SG176304A1 - Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug - Google Patents
Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug Download PDFInfo
- Publication number
- SG176304A1 SG176304A1 SG2011089273A SG2011089273A SG176304A1 SG 176304 A1 SG176304 A1 SG 176304A1 SG 2011089273 A SG2011089273 A SG 2011089273A SG 2011089273 A SG2011089273 A SG 2011089273A SG 176304 A1 SG176304 A1 SG 176304A1
- Authority
- SG
- Singapore
- Prior art keywords
- particulates
- dosage form
- drug
- melt
- extrudate
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title claims abstract description 278
- 239000003814 drug Substances 0.000 title claims abstract description 133
- 229940079593 drug Drugs 0.000 title claims abstract description 122
- 239000011159 matrix material Substances 0.000 title claims abstract description 70
- 239000000203 mixture Substances 0.000 claims description 72
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 69
- 229920000642 polymer Polymers 0.000 claims description 52
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 49
- 229960002085 oxycodone Drugs 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 47
- 239000003795 chemical substances by application Substances 0.000 claims description 43
- 229960004127 naloxone Drugs 0.000 claims description 39
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 36
- -1 poly(acrylic acid) Polymers 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 29
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 27
- 229960001410 hydromorphone Drugs 0.000 claims description 27
- 239000000155 melt Substances 0.000 claims description 22
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- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 18
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 18
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 18
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- 230000008569 process Effects 0.000 claims description 15
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 14
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- 239000001069 triethyl citrate Substances 0.000 claims description 8
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 8
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
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- 230000004799 sedative–hypnotic effect Effects 0.000 claims description 3
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- VKNASXZDGZNEDA-UHFFFAOYSA-N 2-cyanoethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC#N VKNASXZDGZNEDA-UHFFFAOYSA-N 0.000 claims description 2
- SFPNZPQIIAJXGL-UHFFFAOYSA-N 2-ethoxyethyl 2-methylprop-2-enoate Chemical class CCOCCOC(=O)C(C)=C SFPNZPQIIAJXGL-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims description 2
- 229960001736 buprenorphine Drugs 0.000 claims description 2
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 2
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| GBGB0909680.1A GB0909680D0 (en) | 2009-06-05 | 2009-06-05 | Dosage form |
| PCT/GB2010/050948 WO2010140007A2 (en) | 2009-06-05 | 2010-06-07 | Dosage form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG176304A1 true SG176304A1 (en) | 2012-01-30 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201402810XA SG10201402810XA (en) | 2009-06-05 | 2010-06-07 | Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug |
| SG2011089273A SG176304A1 (en) | 2009-06-05 | 2010-06-07 | Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201402810XA SG10201402810XA (en) | 2009-06-05 | 2010-06-07 | Tamper resistant dosage form comprising a matrix and melt - extruded particulates comprising a drug |
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| JP (1) | JP5635082B2 (enExample) |
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| CN (2) | CN106667919A (enExample) |
| AU (1) | AU2010255502B2 (enExample) |
| BR (1) | BRPI1012004A2 (enExample) |
| CA (1) | CA2764517C (enExample) |
| EA (1) | EA022801B1 (enExample) |
| ES (1) | ES2713957T3 (enExample) |
| GB (1) | GB0909680D0 (enExample) |
| IL (1) | IL216748A0 (enExample) |
| MX (1) | MX2011012929A (enExample) |
| MY (1) | MY173629A (enExample) |
| NZ (1) | NZ596879A (enExample) |
| SG (2) | SG10201402810XA (enExample) |
| WO (1) | WO2010140007A2 (enExample) |
| ZA (1) | ZA201109221B (enExample) |
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| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| ATE495732T1 (de) | 2003-03-26 | 2011-02-15 | Egalet As | Morphin-system mit kontrollierter freisetzung |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| PL2187873T3 (pl) * | 2007-08-13 | 2019-01-31 | Abuse Deterrent Pharmaceutical Llc | Leki odporne na nadużywanie, metoda stosowania i metoda wytwarzania |
| EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
