SG11202106977PA - Polypeptides useful for gene editing and methods of use - Google Patents
Polypeptides useful for gene editing and methods of useInfo
- Publication number
- SG11202106977PA SG11202106977PA SG11202106977PA SG11202106977PA SG11202106977PA SG 11202106977P A SG11202106977P A SG 11202106977PA SG 11202106977P A SG11202106977P A SG 11202106977PA SG 11202106977P A SG11202106977P A SG 11202106977PA SG 11202106977P A SG11202106977P A SG 11202106977PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- gene editing
- polypeptides useful
- polypeptides
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04004—Adenosine deaminase (3.5.4.4)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862785391P | 2018-12-27 | 2018-12-27 | |
| US201962790262P | 2019-01-09 | 2019-01-09 | |
| US201962790256P | 2019-01-09 | 2019-01-09 | |
| US201962790258P | 2019-01-09 | 2019-01-09 | |
| US201962790266P | 2019-01-09 | 2019-01-09 | |
| US201962790261P | 2019-01-09 | 2019-01-09 | |
| US201962932169P | 2019-11-07 | 2019-11-07 | |
| PCT/US2019/068079 WO2020139783A2 (en) | 2018-12-27 | 2019-12-20 | Polypeptides useful for gene editing and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202106977PA true SG11202106977PA (en) | 2021-07-29 |
Family
ID=69182752
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202106977PA SG11202106977PA (en) | 2018-12-27 | 2019-12-20 | Polypeptides useful for gene editing and methods of use |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20220145296A1 (enExample) |
| EP (2) | EP3902911B1 (enExample) |
| JP (3) | JP7572360B2 (enExample) |
| KR (1) | KR20210149686A (enExample) |
| CN (1) | CN113631704A (enExample) |
| AU (2) | AU2019416108B2 (enExample) |
| BR (1) | BR112021012665A2 (enExample) |
| ES (1) | ES2970169T3 (enExample) |
| IL (2) | IL312708A (enExample) |
| MX (1) | MX2021007835A (enExample) |
| NZ (1) | NZ778392A (enExample) |
| SG (1) | SG11202106977PA (enExample) |
| TW (1) | TW202039847A (enExample) |
| WO (1) | WO2020139783A2 (enExample) |
| ZA (1) | ZA202105281B (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL321042A (en) * | 2018-06-05 | 2025-07-01 | Lifeedit Therapeutics Inc | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| TW202208626A (zh) * | 2020-04-24 | 2022-03-01 | 美商生命編輯公司 | Rna引導核酸酶及其活性片段與變體，以及使用方法 |
| EP4176047A1 (en) | 2020-07-01 | 2023-05-10 | Elevatebio Technologies, Inc | Compositions and methods for cellular reprogramming using circular rna |
| CA3173949A1 (en) | 2020-07-15 | 2022-01-20 | LifeEDIT Therapeutics, Inc. | Uracil stabilizing proteins and active fragments and variants thereof and methods of use |
| JP7719172B2 (ja) | 2020-09-11 | 2025-08-05 | ライフ エディット セラピューティクス，インコーポレイティド | Ｄｎａ修飾酵素並びにその活性断片及びバリアント並びにその使用方法 |
| US20240301385A1 (en) | 2021-03-22 | 2024-09-12 | LifeEDIT Therapeutics, Inc. | Dna modifying enzymes and active fragments and variants thereof and methods of use |
| CN117729931A (zh) * | 2021-05-14 | 2024-03-19 | 比姆医疗股份有限公司 | 用于治疗转甲状腺素蛋白淀粉样变性的组合物和方法 |
| WO2022261394A1 (en) | 2021-06-11 | 2022-12-15 | LifeEDIT Therapeutics, Inc. | Rna polymerase iii promoters and methods of use |
| EP4101928A1 (en) * | 2021-06-11 | 2022-12-14 | Bayer AG | Type v rna programmable endonuclease systems |
| CA3222950A1 (en) * | 2021-06-11 | 2022-12-15 | Bayer Aktiengesellschaft | Type v rna programmable endonuclease systems |
| WO2023031856A1 (en) | 2021-09-02 | 2023-03-09 | Sanofi | Compositions and methods for rna affinity purification |
| WO2023057444A1 (en) | 2021-10-05 | 2023-04-13 | Sanofi | METHODS FOR FREEZING AND FREEZE-DRYING LIPID NANOPARTICLES (LNPs) AND LNPs OBTAINED WITH THE SAME |
| WO2023118068A1 (en) * | 2021-12-23 | 2023-06-29 | Bayer Aktiengesellschaft | Novel small type v rna programmable endonuclease systems |
| AU2023206629A1 (en) | 2022-01-17 | 2024-08-29 | Sanofi | Lipidic compounds, and uses thereof |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| EP4466349A1 (en) * | 2022-01-24 | 2024-11-27 | LifeEDIT Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| JP2025520538A (ja) | 2022-06-17 | 2025-07-03 | サノフィ パスツール インコーポレイテッド | 環状ｒｎａ親和性精製のための組成物及び方法 |
