SG182137A1 - Mono ( iron hydroxypyrone ) and combination ( iron hydroxypyrone and gi inflammation inhibiting agents ) compositions for anaemia or h. pylori infections - Google Patents
Mono ( iron hydroxypyrone ) and combination ( iron hydroxypyrone and gi inflammation inhibiting agents ) compositions for anaemia or h. pylori infections Download PDFInfo
- Publication number
- SG182137A1 SG182137A1 SG2012038915A SG2012038915A SG182137A1 SG 182137 A1 SG182137 A1 SG 182137A1 SG 2012038915 A SG2012038915 A SG 2012038915A SG 2012038915 A SG2012038915 A SG 2012038915A SG 182137 A1 SG182137 A1 SG 182137A1
- Authority
- SG
- Singapore
- Prior art keywords
- iron
- composition according
- composition
- gastrointestinal tract
- inflammatory disease
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 111
- QQTUBEKQMMRXHC-UHFFFAOYSA-N 3-hydroxypyran-2-one;iron Chemical compound [Fe].OC1=CC=COC1=O QQTUBEKQMMRXHC-UHFFFAOYSA-N 0.000 title claims abstract description 71
- 208000007502 anemia Diseases 0.000 title claims abstract description 28
- 239000003795 chemical substances by application Substances 0.000 title abstract description 7
- 230000002401 inhibitory effect Effects 0.000 title abstract description 4
- 206010061218 Inflammation Diseases 0.000 title abstract description 3
- 230000004054 inflammatory process Effects 0.000 title abstract description 3
- 208000015181 infectious disease Diseases 0.000 title description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 184
- 229910052742 iron Inorganic materials 0.000 claims abstract description 91
- 150000001875 compounds Chemical class 0.000 claims abstract description 69
- 210000001035 gastrointestinal tract Anatomy 0.000 claims abstract description 54
- 208000027866 inflammatory disease Diseases 0.000 claims abstract description 52
- 230000002496 gastric effect Effects 0.000 claims abstract description 26
- 208000002310 Achlorhydria Diseases 0.000 claims abstract description 17
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims abstract description 11
- 239000002253 acid Substances 0.000 claims description 63
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 35
- 239000010941 cobalt Substances 0.000 claims description 26
- 229910017052 cobalt Inorganic materials 0.000 claims description 26
- 210000002784 stomach Anatomy 0.000 claims description 19
- 238000010521 absorption reaction Methods 0.000 claims description 18
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 16
- 239000003638 chemical reducing agent Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 16
- 238000011269 treatment regimen Methods 0.000 claims description 15
- 206010017964 Gastrointestinal infection Diseases 0.000 claims description 14
- 150000001868 cobalt Chemical class 0.000 claims description 14
- 150000001869 cobalt compounds Chemical class 0.000 claims description 13
- -1 iron (I) carboxylate Chemical class 0.000 claims description 13
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 12
- 229940050410 gluconate Drugs 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 12
- 208000019836 digestive system infectious disease Diseases 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 10
- 241000590002 Helicobacter pylori Species 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- 229940037467 helicobacter pylori Drugs 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 6
- 229960000381 omeprazole Drugs 0.000 claims description 6
- 229940126409 proton pump inhibitor Drugs 0.000 claims description 6
- 239000000612 proton pump inhibitor Substances 0.000 claims description 6
- 150000007942 carboxylates Chemical class 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 5
- 239000011736 potassium bicarbonate Substances 0.000 claims description 5
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 5
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 5
- 229960000620 ranitidine Drugs 0.000 claims description 5
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 claims description 5
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 5
- 208000004300 Atrophic Gastritis Diseases 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 208000036495 Gastritis atrophic Diseases 0.000 claims description 4
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims description 4
- 208000016644 chronic atrophic gastritis Diseases 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 claims description 4
