SG185490A1 - New forms of rifaximin and uses thereof - Google Patents
New forms of rifaximin and uses thereof Download PDFInfo
- Publication number
- SG185490A1 SG185490A1 SG2012082541A SG2012082541A SG185490A1 SG 185490 A1 SG185490 A1 SG 185490A1 SG 2012082541 A SG2012082541 A SG 2012082541A SG 2012082541 A SG2012082541 A SG 2012082541A SG 185490 A1 SG185490 A1 SG 185490A1
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- SG
- Singapore
- Prior art keywords
- rifaximin
- cocrystal
- piperazine
- peaks
- xrpd
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US35128110P | 2010-06-03 | 2010-06-03 | |
| US35750510P | 2010-06-22 | 2010-06-22 | |
| US36324110P | 2010-07-10 | 2010-07-10 | |
| US36351110P | 2010-07-12 | 2010-07-12 | |
| US36718510P | 2010-07-23 | 2010-07-23 | |
| US41659310P | 2010-11-23 | 2010-11-23 | |
| PCT/US2011/039085 WO2011153444A1 (en) | 2010-06-03 | 2011-06-03 | New forms of rifaximin and uses thereof |
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| SG185490A1 true SG185490A1 (en) | 2012-12-28 |
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| SG10201507035UA SG10201507035UA (en) | 2010-06-03 | 2011-06-03 | New forms of rifaximin and uses thereof |
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| SG10201507035UA SG10201507035UA (en) | 2010-06-03 | 2011-06-03 | New forms of rifaximin and uses thereof |
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| US (2) | US8513275B2 (https=) |
| EP (1) | EP2575464A4 (https=) |
| JP (1) | JP2013527246A (https=) |
| KR (1) | KR20130086338A (https=) |
| CN (1) | CN103269587A (https=) |
| AU (1) | AU2011261283B2 (https=) |
| BR (1) | BR112012030783A2 (https=) |
| CA (1) | CA2800668A1 (https=) |
| CR (1) | CR20120620A (https=) |
| EA (1) | EA022490B1 (https=) |
| IL (1) | IL222900A (https=) |
| MX (1) | MX2012013945A (https=) |
| NZ (2) | NZ710780A (https=) |
| PH (1) | PH12012502393A1 (https=) |
| SG (2) | SG185490A1 (https=) |
| TN (1) | TN2012000533A1 (https=) |
| WO (1) | WO2011153444A1 (https=) |
| ZA (1) | ZA201208770B (https=) |
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| PT1698630E (pt) | 2005-03-03 | 2014-09-15 | Alfa Wassermann Spa | Novas formas polimorfas de rifaximina, processos para a sua produção e a sua utilização nas preparações medicinais |
| US8486956B2 (en) | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| UA113275C2 (xx) | 2008-02-25 | 2017-01-10 | ζ-ФОРМА РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ | |
| US9018684B2 (en) | 2009-11-23 | 2015-04-28 | California Institute Of Technology | Chemical sensing and/or measuring devices and methods |
| IT1398550B1 (it) | 2010-03-05 | 2013-03-01 | Alfa Wassermann Spa | Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo |
| AU2011225810B2 (en) * | 2010-03-10 | 2014-11-06 | Lupin Limited | Rifaximin ready-to-use suspension |
| SG192122A1 (en) * | 2011-02-11 | 2013-08-30 | Salix Pharmaceuticals Ltd | Forms of rifaximin and uses thereof |
| WO2012150561A1 (en) * | 2011-05-02 | 2012-11-08 | Ranbaxy Laboratories Limited | Rifaximin dimethylformamide solvate |
| ITBO20110461A1 (it) | 2011-07-29 | 2013-01-30 | Alfa Wassermann Spa | Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali. |
| CA2854380A1 (en) | 2011-11-02 | 2013-05-10 | Salix Pharmaceuticals, Ltd. | Methods for treating irritable bowel syndrome (ibs) and infections |
| CA2876737A1 (en) | 2012-06-13 | 2013-12-19 | Apotex Pharmachem Inc. | Polymorphic forms of rifaximin |
| ITBO20120368A1 (it) | 2012-07-06 | 2014-01-07 | Alfa Wassermann Spa | Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso. |
| MX2015002934A (es) * | 2012-09-13 | 2015-10-29 | Salix Pharmaceuticals Inc | Metodos de administracion de rifaximina para perdida de peso y tratamiento de obesidad. |
| CN105142636A (zh) | 2013-03-15 | 2015-12-09 | 意大利阿尔法韦士曼制药公司 | 用于治疗阴道感染的利福昔明 |
| WO2014140995A2 (en) | 2013-03-15 | 2014-09-18 | Alfa Wassermann S.P.A. | Method for diagnosing vaginal infections |
| EP2983647B1 (en) | 2013-04-12 | 2020-09-09 | Alfasigma S.p.A. | Nsaid administration and related compositions, methods and systems |
| ITMI20131307A1 (it) * | 2013-08-02 | 2015-02-02 | A M S A Anonima Materie Sint & Affini S P A | Processo per la preparazione di refaximina k |
| ES2621557T3 (es) | 2014-03-31 | 2017-07-04 | Euticals S.P.A. | Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas |
| EP3140313B1 (en) | 2014-05-04 | 2020-02-26 | Salix Pharmaceuticals, Inc. | Ibs microbiota and uses thereof |
| NZ723571A (en) * | 2014-05-12 | 2020-02-28 | Alfasigma Spa | New solvated crystal form of rifaximin, production, compositions and uses thereof |
| WO2025170483A1 (ru) * | 2024-02-07 | 2025-08-14 | Общество с ограниченной ответственностью "БИННОФАРМ ГРУПП" | Фармацевтическая композиция, обладающая антибиотической активностью |
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| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| ITMI20032144A1 (it) * | 2003-11-07 | 2005-05-08 | Alfa Wassermann Spa | Forme polimorfe di rifaximina, processi per ottenerle e |
| US7902206B2 (en) * | 2003-11-07 | 2011-03-08 | Alfa Wassermann, S.P.A. | Polymorphic forms α, β and γ of rifaximin |
| CA2548281C (en) * | 2003-12-09 | 2013-11-12 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| WO2006007448A2 (en) * | 2004-06-17 | 2006-01-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions and related methods of use |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| US8486956B2 (en) * | 2008-02-25 | 2013-07-16 | Salix Pharmaceuticals, Ltd | Forms of rifaximin and uses thereof |
| UA113275C2 (xx) * | 2008-02-25 | 2017-01-10 | ζ-ФОРМА РИФАКСИМІНУ І ЇЇ ЗАСТОСУВАННЯ |
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| AU2011261283A1 (en) | 2012-12-06 |
| US8815888B2 (en) | 2014-08-26 |
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| WO2011153444A1 (en) | 2011-12-08 |
| NZ603590A (en) | 2015-08-28 |
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| EP2575464A1 (en) | 2013-04-10 |
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| IL222900A0 (en) | 2012-12-31 |
| US20130317225A1 (en) | 2013-11-28 |
| BR112012030783A2 (pt) | 2015-09-29 |
| JP2013527246A (ja) | 2013-06-27 |
| CR20120620A (es) | 2014-05-23 |
| IL222900A (en) | 2017-11-30 |
| EA201270808A1 (ru) | 2013-04-30 |
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