SG185946A1 - Novel neurturin conjugates for pharmaceutical use - Google Patents
Novel neurturin conjugates for pharmaceutical use Download PDFInfo
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- SG185946A1 SG185946A1 SG2012081220A SG2012081220A SG185946A1 SG 185946 A1 SG185946 A1 SG 185946A1 SG 2012081220 A SG2012081220 A SG 2012081220A SG 2012081220 A SG2012081220 A SG 2012081220A SG 185946 A1 SG185946 A1 SG 185946A1
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- neurturin
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- protein product
- human
- polyethylene glycol
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- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07021493 | 2007-11-05 |
Publications (1)
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| SG185946A1 true SG185946A1 (en) | 2012-12-28 |
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| SG2012081220A SG185946A1 (en) | 2007-11-05 | 2008-11-05 | Novel neurturin conjugates for pharmaceutical use |
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| EP (1) | EP2217282A2 (enExample) |
| JP (2) | JP2011503019A (enExample) |
| KR (2) | KR20150139982A (enExample) |
| CN (2) | CN104288775A (enExample) |
| AU (1) | AU2008324426B2 (enExample) |
| BR (1) | BRPI0819220A2 (enExample) |
| CA (1) | CA2742839A1 (enExample) |
| CO (1) | CO6280503A2 (enExample) |
| CR (1) | CR11406A (enExample) |
| EA (1) | EA201070484A1 (enExample) |
| IL (1) | IL205290A (enExample) |
| MX (1) | MX2010004899A (enExample) |
| NZ (1) | NZ585262A (enExample) |
| SG (1) | SG185946A1 (enExample) |
| WO (1) | WO2009059755A2 (enExample) |
| ZA (1) | ZA201003227B (enExample) |
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| US20050222070A1 (en) | 2002-05-29 | 2005-10-06 | Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung | Pancreas-specific proteins |
| DK1694354T3 (da) | 2003-11-27 | 2009-10-26 | Develogen Ag | Fremgangsmåde til at forhindre og behandle diabetes ved anvendelse af neurturin |
| BR112012009801A8 (pt) * | 2009-10-30 | 2016-08-30 | Cns Therapeutics Inc | Polipeptídeo neurturina e variante de neurturina |
| US9127083B2 (en) | 2009-10-30 | 2015-09-08 | Ntf Therapeutics, Inc. | Neurturin molecules |
| US8445432B2 (en) | 2009-10-30 | 2013-05-21 | Ntf Therapeutics Inc | Neurturin molecules |
| US8742677B2 (en) * | 2010-01-11 | 2014-06-03 | System General Corp. | LED drive circuit with a programmable input for LED lighting |
| CN102453725B (zh) * | 2010-11-02 | 2014-06-11 | 杭州纽龙生物科技有限公司 | 一种重组载体、包含该重组载体的重组菌株及制备方法 |
| JP6051378B2 (ja) * | 2011-05-02 | 2016-12-27 | 国立大学法人 熊本大学 | 幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法 |
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| US5739307A (en) * | 1995-08-28 | 1998-04-14 | Washington University | Polynucleotide encoding neurturin neurotrophic factor |
| US6043221A (en) * | 1997-07-30 | 2000-03-28 | Amgen Inc. | Method for preventing and treating hearing loss using a neuturin protein product |
| JP2003524381A (ja) * | 1998-09-22 | 2003-08-19 | ユニヴァーシティ オブ メリーランド，ボルチモア | システインノット成長因子ミュータント |
| US7442370B2 (en) * | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| US20050222070A1 (en) * | 2002-05-29 | 2005-10-06 | Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung | Pancreas-specific proteins |
| EP2275118A3 (en) | 2002-05-29 | 2011-10-19 | DeveloGen Aktiengesellschaft | Pancreas-specific proteins |
| ES2342397T3 (es) * | 2003-10-20 | 2010-07-06 | Nsgene A/S | Vector virico para su uso en terapia genica in vivo de la enfermedad de parkinson. |
| DK1694354T3 (da) * | 2003-11-27 | 2009-10-26 | Develogen Ag | Fremgangsmåde til at forhindre og behandle diabetes ved anvendelse af neurturin |
| EP1872790A1 (en) * | 2006-06-26 | 2008-01-02 | DeveloGen Aktiengesellschaft | New formulation for increasing bioavailability of neurturin |
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2008
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2217282A2 (en) | 2010-08-18 |
| IL205290A (en) | 2014-01-30 |
| WO2009059755A2 (en) | 2009-05-14 |
| BRPI0819220A2 (pt) | 2019-02-26 |
| CR11406A (es) | 2010-10-25 |
| US20130231283A1 (en) | 2013-09-05 |
| US20160060317A1 (en) | 2016-03-03 |
| CN101848735A (zh) | 2010-09-29 |
| JP2015057384A (ja) | 2015-03-26 |
| ZA201003227B (en) | 2011-03-30 |
| US20110003741A1 (en) | 2011-01-06 |
| CO6280503A2 (es) | 2011-05-20 |
| MX2010004899A (es) | 2010-09-07 |
| JP2011503019A (ja) | 2011-01-27 |
| CN104288775A (zh) | 2015-01-21 |
| KR20100098619A (ko) | 2010-09-08 |
| KR20150139982A (ko) | 2015-12-14 |
| US9029323B2 (en) | 2015-05-12 |
| AU2008324426B2 (en) | 2014-03-27 |
| NZ585262A (en) | 2012-06-29 |
| EA201070484A1 (ru) | 2011-04-29 |
| CA2742839A1 (en) | 2009-05-14 |
| AU2008324426A1 (en) | 2009-05-14 |
| IL205290A0 (en) | 2010-12-30 |
| WO2009059755A3 (en) | 2009-09-24 |
| CN101848735B (zh) | 2014-07-23 |
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