SG11202101042SA - Gene therapy methods to control organ function - Google Patents

Gene therapy methods to control organ function

Info

Publication number
SG11202101042SA
SG11202101042SA SG11202101042SA SG11202101042SA SG11202101042SA SG 11202101042S A SG11202101042S A SG 11202101042SA SG 11202101042S A SG11202101042S A SG 11202101042SA SG 11202101042S A SG11202101042S A SG 11202101042SA SG 11202101042S A SG11202101042S A SG 11202101042SA
Authority
SG
Singapore
Prior art keywords
gene therapy
organ function
therapy methods
control organ
control
Prior art date
Application number
SG11202101042SA
Other languages
English (en)
Inventor
Roberta Marongiu
Michael G Kaplitt
Original Assignee
Univ Cornell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Cornell filed Critical Univ Cornell
Publication of SG11202101042SA publication Critical patent/SG11202101042SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1787—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11202101042SA 2018-07-31 2019-07-31 Gene therapy methods to control organ function SG11202101042SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862712669P 2018-07-31 2018-07-31
PCT/US2019/044290 WO2020028466A1 (fr) 2018-07-31 2019-07-31 Procédés de thérapie génique pour contrôler la fonction d'un organe

Publications (1)

Publication Number Publication Date
SG11202101042SA true SG11202101042SA (en) 2021-02-25

Family

ID=69230802

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202101042SA SG11202101042SA (en) 2018-07-31 2019-07-31 Gene therapy methods to control organ function

Country Status (14)

Country Link
US (1) US20210301306A1 (fr)
EP (1) EP3829718A4 (fr)
JP (2) JP2021533126A (fr)
KR (1) KR20210052450A (fr)
CN (1) CN113301956A (fr)
AU (1) AU2019315445A1 (fr)
BR (1) BR112021001878A2 (fr)
CA (1) CA3108324A1 (fr)
EA (1) EA202190358A1 (fr)
IL (1) IL280531A (fr)
MX (1) MX2021001336A (fr)
PH (1) PH12021550243A1 (fr)
SG (1) SG11202101042SA (fr)
WO (1) WO2020028466A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023019565A1 (fr) * 2021-08-20 2023-02-23 中国科学院深圳先进技术研究院 Procédé de contrôle de l'hétérogénéité de cellules endothéliales vasculaires à l'aide des nerfs sympathiques
CN116115758A (zh) * 2022-11-22 2023-05-16 上海市内分泌代谢病研究所 Gabaa受体作为靶点在制备或筛选降血脂、治疗肥胖和/或改善代谢的药物中的应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5378475A (en) 1991-02-21 1995-01-03 University Of Kentucky Research Foundation Sustained release drug delivery devices
US5814618A (en) 1993-06-14 1998-09-29 Basf Aktiengesellschaft Methods for regulating gene expression
US5464758A (en) 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
US6342390B1 (en) 1994-11-23 2002-01-29 The United States Of America As Represented By The Secretary Of Health And Human Services Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
FR2814642B1 (fr) 2000-10-03 2005-07-01 Ass Pour Le Dev De La Rech En Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee
US6723551B2 (en) 2001-11-09 2004-04-20 The United States Of America As Represented By The Department Of Health And Human Services Production of adeno-associated virus in insect cells
WO2005110039A2 (fr) 2004-05-07 2005-11-24 Applera Corporation Polymorphismes genetiques associes a des maladies vasculaires, procedes de detection et utilisations de ceux-ci
DK2359867T3 (en) * 2005-04-07 2015-01-05 Univ Pennsylvania A method for increasing an AAV vector function
GB201403684D0 (en) * 2014-03-03 2014-04-16 King S College London Vector
US10711270B2 (en) * 2014-10-03 2020-07-14 University Of Massachusetts High efficiency library-identified AAV vectors
KR20200108514A (ko) * 2015-09-17 2020-09-21 코다 바이오테라퓨틱스 인코포레이티드 신경 장애를 치료하기 위한 조성물 및 방법
WO2017136536A1 (fr) * 2016-02-02 2017-08-10 University Of Massachusetts Procédé pour améliorer l'efficacité de l'administration au système nerveux central d'un gène aav par voie systémique
US20170218842A1 (en) * 2016-02-02 2017-08-03 General Electric Company Adjusting Airflow Distortion in Gas Turbine Engine
JP6968331B2 (ja) * 2016-03-09 2021-11-17 アサフ，ファディ ニューロン性疾患の治療におけるニューロン調節のためのｄｒｅａｄｄの使用
MA44546B1 (fr) * 2016-06-15 2021-03-31 Univ California Virus adéno-associés variants et procédés d'utilisation
JPWO2018008770A1 (ja) * 2016-07-06 2019-04-18 厚範 神谷 末梢神経を操作する方法、脳および脊髄を除く臓器などにおいて神経細胞機能を変化させる機能を発生させる方法、および新規疾病の予防または治療方法、ならびに末梢神経投与用医薬
WO2021081201A1 (fr) * 2019-10-22 2021-04-29 Applied Genetic Technologies Corporation Systèmes de virus adéno-associés (vaa) pour le traitement de maladies ou de troubles neurodégénératifs associés à la progranuline

Also Published As

Publication number Publication date
EP3829718A4 (fr) 2022-06-22
WO2020028466A1 (fr) 2020-02-06
AU2019315445A1 (en) 2021-03-18
US20210301306A1 (en) 2021-09-30
IL280531A (en) 2021-03-25
JP2021533126A (ja) 2021-12-02
BR112021001878A2 (pt) 2021-04-27
CN113301956A (zh) 2021-08-24
JP2024041871A (ja) 2024-03-27
KR20210052450A (ko) 2021-05-10
EA202190358A1 (ru) 2021-05-04
MX2021001336A (es) 2021-09-10
EP3829718A1 (fr) 2021-06-09
PH12021550243A1 (en) 2021-11-22
CA3108324A1 (fr) 2020-02-06

Similar Documents

Publication Publication Date Title
MX2024004386A (es) Dianas terapeuticas para la correccion del gen de la distrofina humana por edicion genica y metodos de uso.
IL268894A (en) Medical RNA
IL282794A (en) therapeutic method
GB201804255D0 (en) Macrophage-based therapy
IL279685A (en) Gene therapy
PL3612237T3 (pl) Terapia genowa
EP3568694A4 (fr) Nanoconjugués de doxorubicine-or ciblés pour la thérapie antitumorale
EP3787693A4 (fr) Procédés de thérapie génique
ZA201907279B (en) Methods of pest control
IL280531A (en) Methods for gene therapy to control organ function
GB201905301D0 (en) Gene therapy
GB201707212D0 (en) Gene therapy for ciliopathies
GB201817470D0 (en) Gene therapy
GB201802326D0 (en) Gene therapy
GB201701968D0 (en) Gene therapy
EP3760209C0 (fr) Thérapie génique spécifique du siège d'une lésion ischémique
IL263085A (en) Garden healing
GB201817385D0 (en) Therapy
GB201820982D0 (en) Gene Therapy
GB201811541D0 (en) Gene therapy
GB201801511D0 (en) Gene therapy
IL289338A (en) Therapeutic interactions of leucomethylthionine
GB201819936D0 (en) Therapeutic methods
GB201907647D0 (en) Therapeutic methods
GB201904341D0 (en) Therapeutic methods