- 229960001596 famotidine Drugs 0.000 claims description 4
- 230000003472 neutralizing effect Effects 0.000 claims description 4
- 229960005019 pantoprazole Drugs 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- NNNRGWOWXNCGCV-UHFFFAOYSA-N 4-(2-bromoethyl)benzonitrile Chemical compound BrCCC1=CC=C(C#N)C=C1 NNNRGWOWXNCGCV-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 229960001380 cimetidine Drugs 0.000 claims description 3
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 3
- 229940049699 cobalt gluconate Drugs 0.000 claims description 3
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 3
- 229960003174 lansoprazole Drugs 0.000 claims description 3
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 claims description 3
- 229960004872 nizatidine Drugs 0.000 claims description 3
- SGXXNSQHWDMGGP-IZZDOVSWSA-N nizatidine Chemical compound [O-][N+](=O)\C=C(/NC)NCCSCC1=CSC(CN(C)C)=N1 SGXXNSQHWDMGGP-IZZDOVSWSA-N 0.000 claims description 3
- 229940044551 receptor antagonist Drugs 0.000 claims description 3
- 239000002464 receptor antagonist Substances 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 2
- 229940024545 aluminum hydroxide Drugs 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229960003563 calcium carbonate Drugs 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 150000004700 cobalt complex Chemical class 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 229960001708 magnesium carbonate Drugs 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
- 229940094025 potassium bicarbonate Drugs 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims 1
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 35
- LIPRKYKMVQPYPG-UHFFFAOYSA-N 3-Hydroxy-2H-pyran-2-one Chemical compound OC1=CC=COC1=O LIPRKYKMVQPYPG-UHFFFAOYSA-N 0.000 description 18
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 17
- 229940043353 maltol Drugs 0.000 description 17
- 239000007788 liquid Substances 0.000 description 16
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 14
- 238000011282 treatment Methods 0.000 description 14
- 208000007882 Gastritis Diseases 0.000 description 12
- 208000008469 Peptic Ulcer Diseases 0.000 description 11
- VEYIMQVTPXPUHA-UHFFFAOYSA-N 3-hydroxypyran-4-one Chemical compound OC1=COC=CC1=O VEYIMQVTPXPUHA-UHFFFAOYSA-N 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 208000011906 peptic ulcer disease Diseases 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 208000007107 Stomach Ulcer Diseases 0.000 description 6
- 150000001450 anions Chemical class 0.000 description 6
- 206010009900 Colitis ulcerative Diseases 0.000 description 5
- 208000011231 Crohn disease Diseases 0.000 description 5
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 description 5
- 201000006704 Ulcerative Colitis Diseases 0.000 description 5
- 239000003242 anti bacterial agent Substances 0.000 description 5
- 229910001429 cobalt ion Inorganic materials 0.000 description 5
- XLJKHNWPARRRJB-UHFFFAOYSA-N cobalt(2+) Chemical compound [Co+2] XLJKHNWPARRRJB-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000012423 maintenance Methods 0.000 description 5
- 206010019375 Helicobacter infections Diseases 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 description 4
- 229940093503 ethyl maltol Drugs 0.000 description 4
- 239000004222 ferrous gluconate Substances 0.000 description 4
- 235000013924 ferrous gluconate Nutrition 0.000 description 4
- 229960001645 ferrous gluconate Drugs 0.000 description 4
- 201000000052 gastrinoma Diseases 0.000 description 4
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 206010017943 Gastrointestinal conditions Diseases 0.000 description 3
- ZEGRKMXCOCRTCS-UHFFFAOYSA-N Poppy acid Chemical compound OC(=O)C1=CC(=O)C(O)=C(C(O)=O)O1 ZEGRKMXCOCRTCS-UHFFFAOYSA-N 0.000 description 3
- 229940069428 antacid Drugs 0.000 description 3
- 239000003159 antacid agent Substances 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000003891 ferrous sulphate Nutrition 0.000 description 3
- 239000011790 ferrous sulphate Substances 0.000 description 3
- 210000004211 gastric acid Anatomy 0.000 description 3
- 201000005917 gastric ulcer Diseases 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical class [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 208000015439 Lysosomal storage disease Diseases 0.000 description 2
