SI1051393T1 - New derivatives of sulfonic, phosphonic and phosphinic aminoalkane acids, their production and their use as medicaments - Google Patents

New derivatives of sulfonic, phosphonic and phosphinic aminoalkane acids, their production and their use as medicaments

Info

Publication number
SI1051393T1
SI1051393T1 SI9830537T SI9830537T SI1051393T1 SI 1051393 T1 SI1051393 T1 SI 1051393T1 SI 9830537 T SI9830537 T SI 9830537T SI 9830537 T SI9830537 T SI 9830537T SI 1051393 T1 SI1051393 T1 SI 1051393T1
Authority
SI
Slovenia
Prior art keywords
radical
aminoalkane
acids
phosphinic
phosphonic
Prior art date
Application number
SI9830537T
Other languages
English (en)
Slovenian (sl)
Inventor
Jean-Jacques Berthelon
Philippe Durbin
Original Assignee
Merck Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sante filed Critical Merck Sante
Publication of SI1051393T1 publication Critical patent/SI1051393T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • C07C309/15—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton the nitrogen atom of at least one of the amino groups being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
SI9830537T 1998-01-27 1998-01-27 New derivatives of sulfonic, phosphonic and phosphinic aminoalkane acids, their production and their use as medicaments SI1051393T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/FR1998/000147 WO1999037606A1 (fr) 1998-01-27 1998-01-27 Nouveaux derives d'acides aminoalkane sulfoniques, phosphoniques et phosphiniques, leur preparation et leur utilisation comme medicaments
EP98904231A EP1051393B1 (fr) 1998-01-27 1998-01-27 Nouveaux derives d'acides aminoalkane sulfoniques, phosphoniques et phosphiniques, leur preparation et leur utilisation comme medicaments

Publications (1)

Publication Number Publication Date
SI1051393T1 true SI1051393T1 (en) 2004-02-29

Family

ID=9521619

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9830537T SI1051393T1 (en) 1998-01-27 1998-01-27 New derivatives of sulfonic, phosphonic and phosphinic aminoalkane acids, their production and their use as medicaments

Country Status (12)

Country Link
US (1) US6265437B1 (enExample)
EP (1) EP1051393B1 (enExample)
JP (1) JP4156795B2 (enExample)
AT (1) ATE251129T1 (enExample)
AU (1) AU762988B2 (enExample)
CA (1) CA2319272C (enExample)
DE (1) DE69818709T2 (enExample)
DK (1) DK1051393T3 (enExample)
ES (1) ES2209110T3 (enExample)
PT (1) PT1051393E (enExample)
SI (1) SI1051393T1 (enExample)
WO (1) WO1999037606A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
AR049199A1 (es) 2004-06-04 2006-07-05 Aventis Pharma Inc Derivados de acido propano-fosfinico sustituido
EP1836161B1 (en) * 2004-12-22 2016-07-20 BHI Limited Partnership Methods and compositions for treating amyloid-related diseases
FR2899895B1 (fr) * 2006-04-12 2010-09-17 Servier Lab Nouveaux sels de strontium d'acides sulfoniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
SI2089417T1 (sl) * 2006-10-12 2015-04-30 Bhi Limited Partnership Metode, spojine, sestavki in vektorji za dostavo 3-amino-1-propansulfonske kisline
KR100877134B1 (ko) * 2007-05-03 2009-01-09 주식회사 엔지켐 아캄프로세이트 칼슘의 제조방법
TW200924746A (en) * 2007-09-07 2009-06-16 Xenoport Inc Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
WO2009033079A1 (en) * 2007-09-07 2009-03-12 Xenoport, Inc. Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
US20090099253A1 (en) * 2007-10-15 2009-04-16 Xenoport, Inc. Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use
DE102008048791A1 (de) * 2008-09-24 2010-03-25 Merck Patent Gmbh Neue Kristallform von Calcium-3-Acetylaminopropan-1-sulfonat
IT1392327B1 (it) * 2008-09-26 2012-02-28 Laboratorio Chimico Int Spa Nuova forma polimorfa del calcio acamprosato

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2384751A1 (fr) * 1977-03-23 1978-10-20 Francaise Coop Pharma Nouveaux derives de la taurine a activite neuro-musculaire renforcee
FR2457281A1 (fr) * 1979-05-23 1980-12-19 Meram Lab Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee

Also Published As

Publication number Publication date
ATE251129T1 (de) 2003-10-15
JP4156795B2 (ja) 2008-09-24
ES2209110T3 (es) 2004-06-16
EP1051393B1 (fr) 2003-10-01
DK1051393T3 (da) 2004-02-02
CA2319272A1 (en) 1999-07-29
CA2319272C (en) 2005-11-08
DE69818709D1 (en) 2003-11-06
PT1051393E (pt) 2004-02-27
WO1999037606A1 (fr) 1999-07-29
AU762988B2 (en) 2003-07-10
AU6219098A (en) 1999-08-09
JP2002501040A (ja) 2002-01-15
DE69818709T2 (de) 2004-08-19
EP1051393A1 (fr) 2000-11-15
US6265437B1 (en) 2001-07-24

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