SG19995G - Novel 3-arylindole and 3-arylindazole derivatives - Google Patents

Novel 3-arylindole and 3-arylindazole derivatives

Info

Publication number
SG19995G
SG19995G SG19995A SG19995A SG19995G SG 19995 G SG19995 G SG 19995G SG 19995 A SG19995 A SG 19995A SG 19995 A SG19995 A SG 19995A SG 19995 G SG19995 G SG 19995G
Authority
SG
Singapore
Prior art keywords
alkyl
hydrogen
group
arylindole
trifluoromethyl
Prior art date
Application number
SG19995A
Other languages
English (en)
Inventor
Jens Kristian Perregaard
Kim Andersen
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK181190A priority Critical patent/DK181190D0/da
Priority to IE240391A priority patent/IE65673B1/en
Priority to NZ238956A priority patent/NZ238956A/xx
Priority to NO912739A priority patent/NO178192C/no
Priority to IL98829A priority patent/IL98829A/he
Priority to AT91610058T priority patent/ATE115128T1/de
Priority to DK91610058.9T priority patent/DK0470039T3/da
Priority to DE69105659T priority patent/DE69105659T2/de
Priority to EP91610058A priority patent/EP0470039B1/en
Priority to ES91610058T priority patent/ES2064974T3/es
Priority to ZA915805A priority patent/ZA915805B/xx
Priority to KR1019910012971A priority patent/KR100233955B1/ko
Priority to FI913613A priority patent/FI99111C/fi
Priority to PT98483A priority patent/PT98483B/pt
Priority to AU81411/91A priority patent/AU646679B2/en
Priority to JP18892391A priority patent/JP3165181B2/ja
Priority to CA002048027A priority patent/CA2048027C/en
Priority to US08/131,438 priority patent/US5393761A/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to SG19995A priority patent/SG19995G/en
Priority to GR940404079T priority patent/GR3015274T3/el
Priority to HK51495A priority patent/HK51495A/xx
Publication of SG19995G publication Critical patent/SG19995G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
SG19995A 1990-07-30 1995-02-07 Novel 3-arylindole and 3-arylindazole derivatives SG19995G (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DK181190A DK181190D0 (da) 1990-07-30 1990-07-30 3-aryl-indol- eller 3-aryl-indazolderivater
IE240391A IE65673B1 (en) 1990-07-30 1991-07-09 Novel 3-arylindole and 3-arylindazole derivatives
NZ238956A NZ238956A (en) 1990-07-30 1991-07-12 3-arylindole or 3-arylindazole derivatives and medicaments thereof.
NO912739A NO178192C (no) 1990-07-30 1991-07-12 Analogifremgangsmåte ved fremstilling av terapeutisk aktive 3-arylindol- og 3-arylindazolderivater
IL98829A IL98829A (he) 1990-07-30 1991-07-15 תולדות 3-ארילאינדול ו-3-ארילאינדזולהכנתן ותכשירי רוקחות המכילים אותן
ES91610058T ES2064974T3 (es) 1990-07-30 1991-07-22 Nuevos derivados de 3-arilindol y 3-arilindazol.
DK91610058.9T DK0470039T3 (da) 1990-07-30 1991-07-22 3-arylindol- og 3-arylindazolforbindelser
DE69105659T DE69105659T2 (de) 1990-07-30 1991-07-22 3-Arylindol- und 3-Arylindazolderivate.
EP91610058A EP0470039B1 (en) 1990-07-30 1991-07-22 Novel 3-arylindole and 3-arylindazole derivatives
AT91610058T ATE115128T1 (de) 1990-07-30 1991-07-22 3-arylindol- und 3-arylindazolderivate.
ZA915805A ZA915805B (en) 1990-07-30 1991-07-24 3-arylindole and 3-arylindazole derivatives
KR1019910012971A KR100233955B1 (ko) 1990-07-30 1991-07-27 신규 3-아릴인돌 및 3-아릴인다졸 유도체
PT98483A PT98483B (pt) 1990-07-30 1991-07-29 Processo para a preparacao de derivados de 3-aril-indol e 3-aril-indazol
AU81411/91A AU646679B2 (en) 1990-07-30 1991-07-29 Novel 3-arylindole and 3-arylindazole derivatives
JP18892391A JP3165181B2 (ja) 1990-07-30 1991-07-29 新規の３−アリールインドールおよび３−アリールインダゾール誘導体
CA002048027A CA2048027C (en) 1990-07-30 1991-07-29 3-arylindole and 3-arylindazole derivatives
FI913613A FI99111C (fi) 1990-07-30 1991-07-29 Menetelmä uusien terapeuttisesti käyttökelpoisten 3-aryyli-indoli- ja 3-aryyli-indatsolijohdannaisten valmistamiseksi
US08/131,438 US5393761A (en) 1990-07-30 1993-10-04 3-arylindole compounds
SG19995A SG19995G (en) 1990-07-30 1995-02-07 Novel 3-arylindole and 3-arylindazole derivatives
GR940404079T GR3015274T3 (en) 1990-07-30 1995-03-03 Novel 3-arylindole and 3-arylindazole derivatives.
HK51495A HK51495A (en) 1990-07-30 1995-04-06 Novel 3-arylindole and 3-arylindazole derivatives.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK181190A DK181190D0 (da) 1990-07-30 1990-07-30 3-aryl-indol- eller 3-aryl-indazolderivater
SG19995A SG19995G (en) 1990-07-30 1995-02-07 Novel 3-arylindole and 3-arylindazole derivatives

