SG11202112187YA - Amino quinazoline derivatives as p2x3 inhibitors - Google Patents
Amino quinazoline derivatives as p2x3 inhibitorsInfo
- Publication number
- SG11202112187YA SG11202112187YA SG11202112187YA SG11202112187YA SG11202112187YA SG 11202112187Y A SG11202112187Y A SG 11202112187YA SG 11202112187Y A SG11202112187Y A SG 11202112187YA SG 11202112187Y A SG11202112187Y A SG 11202112187YA SG 11202112187Y A SG11202112187Y A SG 11202112187YA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- quinazoline derivatives
- amino quinazoline
- amino
- derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- CZAAKPFIWJXPQT-UHFFFAOYSA-N quinazolin-2-amine Chemical class C1=CC=CC2=NC(N)=NC=C21 CZAAKPFIWJXPQT-UHFFFAOYSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19177604 | 2019-05-31 | ||
| EP19201168 | 2019-10-02 | ||
| PCT/EP2020/064913 WO2020239951A1 (fr) | 2019-05-31 | 2020-05-28 | Dérivés d'amino quinazoline servant d'inhibiteurs de p2x3 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202112187YA true SG11202112187YA (en) | 2021-12-30 |
Family
ID=70861506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202112187YA SG11202112187YA (en) | 2019-05-31 | 2020-05-28 | Amino quinazoline derivatives as p2x3 inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20230092892A1 (fr) |
| EP (2) | EP3976179A1 (fr) |
| JP (2) | JP2022534751A (fr) |
| KR (2) | KR20220016499A (fr) |
| CN (3) | CN118239931A (fr) |
| AU (2) | AU2020285336A1 (fr) |
| BR (2) | BR112021022099A2 (fr) |
| CA (2) | CA3139018A1 (fr) |
| CL (1) | CL2021003165A1 (fr) |
| CO (1) | CO2021017031A2 (fr) |
| IL (1) | IL288405A (fr) |
| MA (2) | MA56022A (fr) |
| MX (2) | MX2021014115A (fr) |
| PE (1) | PE20220934A1 (fr) |
| SG (1) | SG11202112187YA (fr) |
| WO (2) | WO2020239952A1 (fr) |
| ZA (1) | ZA202108273B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY38721A (es) | 2019-05-31 | 2020-11-30 | Janssen Pharmaceutica Nv | INHIBIDORES DE MOLÉCULAS PEQUEÑAS DE QUINASA INDUCTORA DE NF-kB |
| CN114502540A (zh) | 2019-05-31 | 2022-05-13 | 医肯纳肿瘤学公司 | Tead抑制剂和其用途 |
| CN115884970A (zh) * | 2020-09-24 | 2023-03-31 | 中国医药研究开发中心有限公司 | 芳基甲酰胺类化合物及其制备方法和医药用途 |
| CN116583510A (zh) * | 2020-11-27 | 2023-08-11 | 奇斯药制品公司 | 作为p2x3抑制剂的(氮杂)喹啉4-胺衍生物 |
| US20240025880A1 (en) * | 2020-11-27 | 2024-01-25 | Chiesi Farmaceutici S.P.A. | Amino quinazoline derivatives as p2x3 inhibitors |
| CN112661803A (zh) * | 2020-12-17 | 2021-04-16 | 上海药明康德新药开发有限公司 | DNA编码化合物库构建中On-DNA 4-胺基喹唑啉化合物的合成方法 |
| KR20230155422A (ko) * | 2020-12-22 | 2023-11-10 | 메카니스틱 테라퓨틱스 엘엘씨 | Egfr 및/또는 pi3k 억제제로서의 치환된 아미노벤질헤테로아릴 화합물 |
| CN114907284B (zh) * | 2021-02-10 | 2023-11-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种具有抗肿瘤活性的化合物及其用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH31122A (en) * | 1993-03-31 | 1998-02-23 | Eisai Co Ltd | Nitrogen-containing fused-heterocycle compounds. |
| BRPI0508461B8 (pt) * | 2004-03-05 | 2021-05-25 | Hoffmann La Roche | diaminopirimidinas, seus usos, e composição farmacêutica |
| EP1917262B1 (fr) * | 2005-08-15 | 2011-12-14 | F. Hoffmann-La Roche AG | Derives de piperidine et de piperazine en tant qu'antagonistes de p2x3 |
| CN103159692B (zh) | 2006-06-29 | 2015-03-18 | 弗·哈夫曼-拉罗切有限公司 | 四唑取代的芳基酰胺类 |
| JP5396379B2 (ja) | 2007-04-02 | 2014-01-22 | エボテック・アーゲー | ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 |
| US8076345B2 (en) | 2007-04-17 | 2011-12-13 | Evotec Ag | 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof |
| WO2009110985A2 (fr) | 2008-02-29 | 2009-09-11 | Renovis, Inc. | Composés amides, compositions à base de ces composés et leurs utilisations |
| CA2737038A1 (fr) | 2008-09-18 | 2010-03-25 | Evotec Ag | Composes amides, compositions et utilisations des composes et compositions |
| RU2642779C2 (ru) * | 2012-12-27 | 2018-01-26 | Ф.Хоффманн-Ля Рош Аг | Ингибиторы сомт |
| US20170239249A1 (en) * | 2014-09-30 | 2017-08-24 | Bristol-Myers Squibb Company | Quinazoline-based kinase inhibitors |
| WO2016084922A1 (fr) | 2014-11-28 | 2016-06-02 | 塩野義製薬株式会社 | Dérivé 1,2,4-triazine et composition pharmaceutique correspondante |
