SG48025A1 - Novel 2-szccarinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof - Google Patents

Novel 2-szccarinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Info

Publication number
SG48025A1
SG48025A1 SG1996006248A SG1996006248A SG48025A1 SG 48025 A1 SG48025 A1 SG 48025A1 SG 1996006248 A SG1996006248 A SG 1996006248A SG 1996006248 A SG1996006248 A SG 1996006248A SG 48025 A1 SG48025 A1 SG 48025A1
Authority
SG
Singapore
Prior art keywords
szccarinylmethyl
aryl
compositions
novel
proteolytic enzyme
Prior art date
Application number
SG1996006248A
Other languages
English (en)
Inventor
Richard Paul Dunlap
Lee Hamilton Latimer
Original Assignee
Sterling Winthhrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Winthhrop Inc filed Critical Sterling Winthhrop Inc
Publication of SG48025A1 publication Critical patent/SG48025A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG1996006248A 1991-12-30 1992-12-23 Novel 2-szccarinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof SG48025A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81574091A 1991-12-30 1991-12-30

Publications (1)

Publication Number Publication Date
SG48025A1 true SG48025A1 (en) 1998-04-17

Family

ID=25218721

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996006248A SG48025A1 (en) 1991-12-30 1992-12-23 Novel 2-szccarinylmethyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof

Country Status (17)

Country Link
US (3) US5385923A (fr)
EP (1) EP0550112A1 (fr)
JP (1) JPH05255286A (fr)
AU (1) AU651746B2 (fr)
CA (1) CA2086348A1 (fr)
CZ (1) CZ386992A3 (fr)
FI (1) FI925946A (fr)
HU (2) HUT65736A (fr)
IL (1) IL104259A (fr)
MX (1) MX9207274A (fr)
MY (1) MY108926A (fr)
NO (1) NO303446B1 (fr)
NZ (1) NZ245586A (fr)
PH (1) PH30411A (fr)
RU (1) RU2081871C1 (fr)
SG (1) SG48025A1 (fr)
TW (1) TW226016B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380737A (en) * 1989-05-04 1995-01-10 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
DE19533643A1 (de) * 1995-09-12 1997-03-13 Nycomed Arzneimittel Gmbh Neue cyclische Derivate von Benzolsulfonamiden
DE19748470A1 (de) * 1997-11-03 1999-05-06 Hoechst Schering Agrevo Gmbh Carbamoylphenylsulfonylharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US20090053221A1 (en) * 2006-01-17 2009-02-26 Cheung Nai-Kong V Immune response enhancing glucan
EP2445343B1 (fr) 2009-06-25 2021-08-04 Alkermes Pharma Ireland Limited Promédicaments de composés nh acides
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
AU2010339689B2 (en) * 2010-01-07 2015-02-19 Alkermes Pharma Ireland Limited Quaternary ammonium salt prodrugs
NZ604423A (en) 2010-06-24 2015-01-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP4327872A3 (fr) 2011-03-18 2024-07-10 Alkermes Pharma Ireland Limited Compositions pharmaceutiques comprenant des esters de sorbitan
US8969337B2 (en) 2011-12-15 2015-03-03 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
NZ630428A (en) 2012-03-19 2017-02-24 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising benzyl alcohol
ES2764383T3 (es) 2012-03-19 2020-06-03 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden ésteres de glicerol
NZ630643A (en) 2012-03-19 2017-08-25 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising fatty acid esters
CA2885196C (fr) 2012-09-19 2021-06-22 Alkermes Pharma Ireland Limited Compositions pharmaceutiques ayant une plus grande stabilite au stockage
US9566689B2 (en) 2013-12-31 2017-02-14 Saint-Gobain Abrasives, Inc. Abrasive article including shaped abrasive particles
US20150253127A1 (en) * 2014-03-04 2015-09-10 Honeywell Asca Inc. Thickness Determination of Web Product by Mid-infrared Wavelength Scanning Interferometry
WO2015143145A1 (fr) 2014-03-20 2015-09-24 Alkermes Pharma Ireland Limited Formulations d'aripiprazole présentant des vitesses d'injection plus élevées
US10346168B2 (en) 2015-06-26 2019-07-09 Microsoft Technology Licensing, Llc Decoupled processor instruction window and operand buffer
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002884A (en) * 1959-04-15 1961-10-03 Rohm & Haas Horticultural process with n-halomethyl-1,2-benzisothiazolin - 3 - one-1,1-dioxides for controlling fungus diseases
US3314960A (en) * 1964-08-25 1967-04-18 American Home Prod Benzisothiazol glutarimides
FR1451417A (fr) * 1965-07-15 1966-01-07 Roussel Uclaf Nouveaux esters d'acides cycliques et leur procédé de préparation
JPS4835457A (fr) * 1971-09-02 1973-05-24
US4195023A (en) * 1975-08-20 1980-03-25 Merck & Co., Inc. 2-(2-Furoyl)1,2-benzisothiazole-3-one, 2-(2-furoyl) saccharin, and 2-(2-thenoyl) saccharin
US4276298A (en) * 1978-03-24 1981-06-30 Merck & Co., Inc. 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
US4263393A (en) * 1979-09-06 1981-04-21 Eastman Kodak Company Novel electron donor precursors and photographic element containing them
US4350752A (en) * 1980-12-29 1982-09-21 Eastman Kodak Company Photographic elements and film units containing imidomethyl blocked photographic reagents
US4363865A (en) * 1981-03-04 1982-12-14 Eastman Kodak Company Imido methyl blocked photographic dyes and dye releasing compounds
US4410618A (en) * 1982-06-11 1983-10-18 Eastman Kodak Company Blocked photographic reagents
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
US4623645A (en) * 1983-04-18 1986-11-18 Merck & Co., Inc. Substituted cephalosporin sulfoxides as anti-inflammatory and antidegenerative agents
US4659855A (en) * 1983-05-09 1987-04-21 Georgia Tech Research Corporation Aryl sulfonyl fluoride compounds
DE3617976A1 (de) * 1986-05-28 1988-01-14 Alter Sa 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten
EP0253029A1 (fr) * 1986-07-10 1988-01-20 Keng-Ben Wang Dispositif de distillation d'eau potable
ES2110414T3 (es) * 1989-05-04 1998-02-16 Sanofi Sa Derivados de sacarina utiles como inhibidores de enzimas proteoliticas y su preparacion.
US5128339A (en) * 1990-11-01 1992-07-07 Sterling Winthrop Inc. Proteolytic enzyme inhibition method
FR2659327A1 (fr) * 1990-03-08 1991-09-13 Centre Nat Rech Scient Derives du benzisothiazolinone-1-dioxyde, utilisables comme inhibiteurs des elastases.
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5279758A (en) * 1991-10-22 1994-01-18 The Clorox Company Thickened aqueous cleaning compositions
AU656027B2 (en) * 1991-11-15 1995-01-19 Sanofi Saccharin derivative proteolytic enzime inhibitors
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
JPH07200419A (ja) * 1993-12-28 1995-08-04 Nec Corp バスインタフェース装置
DE4420271B4 (de) * 1994-06-10 2007-09-27 Robert Bosch Gmbh Zündspulensatz für eine Mehrzylinder-Brennkraftmaschine

