SG11202108311RA - Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies - Google Patents
Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodiesInfo
- Publication number
- SG11202108311RA SG11202108311RA SG11202108311RA SG11202108311RA SG11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA SG 11202108311R A SG11202108311R A SG 11202108311RA
- Authority
- SG
- Singapore
- Prior art keywords
- egfr
- combination therapies
- bispecific anti
- met antibodies
- patient stratification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962810716P | 2019-02-26 | 2019-02-26 | |
US201962930190P | 2019-11-04 | 2019-11-04 | |
PCT/IB2020/051559 WO2020174370A2 (en) | 2019-02-26 | 2020-02-24 | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202108311RA true SG11202108311RA (en) | 2021-09-29 |
Family
ID=72142314
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202108311RA SG11202108311RA (en) | 2019-02-26 | 2020-02-24 | Combination therapies and patient stratification with bispecific anti-egfr/c-met antibodies |
Country Status (14)
Country | Link |
---|---|
US (2) | US11459391B2 (ja) |
EP (1) | EP3931224A4 (ja) |
JP (1) | JP2022521610A (ja) |
KR (1) | KR20210132117A (ja) |
CN (1) | CN113840842A (ja) |
AU (1) | AU2020229467A1 (ja) |
BR (1) | BR112021016149A2 (ja) |
CA (1) | CA3131654A1 (ja) |
IL (1) | IL285718A (ja) |
JO (1) | JOP20210233A1 (ja) |
MA (1) | MA55089A (ja) |
MX (1) | MX2021010265A (ja) |
SG (1) | SG11202108311RA (ja) |
WO (1) | WO2020174370A2 (ja) |
Families Citing this family (6)
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---|---|---|---|---|
US11850248B2 (en) * | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
IL305700A (en) * | 2021-03-09 | 2023-11-01 | Janssen Biotech Inc | Treatment of cancers lacking EFGR-activating mutations |
KR20240051145A (ko) * | 2021-07-29 | 2024-04-19 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Kras 돌연변이 암의 치료를 위한 방법 및 조성물 |
KR20230049243A (ko) | 2021-10-06 | 2023-04-13 | 주식회사 엘지에너지솔루션 | 태양광 시스템과 연계하는 에너지 저장 시스템 및 에너지 저장 시스템의 제어 방법 |
US20230183360A1 (en) * | 2021-12-09 | 2023-06-15 | Janssen Biotech, Inc. | Use of Amivantamab to Treat Colorectal Cancer |
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ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
US7767792B2 (en) | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
BRPI0508286B8 (pt) | 2004-03-31 | 2021-05-25 | Dana Farber Cancer Inst Inc | método para determinar a probabilidade de eficácia de um inibidor da tirosina quinase egfr para tratar câncer, uso de um inibidor da tirosina quinase de egfr, sonda, kit, e, par de iniciadores |
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CA2597673C (en) | 2005-02-11 | 2014-07-08 | Harold Varmus | Methods and compositions for detecting a drug resistant egfr mutant |
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RU2404193C2 (ru) | 2005-03-25 | 2010-11-20 | Дженентек, Инк. | Способ лечения опухоли у субъекта |
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EP2035456A1 (en) | 2006-06-22 | 2009-03-18 | Novo Nordisk A/S | Production of bispecific antibodies |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
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US7892770B2 (en) | 2007-08-24 | 2011-02-22 | Van Andel Research Institute | Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods |
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WO2018050733A1 (en) | 2016-09-14 | 2018-03-22 | Merck Patent Gmbh | Anti-c-met antibodies and antibody drug conjugates thereof for efficient tumor inhibition |
KR20230145496A (ko) | 2016-11-17 | 2023-10-17 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Egfr 또는 her2 엑손 20 돌연변이를 갖는 암 세포에 대한 항종양 활성을 갖는 화합물 |
EP3585814A4 (en) | 2017-02-22 | 2021-04-14 | University of Saskatchewan | EGFR LIAISON AGENTS AND THEIR USES |
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JP2021536507A (ja) | 2018-09-04 | 2021-12-27 | レイン セラピューティクス インコーポレイティド | Her駆動性がんを治療または予防するための化合物、組成物、及び方法 |
SG11202110669WA (en) | 2019-03-29 | 2021-10-28 | Univ Texas | Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 insertions |
CA3132819A1 (en) | 2019-04-17 | 2020-10-22 | Jacqulyne ROBICHAUX | Compounds against cancer bearing tyrosine kinase inhibitor resistant egfr mutations |
WO2020214831A1 (en) | 2019-04-17 | 2020-10-22 | Board Of Regents, The University Of Texas System | Compounds with anti-tumor activity against cancer cells bearing tyrosine kinase inhibitor resistant egfr mutations |
WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
-
2020
- 2020-02-24 JO JOP/2021/0233A patent/JOP20210233A1/ar unknown
- 2020-02-24 BR BR112021016149-0A patent/BR112021016149A2/pt unknown
- 2020-02-24 MA MA055089A patent/MA55089A/fr unknown
- 2020-02-24 WO PCT/IB2020/051559 patent/WO2020174370A2/en active Application Filing
- 2020-02-24 MX MX2021010265A patent/MX2021010265A/es unknown
- 2020-02-24 CA CA3131654A patent/CA3131654A1/en active Pending
- 2020-02-24 CN CN202080017112.1A patent/CN113840842A/zh active Pending
- 2020-02-24 KR KR1020217030301A patent/KR20210132117A/ko unknown
- 2020-02-24 US US16/798,662 patent/US11459391B2/en active Active
- 2020-02-24 JP JP2021549746A patent/JP2022521610A/ja active Pending
- 2020-02-24 EP EP20763439.5A patent/EP3931224A4/en active Pending
- 2020-02-24 AU AU2020229467A patent/AU2020229467A1/en active Pending
- 2020-02-24 SG SG11202108311RA patent/SG11202108311RA/en unknown
-
2021
- 2021-08-18 IL IL285718A patent/IL285718A/en unknown
-
2022
- 2022-08-03 US US17/817,295 patent/US20230130600A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3931224A2 (en) | 2022-01-05 |
MA55089A (fr) | 2022-01-05 |
US20230130600A1 (en) | 2023-04-27 |
WO2020174370A3 (en) | 2020-12-03 |
AU2020229467A1 (en) | 2021-08-12 |
CN113840842A (zh) | 2021-12-24 |
WO2020174370A2 (en) | 2020-09-03 |
JOP20210233A1 (ar) | 2023-01-30 |
CA3131654A1 (en) | 2020-09-03 |
EP3931224A4 (en) | 2023-03-01 |
KR20210132117A (ko) | 2021-11-03 |
BR112021016149A2 (pt) | 2021-10-13 |
US11459391B2 (en) | 2022-10-04 |
IL285718A (en) | 2021-10-31 |
US20200270351A1 (en) | 2020-08-27 |
MX2021010265A (es) | 2021-09-23 |
JP2022521610A (ja) | 2022-04-11 |
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