SG177601A1 - Improved anti-serum albumin binding single variable domains - Google Patents
Improved anti-serum albumin binding single variable domains Download PDFInfo
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Classifications
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
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| US22602809P | 2009-07-16 | 2009-07-16 | |
| US30755410P | 2010-02-24 | 2010-02-24 | |
| PCT/EP2010/060112 WO2011006915A2 (en) | 2009-07-16 | 2010-07-14 | Improved anti-serum albumin binding single variable domains |
Publications (1)
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| SG177601A1 true SG177601A1 (en) | 2012-02-28 |
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| SG2012001855A SG177601A1 (en) | 2009-07-16 | 2010-07-14 | Improved anti-serum albumin binding single variable domains |
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| Country | Link |
|---|---|
| US (2) | US8679496B2 (OSRAM) |
| EP (1) | EP2454285A2 (OSRAM) |
| JP (1) | JP2012532620A (OSRAM) |
| KR (1) | KR20120038494A (OSRAM) |
| CN (1) | CN102574914A (OSRAM) |
| AU (1) | AU2010272590B2 (OSRAM) |
| BR (1) | BR112012001681A2 (OSRAM) |
| CA (1) | CA2768462A1 (OSRAM) |
| EA (1) | EA201270174A1 (OSRAM) |
| IL (1) | IL217520A0 (OSRAM) |
| IN (1) | IN2012DN00640A (OSRAM) |
| MX (1) | MX2012000765A (OSRAM) |
| SG (1) | SG177601A1 (OSRAM) |
| WO (1) | WO2011006915A2 (OSRAM) |
| ZA (1) | ZA201200276B (OSRAM) |
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| EA022925B1 (ru) * | 2009-02-19 | 2016-03-31 | Глаксо Груп Лимитед | Улучшенные полипептиды, вариабельные домены антител и антагонисты против tnfr1 |
| SG177601A1 (en) * | 2009-07-16 | 2012-02-28 | Glaxo Group Ltd | Improved anti-serum albumin binding single variable domains |
| WO2012020143A1 (en) * | 2010-08-13 | 2012-02-16 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| EP2646467A2 (en) * | 2010-12-01 | 2013-10-09 | Glaxo Group Limited | Improved anti-serum albumin binding single variable domains |
| MX351502B (es) * | 2011-11-11 | 2017-10-18 | Ucb Pharma Sa | Anticuerpos de union de albumina y fragmentos de union de los mismos. |
| GB201200563D0 (en) * | 2012-01-13 | 2012-02-29 | Imp Innovations Ltd | Binding molecule |
| WO2017041114A2 (en) * | 2015-09-03 | 2017-03-09 | The Children's Mercy Hospital | Anti-nicotinamide phosphoribosyltransferase antibody genes and methods of use thereof |
| NO2768984T3 (OSRAM) | 2015-11-12 | 2018-06-09 | ||
| US11142569B2 (en) * | 2015-11-13 | 2021-10-12 | Ablynx N.V. | Serum albumin-binding immunoglobulin variable domains |
| KR102220275B1 (ko) | 2015-11-18 | 2021-02-26 | 머크 샤프 앤드 돔 코포레이션 | Pd1 및/또는 lag3 결합제 |
| CA3005488A1 (en) | 2015-11-18 | 2017-05-26 | Ablynx Nv | Improved serum albumin binders |
| EA038179B1 (ru) | 2015-11-18 | 2021-07-20 | Мерк Шарп И Доум Корп. | Ctla4-связывающие вещества |
| MX2018006243A (es) | 2015-11-18 | 2018-11-09 | Merck Sharp & Dohme | Proteinas de union a pd1/ctla4. |
| AU2017268394A1 (en) | 2016-05-18 | 2019-01-03 | Modernatx, Inc. | Polynucleotides encoding relaxin |
| IL310340A (en) * | 2016-12-07 | 2024-03-01 | Ablynx Nv | Improved serum albumin binding immunoglobulin single variable domains |
| SG11201906264YA (en) | 2017-01-17 | 2019-08-27 | Ablynx Nv | Improved serum albumin binders |
| EP3571224B1 (en) * | 2017-01-17 | 2024-08-07 | Ablynx NV | Improved serum albumin binders |
| HRP20250319T1 (hr) | 2017-02-16 | 2025-05-09 | Sonnet BioTherapeutics, Inc. | Fuzijski proteini s domenom za vezanje na albumin |
| EP3470426A1 (en) | 2017-10-10 | 2019-04-17 | Numab Therapeutics AG | Multispecific antibody |
| US12202911B2 (en) | 2017-10-10 | 2025-01-21 | Numab Therapeutics AG | Multispecific antibody comprising CD137 binding domain and PDL1 binding domain |
| WO2020172528A1 (en) * | 2019-02-22 | 2020-08-27 | Anwita Biosciences, Inc. | Albumin binding antibodies and use thereof |
| EP3816185A1 (en) | 2019-11-04 | 2021-05-05 | Numab Therapeutics AG | Multispecific antibody directed against pd-l1 and a tumor-associated antigen |
| GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
| WO2021205183A1 (en) | 2020-04-09 | 2021-10-14 | Autolus Limited | Polypeptide |
| GB202007441D0 (en) | 2020-05-19 | 2020-07-01 | Autolus Ltd | Polypeptide |
| EP3915580A1 (en) | 2020-05-29 | 2021-12-01 | Numab Therapeutics AG | Multispecific antibody |
| IT202000013006A1 (it) * | 2020-06-01 | 2021-12-01 | Bioreweal S R L | Processo per la produzione biologica di idrogeno e/o di metano mediante assorbimento e conversione biologica di anidride carbonica. |
| EP3988568A1 (en) | 2020-10-21 | 2022-04-27 | Numab Therapeutics AG | Combination treatment |
| AU2021395729A1 (en) | 2020-12-07 | 2023-07-13 | UCB Biopharma SRL | Multi-specific antibodies and antibody combinations |
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| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
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| JP2009518024A (ja) * | 2005-12-06 | 2009-05-07 | ドマンティス リミテッド | Ｅｇｆｒおよび／またはｖｅｇｆに対して結合特異性を有するリガンドおよびその使用法 |
| AU2007209202A1 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind IL-4 and/or IL-13 |
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| WO2009149143A1 (en) * | 2008-06-03 | 2009-12-10 | E. I. Du Pont De Nemours And Company | Adhesion of polyamides to epoxy resins |
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- 2010-07-14 EA EA201270174A patent/EA201270174A1/ru unknown
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- 2010-07-14 BR BR112012001681A patent/BR112012001681A2/pt not_active IP Right Cessation
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| EP2454285A2 (en) | 2012-05-23 |
| AU2010272590A1 (en) | 2012-02-02 |
| US8679496B2 (en) | 2014-03-25 |
| IN2012DN00640A (OSRAM) | 2015-08-21 |
| CN102574914A (zh) | 2012-07-11 |
| KR20120038494A (ko) | 2012-04-23 |
| BR112012001681A2 (pt) | 2019-09-24 |
| JP2012532620A (ja) | 2012-12-20 |
| ZA201200276B (en) | 2012-09-26 |
| US20140140996A1 (en) | 2014-05-22 |
| MX2012000765A (es) | 2012-02-13 |
| IL217520A0 (en) | 2012-02-29 |
| WO2011006915A2 (en) | 2011-01-20 |
| WO2011006915A3 (en) | 2011-03-03 |
| US20120114647A1 (en) | 2012-05-10 |
| CA2768462A1 (en) | 2011-01-20 |
| EA201270174A1 (ru) | 2012-07-30 |
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