| JPWO2016088838A1 (ja) | 2014-12-04 | 2017-09-14 | 塩野義製薬株式会社 | プリン誘導体およびその医薬組成物 |
| KR20230098368A (ko) | 2014-12-09 | 2023-07-03 | 바이엘 악티엔게젤샤프트 | 1,3-티아졸-2-일 치환된 벤즈아미드 |
| WO2017011729A1 (fr) | 2015-07-16 | 2017-01-19 | Patara Pharma, LLC | Polythérapies pour le traitement de maladies pulmonaires |
| US11260056B2 (en) | 2015-09-29 | 2022-03-01 | Afferent Pharmaceuticals, Inc. | Diaminopyrimidine P2X3 and P2X2/3 receptor modulators for use in the treatment of cough |
| WO2017091661A1 (fr) * | 2015-11-25 | 2017-06-01 | Strovel Jeffrey William | Inhibiteurs de bromodomaines bet bicycliques et leurs utilisations |
| ES2800339T3 (es) * | 2016-06-30 | 2020-12-29 | Gilead Sciences Inc | 4,6-diaminoquinazolinas como moduladores de cuna y métodos de uso de los mismos |
| EP3619193B1 (fr) * | 2017-05-05 | 2023-03-22 | Hepanova, Inc. | Composés amino-aryl-benzamide et leurs procédés d'utilisation |
-
2020
- 2020-05-28 AU AU2020285336A patent/AU2020285336A1/en active Pending
- 2020-05-28 MX MX2021014115A patent/MX2021014115A/es unknown
- 2020-05-28 MX MX2021014113A patent/MX2021014113A/es unknown
- 2020-05-28 AU AU2020281923A patent/AU2020281923A1/en active Pending
- 2020-05-28 WO PCT/EP2020/064914 patent/WO2020239952A1/fr unknown
- 2020-05-28 CN CN202410508911.9A patent/CN118239931A/zh active Pending
- 2020-05-28 US US17/615,056 patent/US20230092892A1/en active Pending
- 2020-05-28 CA CA3139018A patent/CA3139018A1/fr active Pending
- 2020-05-28 MA MA056022A patent/MA56022A/fr unknown
- 2020-05-28 CN CN202080040266.2A patent/CN114269432B/zh active Active
- 2020-05-28 BR BR112021022099A patent/BR112021022099A2/pt unknown
- 2020-05-28 EP EP20728765.7A patent/EP3976179A1/fr active Pending
- 2020-05-28 EP EP20728766.5A patent/EP3976180A1/fr active Pending
- 2020-05-28 BR BR112021021738A patent/BR112021021738A2/pt unknown
- 2020-05-28 PE PE2021001962A patent/PE20220934A1/es unknown
- 2020-05-28 US US17/615,017 patent/US20220227749A1/en active Pending
- 2020-05-28 SG SG11202112187YA patent/SG11202112187YA/en unknown
- 2020-05-28 KR KR1020217043074A patent/KR20220016499A/ko unknown
- 2020-05-28 JP JP2021570931A patent/JP2022534751A/ja active Pending
- 2020-05-28 MA MA056021A patent/MA56021A/fr unknown
- 2020-05-28 WO PCT/EP2020/064913 patent/WO2020239951A1/fr active Application Filing
- 2020-05-28 JP JP2021570930A patent/JP2022534303A/ja active Pending
- 2020-05-28 CA CA3139019A patent/CA3139019A1/fr active Pending
- 2020-05-28 KR KR1020217043072A patent/KR20220016498A/ko unknown
- 2020-05-28 CN CN202080039837.0A patent/CN113891745B/zh active Active
-
2021
- 2021-10-26 ZA ZA2021/08273A patent/ZA202108273B/en unknown
- 2021-11-25 IL IL288405A patent/IL288405A/en unknown
- 2021-11-29 CL CL2021003165A patent/CL2021003165A1/es unknown
- 2021-12-14 CO CONC2021/0017031A patent/CO2021017031A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3976180A1 (fr) | 2022-04-06 |
| MX2021014115A (es) | 2021-12-10 |
| CN113891745B (zh) | 2024-05-07 |
| MA56021A (fr) | 2022-04-06 |
| AU2020285336A1 (en) | 2022-01-06 |
| CN113891745A (zh) | 2022-01-04 |
| WO2020239951A1 (fr) | 2020-12-03 |
| MA56022A (fr) | 2022-04-06 |
| CN114269432A (zh) | 2022-04-01 |
| US20220227749A1 (en) | 2022-07-21 |
| KR20220016498A (ko) | 2022-02-09 |
| US20230092892A1 (en) | 2023-03-23 |
| MX2021014113A (es) | 2021-12-10 |
| BR112021022099A2 (pt) | 2021-12-28 |
| KR20220016499A (ko) | 2022-02-09 |
| JP2022534303A (ja) | 2022-07-28 |
| CA3139019A1 (fr) | 2020-12-03 |
| ZA202108273B (en) | 2023-07-26 |
| IL288405A (en) | 2022-01-01 |
| WO2020239952A1 (fr) | 2020-12-03 |
| CN114269432B (zh) | 2024-05-07 |
| CO2021017031A2 (es) | 2022-01-17 |
| CA3139018A1 (fr) | 2020-12-03 |
| CN118239931A (zh) | 2024-06-25 |
| CL2021003165A1 (es) | 2022-09-23 |
| EP3976179A1 (fr) | 2022-04-06 |
| JP2022534751A (ja) | 2022-08-03 |
| PE20220934A1 (es) | 2022-05-31 |
| AU2020281923A1 (en) | 2022-01-06 |
| BR112021021738A2 (pt) | 2021-12-28 |
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