Publications (1)

Publication Number Publication Date
SG19995G true SG19995G (en) 1995-08-18

Family

ID=26066139

Family Applications (1)

Application Number Title Priority Date Filing Date
SG19995A SG19995G (en) 1990-07-30 1995-02-07 Novel 3-arylindole and 3-arylindazole derivatives

Country Status (20)

Country Link
US (1) US5393761A (he)
EP (1) EP0470039B1 (he)
JP (1) JP3165181B2 (he)
KR (1) KR100233955B1 (he)
AT (1) ATE115128T1 (he)
AU (1) AU646679B2 (he)
CA (1) CA2048027C (he)
DE (1) DE69105659T2 (he)
DK (2) DK181190D0 (he)
ES (1) ES2064974T3 (he)
FI (1) FI99111C (he)
GR (1) GR3015274T3 (he)
HK (1) HK51495A (he)
IE (1) IE65673B1 (he)
IL (1) IL98829A (he)
NO (1) NO178192C (he)
NZ (1) NZ238956A (he)
PT (1) PT98483B (he)
SG (1) SG19995G (he)
ZA (1) ZA915805B (he)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK8492D0 (da) * 1992-01-23 1992-01-23 Lundbeck & Co As H Behandling af psykoser
US5264576A (en) * 1992-10-22 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Pyrazolo[4,3-c]pyridines which are intermediates
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
FR2744452B1 (fr) * 1996-02-06 1998-03-06 Cird Galderma Composes biaryles heterocycliques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
DE19642255A1 (de) * 1996-10-14 1998-04-16 Bayer Ag Verwendung von 1-Benzyl-3-(substituierten-hetaryl) -kondensierten Pyrazol-Derivaten
TWI242011B (en) 1997-03-31 2005-10-21 Eisai Co Ltd 1,4-substituted cyclic amine derivatives
FR2788772B1 (fr) * 1999-01-26 2001-03-02 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN1217930C (zh) * 2000-05-26 2005-09-07 西巴特殊化学品控股有限公司 吲哚衍生物的制备方法和该方法的中间体
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
IL157363A0 (en) * 2001-02-16 2004-02-19 Aventis Pharma Inc Novel heterocyclic urea derivatives and their use as dopamine d3 receptor ligands
MY135686A (en) 2002-06-24 2008-06-30 Schering Corp Indole derivatives useful as histamine h3 antagonists
TW200409759A (en) 2002-09-25 2004-06-16 Wyeth Corp Substituted 4-(indazol-3-yl)phenols
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
EP2065383A1 (en) 2003-11-19 2009-06-03 Signal Pharmaceuticals, Inc. Indazole compounds and methods of use thereof as protein kinase inhibitors
DE102006043443A1 (de) * 2006-09-15 2008-03-27 Bayer Healthcare Ag Neue aza-bicyclische Verbindungen und ihre Verwendung
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
US9963458B2 (en) 2012-12-27 2018-05-08 Purdue Pharma L.P. Indole and indoline-type piperidine compounds and uses thereof
MX2015010725A (es) 2013-02-21 2016-05-31 Adverio Pharma Gmbh Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2354766A1 (fr) * 1976-06-17 1978-01-13 Labaz Derives n-aminoalkyles d'indole et procedes pour les preparer
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
DK704488D0 (da) * 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives

Also Published As

Publication number Publication date
CA2048027C (en) 2001-10-30
IL98829A0 (en) 1992-07-15
NO912739L (no) 1992-01-31
EP0470039A3 (en) 1992-05-27
EP0470039B1 (en) 1994-12-07
DE69105659D1 (de) 1995-01-19
IE65673B1 (en) 1995-11-15
US5393761A (en) 1995-02-28
KR920002588A (ko) 1992-02-28
IL98829A (he) 1996-06-18
GR3015274T3 (en) 1995-06-30
JP3165181B2 (ja) 2001-05-14
DE69105659T2 (de) 1995-04-27
ATE115128T1 (de) 1994-12-15
HK51495A (en) 1995-04-13
ES2064974T3 (es) 1995-02-01
IE912403A1 (en) 1992-02-12
FI99111C (fi) 1997-10-10
DK181190D0 (da) 1990-07-30
ZA915805B (en) 1992-04-29
JPH04368367A (ja) 1992-12-21
FI913613A0 (fi) 1991-07-29
FI913613A (fi) 1992-01-31
FI99111B (fi) 1997-06-30
NZ238956A (en) 1993-12-23
CA2048027A1 (en) 1992-01-31
AU8141191A (en) 1992-02-06
DK0470039T3 (da) 1995-05-15
PT98483B (pt) 1997-09-30
NO178192C (no) 1996-02-07
NO178192B (no) 1995-10-30
KR100233955B1 (ko) 2000-02-01
AU646679B2 (en) 1994-03-03
NO912739D0 (no) 1991-07-12
PT98483A (pt) 1992-05-29
EP0470039A2 (en) 1992-02-05

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