| AU2023311964A1 (en) | 2022-07-18 | 2025-01-30 | Renagade Therapeutics Management Inc. | Gene editing components, systems, and methods of use |
| KR20250058785A (ko) | 2022-08-12 | 2025-04-30 | 라이프 에디트 테라퓨틱스, 인크. | Rna-가이드된 뉴클레아제 및 그의 활성 단편 및 변이체 및 사용 방법 |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| CA3265664A1 (en) | 2022-08-25 | 2024-02-29 | Life Edit Therapeutics, Inc. | CHEMICAL MODIFICATION OF GUIDE RNA WITH A LOCKED NUCLEIC ACID FOR RNA-GUIDED NUCLEASE-MEDIATED GENE EDITING |
| KR20250126155A (ko) | 2022-11-04 | 2025-08-22 | 라이프 에디트 테라퓨틱스, 인크. | 내부 삽입 부위를 갖는 진화된 아데닌 데아미나제 및 rna-가이드 뉴클레아제 융합 단백질 및 사용 방법 |
| EP4634384A1 (en) | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target trac gene and methods of use |
| EP4634383A1 (en) | 2022-12-16 | 2025-10-22 | Life Edit Therapeutics, Inc. | Guide rnas that target foxp3 gene and methods of use |
| WO2024178397A2 (en) | 2023-02-24 | 2024-08-29 | Elevatebio Technologies, Inc. | Modified immune effector cells and methods of use |
| WO2024235991A1 (en) * | 2023-05-15 | 2024-11-21 | UCB Biopharma SRL | Rna-guided nucleases and nucleic acid targeting systems comprising such rna-guided nucleases |
| WO2025003344A1 (en) * | 2023-06-28 | 2025-01-02 | Alia Therapeutics Srl | Type ii cas proteins and applications thereof |
| WO2025022367A2 (en) | 2023-07-27 | 2025-01-30 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and active fragments and variants thereof and methods of use |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025083619A1 (en) | 2023-10-18 | 2025-04-24 | Life Edit Therapeutics, Inc. | Rna-guided nucleases and acive fragments and variants thereof and methods of use |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025174908A1 (en) | 2024-02-12 | 2025-08-21 | Life Edit Therapeutics, Inc. | Novel rna-guided nucleases and proteins for polymerase editing |
| WO2025231360A1 (en) * | 2024-05-03 | 2025-11-06 | Modernatx, Inc. | Novel cas nucleases and polynucleotides encoding the same |
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| JP2020505062A (ja) * | 2017-01-17 | 2020-02-20 | インスティテュート フォー ベーシック サイエンスＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｂａｓｉｃ Ｓｃｉｅｎｃｅ | Ｄｎａ一本鎖切断による塩基編集非標的位置確認方法 |
| EP3601576A1 (en) * | 2017-03-24 | 2020-02-05 | CureVac AG | Nucleic acids encoding crispr-associated proteins and uses thereof |
| EP3625342B1 (en) * | 2017-05-18 | 2022-08-24 | The Broad Institute, Inc. | Systems, methods, and compositions for targeted nucleic acid editing |
| AR114014A1 (es) * | 2017-12-22 | 2020-07-08 | Inst Genetics & Developmental Biology Cas | Sistema de edición de bases y método basado en proteína cpf1 |
| CN112961853B (zh) * | 2018-11-02 | 2024-09-06 | 中国科学院动物研究所 | 基于C2c1核酸酶的基因组编辑系统和方法 |
| TW202120688A (zh) * | 2019-08-12 | 2021-06-01 | 美商生命編輯公司 | Rna導引之核酸酶及其活性片段及變體以及使用方法 |
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| TW202039847A (zh) | 2020-11-01 |
| JP2024050676A (ja) | 2024-04-10 |
| US12188018B2 (en) | 2025-01-07 |
| US20250066783A1 (en) | 2025-02-27 |
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| ZA202105281B (en) | 2024-05-30 |
| US20220145296A1 (en) | 2022-05-12 |
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| JP7572360B2 (ja) | 2024-10-23 |
| US20230272398A1 (en) | 2023-08-31 |
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| JP2022516130A (ja) | 2022-02-24 |
| EP4339286A3 (en) | 2024-08-28 |
| CN113631704A (zh) | 2021-11-09 |
| EP3902911B1 (en) | 2023-12-13 |
| US20250092398A1 (en) | 2025-03-20 |
| AU2019416108B2 (en) | 2025-10-23 |
| NZ778392A (en) | 2025-11-28 |
| AU2019416108A1 (en) | 2021-08-12 |
| WO2020139783A2 (en) | 2020-07-02 |
| JP2024137967A (ja) | 2024-10-07 |
| IL284400A (en) | 2021-08-31 |
| ES2970169T3 (es) | 2024-05-27 |
| IL312708A (en) | 2024-07-01 |
| MX2021007835A (es) | 2021-08-11 |
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