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- 208000008955 Mucolipidoses Diseases 0.000 description 2
- 206010072930 Mucolipidosis type IV Diseases 0.000 description 2
- 102100026502 Mucolipin-1 Human genes 0.000 description 2
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 description 2
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- 230000001363 autoimmune Effects 0.000 description 2
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- 208000010928 autoimmune thyroid disease Diseases 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
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- 210000004027 cell Anatomy 0.000 description 2
- 208000023652 chronic gastritis Diseases 0.000 description 2
- 229960002626 clarithromycin Drugs 0.000 description 2
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
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- 229950008006 ferric maltol Drugs 0.000 description 2
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- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 150000004679 hydroxides Chemical class 0.000 description 2
- 239000002563 ionic surfactant Substances 0.000 description 2
- AHPWLYJHTFAWKI-UHFFFAOYSA-K iron(3+);2-methyl-4-oxopyran-3-olate Chemical compound [Fe+3].CC=1OC=CC(=O)C=1[O-].CC=1OC=CC(=O)C=1[O-].CC=1OC=CC(=O)C=1[O-] AHPWLYJHTFAWKI-UHFFFAOYSA-K 0.000 description 2
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Chemical compound CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- LIVNCPMCQTZXRZ-UHFFFAOYSA-N meconic acid Natural products CC(=O)C1=CC(=O)C(O)=C(C(C)=O)O1 LIVNCPMCQTZXRZ-UHFFFAOYSA-N 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229960000282 metronidazole Drugs 0.000 description 2
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 210000001711 oxyntic cell Anatomy 0.000 description 2
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
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- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
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- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- SFOKDWPZOYRZFF-UHFFFAOYSA-H 2,3-dihydroxybutanedioate;iron(3+) Chemical compound [Fe+3].[Fe+3].[O-]C(=O)C(O)C(O)C([O-])=O.[O-]C(=O)C(O)C(O)C([O-])=O.[O-]C(=O)C(O)C(O)C([O-])=O SFOKDWPZOYRZFF-UHFFFAOYSA-H 0.000 description 1
- FYFLKJJEBGDUEF-UHFFFAOYSA-N 5-hydroxypyran-2-one Chemical compound OC=1C=CC(=O)OC=1 FYFLKJJEBGDUEF-UHFFFAOYSA-N 0.000 description 1
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- PEWYPDFNHLVBNL-UHFFFAOYSA-L C([O-])([O-])=O.[Fe+].[Fe+] Chemical group C([O-])([O-])=O.[Fe+].[Fe+] PEWYPDFNHLVBNL-UHFFFAOYSA-L 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
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- 229910021580 Cobalt(II) chloride Inorganic materials 0.000 description 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
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- CZNVSLGYWMSMKE-OPDGVEILSA-K Ferric gluconate Chemical compound [Fe+3].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O CZNVSLGYWMSMKE-OPDGVEILSA-K 0.000 description 1
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
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- MQEUGMWHWPYFDD-UHFFFAOYSA-N magnesium;6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1h-benzimidazole Chemical compound [Mg].N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C MQEUGMWHWPYFDD-UHFFFAOYSA-N 0.000 description 1
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- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
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- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0808835.3A GB0808835D0 (en) | 2008-05-15 | 2008-05-15 | Therapeutic compositions |
Publications (1)
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|---|---|
| SG182137A1 true SG182137A1 (en) | 2012-07-30 |
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| SG2012038915A SG182137A1 (en) | 2008-05-15 | 2009-05-14 | Mono ( iron hydroxypyrone ) and combination ( iron hydroxypyrone and gi inflammation inhibiting agents ) compositions for anaemia or h. pylori infections |
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| Country | Link |
|---|---|
| US (2) | US9248148B2 (https=) |
| EP (1) | EP2303289A1 (https=) |
| JP (2) | JP5769308B2 (https=) |
| CN (1) | CN102099042B (https=) |
| AU (1) | AU2009247762B2 (https=) |
| CA (1) | CA2724172C (https=) |
