SG11202107441RA - Automated biomanufacturing systems, facilities, and processes - Google Patents

Automated biomanufacturing systems, facilities, and processes

Info

Publication number
SG11202107441RA
SG11202107441RA SG11202107441RA SG11202107441RA SG11202107441RA SG 11202107441R A SG11202107441R A SG 11202107441RA SG 11202107441R A SG11202107441R A SG 11202107441RA SG 11202107441R A SG11202107441R A SG 11202107441RA SG 11202107441R A SG11202107441R A SG 11202107441RA
Authority
SG
Singapore
Prior art keywords
facilities
automated
processes
biomanufacturing systems
biomanufacturing
Prior art date
Application number
SG11202107441RA
Other languages
English (en)
Inventor
Michael Vandiver
Eva Gefroh
Rebecca McCOY
Robert Piper
Mark Brower
Nuno Pinto
William Napoli
Rachel Straughn
Lisa Connell-Crowley
Megan Mcclure
Original Assignee
Just Evotec Biologics Inc
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Just Evotec Biologics Inc, Merck Sharp & Dohme filed Critical Just Evotec Biologics Inc
Publication of SG11202107441RA publication Critical patent/SG11202107441RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
SG11202107441RA 2019-02-15 2020-02-16 Automated biomanufacturing systems, facilities, and processes SG11202107441RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962806448P 2019-02-15 2019-02-15
PCT/US2020/018463 WO2020168315A1 (en) 2019-02-15 2020-02-16 Automated biomanufacturing systems, facilities, and processes

Publications (1)

Publication Number Publication Date
SG11202107441RA true SG11202107441RA (en) 2021-08-30

Family

ID=69845571

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107441RA SG11202107441RA (en) 2019-02-15 2020-02-16 Automated biomanufacturing systems, facilities, and processes

Country Status (11)

Country Link
US (4) US20220119757A1 (zh)
EP (1) EP3924458A1 (zh)
JP (1) JP2022520793A (zh)
KR (1) KR20210127947A (zh)
CN (1) CN113439118A (zh)
AU (1) AU2020223376A1 (zh)
BR (1) BR112021014582A2 (zh)
CA (1) CA3124711A1 (zh)
SG (1) SG11202107441RA (zh)
WO (1) WO2020168315A1 (zh)
ZA (1) ZA202106720B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3067735A1 (en) * 2017-08-17 2019-02-21 Just Biotherapeutics, Inc. Method of purifying glycosylated protein from host cell galectins and other contaminants
MX2023005058A (es) * 2020-11-09 2023-05-12 Amgen Inc Verificacion en proceso del estado de calibracion de las sondas de ph.
TW202237657A (zh) 2021-01-29 2022-10-01 美商默沙東藥廠 計畫性死亡受體1(pd-1)抗體之組合物及獲得該組合物之方法
EP4347778A1 (en) * 2021-05-26 2024-04-10 Simabs NV Integrated continuous bioprocess production platform
WO2023287707A1 (en) 2021-07-15 2023-01-19 Just-Evotec Biologics, Inc. Bidirectional tangential flow filtration (tff) perfusion system
US20230201817A1 (en) * 2021-12-23 2023-06-29 Biontech Delivery Technologies Gmbh Modular drug production system
WO2023154245A2 (en) 2022-02-10 2023-08-17 Just-Evotec Biologics, Inc. Depth filter and viral filter (df/vf) cart for batch and continuous processing
WO2023200918A1 (en) * 2022-04-14 2023-10-19 Terasaki Institute For Biomedical Innovation Systems and methods for recycling growth factors and other components

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
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ATE135397T1 (de) 1988-09-23 1996-03-15 Cetus Oncology Corp Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
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JP2002538841A (ja) 1999-03-18 2002-11-19 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ２７個のヒト分泌タンパク質
HUE032538T2 (en) * 2004-09-30 2017-10-30 Bayer Healthcare Llc Tools and procedures for the integrated, continuous production of biological molecules
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MX2015012114A (es) * 2013-03-08 2016-01-12 Genzyme Corp Fabricacion continua integrada de principios activos proteinicos terapeuticos.
WO2015003012A2 (en) * 2013-07-01 2015-01-08 Olivier Berteau Distributed perfusion bioreactor system for continuous culture of biological cells
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Also Published As

Publication number Publication date
EP3924458A1 (en) 2021-12-22
KR20210127947A (ko) 2021-10-25
ZA202106720B (en) 2022-07-27
US20220017851A1 (en) 2022-01-20
JP2022520793A (ja) 2022-04-01
US20220235311A1 (en) 2022-07-28
WO2020168315A1 (en) 2020-08-20
AU2020223376A9 (en) 2022-01-13
CA3124711A1 (en) 2020-08-20
US20220119757A1 (en) 2022-04-21
CN113439118A (zh) 2021-09-24
BR112021014582A2 (pt) 2021-10-05
US20220235312A1 (en) 2022-07-28
AU2020223376A1 (en) 2021-07-22

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