| KR101690094B1 (ko) | 2008-05-09 | 2016-12-27 | 그뤼넨탈 게엠베하 | 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법 |
| WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
| EP2445487A2 (en) | 2009-06-24 | 2012-05-02 | Egalet Ltd. | Controlled release formulations |
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| AR077493A1 (es) | 2009-07-22 | 2011-08-31 | Gruenenthal Gmbh | Composicion farmaceutica extruida en caliente con liberacion controlada. procedimiento de preparacion |
| US9993433B2 (en) | 2010-05-10 | 2018-06-12 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| NZ603170A (en) | 2010-05-10 | 2015-04-24 | Euro Celtique Sa | Combination of active loaded granules with additional actives |
| US9700508B2 (en) * | 2010-05-10 | 2017-07-11 | Euro-Celtique S.A. | Pharmaceutical compositions comprising hydromorphone and naloxone |
| MX2013002377A (es) | 2010-09-02 | 2013-04-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica. |
| PL2611425T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Odporna na ingerencję postać dawki zawierająca polimer anionowy |
| EP2635258A1 (en) * | 2010-11-04 | 2013-09-11 | AbbVie Inc. | Drug formulations |
| US9278052B2 (en) | 2010-11-04 | 2016-03-08 | Abbvie Inc. | Method for producing monolithic tablets |
| GB201020895D0 (en) * | 2010-12-09 | 2011-01-26 | Euro Celtique Sa | Dosage form |
| PH12013501244A1 (en) * | 2010-12-28 | 2013-07-15 | Euro Celtique Sa | A combination of an opioid agonist and an opioid antagonist in the treatment of parkinson's disease |
| EP2736497B1 (en) | 2011-07-29 | 2017-08-23 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
| JP2014524925A (ja) | 2011-07-29 | 2014-09-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 即時薬剤放出を提供するタンパーレジスタント錠剤 |
| US20140341984A1 (en) * | 2011-09-16 | 2014-11-20 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| AR088250A1 (es) * | 2011-10-06 | 2014-05-21 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica oral resistente a alteracion comprendiendo agonista opioide y antagonista opioide |
| MX349725B (es) * | 2011-11-17 | 2017-08-10 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica oral a prueba de manipulacion que comprende un agente antagonista y/o aversivo opioide, oxido de polialquileno y un polimero anionico. |
| MX356421B (es) | 2012-02-28 | 2018-05-29 | Gruenenthal Gmbh | Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico. |
| AR090695A1 (es) * | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| NZ704011A (en) | 2012-07-06 | 2016-04-29 | Egalet Ltd | Abuse deterrent pharmaceutical compositions for controlled release |
| PL2872121T3 (pl) | 2012-07-12 | 2019-02-28 | SpecGx LLC | Kompozycje farmaceutyczne o przedłużonym uwalnianiu, zniechęcające do nadużywania |
| CA2881144A1 (en) * | 2012-11-09 | 2014-05-09 | Purdue Pharma | Pharmaceutical compositions comprising hydromorphone and naloxone |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
| MX371432B (es) * | 2013-05-29 | 2020-01-30 | Gruenenthal Gmbh | Forma de dosificacion resistente al uso indebido que contiene una o mas particulas. |
| EA032465B1 (ru) | 2013-07-12 | 2019-05-31 | Грюненталь Гмбх | Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления |
| CA2919892C (en) | 2013-08-12 | 2019-06-18 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| EA030310B1 (ru) | 2013-11-13 | 2018-07-31 | Эро-Селтик С.А. | Гидроморфон и налоксон для лечения боли и индуцированного опиоидами синдрома дисфункции кишечника |
| WO2015071248A1 (en) | 2013-11-15 | 2015-05-21 | Synthon B.V. | Abuse-proofed extended release pharmaceutical composition comprising tapentadol |
| BR112016010482B1 (pt) | 2013-11-26 | 2022-11-16 | Grünenthal GmbH | Preparação de uma composição farmacêutica em pó por meio de criomoagem |
| WO2015095387A1 (en) * | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015089530A1 (de) * | 2013-12-20 | 2015-06-25 | G.L. PHARMA GmbH | Orale darreichungsform mit verzögerter freisetzung enthaltend morphin und naloxon |
| CA2847781C (en) * | 2014-03-28 | 2019-03-12 | Purdue Pharma | Reducing drug liking in a subject |
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| MX2016015417A (es) | 2014-05-26 | 2017-02-22 | Gruenenthal Gmbh | Multiparticulas protegidas contra vertido de dosis etanolico. |
| US11617712B2 (en) | 2014-07-03 | 2023-04-04 | SpecGx LLC | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
| DK3169315T3 (da) | 2014-07-17 | 2020-08-10 | Pharmaceutical Manufacturing Res Services In | Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse |
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| BR112017022856A2 (pt) | 2015-04-24 | 2018-07-17 | Gruenenthal Gmbh | combinação de dose fixa inviolável que proporciona rápida liberação de duas drogas a partir de partículas |
