SG129998A1 - Compounds possessing neuronal activity - Google Patents

Compounds possessing neuronal activity

Info

Publication number
SG129998A1
SG129998A1 SG200201262-3A SG2002012623A SG129998A1 SG 129998 A1 SG129998 A1 SG 129998A1 SG 2002012623 A SG2002012623 A SG 2002012623A SG 129998 A1 SG129998 A1 SG 129998A1
Authority
SG
Singapore
Prior art keywords
neuronal activity
compounds possessing
possessing neuronal
compounds
activity
Prior art date
Application number
SG200201262-3A
Other languages
English (en)
Inventor
Patricia Mccaffrey
Perry M Novak
Michael Mullican
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/085,441 external-priority patent/US6268384B1/en
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of SG129998A1 publication Critical patent/SG129998A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG200201262-3A 1997-08-29 1998-08-27 Compounds possessing neuronal activity SG129998A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92083897A 1997-08-29 1997-08-29
US09/085,441 US6268384B1 (en) 1997-08-29 1998-05-27 Compounds possessing neuronal activity

Publications (1)

Publication Number Publication Date
SG129998A1 true SG129998A1 (en) 2007-03-20

Family

ID=26772724

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200201262-3A SG129998A1 (en) 1997-08-29 1998-08-27 Compounds possessing neuronal activity

Country Status (17)

Country Link
US (1) US7109215B2 (fr)
EP (1) EP1007521A1 (fr)
JP (1) JP2001514177A (fr)
CN (1) CN100436447C (fr)
AU (1) AU766579B2 (fr)
BR (1) BR9811923A (fr)
CA (1) CA2300134A1 (fr)
ID (1) ID23675A (fr)
IL (1) IL134536A0 (fr)
IN (1) IN191127B (fr)
IS (1) IS5379A (fr)
NO (1) NO321790B1 (fr)
NZ (1) NZ502820A (fr)
PL (1) PL195273B1 (fr)
SG (1) SG129998A1 (fr)
TW (1) TW570919B (fr)
WO (1) WO1999010340A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
WO1999062880A1 (fr) * 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. Sulfonamides a liaison n d'acides carboxyliques n-heterocycliques ou d'isosteres d'acide carboxylique
US6339101B1 (en) * 1998-08-14 2002-01-15 Gpi Nil Holdings, Inc. N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders
US6333340B1 (en) * 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
JP2003503480A (ja) 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド ニューロン活性を有するｎ−ヘテロ環誘導体
WO2001002362A1 (fr) * 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated Derives d'acides amines azoiques pour le traitement des maladies neurologiques
WO2001002361A1 (fr) * 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated Derives de beta-aminoacide destines au traitement de maladies neurologiques
AU6076000A (en) * 1999-07-30 2001-02-19 Vertex Pharmaceuticals Incorporated Cyclic amine derivatives for the treatment of neurological diseases
AU6497200A (en) * 1999-07-30 2001-02-19 Vertex Pharmaceuticals Incorporated Acyclic and cyclic amine derivatives
AU6913700A (en) * 1999-08-18 2001-03-13 Schering Aktiengesellschaft Piperidine and pyrrolidine derivatives displaying neuronal activity
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
JP2002068973A (ja) * 2000-06-16 2002-03-08 Meiji Milk Prod Co Ltd 幹細胞分化誘導促進剤
CN100395236C (zh) * 2002-10-03 2008-06-18 沃泰克斯药物股份有限公司 用于治疗神经病的哌嗪和哌啶衍生物
WO2005033068A1 (fr) * 2003-10-06 2005-04-14 Oy Juvantia Pharma Ltd Recepteur 1 et/ou 4 de somatostatine, agonistes et antagonistes selectifs
CA2556923A1 (fr) * 2004-02-20 2005-09-09 Rinat Neuroscience Corp. Methodes de traitement de l'obesite ou de diabetes au moyen de nt-4/5
US20070248611A1 (en) * 2006-02-02 2007-10-25 Pfizer Inc Methods wanted for treating unwanted weight loss or eating disorders by administering a trkb agonist
WO2007088479A1 (fr) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Procédés de traitement de l'obésité par administration d'un antagoniste trkb
BRPI0720473A2 (pt) * 2006-12-20 2014-01-14 Rinat Neuroscience Corp Agonistas de trkb para tratamento de distúbios autoimunes
US9152929B2 (en) 2013-01-23 2015-10-06 Splunk Inc. Real time display of statistics and values for selected regular expressions
TWI744300B (zh) * 2016-03-23 2021-11-01 里爾中央醫學中心 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021313A2 (fr) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Nouveaux composes immunosuppresseurs
WO1995026337A1 (fr) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Nouveaux carbamates et urees utilises pour modifier la resistance multi-medicamenteuse
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4792555A (en) * 1987-03-20 1988-12-20 American Home Products Corporation Phospholipase A2 inhibitors
NZ314207A (en) * 1992-09-28 2000-12-22 Vertex Pharma 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021313A2 (fr) * 1991-05-24 1992-12-10 Vertex Pharmaceuticals Incorporated Nouveaux composes immunosuppresseurs
WO1995026337A1 (fr) * 1994-03-25 1995-10-05 Vertex Pharmaceuticals Incorporated Nouveaux carbamates et urees utilises pour modifier la resistance multi-medicamenteuse
US5721256A (en) * 1997-02-12 1998-02-24 Gpi Nil Holdings, Inc. Method of using neurotrophic sulfonamide compounds

Also Published As

Publication number Publication date
NO20000953D0 (no) 2000-02-25
US7109215B2 (en) 2006-09-19
ID23675A (id) 2000-05-11
AU8923698A (en) 1999-03-16
NZ502820A (en) 2002-10-25
EP1007521A1 (fr) 2000-06-14
IS5379A (is) 2000-02-18
TW570919B (en) 2004-01-11
JP2001514177A (ja) 2001-09-11
WO1999010340A1 (fr) 1999-03-04
AU766579B2 (en) 2003-10-16
US20020013351A1 (en) 2002-01-31
NO321790B1 (no) 2006-07-03
CN100436447C (zh) 2008-11-26
PL338791A1 (en) 2000-11-20
IN191127B (fr) 2003-09-27
NO20000953L (no) 2000-05-02
CA2300134A1 (fr) 1999-03-04
BR9811923A (pt) 2000-08-15
CN1271354A (zh) 2000-10-25
PL195273B1 (pl) 2007-08-31
IL134536A0 (en) 2001-04-30

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