SG2195G - Process for preparing S-metoprolol and intermediates therefor - Google Patents

Process for preparing S-metoprolol and intermediates therefor

Info

Publication number
SG2195G
SG2195G SG2195A SG2195A SG2195G SG 2195 G SG2195 G SG 2195G SG 2195 A SG2195 A SG 2195A SG 2195 A SG2195 A SG 2195A SG 2195 G SG2195 G SG 2195G
Authority
SG
Singapore
Prior art keywords
formula
chem
metoprolol
isopropyloxazolidin
hydroxymethyl
Prior art date
Application number
SG2195A
Other languages
English (en)
Inventor
Britt Ingela Keding
Bo Axel Richard Lindqvist
Bengt Bertil Samuelsson
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SG2195A priority Critical patent/SG2195G/en
Publication of SG2195G publication Critical patent/SG2195G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG2195A 1988-04-22 1995-01-09 Process for preparing S-metoprolol and intermediates therefor SG2195G (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SG2195A SG2195G (en) 1988-04-22 1995-01-09 Process for preparing S-metoprolol and intermediates therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8801518A SE8801518D0 (sv) 1988-04-22 1988-04-22 A novel process
SG2195A SG2195G (en) 1988-04-22 1995-01-09 Process for preparing S-metoprolol and intermediates therefor

Publications (1)

Publication Number Publication Date
SG2195G true SG2195G (en) 1995-06-16

Family

ID=20372103

Family Applications (1)

Application Number Title Priority Date Filing Date
SG2195A SG2195G (en) 1988-04-22 1995-01-09 Process for preparing S-metoprolol and intermediates therefor

Country Status (12)

Country Link
US (1) US5034535A (fr)
EP (1) EP0339006B1 (fr)
JP (1) JP2550410B2 (fr)
AT (1) ATE78026T1 (fr)
AU (1) AU607323B2 (fr)
DE (1) DE68902001T2 (fr)
ES (1) ES2043106T3 (fr)
GR (1) GR3005827T3 (fr)
HK (1) HK25095A (fr)
NZ (1) NZ228780A (fr)
SE (1) SE8801518D0 (fr)
SG (1) SG2195G (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660984B2 (en) * 1991-03-18 1995-07-13 Sepracor, Inc. Composition and method containing optically pure (S) metoprolol
EP0647633A1 (fr) * 1993-10-08 1995-04-12 Duphar International Research B.V Procédé de préparation d'un intermédiaire hétérocyclique pour l'obtention d'aryloxy amino-alcools vicinaux optiquement actifs
EP0647634A1 (fr) * 1993-10-08 1995-04-12 Duphar International Research B.V Procédé de préparation d'un intermédiaire hétérocyclique pour l'obtention d'aryloxy amino alcools vicinaux optiquement actifs
US5942633A (en) * 1996-06-19 1999-08-24 Abbott Laboratories Process for the selective alkylation of betaxolol intermediates
US5731463A (en) * 1996-09-23 1998-03-24 Abbott Laboratories Selective alkylation of an alcohol substituted phenol compound
IES20090901A2 (en) * 2008-11-28 2010-07-07 Corden Pharma Ip Ltd Manufacture of beta blockers
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
ES2877641T3 (es) * 2017-02-10 2021-11-17 Basf Se Proceso para la remoción de gases ácidos de una corriente de fluido y los correspondientes usos
CN111812228B (zh) * 2020-06-19 2021-11-05 山东省药学科学院 一种超高效液相色谱测定酒石酸美托洛尔及其片剂杂质的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641152A (en) * 1968-09-23 1972-02-08 Warner Lambert Pharmaceutical 3 4-dihydronaphthalenoneoxy-2-hydroxy-propylamines
SE386892B (sv) * 1972-07-06 1976-08-23 Haessle Ab Forfarande for framstellning av oxaminoforeningar
CH635573A5 (en) * 1977-03-24 1983-04-15 Sandoz Ag Process for preparing novel 1,2-dihydroxypropane derivatives
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
US4296242A (en) * 1979-06-06 1981-10-20 Schering Corporation Process for the preparation of chiral 3-amino-2-hydroxypropionic acid and N-blocked derivatives thereof
JPS5767544A (en) * 1980-10-13 1982-04-24 Maruko Seiyaku Kk Improved preparation of 1-2(allylphenyxy)-3-isopropylaminopropan-2-ol
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
JPS62108870A (ja) * 1985-11-06 1987-05-20 Kanegafuchi Chem Ind Co Ltd 光学活性５−スルホニルオキシメチル−２−オキサゾリジノン誘導体及びその製造方法
US4990668A (en) * 1985-12-04 1991-02-05 E. I. Du Pont De Nemours And Company Optically active aryloxypropanolamines and arylethanolamines
JPS63502585A (ja) * 1985-12-04 1988-09-29 ザ　デュポン　メルク　ファーマシュウティカル　カンパニー アリルオキシプロパノ−ルアミン類及びアリルエタノ−ルアミン類の合成法
EP0279844A4 (fr) * 1986-09-02 1990-06-05 Du Pont AFLÖSUNG VON DE dl-METHYL-3-4-(2-HYDROXY-3-ISOPROPYLAMINO)PROPOXY]PHENYLPROPIONAT (DL-ESMOLOL)].

Also Published As

Publication number Publication date
HK25095A (en) 1995-03-03
JP2550410B2 (ja) 1996-11-06
ES2043106T3 (es) 1993-12-16
GR3005827T3 (fr) 1993-06-07
DE68902001T2 (de) 1993-02-11
ATE78026T1 (de) 1992-07-15
NZ228780A (en) 1991-10-25
EP0339006B1 (fr) 1992-07-08
US5034535A (en) 1991-07-23
SE8801518D0 (sv) 1988-04-22
JPH0222253A (ja) 1990-01-25
AU3311589A (en) 1989-10-26
EP0339006A1 (fr) 1989-10-25
DE68902001D1 (de) 1992-08-13
AU607323B2 (en) 1991-02-28

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