| WO2016170093A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant fixed dose combination providing fast release of two drugs from particles and a matrix |
| BR112017022846A2 (pt) | 2015-04-24 | 2018-07-17 | Gruenenthal Gmbh | combinação de dose fixa inviolável que proporciona rápida liberação de dois fármacos de partículas diferentes |
| EA035434B1 (ru) | 2015-04-24 | 2020-06-15 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями |
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| WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
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| WO2020068510A1 (en) | 2018-09-25 | 2020-04-02 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
| EP3698776A1 (en) | 2019-02-19 | 2020-08-26 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
| KR20240095253A (ko) * | 2021-10-27 | 2024-06-25 | 오11 바이오메디컬 게엠베하 | Co2의 제어된 생체내 흡수를 위한 코팅된 활성 성분 제형 |
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| BRPI0606339A2 (pt) * | 2005-01-28 | 2009-06-16 | Euro Celtique Sa | formas farmacêuticas resistentes a álcool |
| US20070026025A1 (en) | 2005-04-12 | 2007-02-01 | Aquegel Cosmetics, Llc | Topical ointment and method for making and using same |
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| DE102005047561A1 (de) | 2005-10-04 | 2007-04-05 | Bayer Healthcare Ag | Feste, oral applizierbare pharmazeutische Darreichungsformen mit schneller Wirkstofffreisetzung |
| AU2006326130B2 (en) | 2005-12-14 | 2011-09-22 | F. Hoffmann-La Roche Ag | HCV prodrug formulation |
| EP1813276A1 (en) | 2006-01-27 | 2007-08-01 | Euro-Celtique S.A. | Tamper resistant dosage forms |
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| EP1935405A1 (en) | 2006-12-22 | 2008-06-25 | LEK Pharmaceuticals D.D. | Orally disintegrating tablets |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| GB2447898B (en) | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
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| DE102009015702A1 (de) | 2009-03-31 | 2010-10-07 | Ratiopharm Gmbh | Tabletten enthaltend Dapoxetin und Trockenverarbeitungsverfahren zu deren Herstellung |
| GB201020895D0 (en) | 2010-12-09 | 2011-01-26 | Euro Celtique Sa | Dosage form |
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2009
- 2009-06-05 GB GBGB0909680.1A patent/GB0909680D0/en not_active Ceased
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2010
- 2010-06-07 MY MYPI2011005869A patent/MY173629A/en unknown
- 2010-06-07 SG SG10201402810XA patent/SG10201402810XA/en unknown
- 2010-06-07 ES ES10725263T patent/ES2713957T3/es active Active
- 2010-06-07 MX MX2011012929A patent/MX2011012929A/es active IP Right Grant
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- 2010-06-07 JP JP2012513685A patent/JP5635082B2/ja not_active Expired - Fee Related
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- 2010-06-07 US US13/376,113 patent/US9814679B2/en active Active
- 2010-06-07 SG SG2011089273A patent/SG176304A1/en unknown
- 2010-06-07 CA CA2764517A patent/CA2764517C/en not_active Expired - Fee Related
- 2010-06-07 CN CN201610970584.4A patent/CN106667919A/zh active Pending
- 2010-06-07 BR BRPI1012004A patent/BRPI1012004A2/pt not_active Application Discontinuation
- 2010-06-07 WO PCT/GB2010/050948 patent/WO2010140007A2/en not_active Ceased
- 2010-06-07 CN CN2010800344131A patent/CN102481260A/zh active Pending
- 2010-06-07 KR KR1020127000058A patent/KR101816130B1/ko not_active Expired - Fee Related
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- 2010-06-07 EA EA201171389A patent/EA022801B1/ru not_active IP Right Cessation
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2011
- 2011-12-04 IL IL216748A patent/IL216748A0/en unknown
- 2011-12-14 ZA ZA2011/09221A patent/ZA201109221B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010140007A9 (en) | 2012-01-19 |
| KR101816130B1 (ko) | 2018-01-08 |
| CA2764517A1 (en) | 2010-12-09 |
| CN102481260A (zh) | 2012-05-30 |
| AU2010255502B2 (en) | 2016-09-22 |
| EA201171389A1 (ru) | 2012-05-30 |
| JP5635082B2 (ja) | 2014-12-03 |
| ZA201109221B (en) | 2012-08-29 |
| CN106667919A (zh) | 2017-05-17 |
| MX2011012929A (es) | 2012-04-20 |
| GB0909680D0 (en) | 2009-07-22 |
| IL216748A0 (en) | 2012-02-29 |
| ES2713957T3 (es) | 2019-05-24 |
| KR20120026595A (ko) | 2012-03-19 |
| EP2437729A2 (en) | 2012-04-11 |
| WO2010140007A3 (en) | 2011-11-17 |
| EP2437729B1 (en) | 2019-01-23 |
| US20120135075A1 (en) | 2012-05-31 |
| WO2010140007A2 (en) | 2010-12-09 |
| AU2010255502A1 (en) | 2012-01-12 |
| MY173629A (en) | 2020-02-12 |
| BRPI1012004A2 (pt) | 2016-05-10 |
| SG10201402810XA (en) | 2014-08-28 |
| CA2764517C (en) | 2017-07-04 |
| JP2012528845A (ja) | 2012-11-15 |
| NZ596879A (en) | 2013-06-28 |
| EA022801B1 (ru) | 2016-03-31 |
| US9814679B2 (en) | 2017-11-14 |
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