SG11202107259QA - Formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile - Google Patents
Formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrileInfo
- Publication number
- SG11202107259QA SG11202107259QA SG11202107259QA SG11202107259QA SG11202107259QA SG 11202107259Q A SG11202107259Q A SG 11202107259QA SG 11202107259Q A SG11202107259Q A SG 11202107259QA SG 11202107259Q A SG11202107259Q A SG 11202107259QA SG 11202107259Q A SG11202107259Q A SG 11202107259QA
- Authority
- SG
- Singapore
- Prior art keywords
- quinazolin
- benzonitrile
- oxo
- formulations
- isopropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962806705P | 2019-02-15 | 2019-02-15 | |
| PCT/IB2020/051211 WO2020165839A1 (fr) | 2019-02-15 | 2020-02-13 | Formulations de 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202107259QA true SG11202107259QA (en) | 2021-08-30 |
Family
ID=69740424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202107259QA SG11202107259QA (en) | 2019-02-15 | 2020-02-13 | Formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4h-quinazolin-3-yl)-benzonitrile |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US11478480B2 (fr) |
| EP (1) | EP3923912A1 (fr) |
| JP (5) | JP6994061B2 (fr) |
| KR (1) | KR20210127197A (fr) |
| CN (2) | CN117752662A (fr) |
| AU (2) | AU2020220957B2 (fr) |
| BR (1) | BR112021015737A2 (fr) |
| CA (1) | CA3130237A1 (fr) |
| CL (1) | CL2021002153A1 (fr) |
| CO (1) | CO2021010689A2 (fr) |
| CR (1) | CR20210428A (fr) |
| EC (1) | ECSP21059628A (fr) |
| IL (1) | IL284628A (fr) |
| JO (1) | JOP20210224A1 (fr) |
| MX (2) | MX2021009704A (fr) |
| PE (1) | PE20212106A1 (fr) |
| SA (1) | SA521430043B1 (fr) |
| SG (1) | SG11202107259QA (fr) |
| TW (1) | TWI827800B (fr) |
| WO (1) | WO2020165839A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6994061B2 (ja) * | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
| TW202045179A (zh) | 2019-02-15 | 2020-12-16 | 瑞士商諾華公司 | 治療眼表痛之方法 |
| TW202222298A (zh) * | 2020-10-07 | 2022-06-16 | 瑞士商諾華公司 | 含有可溶解的眼部插入物之藥物及其使用方法 |
| US20230159202A1 (en) * | 2021-11-23 | 2023-05-25 | Bausch + Lomb Ireland Limited | Method for making a preservative-free packaged ophthalmic device product |
| US20240197691A1 (en) * | 2022-12-15 | 2024-06-20 | Cn2 Therapeutics, Inc. | Tacrolimus compositions and methods of use |
| CN118340775A (zh) * | 2023-01-09 | 2024-07-16 | 维眸生物科技(浙江)有限公司 | 一种含vvn539的眼用组合物及其用途 |
Family Cites Families (43)
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| DE1280874B (de) | 1963-10-09 | 1968-10-24 | Boehringer Sohn Ingelheim | 2-Methyl-3-(2-dimethylaminophenyl)-8-amino-3H-chinazolon-(4) |
| US4027020A (en) | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US3931319A (en) | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4525346A (en) | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4836986A (en) | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5037647A (en) | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5145643A (en) | 1990-01-05 | 1992-09-08 | Allergan, Inc. | Nonoxidative ophthalmic compositions and methods for preserving and using same |
| US5300287A (en) | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| BR0014203A (pt) | 1999-09-24 | 2002-05-21 | Alcon Inc | Formulações de suspensão tópicas contendo ciprofloxacina e dexametasona |
| GB0412769D0 (en) | 2004-06-08 | 2004-07-07 | Novartis Ag | Organic compounds |
| TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| TWI409070B (zh) | 2005-11-04 | 2013-09-21 | Hydra Biosciences Inc | 用於調節ｔｒｐｖ３功能之化合物 |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| GB0525069D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| AU2006330883A1 (en) | 2005-12-22 | 2007-07-05 | Prolexys Pharmaceuticals, Inc. | 3-aryl-substituted quinazolones, and uses thereof |
| TW200738232A (en) | 2006-01-31 | 2007-10-16 | Alcon Mfg Ltd | Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma |
| EP1964548A1 (fr) | 2007-03-02 | 2008-09-03 | Novartis AG | Compositions pharmaceutiques comprenant un agent calcilytique |
| WO2008140750A1 (fr) | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Composés modulant la fonction du trp v3 |
| AU2008277627B2 (en) | 2007-07-18 | 2011-10-27 | Novartis Ag | Synergistic combinations of VR-1 antagonists and COX-2 inhibitors |
| TW200927192A (en) * | 2007-11-19 | 2009-07-01 | Alcon Res Ltd | Use of TRPV1 receptor antagonists for treating dry eye and ocular pain |
| WO2009081222A1 (fr) | 2007-12-21 | 2009-07-02 | Glenmark Pharmaceuticals, S.A. | Pyrimidines ou pyridines tricycliques substituées ligands des récepteurs des vanilloïdes |
