SI1010694T1 - Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers - Google Patents

Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers

Info

Publication number
SI1010694T1
SI1010694T1 SI9930368T SI9930368T SI1010694T1 SI 1010694 T1 SI1010694 T1 SI 1010694T1 SI 9930368 T SI9930368 T SI 9930368T SI 9930368 T SI9930368 T SI 9930368T SI 1010694 T1 SI1010694 T1 SI 1010694T1
Authority
SI
Slovenia
Prior art keywords
derivatives
spiroimidazoline
alpha2
monoamines
adrenergic antagonists
Prior art date
Application number
SI9930368T
Other languages
English (en)
Slovenian (sl)
Inventor
Alex Cordi
Mark Millan
Adrian Newman-Tancredi
Mauricette Brocco
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SI1010694T1 publication Critical patent/SI1010694T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI9930368T 1998-12-18 1999-12-17 Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers SI1010694T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9816000A FR2787450B1 (fr) 1998-12-18 1998-12-18 Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP99403189A EP1010694B1 (fr) 1998-12-18 1999-12-17 Dérivés spiroimidazoliniques et leur utilisation comme antagonistes alpha2-adrénergiques et bloqueurs de la recapture de monoamines

Publications (1)

Publication Number Publication Date
SI1010694T1 true SI1010694T1 (en) 2003-12-31

Family

ID=9534134

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930368T SI1010694T1 (en) 1998-12-18 1999-12-17 Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers

Country Status (22)

Country Link
US (1) US6172097B1 (pl)
EP (1) EP1010694B1 (pl)
JP (1) JP3457241B2 (pl)
KR (1) KR100472522B1 (pl)
CN (1) CN1149201C (pl)
AT (1) ATE246680T1 (pl)
AU (1) AU760373B2 (pl)
BR (1) BR9905904A (pl)
CA (1) CA2292920C (pl)
DE (1) DE69910156T2 (pl)
DK (1) DK1010694T3 (pl)
EA (1) EA002979B1 (pl)
ES (1) ES2205741T3 (pl)
FR (1) FR2787450B1 (pl)
HK (1) HK1029117A1 (pl)
HU (1) HU225820B1 (pl)
NO (1) NO314402B1 (pl)
NZ (1) NZ501890A (pl)
PL (1) PL202368B1 (pl)
PT (1) PT1010694E (pl)
SI (1) SI1010694T1 (pl)
ZA (1) ZA997735B (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6638981B2 (en) 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
EP2254420A4 (en) 2008-02-20 2012-02-15 Targia Pharmaceuticals CNS PHARMACEUTICALS AND METHOD FOR THEIR USE

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294185B1 (en) * 1993-03-12 2001-09-25 Auburn University Monomeric and polymeric cyclic amine and N-halamine compounds
FR2707981B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2707982B1 (fr) * 1993-07-20 1995-09-01 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2709306B1 (fr) * 1993-07-20 1995-10-20 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ATE246680T1 (de) 2003-08-15
CN1149201C (zh) 2004-05-12
EP1010694A3 (fr) 2000-07-26
EP1010694B1 (fr) 2003-08-06
BR9905904A (pt) 2000-08-29
PL337265A1 (en) 2000-06-19
EA002979B1 (ru) 2002-12-26
US6172097B1 (en) 2001-01-09
AU6529199A (en) 2000-06-22
HUP9904629A3 (en) 2000-12-28
CA2292920C (fr) 2004-01-27
HU9904629D0 (en) 2000-02-28
JP3457241B2 (ja) 2003-10-14
FR2787450A1 (fr) 2000-06-23
DE69910156D1 (de) 2003-09-11
ES2205741T3 (es) 2004-05-01
CN1264704A (zh) 2000-08-30
EA199901049A2 (ru) 2000-08-28
PL202368B1 (pl) 2009-06-30
NO996285D0 (no) 1999-12-17
EA199901049A3 (ru) 2000-08-28
EP1010694A2 (fr) 2000-06-21
HK1029117A1 (en) 2001-03-23
NZ501890A (en) 2001-03-30
KR100472522B1 (ko) 2005-03-07
DE69910156T2 (de) 2004-06-09
FR2787450B1 (fr) 2001-01-26
ZA997735B (en) 2000-06-19
NO996285L (no) 2000-06-19
HUP9904629A2 (hu) 2000-08-28
KR20000067830A (ko) 2000-11-25
AU760373B2 (en) 2003-05-15
JP2000178257A (ja) 2000-06-27
HU225820B1 (en) 2007-10-29
PT1010694E (pt) 2003-10-31
CA2292920A1 (fr) 2000-06-18
DK1010694T3 (da) 2003-11-24
NO314402B1 (no) 2003-03-17

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