JP7572360B2 - 遺伝子編集に有用なポリペプチドと利用方法 - Google Patents

遺伝子編集に有用なポリペプチドと利用方法 Download PDF

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JP7572360B2
JP7572360B2 JP2021538143A JP2021538143A JP7572360B2 JP 7572360 B2 JP7572360 B2 JP 7572360B2 JP 2021538143 A JP2021538143 A JP 2021538143A JP 2021538143 A JP2021538143 A JP 2021538143A JP 7572360 B2 JP7572360 B2 JP 7572360B2
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sequence
rgn
seq
polypeptide
rna
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JPWO2020139783A5 (enExample
JP2022516130A (ja
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ディー．ボーエン タイソン
ブライナー クローリー アレクサンドラ
ディー．エリック テッド
ムーア マーク
バーランゴー ロドルフ
ラスナー マイケル
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ライフエディット セラピューティクス，インコーポレイティド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04004—Adenosine deaminase (3.5.4.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021538143A 2018-12-27 2019-12-20 遺伝子編集に有用なポリペプチドと利用方法 Active JP7572360B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024008844A JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US201862785391P 2018-12-27 2018-12-27
US62/785,391 2018-12-27
US201962790258P 2019-01-09 2019-01-09
US201962790261P 2019-01-09 2019-01-09
US201962790262P 2019-01-09 2019-01-09
US201962790256P 2019-01-09 2019-01-09
US201962790266P 2019-01-09 2019-01-09
US62/790,262 2019-01-09
US62/790,266 2019-01-09
US62/790,258 2019-01-09
US62/790,256 2019-01-09
US62/790,261 2019-01-09
US201962932169P 2019-11-07 2019-11-07
US62/932,169 2019-11-07
PCT/US2019/068079 WO2020139783A2 (en) 2018-12-27 2019-12-20 Polypeptides useful for gene editing and methods of use

Related Child Applications (2)

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JP2024008844A Division JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A Division JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

Publications (3)

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JP2022516130A JP2022516130A (ja) 2022-02-24
JPWO2020139783A5 JPWO2020139783A5 (enExample) 2022-12-27
JP7572360B2 true JP7572360B2 (ja) 2024-10-23

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JP2021538143A Active JP7572360B2 (ja) 2018-12-27 2019-12-20 遺伝子編集に有用なポリペプチドと利用方法
JP2024008844A Pending JP2024050676A (ja) 2018-12-27 2024-01-24 遺伝子編集に有用なポリペプチドと利用方法
JP2024112452A Pending JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

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JP2024112452A Pending JP2024137967A (ja) 2018-12-27 2024-07-12 遺伝子編集に有用なポリペプチドと利用方法

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US (4) US20220145296A1 (enExample)
EP (2) EP3902911B1 (enExample)
JP (3) JP7572360B2 (enExample)
KR (1) KR20210149686A (enExample)
CN (1) CN113631704A (enExample)
AU (2) AU2019416108B2 (enExample)
BR (1) BR112021012665A2 (enExample)
ES (1) ES2970169T3 (enExample)
IL (2) IL312708A (enExample)
MX (1) MX2021007835A (enExample)
NZ (1) NZ778392A (enExample)
SG (1) SG11202106977PA (enExample)
TW (1) TW202039847A (enExample)
WO (1) WO2020139783A2 (enExample)
ZA (1) ZA202105281B (enExample)

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