| JP2011509296A (ja) | 2008-01-09 | 2011-03-24 | レノビス， インコーポレイテッド | イオンチャネルリガンドとしてのアミド誘導体およびそれを使用する薬学的組成物および方法 |
| WO2009090548A2 (fr) | 2008-01-17 | 2009-07-23 | Glenmark Pharmaceuticals, S.A. | Dérivés de 3-azabicyclo[3.1.0]hexane utilisés comme ligands des récepteurs vanilloïdes |
| US8394779B2 (en) | 2008-06-04 | 2013-03-12 | Children's Medical Center Corporation | Methods of modulating angiogenesis via TRPV4 |
| WO2010023512A1 (fr) | 2008-08-28 | 2010-03-04 | Matrix Laboratories Ltd. | Nouveaux modulateurs de récepteur vanilloïde, procédé pour leur préparation et compositions pharmaceutiques contenant ceux-ci |
| US8349852B2 (en) * | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| EP2316420B1 (fr) | 2009-10-22 | 2014-02-26 | Consorzio Universitario Unifarm | Composition ophthalmique topique pour réduire la douleur |
| EP2377850A1 (fr) | 2010-03-30 | 2011-10-19 | Pharmeste S.r.l. | Antagonistes de récepteur vanilloïde TRPV1 avec portion bicyclique |
| EP2627178B1 (fr) | 2010-10-11 | 2018-05-02 | Merck Sharp & Dohme Corp. | Composés de type quinazolinone convenant comme antagonistes de crth2 |
| CN102659629B (zh) * | 2012-02-14 | 2014-03-19 | 杭州华东医药集团新药研究院有限公司 | 化合物及其在制备埃罗替尼中的用途 |
| CN102875480A (zh) | 2012-04-23 | 2013-01-16 | 中国药科大学 | 喹唑啉酮类血管抑制剂、其制备方法及其医药用途 |
| GB201215857D0 (en) | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| NZ630759A (en) | 2013-03-15 | 2017-07-28 | Inotek Pharmaceuticals Corp | Ophthalmic formulations comprising an a1 agonist |
| US20150352176A1 (en) * | 2014-06-06 | 2015-12-10 | Newport Research, Inc. | Oil-free and fat-free aqueous suspensions of cyclosporin |
| WO2016016908A1 (fr) | 2014-07-28 | 2016-02-04 | Sun Pharma Advanced Research Company Limited | Méthode d'amélioration de la biodisponibilité et/ou de prolongement de l'action ophtalmique d'un médicament |
| WO2016042313A1 (fr) * | 2014-09-15 | 2016-03-24 | Verona Pharma Plc | Formulation liquide pour inhalation comprenant du rpl554 |
| PL4082531T3 (pl) | 2015-01-26 | 2024-04-08 | Bausch & Lomb Incorporated | Oftalmiczna kompozycja zawiesinowa |
| EP3515889A1 (fr) | 2016-09-20 | 2019-07-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Antagonistes de trpv4 |
| TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | Ｔｒｐｖ４拮抗劑 |
| BR112019005416A2 (pt) | 2016-09-20 | 2019-06-18 | Glaxosmithkline Ip No 2 Ltd | antagonistas de trpv4 |
| TW202045179A (zh) * | 2019-02-15 | 2020-12-16 | 瑞士商諾華公司 | 治療眼表痛之方法 |
| JP6994061B2 (ja) * | 2019-02-15 | 2022-01-14 | ノバルティス アーゲー | ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤 |
-
2020
- 2020-02-12 JP JP2020021093A patent/JP6994061B2/ja active Active
- 2020-02-13 JO JOP/2021/0224A patent/JOP20210224A1/ar unknown
- 2020-02-13 SG SG11202107259QA patent/SG11202107259QA/en unknown
- 2020-02-13 CN CN202310997308.7A patent/CN117752662A/zh active Pending
- 2020-02-13 CA CA3130237A patent/CA3130237A1/fr active Pending
- 2020-02-13 BR BR112021015737-9A patent/BR112021015737A2/pt unknown
- 2020-02-13 EP EP20708630.7A patent/EP3923912A1/fr active Pending
- 2020-02-13 PE PE2021001336A patent/PE20212106A1/es unknown
- 2020-02-13 JP JP2021547131A patent/JP2022520795A/ja active Pending
- 2020-02-13 CR CR20210428A patent/CR20210428A/es unknown
- 2020-02-13 TW TW109104510A patent/TWI827800B/zh active
- 2020-02-13 WO PCT/IB2020/051211 patent/WO2020165839A1/fr active Application Filing
- 2020-02-13 MX MX2021009704A patent/MX2021009704A/es unknown
- 2020-02-13 AU AU2020220957A patent/AU2020220957B2/en active Active
- 2020-02-13 CN CN202010091672.3A patent/CN111568906B/zh active Active
- 2020-02-13 KR KR1020217028995A patent/KR20210127197A/ko unknown
- 2020-02-13 US US16/789,976 patent/US11478480B2/en active Active
- 2020-08-24 US US17/000,953 patent/US20200390767A1/en not_active Abandoned
-
2021
- 2021-07-05 IL IL284628A patent/IL284628A/en unknown
- 2021-08-12 SA SA521430043A patent/SA521430043B1/ar unknown
- 2021-08-12 MX MX2024002989A patent/MX2024002989A/es unknown
- 2021-08-12 EC ECSENADI202159628A patent/ECSP21059628A/es unknown
- 2021-08-13 CO CONC2021/0010689A patent/CO2021010689A2/es unknown
- 2021-08-13 CL CL2021002153A patent/CL2021002153A1/es unknown
- 2021-10-06 JP JP2021164372A patent/JP7465453B2/ja active Active
-
2022
- 2022-09-08 US US17/930,578 patent/US20230139170A1/en active Pending
-
2023
- 2023-06-21 AU AU2023203933A patent/AU2023203933A1/en active Pending
- 2023-12-06 JP JP2023206043A patent/JP2024037806A/ja active Pending
-
2024
- 2024-03-14 JP JP2024039978A patent/JP2024095674A/ja active Pending
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