Also Published As

Publication number Publication date
HUT65736A (en) 1994-07-28
HU211625A9 (en) 1995-12-28
TW226016B (fr) 1994-07-01
NO303446B1 (no) 1998-07-13
CA2086348A1 (fr) 1993-07-01
MX9207274A (es) 1993-06-01
FI925946A0 (fi) 1992-12-30
MY108926A (en) 1996-11-30
US5489604A (en) 1996-02-06
EP0550112A1 (fr) 1993-07-07
AU651746B2 (en) 1994-07-28
CZ386992A3 (en) 1993-09-15
US5783589A (en) 1998-07-21
NO925041L (no) 1993-07-01
RU2081871C1 (ru) 1997-06-20
FI925946A (fi) 1993-07-01
IL104259A (en) 1997-09-30
IL104259A0 (en) 1993-05-13
NZ245586A (en) 1994-11-25
NO925041D0 (no) 1992-12-30
HU9204166D0 (en) 1993-04-28
AU2966992A (en) 1993-07-01
US5385923A (en) 1995-01-31
PH30411A (en) 1997-05-09
JPH05255286A (ja) 1993-10-05

Similar Documents

Publication Publication Date Title
PH30411A (en) Novel 2-saccharinyl-methyl aryl and aryloxy acetates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
EP0272671A3 (en) Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
ZA916393B (en) Inhibitors of serine proteases
GR3026222T3 (en) Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU5748194A (en) Mannitol derivatives and their use as inhibitors of aspartyl protease
MC2313A1 (fr) Inhibiteurs d'enzymes
HU9202842D0 (en) Climotripsine-type proteases and inhibitors
AU2790895A (en) Purification of serine protease and synthetic inhibitors thereof
PL333505A1 (en) Benzamido-aldehydes and their application as inhibitors of cysteinic proteases
IL104716A0 (en) Aminoacetylmercapto derivatives useful as inhibitors of enkephalinase and ace
PL331047A1 (en) Novel amidinic derivatives and their application as inhibitors of thrombosin
IL111176A0 (en) Dipeptide boronic acid inhibitors of trypsin-like enzymes and pharmaceutical compositions containing them
AU7780391A (en) Low level blasting composition and method of blasting same
SG69977A1 (en) Novel 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU566601B2 (en) Derivatives of glutamic and aspartic acids
PL307854A1 (en) Method of obtaining dust-free enzyme
AU2251892A (en) Inhibitors of picornavirus proteases
ZA915271B (en) Inhibitors of retroviral proteases
AU8920191A (en) Methods and compositions for minimizing inhibition of nucleic acid amplification
AU8231391A (en) Inhibitors of aspartic proteases
IL103969A0 (en) Proteolytic mixture containing escharase and method of isolating same
GB2239455B (en) Formulations of lipolytic enzyme inhibitors and use of said inhibitors
IL72487A0 (en) Octahydroindolizinepropanoic acids and related compounds as enzyme inhibitors
SG50603A1 (en) Novel 2-saccharinylmethyl phosphates phosphonates and phosphinates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
ZA903242B (en) Stabilization of carboxyl esterase