SG11202110534QA - Cd73 inhibitors - Google Patents
Cd73 inhibitorsInfo
- Publication number
- SG11202110534QA SG11202110534QA SG11202110534QA SG11202110534QA SG11202110534QA SG 11202110534Q A SG11202110534Q A SG 11202110534QA SG 11202110534Q A SG11202110534Q A SG 11202110534QA SG 11202110534Q A SG11202110534Q A SG 11202110534QA SG 11202110534Q A SG11202110534Q A SG 11202110534QA
- Authority
- SG
- Singapore
- Prior art keywords
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/CN2019/082816 WO2020210970A1 (en) | 2019-04-16 | 2019-04-16 | Imidazotriazine derivatives as cd73 inhibitors |
PCT/CN2020/083233 WO2020211672A1 (en) | 2019-04-16 | 2020-04-03 | Cd73 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202110534QA true SG11202110534QA (en) | 2021-11-29 |
Family
ID=72836784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202110534QA SG11202110534QA (en) | 2019-04-16 | 2020-04-03 | Cd73 inhibitors |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220204539A1 (en) |
EP (1) | EP3956341A4 (en) |
JP (1) | JP2022529152A (en) |
KR (1) | KR20210151923A (en) |
CN (1) | CN114286824A (en) |
AU (1) | AU2020258568A1 (en) |
CA (1) | CA3136367A1 (en) |
SG (1) | SG11202110534QA (en) |
TW (1) | TW202103710A (en) |
WO (2) | WO2020210970A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI821559B (en) * | 2019-04-28 | 2023-11-11 | 大陸商上海和譽生物醫藥科技有限公司 | A CD73 inhibitor, its preparation method and application |
TW202131932A (en) * | 2019-11-05 | 2021-09-01 | 美商博奥阿迪斯有限公司 | Compounds as cd73 inhibitors |
WO2023125681A1 (en) * | 2021-12-29 | 2023-07-06 | Beigene, Ltd. | Heterocyclic compounds |
WO2023201267A1 (en) | 2022-04-13 | 2023-10-19 | Gilead Sciences, Inc. | Combination therapy for treating trop-2 expressing cancers |
WO2023220439A1 (en) * | 2022-05-12 | 2023-11-16 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE271058T1 (en) * | 1996-10-09 | 2004-07-15 | Pharmasset Ltd | MYCOPHENOL BISPHOSPONATE COMPOUNDS |
CN106536538A (en) * | 2014-04-24 | 2017-03-22 | 共晶制药股份有限公司 | 2'-disubstituted nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
WO2016069975A1 (en) * | 2014-10-31 | 2016-05-06 | Cocrystal Pharma, Inc. | 2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
MX2017013956A (en) * | 2015-05-01 | 2018-09-05 | Cocrystal Pharma Inc | Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer. |
LT3399984T (en) * | 2016-01-08 | 2023-11-10 | Arcus Biosciences, Inc. | Modulators of 5'-nucleotidase, ecto and the use thereof |
US11058704B2 (en) * | 2016-10-03 | 2021-07-13 | Arcus Biosciences, Inc. | Inhibitors of adenosine 5′-nucleotidase |
WO2018183635A1 (en) * | 2017-03-31 | 2018-10-04 | Peloton Therapeutics, Inc. | Cd73 inhibitors and uses thereof |
WO2018208980A1 (en) * | 2017-05-10 | 2018-11-15 | Oric Pharmaceuticals, Inc. | Cd73 inhibitors |
CN111094317B (en) * | 2017-12-29 | 2023-03-31 | 上海和誉生物医药科技有限公司 | Phosphonic acid derivative with CD73 inhibitory activity, and preparation method and application thereof |
-
2019
- 2019-04-16 WO PCT/CN2019/082816 patent/WO2020210970A1/en active Application Filing
-
2020
- 2020-04-03 CN CN202080042511.3A patent/CN114286824A/en active Pending
- 2020-04-03 KR KR1020217036923A patent/KR20210151923A/en unknown
- 2020-04-03 EP EP20791035.7A patent/EP3956341A4/en not_active Withdrawn
- 2020-04-03 US US17/603,553 patent/US20220204539A1/en active Pending
- 2020-04-03 CA CA3136367A patent/CA3136367A1/en active Pending
- 2020-04-03 SG SG11202110534QA patent/SG11202110534QA/en unknown
- 2020-04-03 AU AU2020258568A patent/AU2020258568A1/en not_active Abandoned
- 2020-04-03 JP JP2021560958A patent/JP2022529152A/en active Pending
- 2020-04-03 WO PCT/CN2020/083233 patent/WO2020211672A1/en unknown
- 2020-04-16 TW TW109112782A patent/TW202103710A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3956341A1 (en) | 2022-02-23 |
WO2020210970A1 (en) | 2020-10-22 |
WO2020211672A1 (en) | 2020-10-22 |
EP3956341A4 (en) | 2023-01-04 |
CA3136367A1 (en) | 2020-10-22 |
TW202103710A (en) | 2021-02-01 |
CN114286824A (en) | 2022-04-05 |
AU2020258568A1 (en) | 2021-11-04 |
JP2022529152A (en) | 2022-06-17 |
AU2020258568A8 (en) | 2021-11-18 |
KR20210151923A (en) | 2021-12-14 |
US20220204539A1 (en) | 2022-06-30 |
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