutylidene
producing
bisphosphonic acid
Prior art date
Application number
SI200030140T
Other languages
English (en)
Slovenian (sl)
Inventor
I Llado Jordi Bosch
Lista Eugenia Pagans
Miguel M Del Carmen Onrubia
Original Assignee
Medichem S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem S.A. filed Critical Medichem S.A.
Publication of SI1205484T1 publication Critical patent/SI1205484T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SI200030140T 1999-08-06 2000-07-17 Process for producing 4-amino-1-hidroxybutylidene-1,1-bisphosphonic acid and its trihydrated monosodic salt SI1205484T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES009901806A ES2153794B1 (es) 1999-08-06 1999-08-06 Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PCT/ES2000/000254 WO2001010874A1 (fr) 1999-08-06 2000-07-17 Procede d'obtention d'acide 4-amino-1-hidroxybutylidene-1,1-bisphosphonique et de son sel monosodique trihydrate
EP00945957A EP1205484B1 (fr) 1999-08-06 2000-07-17 Procede d'obtention d'acide 4-amino-1-hidroxybutylidene-1,1-bisphosphonique et de son sel monosodique trihydrate

Publications (1)

Publication Number Publication Date
SI1205484T1 true SI1205484T1 (en) 2003-12-31

Family

ID=8309563

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200030140T SI1205484T1 (en) 1999-08-06 2000-07-17 Process for producing 4-amino-1-hidroxybutylidene-1,1-bisphosphonic acid and its trihydrated monosodic salt

Country Status (18)

Country Link
US (1) US6573401B1 (fr)
EP (1) EP1205484B1 (fr)
KR (1) KR100688287B1 (fr)
AT (1) ATE238317T1 (fr)
AU (1) AU5987300A (fr)
BR (1) BR0013031A (fr)
CA (1) CA2380841C (fr)
CR (1) CR6575A (fr)
DE (1) DE60002347T2 (fr)
DK (1) DK1205484T3 (fr)
ES (2) ES2153794B1 (fr)
HU (1) HUP0202196A3 (fr)
IL (1) IL148000A (fr)
MX (1) MXPA02001293A (fr)
PL (1) PL191733B1 (fr)
PT (1) PT1205484E (fr)
SI (1) SI1205484T1 (fr)
WO (1) WO2001010874A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
NZ552513A (en) * 2001-12-24 2008-08-29 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
CA2485443C (fr) * 2002-05-17 2010-04-06 Teva Pharmaceutical Industries Ltd Utilisation d'hydrocarbures aromatiques et d'huiles de silicone pour la preparation d'acides bisphosphoniques
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005035542A1 (fr) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Forme solide d'alendronate sodique et sa preparation
US20080194525A1 (en) * 2005-05-06 2008-08-14 Jordi Puig Serrano Process of Making Geminal Bisphosphonic Acids and Pharmaceutically Acceptable Salts and/or Hydrates Thereof
WO2006134603A1 (fr) 2005-06-13 2006-12-21 Jubilant Organosys Limited Procédé de production d’acides bisphosphoniques et de formes de ceux-ci
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
WO2007083240A2 (fr) 2006-01-20 2007-07-26 Aurobindo Pharma Limited Procede ameliore de preparation d’acides bisphosphoniques
WO2007132478A2 (fr) * 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Procédé de préparation de l'acide risédronique pur ou de ses sels
EP2483283B1 (fr) 2009-10-02 2015-01-07 Straitmark Holding AG Procédé pour la fabrication d'acides aminohydroxydiphosphoniques

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3016289A1 (de) 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5039819A (en) 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
TW257765B (fr) 1993-08-25 1995-09-21 Merck & Co Inc
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
CA2197267C (fr) * 1997-02-11 2000-02-08 Yong Tao Procede pour la preparation de l'acide 4-amino-1-hydroxybutylidene-1,1-bisphosphonique ou de ses sels
HUP0200342A3 (en) * 1999-02-17 2005-02-28 Teva Pharma Novel process for preparing alendronic acid

Also Published As

Publication number Publication date
EP1205484A1 (fr) 2002-05-15
EP1205484B1 (fr) 2003-04-23
WO2001010874A1 (fr) 2001-02-15
HUP0202196A2 (en) 2002-10-28
US6573401B1 (en) 2003-06-03
ES2153794A1 (es) 2001-03-01
ES2194753T3 (es) 2003-12-01
DK1205484T3 (da) 2003-08-11
PL354033A1 (en) 2003-12-15
AU5987300A (en) 2001-03-05
MXPA02001293A (es) 2002-07-22
IL148000A (en) 2005-12-18
PT1205484E (pt) 2003-08-29
KR100688287B1 (ko) 2007-02-28
IL148000A0 (en) 2002-09-12
PL191733B1 (pl) 2006-06-30
DE60002347D1 (de) 2003-05-28
DE60002347T2 (de) 2004-02-12
KR20020024320A (ko) 2002-03-29
BR0013031A (pt) 2002-04-16
CA2380841C (fr) 2009-09-15
ES2153794B1 (es) 2001-10-16
HUP0202196A3 (en) 2002-12-28
CA2380841A1 (fr) 2001-02-15
ATE238317T1 (de) 2003-05-15
CR6575A (es) 2002-08-16

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