| GB (1) | GB0808835D0 (https=) |
| SG (1) | SG182137A1 (https=) |
| WO (1) | WO2009138761A1 (https=) |
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| CN104829272A (zh) | 2009-12-22 | 2015-08-12 | 拉尔科营养品有限公司 | 有机螯合的矿物组合物及其制备方法 |
| GB201101370D0 (en) | 2011-01-27 | 2011-03-09 | Iron Therapeutics Holdings Ag | Process |
| CN104640825A (zh) * | 2012-07-05 | 2015-05-20 | 拉尔科营养品有限公司(美国) | 利用矿物质化合物的农业组合物和应用 |
| US10179120B2 (en) * | 2014-01-06 | 2019-01-15 | Iron Therapeutics Holdings Ag | Dosage regimen of ferric trimaltol |
| GB201404390D0 (en) * | 2014-03-12 | 2014-04-23 | Iron Therapeutics Holdings Ag | Composition |
| UA117786C2 (uk) | 2014-04-17 | 2018-09-25 | Ралко Нутрітіон, Інк. | Сільськогосподарські композиції та застосування з використанням мінеральних сполук |
| GB201418710D0 (en) | 2014-10-21 | 2014-12-03 | Iron Therapeutics Holdings Ag | Dosage regimen |
| WO2016112381A1 (en) | 2015-01-09 | 2016-07-14 | The Board Of Trustees Of The University Of Illinois | Restoring physiology in iron-deficient organisms using small molecules |
| JP2017032550A (ja) * | 2015-07-30 | 2017-02-09 | 大塚製薬株式会社 | 胃粘膜萎縮の有無を判定する方法 |
| CA3019478C (en) * | 2016-03-31 | 2024-02-13 | United Kingdom Research And Innovation | Ferric maltol compositions for use in the treatment or prevention of cancer and tumours |
| GB2553099A (en) * | 2016-08-19 | 2018-02-28 | Shield Tx Uk Ltd | Use |
| IT201700021676A1 (it) * | 2017-02-28 | 2018-08-28 | Carlo Angelo Ghisalberti | Composizioni e sistemi di estrazione del ferro non-eme dalla dieta per uso nell’anemia sideropenica e carenze marziali |
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| EP0107458B1 (en) | 1982-10-22 | 1987-07-29 | National Research Development Corporation | Pharmaceutical compositions |
| US5177068A (en) | 1984-04-19 | 1993-01-05 | National Research Development Corporation | Pharmaceutical compositions |
| AU6010696A (en) | 1995-06-10 | 1997-01-09 | Vitra Pharmaceuticals Ltd | Iron compounds, compositions, methods of making the same and uses thereof |
| GB9621273D0 (en) * | 1996-10-11 | 1996-11-27 | Cortecs Ltd | Therapeutic method |
| GB9710699D0 (en) | 1997-05-24 | 1997-07-16 | Danbiosyst Uk | Gastro-retentive controlled release system |
| GB0012487D0 (en) | 2000-05-24 | 2000-07-12 | Pfylori Limited | Use of metal compounds to treat gastrointestinal infections |
| US7135196B2 (en) * | 2000-09-19 | 2006-11-14 | Vitra Pharmaceuticals Limited | Iron compositions |
| GB0211500D0 (en) | 2002-05-18 | 2002-06-26 | Vitra Pharmaceuticals Ltd | Method of forming iron hydroxypyrone compounds |
| EP1686982A4 (en) | 2003-11-19 | 2007-03-21 | Vecta Ltd | METHODS AND COMPOSITIONS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH HELICOBACTER PYLORI USING COMPOUNDS CONTAINING ENDOPEROXIDE BRIDGE |
| EP1973549B1 (en) * | 2006-01-06 | 2016-07-20 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| WO2007108712A1 (en) | 2006-03-17 | 2007-09-27 | Tatyana Vyacheslavovna Popkova | Kit and method for treating or preventing anemia caused by iron deficiency |
| TW200843802A (en) * | 2007-02-09 | 2008-11-16 | Drugtech Corp | Compositions for improving gastrointestinal nutrient and drug absorption |
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- 2009-05-14 AU AU2009247762A patent/AU2009247762B2/en not_active Ceased
- 2009-05-14 EP EP09746078A patent/EP2303289A1/en not_active Ceased
- 2009-05-14 WO PCT/GB2009/001231 patent/WO2009138761A1/en not_active Ceased
- 2009-05-14 CA CA2724172A patent/CA2724172C/en active Active
- 2009-05-14 SG SG2012038915A patent/SG182137A1/en unknown
- 2009-05-14 US US12/992,528 patent/US9248148B2/en active Active
-
2014
- 2014-11-24 JP JP2014237229A patent/JP2015083572A/ja active Pending
-
2015
- 2015-12-15 US US14/969,567 patent/US20160120902A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP5769308B2 (ja) | 2015-08-26 |
| WO2009138761A1 (en) | 2009-11-19 |
| GB0808835D0 (en) | 2008-06-18 |
| US20110177172A1 (en) | 2011-07-21 |
| US9248148B2 (en) | 2016-02-02 |
| AU2009247762B2 (en) | 2014-08-14 |
| JP2011520855A (ja) | 2011-07-21 |
| CN102099042A (zh) | 2011-06-15 |
| CA2724172C (en) | 2017-07-25 |
| CN102099042B (zh) | 2014-08-13 |
| AU2009247762A1 (en) | 2009-11-19 |
| CA2724172A1 (en) | 2009-11-19 |
| US20160120902A1 (en) | 2016-05-05 |
| EP2303289A1 (en) | 2011-04-06 |
| JP2015083572A (ja) | 2015-04-30 |
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